@article{wheatley_stowe_mochizuki_2023, title={Eosinophilic cavitary effusions in cats: 48 cases (2010-2020)}, volume={10}, ISSN={["1939-165X"]}, url={https://doi.org/10.1111/vcp.13295}, DOI={10.1111/vcp.13295}, abstractNote={AbstractBackgroundEosinophilic effusions are commonly defined as effusions with ≥10% eosinophils. Eosinophilic cavitary effusions are infrequently observed in cats, with few case reports comprising the majority of the recent literature.ObjectiveThe objective was to review disease associations of cats with eosinophilic cavitary effusions and to assess if a lower threshold of eosinophils (5%–9%) may warrant consideration of similar etiologies associated with effusions with ≥10% eosinophils.MethodsCytology reports were retrospectively reviewed for all feline cavitary effusions submitted for fluid analysis from 2010 to 2020 at a veterinary teaching hospital. Cases were included if the manual leukocyte differential included ≥5% eosinophils and separated into 5%–9% and ≥10% eosinophils groups. Patient records were reviewed for associated medical conditions.ResultsA total of 669 effusions were submitted from 579 cats; 50 effusions from 48 cats had a leukocyte differential with ≥5% eosinophils. The eosinophil proportion was ≥10% in 22 cats; the most common underlying cause was neoplasia (10/22, 45%), followed by inflammatory disease (4/22, 18%), cardiac disease (3/22, 14%), suspect neoplasia (3/22, 14%), and undetermined (2/22, 9%). The underlying causes for the 26 cats with 5%–9% eosinophils were similar; neoplasia (8/26, 31%), cardiac disease (6/26, 23%), inflammatory disease (4/26, 15%), suspect neoplasia (3/26, 12%), undetermined (3/26, 12%), and idiopathic chylothorax (2/26, 8%). Cats with eosinophil proportions ≥10% in the fluid exhibited peripheral eosinophilia more frequently (35%) compared to those with 5%–9% eosinophils (5%).ConclusionsConsistent with the current literature, neoplasia, particularly lymphoma, remains a primary consideration for cats with eosinophilic effusions. Previously unreported associated diseases included cardiovascular and inflammatory disorders. Our findings suggest an eosinophil differential of 5%–9% is seen with similar etiologies considered for classically defined eosinophilic effusions.}, journal={VETERINARY CLINICAL PATHOLOGY}, author={Wheatley, Meagan A. and Stowe, Devorah M. and Mochizuki, Hiroyuki}, year={2023}, month={Oct} }
 @article{wheatley_shamoun_maggi_breitschwerdt_sommer_cullen_stowe_2023, title={Eosinophilic pericardial effusion and pericarditis in a cat}, volume={9}, ISSN={["2055-1169"]}, DOI={10.1177/20551169231213498}, abstractNote={Case summary A 10-year-old domestic shorthair cat presented for lethargy, anorexia and labored breathing. Significant pleural and pericardial effusions prompted thoracocentesis and pericardiocentesis. Cytologic evaluation of the pericardial effusion revealed a highly cellular hemorrhagic, eosinophilic (12%) effusion, with many markedly atypical suspected mesothelial cells, interpreted as concerning for neoplasia. Thoracoscopic subtotal pericardiectomy and histology of the pericardium revealed predominantly eosinophilic inflammation with multifocal mesothelial hypertrophy and ulceration. A peripheral eosinophilia was not present on serial complete blood counts. Initial infectious disease testing was mostly negative. Toxoplasma gondii titers were most consistent with prior exposure, although reactivation could not be excluded. The owner’s medical history included a prior diagnosis of bartonellosis. Owing to the challenges of definitive Bartonella species exclusion, the cat was treated empirically with pradofloxacin and doxycycline, and a subtotal pericardectomy. There was improvement at first but pleural effusion recurred approximately 3 months after discharge. The cat was euthanized and a necropsy was not performed. Subsequent pericardial effusion Piroplasma/Bartonella/Borrelia droplet digital PCR detected DNA of Bartonella vinsonii subspecies berkhoffii, and peripheral blood culture and sequencing revealed a rare apicomplexan organism (90% homology with Colpodella species) of unknown clinical significance. Testing for filamentous bacteria and fungal pathogens was not performed. Relevance and novel information This case offers several unique entities – eosinophilic pericardial effusion and eosinophilic pericarditis of unknown etiology – and illustrates the well-known marked atypia that may occur in reactive and hyperplastic mesothelial cells, particularly of infrequently sampled and cytologically described feline pericardial effusion, supporting a cautious interpretation of this cytology finding. }, number={2}, journal={JOURNAL OF FELINE MEDICINE AND SURGERY OPEN REPORTS}, author={Wheatley, Meagan Alisa and Shamoun, John and Maggi, Ricardo and Breitschwerdt, Edward B. and Sommer, Samantha L. and Cullen, John M. and Stowe, Devorah Marks}, year={2023}, month={Jul} }
 @article{wheatley_stowe_2022, title={Incidental immitis; a microfilaria medley}, volume={51}, ISSN={0275-6382 1939-165X}, url={http://dx.doi.org/10.1111/vcp.13121}, DOI={10.1111/vcp.13121}, abstractNote={Veterinary Clinical PathologyVolume 51, Issue 1 p. 6-7 YESTERDAY • TODAY • TOMORROW Incidental immitis; a microfilaria medley Meagan A. Wheatley, Corresponding Author Meagan A. Wheatley mawheatl@ncsu.edu Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this authorDevorah M. Stowe, Devorah M. Stowe Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this author Meagan A. Wheatley, Corresponding Author Meagan A. Wheatley mawheatl@ncsu.edu Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this authorDevorah M. Stowe, Devorah M. Stowe Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this author First published: 25 March 2022 https://doi.org/10.1111/vcp.13121Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume51, Issue1March 2022Pages 6-7 RelatedInformation}, number={1}, journal={Veterinary Clinical Pathology}, publisher={Wiley}, author={Wheatley, Meagan A. and Stowe, Devorah M.}, year={2022}, month={Mar}, pages={6–7} }