Works (26)
Updated: April 3rd, 2024 17:10
2023 journal article
LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 11.
author keywords: lncRNA; Tuna; placental insufficiency; fetal growth restriction (FGR); Cadmium; Nrf2; oxidative stress
TL;DR:
The lncRNA Tuna is identified as a potential novel player in Cd-induced placental insufficiency and increases NRF2/NRF2 both at the transcript and protein levels, confirming that Tuna activates oxidative stress response genes through this pathway.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: July 3, 2023
2022 article
Epigenetic control of the imprinted growth regulator Cdkn1c in cadmium-induced placental dysfunction
Simmers, M. D., Hudson, K. M., Baptissart, M., & Cowley, M. (2022, July 1). EPIGENETICS, Vol. 7.
author keywords: Genomic imprinting; imprinted genes; DNA methylation; placenta; cadmium; foetal growth restriction; CDKN1C; toxic metal
TL;DR:
It is concluded that the Cd-associated increase in Cdkn1c expression can be fully explained by alterations to placental structure, and it is shown that CdKn1c is expressed primarily in the placental labyrinth which is proportionally increased in size in response to Cd.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: July 11, 2022
2022 article
Genomic map of candidate human imprint control regions: the imprintome
Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.
author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
TL;DR:
This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 11, 2022
2022 article
The imprinted gene Zac1 regulates steatosis in developmental cadmium-induced nonalcoholic fatty liver disease
Riegl, S. D., Starnes, C., Jima, D. D., Baptissart, M., Diehl, A. M., Belcher, S. M., & Cowley, M. (2022, October 6). TOXICOLOGICAL SCIENCES, Vol. 10.
author keywords: nonalcoholic fatty liver disease; developmental toxicology; epigenetics; cadmium; genomic imprinting; developmental programming
MeSH headings : Mice; Animals; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / metabolism; Cadmium; Cadmium Chloride / toxicity; PPAR gamma; Liver / metabolism; Fibrosis
TL;DR:
It is demonstrated that developmental Cd exposure is sufficient to program NAFLD in later life, and Zac1 and the IGN are established as key regulators of prosteatotic and profibrotic pathways, two of the major pathological hallmarks ofNAFLD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: October 29, 2022
2022 article
Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome
Baptissart, M., Bradish, C. M., Jones, B. S., Walsh, E., Tehrani, J., Marrero-Colon, V., … Cowley, M. (2022, February 28). HEPATOLOGY, Vol. 2.
MeSH headings : Animals; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Disease Models, Animal; Gene Regulatory Networks / genetics; Gene Regulatory Networks / physiology; Genes, Tumor Suppressor / physiology; Metabolic Syndrome / complications; Metabolic Syndrome / genetics; Metabolic Syndrome / metabolism; Mice; Non-alcoholic Fatty Liver Disease / complications; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism; Transforming Growth Factor beta1
TL;DR:
It is hypothesized that imprinted genes, defined by expression from a single parental allele, play a key role in maternal MetS‐induced NAFLD, due to their susceptibility to environmental stressors and their functions in liver homeostasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: March 28, 2022
2021 journal article
Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9.
author keywords: dopa decarboxylase; knock-out; imprinting; heart; mouse; human
TL;DR:
Comparative studies in the human developing heart reveal a paternal expression bias with polymorphic imprinting patterns between individual human hearts at DDC_EXON1a, a finding consistent with other imprinted genes in human.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: July 12, 2021
2021 journal article
Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Body Weight / drug effects; Body Weight / genetics; Cadmium / toxicity; Female; Fetal Development / drug effects; Fetal Development / genetics; Humans; Maternal Exposure; Metabolomics / methods; Mice; Mice, Inbred C57BL; Neurodevelopmental Disorders / chemically induced; Neurodevelopmental Disorders / genetics; Placenta / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Proteomics / methods; Transcriptome / genetics
TL;DR:
The identification of multiple pathways perturbed in the developing brain provides a basis for future studies determining the mechanistic links between maternal Cd exposure and altered neurodevelopment and behavior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 30, 2021
2020 journal article
Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing
NUCLEIC ACIDS RESEARCH, 48(15), 8349–8359.
