Matthew Bruce Fisher

Works (53)

Updated: April 6th, 2024 05:01

2024 journal article

A Systems Approach to Biomechanics, Mechanobiology, and Biotransport

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 146(4).

By: S. Peirce-Cottler, E. Sander *, M. Fisher n, A. Deymier *, J. Ladisa *, G. O'Connell *, D. Corr *, B. Han * ...

Source: Web Of Science
Added: April 1, 2024

2023 journal article

Tendon Extracellular Matrix Promotes Myotendinous Junction Protein Expression in Engineered Muscle Tissue under Both Static and Mechanically Stimulated Culture Conditions

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2023.

By: L. Gaffney n, M. Fisher n & D. Freytes n

TL;DR: This research combined a relevant microenvironment to study muscle and tendon interactions with a novel bioreactor to apply mechanical strain, an important regulator of the formation and maintenance of the native MTJ. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 18, 2023

2022 journal article

A Direct Comparison of Node and Element-Based Finite Element Modeling Approaches to Study Tissue Growth

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 144(1).

By: D. Howe n, N. Dixit n, K. Saul n & M. Fisher n

MeSH headings : Bone and Bones; Finite Element Analysis; Models, Biological
TL;DR: The importance of the choice of implementation approach for modeling growth is illustrated, a framework for converting models between implementation approaches is provided, and important considerations for comparing results in prior work and developing new models of tissue growth are highlighted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 3, 2022

2022 journal article

Age- and Sex-Specific Joint Biomechanics in Response to Partial and Complete Anterior Cruciate Ligament Injury in the Porcine Model

JOURNAL OF ATHLETIC TRAINING, 57(9-10), 978–989.

By: D. Howe n, S. Cone  n, J. Piedrahita n, J. Spang* & M. Fisher n

author keywords: knee; transection studies; sex factors
MeSH headings : Male; Female; Humans; Animals; Swine; Anterior Cruciate Ligament Injuries / surgery; Anterior Cruciate Ligament / surgery; Anterior Cruciate Ligament / physiology; Biomechanical Phenomena; Joint Instability; Knee Joint; Cadaver
TL;DR: Increased forces in the MCL and medial meniscus after ACL transection suggest that rehabilitation protocols may need to focus on protecting these tissues, and operative treatment should be considered in active, late adolescent patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: March 6, 2023

2022 journal article

Differences in Gait Biomechanics Between Adolescents and Young Adults With Anterior Cruciate Ligament Reconstruction

JOURNAL OF ATHLETIC TRAINING, 57(9-10), 921–928.

By: C. Lisee *, E. Bjornsen *, W. Horton*, H. Davis-Wilson *, J. Blackburn *, M. Fisher n, B. Pietrosimone *

author keywords: knee; age; pediatric; youth
MeSH headings : Humans; Female; Young Adult; Adolescent; Adult; Biomechanical Phenomena; Case-Control Studies; Cross-Sectional Studies; Anterior Cruciate Ligament Injuries / surgery; Gait; Knee Joint / surgery; Anterior Cruciate Ligament Reconstruction / methods
TL;DR: Adolescents and adults demonstrated different gait patterns post-ACLR, suggesting that age may play a role in altered gait biomechanics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: March 6, 2023

2022 journal article

Effect of epitendinous suture augmentation to a double Krackow suture pattern for canine gastrocnemius tendon repair

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(7).

By: A. Downey  n, D. Duffy n, Y. Chang n, M. Fisher n & G. Moore *

MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Dog Diseases / surgery; Dogs; Suture Techniques / veterinary; Sutures / veterinary; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / surgery; Tensile Strength
TL;DR: Augmentation of a primary DK repair with an ES significantly improved construct strength in canine GT constructs while increasing loads required to cause 1- and 3-mm gap formation, respectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 27, 2022

2022 article

Elucidating the combinatorial effect of substrate stiffness and surface viscoelasticity on cellular phenotype

Chester, D., Lee, V., Wagner, P., Nordberg, M., Fisher, M. B., & Brown, A. C. (2022, February 1). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.

By: D. Chester n, V. Lee n, P. Wagner n, M. Nordberg n, M. Fisher n & A. Brown n

author keywords: loss tangent; mechanotransduction; microgel; viscoelasticity
MeSH headings : Biocompatible Materials / chemistry; Hydrogels / chemistry; Hydrogels / pharmacology; Mechanotransduction, Cellular / physiology; Phenotype; Viscosity
TL;DR: A novel composite hydrogel system capable of decoupling and individually controlling both the bulk stiffness and surface viscoelasticity of the material by combining polyacrylamide gels with microgel thin films is characterized, allowing for a greater understanding of cellular mechanotransduction mechanisms than previously possible through current model material platforms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 7, 2022

2022 article

Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials

Biehl, A., Martins, A. M. G. M., Davis, Z. G. G., Sze, D., Collins, L., Mora-Navarro, C., … Freytes, D. O. O. (2022, December 12). BIOMATERIALS SCIENCE, Vol. 12.

