@article{scott_law_christiansen_lewbart_harms_2020, title={EVALUATION OF LOCALIZED INFLAMMATORY REACTIONS SECONDARY TO INTRAMUSCULAR INJECTIONS OF ENROFLOXACIN IN STRIPED BASS (MORONE SAXATILIS)}, volume={51}, ISSN={["1937-2825"]}, DOI={10.1638/2019-0096}, abstractNote={Abstract: Enrofloxacin is a fluoroquinolone widely used in animals including fish. Intramuscular (IM) injection of enrofloxacin is a feasible and efficacious option for drug delivery. In many species IM injection has been associated with injection site reactions and increases in serum muscle enzymes. Injection site reactions have not been well characterized in fish. Three groups of striped bass (Morone saxatilis) received an IM injection of enrofloxacin 2.27% in the right epaxial musculature 24, 48, or 96 hr prior to evaluation. Mean dose was 7.69 mg/ kg (6.14–9.69 mg/kg). The 24- and 48-hr groups received an injection of equal-volume 0.9% saline in the left epaxial musculature. A corresponding noninjected tissue sample was designated in the left epaxial musculature from each fish of the 96-hr group. Fish were euthanized and injection sites and noninjection control sites were evaluated grossly and histologically. Grades 1–4 were assigned to samples, with grade 1 corresponding to normal tissue and grades 2, 3, and 4 corresponding to mild, moderate, and severe inflammation and/or necrosis respectively. Externally, all control and injection sites appeared visually unremarkable. On cut surface, epaxial muscle of the enrofloxacin-injected tissue appeared moderately to severely hemorrhagic compared to saline and noninjected tissue, which was normal or mildly hemorrhagic. Histologically, eight of eight noninjected tissues were grade 1. For saline-injected tissues, 14 of 16 tissues were grade 2 and 2 samples were grade 3 when 24- and 48-hr groups were combined. For enrofloxacin-injected tissues, 8 of the 8 24-hr samples were grade 3 and 16 of the 16 48- and 96-hr samples were grade 4. These data show that IM injection of enrofloxacin 2.27% is associated with severe hemorrhage, necrosis, and inflammation in striped bass, and may negatively affect animal welfare.}, number={1}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Scott, Gregory and Law, Mac and Christiansen, Emily F. and Lewbart, Gregory A. and Harms, Craig A.}, year={2020}, month={Mar}, pages={46–52} }
 @article{risselada_tuohy_law_james_lascelles_2020, title={Local Administration of Carboplatin in Poloxamer 407 After an Ulnar Osteosarcoma Removal in a Dog}, volume={56}, ISSN={["1547-3317"]}, DOI={10.5326/JAAHA-MS-6926}, abstractNote={An 8 yr old male castrated hound presented for a left distal ulnar osteosarcoma. Staging (computed tomography and nuclear scintigraphy) did not reveal any metastases. A limb-sparing ulnectomy with local adjunctive carboplatin in a poloxamer copolymer gel (poloxamer 407) was performed. The patient recovered without complications after surgery. No wound healing complications or adverse effects occurred after local use of carboplatin in poloxamer 407. The local recurrence-free interval was 296 days from surgery, and the survival time was 445 days from initial diagnosis. This is the first report in the veterinary literature of using poloxamer 407 as a carrier for local delivery of chemotherapeutic drugs in a clinical patient.}, number={6}, journal={JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION}, author={Risselada, Marije and Tuohy, Joanne L. and Law, Mac and James, Mindi L. and Lascelles, B. Duncan X.}, year={2020}, pages={325–330} }
 @article{belcher_cline_conley_groeters_jefferson_law_mackey_suen_williams_dixon_et al._2019, title={Endocrine Disruption and Reproductive Pathology}, volume={47}, ISSN={["1533-1601"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85076490433&partnerID=MN8TOARS}, DOI={10.1177/0192623319879903}, abstractNote={During the past 20 years, investigations involving endocrine active substances (EAS) and reproductive toxicity have dominated the landscape of ecotoxicological research. This has occurred in concert with heightened awareness in the scientific community, general public, and governmental entities of the potential consequences of chemical perturbation in humans and wildlife. The exponential growth of experimentation in this field is fueled by our expanding knowledge into the complex nature of endocrine systems and the intricacy of their interactions with xenobiotic agents. Complicating factors include the ever-increasing number of novel receptors and alternate mechanistic pathways that have come to light, effects of chemical mixtures in the environment versus those of single EAS laboratory exposures, the challenge of differentiating endocrine disruption from direct cytotoxicity, and the potential for transgenerational effects. Although initially concerned with EAS effects chiefly in the thyroid glands and reproductive organs, it is now recognized that anthropomorphic substances may also adversely affect the nervous and immune systems via hormonal mechanisms and play substantial roles in metabolic diseases, such as type 2 diabetes and obesity.}, number={8}, journal={TOXICOLOGIC PATHOLOGY}, author={Belcher, Scott M. and Cline, J. Mark and Conley, Justin and Groeters, Sibylle and Jefferson, Wendy N. and Law, Mac and Mackey, Emily and Suen, Alisa A. and Williams, Carmen J. and Dixon, Darlene and et al.}, year={2019}, month={Dec}, pages={1049–1071} }