MeSH headings : Animals; Cell Differentiation / genetics; Chromatin / genetics; CpG Islands / genetics; DNA Methylation / genetics; Epigenesis, Genetic; Genome / genetics; Histone Code / genetics; Humans; Promoter Regions, Genetic; Protein Processing, Post-Translational / genetics; Pseudogenes / genetics; RNA Precursors / genetics; RNA Precursors / metabolism; Transcription, Genetic
TL;DR:
It is suggested that iCGI transcription, rather than H3K36me3 or DNA methylation, interfere with host gene transcription and pre-mRNA processing genomewide and contributes to the spatiotemporal diversification of both the transcriptome and proteome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: October 19, 2020
2019 journal article
Maternal cadmium exposure in the mouse leads to increased heart weight at birth and programs susceptibility to hypertension in adulthood
SCIENTIFIC REPORTS, 9(1).
Contributors: K. Hudson n, S. Belcher n & n
MeSH headings : Animals; Animals, Newborn; Body Weight / drug effects; Cadmium / adverse effects; Disease Models, Animal; Female; Gene Expression Profiling / methods; Gene Expression Regulation / drug effects; Gene Regulatory Networks / drug effects; Heart / anatomy & histology; Heart / drug effects; Hypotension / chemically induced; Hypotension / genetics; Maternal Exposure / adverse effects; Metabolic Networks and Pathways / drug effects; Mice; Organ Size / drug effects; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Sequence Analysis, RNA
TL;DR:
It is proposed that a maternal Cd exposure-induced iron deficiency leads to altered cellular metabolic pathways and hypoxic conditions during fetal development; this stress may contribute to increased heart weight at birth and the programming of susceptibility to hypertension in adulthood.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 7, 2019
2019 journal article
Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study
EPIGENETICS, 14(4), 325–340.
author keywords: DNA methylation; epigenome-wide association study; maternal obesity; offspring body mass index; offspring blood pressure; cardiometabolic health; ALSPAC; NEST
MeSH headings : Adult; Blood Pressure; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / genetics; Child; Child, Preschool; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Genome-Wide Association Study; Humans; Infant, Newborn / blood; Infant, Newborn / growth & development; Male; Membrane Transport Proteins / genetics; Metabolic Syndrome / epidemiology; Metabolic Syndrome / genetics; Obesity / epidemiology; Obesity / genetics
TL;DR:
Findings suggest sex-specific effects at CpG sites of the TAPBP gene were associated with BMI z-score and systolic BP percentile in female and syStolic and diastolicBP percentile in male offspring, which, if causal, may explain observed sex- specific effects of maternal obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 29, 2019
2018 journal article
Effects of Cadmium Exposure on DNA Methylation at Imprinting Control Regions and Genome-Wide in Mothers and Newborn Children.
Environmental Health Perspectives, 3(3).
MeSH headings : Cadmium / toxicity; DNA Methylation / drug effects; DNA Methylation / genetics; Epigenesis, Genetic / drug effects; Epigenesis, Genetic / ethics; Female; Genomic Imprinting / drug effects; Genomic Imprinting / genetics; Humans; Infant, Newborn; Male; Mothers
TL;DR:
The findings suggest that ICRs may be hot spots for perturbation by Cadmium, motivating further study of these loci to investigate potential mechanisms of cadmium action and suggest that epigenetic changes may contribute to the etiology of cad mium-associated diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam
Proceedings of the Royal Society B: Biological Sciences, 285(1891), 20181237.
Contributors: M. Baptissart n, H. Lamb n, K. To n, C. Bradish n , J. Tehrani n, D. Reif n , n
MeSH headings : Animals; Animals, Newborn / physiology; Diet, High-Fat; Female; Maternal Behavior / physiology; Maternal Exposure; Mice / physiology; Mice, Inbred C57BL; Pregnancy
TL;DR:
In utero exposure to HF diet programmes physiological changes in the offspring which influence the maternal behaviours of their dam after birth are suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID
Added: December 10, 2018
2016 review
Regulatory links between imprinted genes: Evolutionary predictions and consequences
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Regulatory links between imprinted genes: evolutionary predictions and consequences.
author keywords: evolution; genomic imprinting; gene network; trans regulation
MeSH headings : Animals; Biological Evolution; Gene Regulatory Networks; Genomic Imprinting; Mammals / genetics
TL;DR:
An evolutionary view of these trans-regulatory effects provides a novel interpretation of the logic of gene networks within species and has implications for the origin of reproductive isolation between species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 28, 2022
2015 article
Coadaptation between Mother and Offspring: Why Not?
Wolf, J. B., Cowley, M., & Ward, A. (2015, March). PLOS BIOLOGY, Vol. 13.
