Michael A. Timmers

Works (6)

Updated: July 5th, 2023 15:39

2021 article

Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models

Jacquet, A. de R., Ambaw, A., Tambe, M. A., Ma, S. Y., Timmers, M., Grace, M. H., … Rochet, J.-C. (2021, July 16). FOOD & FUNCTION, Vol. 7.

By: A. Jacquet *, A. Ambaw*, M. Tambe *, S. Ma  n, M. Timmers n, M. Grace , Q. Wu *, J. Simon * ...

MeSH headings : Animals; Astrocytes / drug effects; Cells, Cultured; Dietary Supplements; Dopaminergic Neurons / drug effects; Female; Humans; Isoflavones / pharmacology; Male; Models, Biological; Neuroprotective Agents / pharmacology; Parkinson Disease / metabolism; Phytochemicals / pharmacology; Rats; Rats, Sprague-Dawley; Soybeans / chemistry; Trifolium / chemistry
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 10, 2021

2017 journal article

Inter- and intra-seasonal changes in anthocyanin accumulation and global metabolite profiling of six blueberry genotypes

JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 59, 105–110.

By: M. Timmers n, M. Grace n , G. Yousef n & M. Lila n 

Contributors: M. Timmers n, M. Grace n , G. Yousef n & M. Lila n 

author keywords: Anthocyanin; HPLC; PCA; Blueberry; Metabolite profile; Genotype and seasonal variations; Food analysis; Food composition
TL;DR: Genotypes were easily distinguished from one another across each harvest season, indicating that each genotype had distinctly different metabolite profile, whereas each of the rabbiteye genotypes overlapped on the scores plot, indicating commonalities in metabolite profiles. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms

JOURNAL OF ETHNOPHARMACOLOGY, 206, 408–425.

By: A. Jacquet *, M. Timmers n, S. Ma  n, A. Thieme*, G. McCabe *, J. Vest*, M. Lila , J. Rochet *

MeSH headings : Humans; Indians, North American; Medicine, Traditional; Parkinson Disease / drug therapy; Parkinson Disease / physiopathology; Plants, Medicinal / chemistry
TL;DR: Analysis of contemporary herbal medicinal practices used by members of the Lumbee tribe to treat PD-related symptoms highlights potential therapeutic benefits of botanical extracts used in traditional Lumbee medicine, and provides insight into mechanisms by which an elderflower extract could suppress neurotoxicity elicited by environmental and genetic PD- related insults. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts

Food Chemistry, 210, 85–95.

By: M. Grace n , D. Esposito n , M. Timmers n, J. Xiong n , G. Yousef n, S. Komarnytsky n , M. Lila n 

Contributors: M. Grace n , D. Esposito n , M. Timmers n, J. Xiong n , G. Yousef n, S. Komarnytsky n , M. Lila n 

author keywords: Anacardic acids; Triterpene acids; Carotenoids; Tocopherols; Polyphenols; Anti-inflammatory
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / isolation & purification; Antioxidants / pharmacology; Cell Line; Dose-Response Relationship, Drug; Macrophages / drug effects; Macrophages / metabolism; Mice; Pistacia; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Reactive Oxygen Species / antagonists & inhibitors; Reactive Oxygen Species / metabolism
TL;DR: The P extract significantly decreased the non-mitochondrial oxidative burst associated with inflammatory response in macrophages and significantly inhibited the release of nitric oxide and reactive oxygen species in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2016 journal article

In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents

Food & Function, 7(10), 4285–4298.

By: M. Grace n , D. Esposito n , M. Timmers n, J. Xiong n , G. Yousef n, S. Komarnytsky n , M. Lila n 

Contributors: M. Grace n , D. Esposito n , M. Timmers n, J. Xiong n , G. Yousef n, S. Komarnytsky n , M. Lila n 

MeSH headings : Animals; Antioxidants; Cell Survival / drug effects; Cooking; Macrophages / drug effects; Macrophages / metabolism; Mice; Phytochemicals; Pistacia / chemistry; RAW 264.7 Cells; Reactive Oxygen Species; Respiratory Burst; Seeds / chemistry
TL;DR: The SNP had the strongest effect in decreasing non-mitochondrial oxidative burst associated with inflammatory response in macrophages, and was the most potent to inhibit the expression of COX2. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Characterization of Phenolic Compounds and Antioxidant and Antiinflammatory Activities from Mamuyo (Styrax ramirezii Greenm.) Fruit

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(48), 10459–10465.

By: M. Timmers n, J. Guerrero-Medina n, D. Esposito n , M. Grace n , O. Paredes-Lopez *, P. Garcia-Saucedo *, M. Ann Lila  n

Contributors: M. Timmers n, J. Guerrero-Medina n, D. Esposito n , M. Grace n , O. Paredes-López *, P. García-Saucedo *, M. Lila n 

author keywords: LC-TOF-MS; Styrax ramirezii; antioxidant activity; anti-inflammatory activity; norneolignan
MeSH headings : Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Cyclooxygenase 2 / immunology; Fruit / chemistry; Humans; Interleukin-1beta / immunology; Nitric Oxide / immunology; Nitric Oxide Synthase Type II / immunology; Nitric Oxide Synthase Type II / metabolism; Phenols / chemistry; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Reactive Oxygen Species / metabolism; Styrax / chemistry
TL;DR: Egonol potently inhibited the production of NO and also significantly reduced the release of ROS, suggesting the potential of S. ramirezii Greenm. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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