By: A. Biehl  n, A. Martins  n, Z. Davis n , D. Sze n, L. Collins n , C. Mora-Navarro *, M. Fisher n, D. Freytes n

MeSH headings : Tissue Engineering / methods; Proteomics; Extracellular Matrix / chemistry; Hydrogels / chemistry; Biocompatible Materials / analysis; Tissue Scaffolds
TL;DR: The present study is the first proof-of-concept towards the development of a standardized protocol that can be used to derive multiple ECM biomaterials via a previously established automated system and showed gelation and rheological properties consistent with previous ECM hydrogels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023

2021 article

Age- and sex-specific differences in ACL and ACL bundle size during adolescent growth

Cone, S. G., Barnes, R. H., Howe, D., Fordham, L. A., Fisher, M. B., & Spang, J. T. (2021, November 2). JOURNAL OF ORTHOPAEDIC RESEARCH.

By: S. Cone  n, R. Barnes *, D. Howe n, L. Fordham*, M. Fisher n & J. Spang*

author keywords: ACL; bundles; growth; MRI; pediatrics
MeSH headings : Adolescent; Animals; Anterior Cruciate Ligament / diagnostic imaging; Anterior Cruciate Ligament Injuries; Child; Female; Humans; Magnetic Resonance Imaging / methods; Male; Models, Animal; Retrospective Studies
TL;DR: Findings in the length and cross‐sectional area (CSA) of the ACL and its primary bundles in adolescent human subjects may point toward biomechanical changes in the adolescent human ACL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: November 15, 2021

2021 journal article

Biomechanical analysis of accessory tendon graft augmentation for primary gastrocnemius tendon reconstruction in dogs

VETERINARY SURGERY, 50(5), 1147–1156.

By: D. Duffy n, Y. Chang n, M. Fisher n & G. Moore *

MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Dog Diseases / surgery; Dogs; Hindlimb; Muscle, Skeletal / surgery; Orthopedic Procedures / veterinary; Plastic Surgery Procedures / veterinary; Suture Techniques / veterinary; Sutures / veterinary; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / surgery; Tensile Strength; Transplantation, Autologous / veterinary
TL;DR: Autologous ATG augmentation as an adjunct to primary GT repair increased yield, peak and failure forces by approximately 1.6% and 2.1% respectively, which justify studies to determine the effect of ATG on clinical function following graft harvest in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 24, 2021

2021 journal article

Biomechanical evaluation of a novel barbed suture pattern with epitendinous suture augmentation in a canine flexor tendon model

VETERINARY SURGERY, 50(5), 1128–1136.

By: D. Duffy n, Y. Chang n, M. Fisher n & G. Moore *

MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Dog Diseases / surgery; Dogs; Forelimb; Plastic Surgery Procedures / veterinary; Suture Techniques / veterinary; Sutures; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / surgery; Tenotomy / veterinary; Tensile Strength
TL;DR: The NBSP repair tested here may be advantageous over monofilament suture repair as it uses a similar-sized barbed core suture but eliminates the requirement for knot tying. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 17, 2021

2021 article

Ex vivo evaluation of novel core tenorrhaphy patterns in dogs

Chiu, K. W., Duffy, D. J., Chang, Y.-J., Gaffney, L., & Fisher, M. B. (2021, July 6). VETERINARY SURGERY.

By: K. Chiu n, D. Duffy n, Y. Chang n, L. Gaffney n & M. Fisher n

MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Dog Diseases; Dogs; Random Allocation; Suture Techniques / veterinary; Sutures / veterinary; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tensile Strength
TL;DR: Use of novel patterns ExDCrL, EmDCrl, and MTang improved resistance to loads and gap formation and were biomechanically superior compared to 3LP in healthy canine tendon repairs in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 12, 2021

2021 article

Extracellular Matrix Hydrogels Promote Expression of Muscle-Tendon Junction Proteins

Gaffney, L. S., Davis, Z. G., Mora-Navarro, C., Fisher, M. B., & Freytes, D. O. (2021, November 2). TISSUE ENGINEERING PART A, Vol. 11.