MeSH headings : Animals; Body Size / genetics; Female; GRB10 Adaptor Protein / genetics
TL;DR:
A Formal Comment has challenged the interpretation of a study into an imprinted gene, maintaining that conflict, rather than mother-offspring co-adaptation, provides a better mechanistic explanation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: August 6, 2018
2014 journal article
Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes.
BMC Biology, 12, 771,
author keywords: Adiposity; Body proportions; Genomic imprinting; Glucose-regulated metabolism; Growth; Mouse genetics
MeSH headings : Absorptiometry, Photon; Adipose Tissue / metabolism; Animals; Calcium-Binding Proteins; Cell Proliferation; Female; Fetal Development / genetics; Fibroblasts / metabolism; G2 Phase; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Genomic Imprinting; Glucose Tolerance Test; History, Ancient; Insulin-Like Growth Factor II / genetics; Insulin-Like Growth Factor II / metabolism; Intercellular Signaling Peptides and Proteins / genetics; Intercellular Signaling Peptides and Proteins / metabolism; Liver / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; S Phase; Triglycerides / blood
TL;DR:
Genetic and physiological evidence is presented that Dlk1 and Grb10 define a mammalian growth axis that is separate from the IGF pathway, yet also features an antagonistic imprinted gene pair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 28, 2022
2014 journal article
Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.
PLoS Biology, 12(2), 1001799,
MeSH headings : Animals; Body Size / genetics; Female; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Gene Expression Regulation, Developmental; Genomic Imprinting; Karyopherins / physiology; Lactation / genetics; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear / physiology; STAT5 Transcription Factor / physiology
TL;DR:
A mouse genetic study reveals that a single gene acting in both mother and offspring has a central role in the uniquely mammalian phenomenon of nutrient provisioning through the placenta and the mammary gland.
(via Semantic Scholar)
Source: ORCID
Added: September 28, 2022
2013 journal article
Transposable elements re-wire and fine-tune the transcriptome.
9(1), 1003234.
MeSH headings : DNA Transposable Elements / genetics; Evolution, Molecular; Gene Expression Regulation; Genetic Variation; Humans; RNA, Messenger / genetics; Transcription, Genetic; Transcriptome / genetics
TL;DR:
How TEs—particularly retrotransposons—contribute to transcript diversity and consider their potential significance as a source of small RNAs that regulate host gene transcription are explored.
(via Semantic Scholar)
Source: ORCID
Added: September 28, 2022
2012 journal article
Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus.
40(18), 8917–8926.
MeSH headings : Alleles; Animals; DNA Methylation; Genetic Loci; Genomic Imprinting; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Nuclear Proteins; Polyadenylation; Protein Isoforms / genetics; Protein Isoforms / metabolism; RNA, Messenger / metabolism; Transcription, Genetic; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
TL;DR:
Changes in DNA methylation on the maternal allele at the Nap1l5 promoter increases the use of an internal Herc3 polyadenylation site and alters exon splicing, which demonstrate the influence of epigenetic mechanisms in regulating HerC3 alternative mRNA processing.
(via Semantic Scholar)
Source: ORCID
Added: September 28, 2022
2012 journal article
Protection against De Novo Methylation Is Instrumental in Maintaining Parent-of-Origin Methylation Inherited from the Gametes
Molecular Cell, 47(6), 909–920.
MeSH headings : Animals; Blastocyst / metabolism; Cadherins / genetics; DNA Methylation; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Fertilization; Genetic Testing; Genomic Imprinting; Germ Cells / metabolism; Mice; Oocytes / metabolism; Pseudogenes; Sequence Analysis, DNA
TL;DR:
Evidence is provided that protection against de novo methylation acts as an equal major pivot, at implantation and throughout life.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2012 journal article
Resetting for the Next Generation
Molecular Cell, 48(6), 819–821.
TL;DR:
In this issue of Molecular Cell, Seisenberger et al. (2012) refine DNA methylation mapping to interrogate the epigenetic reprogramming of primordial germ cells, defining the timings of methylation loss, linking to pluripotency, and identifying potential routes to transgenerational epigenetic inheritance.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2011 journal article
Distinct physiological and behavioural functions for parental alleles of imprinted Grb10
Nature, 469(7331), 534–538.
