@article{gilger_crabtree_song_llanga_cullen_blanchard_salmon_patel_zarnitsyn_hirsch_2020, title={A Fixed-Depth Microneedle Enhances Reproducibility and Safety for Corneal Gene Therapy}, volume={39}, ISSN={["1536-4798"]}, DOI={10.1097/ICO.0000000000002182}, abstractNote={
            Purpose:
            Drug delivery directly to the corneal stroma currently relies on microscopic injections that demonstrate low reproducibility and clinician-dependent variability. With use of biological drugs such as adeno-associated viral (AAV) vectors, precise and consistent drug deposition is critical to reduce concerns related to off-target transduction and the host's immune response to the viral capsid and/or transgene-derived product. Therefore, a precise corneal injection (PCI) microneedle was designed to allow accurate depth-specific injections into the corneal stroma in a macroscopic setting.
          }, number={3}, journal={CORNEA}, author={Gilger, Brian C. and Crabtree, Elizabeth and Song, Liujiang and Llanga, Telmo and Cullen, Megan and Blanchard, Allison and Salmon, Jacklyn and Patel, Samirkumar and Zarnitsyn, Vladimir and Hirsch, Matthew}, year={2020}, month={Mar}, pages={362–369} }
 @article{crabtree_song_llanga_bower_cullen_salmon_hirsch_gilger_2019, title={AAV-mediated expression of HLA-G1/5 reduces severity of experimental autoimmune uveitis}, volume={9}, ISSN={2045-2322}, url={http://dx.doi.org/10.1038/s41598-019-56462-3}, DOI={10.1038/s41598-019-56462-3}, abstractNote={Abstract}, number={1}, journal={Scientific Reports}, publisher={Springer Science and Business Media LLC}, author={Crabtree, E. and Song, L. and Llanga, T. and Bower, J.J. and Cullen, M. and Salmon, J.H. and Hirsch, M.L. and Gilger, B.C.}, year={2019}, month={Dec}, pages={19864} }
 @article{cullen_jacob_cornish_vanderschel_cotter_cubeta_carbone_gilger_2019, title={Multi-locus DNA sequence analysis, antifungal agent susceptibility, and fungal keratitis outcome in horses from Southeastern United States}, volume={14}, ISSN={1932-6203}, url={http://dx.doi.org/10.1371/journal.pone.0214214}, DOI={10.1371/journal.pone.0214214}, abstractNote={Morphological characterization and multi-locus DNA sequence analysis of fungal isolates obtained from 32 clinical cases of equine fungal keratitis (FK) was performed to identify species and determine associations with antifungal susceptibility, response to therapy and clinical outcome. Two species of Aspergillus (A. flavus and A. fumigatus) and three species of Fusarium (F. falciforme, F. keratoplasticum, and F. proliferatum) were the most common fungi isolated and identified from FK horses. Most (91%) equine FK Fusarium nested within the Fusarium solani species complex (FSSC) with nine genetically diverse strains/lineages, while 83% of equine FK Aspergillus nested within the A. flavus clade with three genetically diverse lineages. Fungal species and evolutionary lineage were not associated with clinical outcome. However, species of equine FK Fusarium were more likely (p = 0.045) to be associated with stromal keratitis. Species of Aspergillus were more susceptible to voriconazole and terbinafine than species of Fusarium, while species of Fusarium were more susceptible to thiabendazole than species of Aspergillus. At the species level, A. fumigatus and A. flavus were more susceptible to voriconazole and terbinafine than F. falciforme. Natamycin susceptibility was higher for F. falciforme and A. fumigatus compared to A. flavus. Furthermore, F. falciforme was more susceptible to thiabendazole than A. flavus and A. fumigatus. These observed associations of antifungal sensitivity to natamycin, terbinafine, and thiabendazole demonstrate the importance of fungal identification to the species rather than genus level. The results of this study suggest that treatment of equine FK with antifungal agents requires accurate fungal species identification.}, number={3}, journal={PLOS ONE}, publisher={Public Library of Science (PLoS)}, author={Cullen, Megan and Jacob, Megan E. and Cornish, Vicki and VanderSchel, Ian Q. and Cotter, Henry Van T. and Cubeta, Marc A. and Carbone, Ignazio and Gilger, Brian C.}, editor={Kniemeyer, OlafEditor}, year={2019}, month={Mar}, pages={e0214214} }