 @article{haschek_berenbaum_hinton_cora_chernoff_travlos_liu_lu_law_2019, title={Pathology in Ecological Research With Implications for One Health: Session Summary}, volume={47}, ISSN={["1533-1601"]}, DOI={10.1177/0192623319880530}, abstractNote={This session explored the effects of pollutants on One Health at the ecosystem level that included microbes, insects, fish, and humans. The concept of One Health seeks to synergize medical, veterinary, and other health science disciplines to more effectively advance human and animal health. Presentations explored the interactions of pesticides, pathogens, phytochemicals, and xenobiotic biotransformation in bee colony losses critical for food security (bees have been recently listed under the 2017 US Food and Drug Administration (FDA) veterinary feed directive); the role of pathology in identifying the effects of pollutants on fish as sentinels for human health; the effects in rats of per- and polyfluoroalkyl substances (PFAS) that can persist in the environment and contaminate drinking water; harmful algal blooms and toxin production leading to animal and human disease; and the processing of environmental carcinogens by intestinal microbiota.}, number={8}, journal={TOXICOLOGIC PATHOLOGY}, author={Haschek, Wanda M. and Berenbaum, May and Hinton, David E. and Cora, Michelle and Chernoff, Neil and Travlos, Gregory and Liu, Chih-Wei and Lu, Kun and Law, Mac}, year={2019}, month={Dec}, pages={1072–1075} }
 @article{barco_law_drummond_koopman_trapani_reinheimer_rose_swingle_williard_2016, title={Loggerhead turtles killed by vessel and fishery interaction in Virginia, USA, are healthy prior to death}, volume={555}, journal={Marine Ecology Progress Series}, author={Barco, S. and Law, M. and Drummond, B. and Koopman, H. and Trapani, C. and Reinheimer, S. and Rose, S. and Swingle, W. M. and Williard, A.}, year={2016}, pages={221–234} }
 @article{sackett_pow_rubino_aday_cope_kullman_rice_kwak_law_2015, title={Sources of endocrine-disrupting compounds in North Carolina waterways: A geographic information systems approach}, volume={34}, ISSN={0730-7268}, url={http://dx.doi.org/10.1002/ETC.2797}, DOI={10.1002/etc.2797}, abstractNote={The presence of endocrine‐disrupting compounds (EDCs), particularly estrogenic compounds, in the environment has drawn public attention across the globe, yet a clear understanding of the extent and distribution of estrogenic EDCs in surface waters and their relationship to potential sources is lacking. The objective of the present study was to identify and examine the potential input of estrogenic EDC sources in North Carolina water bodies using a geographic information system (GIS) mapping and analysis approach. Existing data from state and federal agencies were used to create point and nonpoint source maps depicting the cumulative contribution of potential sources of estrogenic EDCs to North Carolina surface waters. Water was collected from 33 sites (12 associated with potential point sources, 12 associated with potential nonpoint sources, and 9 reference), to validate the predictive results of the GIS analysis. Estrogenicity (measured as 17β‐estradiol equivalence) ranged from 0.06 ng/L to 56.9 ng/L. However, the majority of sites (88%) had water 17β‐estradiol concentrations below 1 ng/L. Sites associated with point and nonpoint sources had significantly higher 17β‐estradiol levels than reference sites. The results suggested that water 17β‐estradiol was reflective of GIS predictions, confirming the relevance of landscape‐level influences on water quality and validating the GIS approach to characterize such relationships. Environ Toxicol Chem 2014;9999:1–9. © 2014 SETAC}, number={2}, journal={Environmental Toxicology and Chemistry}, publisher={Wiley}, author={Sackett, Dana K. and Pow, Crystal Lee and Rubino, Matthew J. and Aday, D. Derek and Cope, W. Gregory and Kullman, Seth and Rice, James A. and Kwak, Thomas J. and Law, Mac}, year={2015}, month={Jan}, pages={437–445} }
 @article{law_stromberg_meuten_cullen_2011, title={Necropsy or Autopsy? It’s All About Communication!}, volume={49}, ISSN={0300-9858 1544-2217}, url={http://dx.doi.org/10.1177/0300985811410722}, DOI={10.1177/0300985811410722}, abstractNote={Several of us have decided that communication is more important than tradition. Yes, Virginia, we were all drilled in the discipline of veterinary pathology by traditionalists. We’re stubborn individualists, aren’t we? Greats like John King have necropsied thousands of animals, and we want our procedure to be distinguished from the ‘‘other’’ side—the RDs (well okay, the MDs). The short answer is that ‘‘necropsy’’ literally means ‘‘death examination’’ or examination of death and finds its application in the study of bodies following death. The term is general without reference to species. ‘‘Autopsy’’ literally means ‘‘self-examination,’’ and some of us were taught that the frame of reference for ‘‘self’’ referred to the postmortem examination of ‘‘ourselves’’ or our own species, humans. As such, postmortem examination of nonhumans was proscribed from using the term and was designated ‘‘necropsy.’’ But hold on there a minute, let’s see what Webster has to say. Or as Don Meuten likes to say, ‘‘Show me the reference!’’}, number={2}, journal={Veterinary Pathology}, publisher={SAGE Publications}, author={Law, M. and Stromberg, P. and Meuten, D. and Cullen, J.}, year={2011}, month={Jun}, pages={271–272} }
 @article{lombardini_law_lewis_2010, title={Nephroblastoma in two Siamese fighting fish Betta splendens}, volume={45}, number={3}, journal={Fish Pathology}, author={Lombardini, E. D. and Law, M. and Lewis, B. S.}, year={2010}, pages={137–139} }