MeSH headings : Alleles; Animals; Behavior, Animal / physiology; Central Nervous System / embryology; Female; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Social Dominance
TL;DR:
It is demonstrated that within the brain Grb10 is expressed from the paternal allele from fetal life into adulthood and that ablation of this expression engenders increased social dominance specifically among other aspects of social behaviour, a finding supported by the observed increase in allogrooming by paternal Grb 10-deficient animals.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2011 journal article
Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes.
Nucleic Acids Research, 39(11), 4577–4586.
MeSH headings : Alleles; Animals; Chromatin / metabolism; DNA Methylation; Genomic Imprinting; Histones / metabolism; Humans; Mice; Promoter Regions, Genetic; Retroelements
TL;DR:
Two human retrogenes showed monoallelic enrichment of active, but not of repressive marks suggesting a partial uncoupling of the relationship between DNA methylation and repressive histone methylation, possibly due to the smaller size and lower CpG density of these DMRs.
(via Semantic Scholar)
Source: ORCID
Added: September 28, 2022
2011 journal article
Short interspersed element (SINE) depletion and long interspersed element (LINE) abundance are not features universally required for imprinting.
PloS One, 6(4), 18953.
MeSH headings : Alleles; Animals; DNA Methylation; Genomic Imprinting; Humans; Long Interspersed Nucleotide Elements / genetics; Mice; Mice, Inbred C57BL; Short Interspersed Nucleotide Elements / genetics
TL;DR:
The repeat element content of imprinted retrogene loci with non-imprinted controls that have a similar locus organisation is compared, suggesting that the paucity of SINEs and relative abundance of LINEs at imprinted loci reported by others is not a sequence feature universally required for imprinting.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: September 28, 2022
2010 journal article
Maternally-inherited Grb10 reduces placental size and efficiency
Developmental Biology, 337(1), 1–8.
author keywords: Adapter protein; Cell signalling; Epigenetics; Genomic imprinting; Growth factor receptor-bound protein; Growth regulation; IGF; Insulin-like growth factor; Mouse; Placenta
MeSH headings : Alleles; Animals; Endothelium / metabolism; Female; GRB10 Adaptor Protein / analysis; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / physiology; Genomic Imprinting; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Placenta / pathology; Placenta / physiology; Pregnancy
TL;DR:
It is shown that following disruption of the maternal allele in mice, the labyrinthine volume was increased in a manner consistent with a cell-autonomous function of Grb10 and the enlarged placenta was more efficient in supporting foetal growth, becoming the first example of a gene that acts to limit placental size and efficiency.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 28, 2020
2010 journal article
Retrotransposition and genomic imprinting.
9(4), 340–346.
author keywords: retrotransposition; retrogenes; genomic imprinting; epigenetics
MeSH headings : Animals; DNA Methylation / genetics; Epigenesis, Genetic / genetics; Genomic Imprinting / genetics; Humans; Models, Genetic; Retroelements / genetics
TL;DR:
A distinct class of imprinted genes, which have arisen by retrotransposition, and which have the potential to be used as models for the dissection of the fundamental features and mechanisms required for imprinting are reviewed.
(via Semantic Scholar)
Source: ORCID
Added: September 28, 2022
Employment
Updated: April 27th, 2021 20:36
2020 - present
North Carolina State University Raleigh, North Carolina, US
Associate Professor
Biological Sciences
2014 - 2020
North Carolina State University Raleigh, NC, US
Assistant Professor
Biological Sciences
2012 - 2014
King's College London London, London, GB
London Law Trust Medal Fellow
Medical & Molecular Genetics
2009 - 2012
King's College London London, London, GB
Postdoctoral Research Scholar
Medical & Molecular Genetics
Education
Updated: March 24th, 2017 15:40
2005 - 2009
University of Bath Bath, Bath and North East Somer, GB
Ph.D., Developmental Genetics
Biology & Biochemistry
2002 - 2005
University of Warwick Coventry, Coventry, GB
B.Sc. (Hons), Biological Sciences with Molecular Genetics
Biological Sciences
Funding History
Funding history based on the linked ORCID record. Updated: April 27th, 2021 20:37
grant
May 19, 2020 - March 31, 2025
The Imprinted Gene Network in the programming of Non-Alcoholic Fatty Liver Disease by early life cadmium exposure
National Institute of Environmental Health Sciences
grant
September 15, 2017 - August 31, 2020
Epigenetic mechanisms linking in utero cadmium exposure to hepatic steatosis
National Institute of Environmental Health Sciences
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