By: L. Gaffney n, Z. Davis n , C. Mora-Navarro  n, M. Fisher n & D. Freytes n

author keywords: extracellular matrix; engineered tissues; myotendinous junction; paxillin
MeSH headings : Collagen / metabolism; Collagen Type I / metabolism; Culture Media, Conditioned; Extracellular Matrix / metabolism; Hydrogels; Muscles; Paxillin / metabolism; Tendons / metabolism
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 15, 2021

2021 journal article

Processing variables of direct-write, near-field electrospinning impact size and morphology of gelatin fibers

Biomedical Materials, 16(4), 045017.

By: Z. Davis* , A. Hussain*  & M. Fisher*

author keywords: tissue engineering; gelatin; additive manufacturing; direct-write electrospinning; parametric control
MeSH headings : Biopolymers / chemistry; Electrochemical Techniques / methods; Gelatin / chemistry; Nanofibers / chemistry; Nanotechnology; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR: This system is capable of replicating the fibrous structure of musculoskeletal tissues with biologically relevant materials which will provide a durable platform for the analysis of single cell-fiber interactions to help better understand the impact scaffold materials and dimensions have on cell behavior. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: May 24, 2021

2021 article

Sex-specific biomechanics and morphology of the anterior cruciate ligament during skeletal growth in a porcine model

Howe, D., Cone, S. G., Piedrahita, J. A., Collins, B., Fordham, L. A., Griffith, E. H., … Fisher, M. B. (2021, November 9). JOURNAL OF ORTHOPAEDIC RESEARCH.

By: D. Howe n, S. Cone  n, J. Piedrahita n, B. Collins n, L. Fordham*, E. Griffith n, J. Spang*, M. Fisher n

author keywords: anterior cruciate ligament; knee; porcine model; skeletal growth
MeSH headings : Adolescent; Aged; Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Biomechanical Phenomena; Child; Female; Humans; Joint Instability; Knee Joint; Male; Swine; Tibia
TL;DR: A porcine model is used to investigate the sex-specific morphology and biomechanics of the ACL and its bundles throughout skeletal growth and has implications for age and sex‐specific surgical intervention strategies and suggests the need for human studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: November 15, 2021

2020 journal article

Biomechanical evaluation of an autologous flexor digitorum lateralis graft to augment the surgical repair of gastrocnemius tendon laceration in a canine ex vivo model

VETERINARY SURGERY, 49(8), 1545–1554.

By: D. Duffy n, C. Curcillo n, Y. Chang n, L. Gaffney n, M. Fisher n & G. Moore *

MeSH headings : Animals; Autografts / physiology; Biomechanical Phenomena; Cadaver; Dogs / injuries; Dogs / surgery; Lacerations / surgery; Lacerations / veterinary; Muscle, Skeletal / surgery; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / transplantation; Transplantation, Autologous / veterinary
TL;DR: Use of FDL tendon augmentation for GT laceration may increase repair site strength and resist gap formation better than 3LP core suture use alone and increase yield, peak, and failure forces by twofold, 2.3-fold and 2.2-fold compared with core 3LP alone while preventing the occurrence of gap formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 24, 2020

2020 journal article

Effect of partial vs complete circumferential epitendinous suture placement on the biomechanical properties and gap formation of canine cadaveric tendons

VETERINARY SURGERY, 49(8), 1571–1579.

By: D. Duffy n, Y. Chang n, M. Fisher n & G. Moore *

MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Dogs / injuries; Dogs / surgery; Plastic Surgery Procedures / veterinary; Suture Techniques / veterinary; Sutures / veterinary; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / surgery; Tensile Strength
TL;DR: Addition of a complete circumferential ES with a single or double knotting technique increased the biomechanical strength of normal tendon repairs while reducing gap formation compared with partial ES placement alone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 7, 2020

2020 journal article

High-Throughput Manufacture of 3D Fiber Scaffolds for Regenerative Medicine

TISSUE ENGINEERING PART C-METHODS, 26(7), 364–374.

By: R. Shirwaiker n , M. Fisher n, B. Anderson n, K. Schuchard n, P. Warren n, B. Maze n, P. Grondin n, F. Ligler n, B. Pourdeyhimi n 

author keywords: 3D printing; melt blowing; fibers; scaffolds
MeSH headings : Animals; Biocompatible Materials / chemistry; Dogs; Hernia / therapy; Herniorrhaphy / methods; Polymers / chemistry; Printing, Three-Dimensional / instrumentation; Regenerative Medicine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR: The 3DMB system described in this study is modified from larger nonwovens manufacturing machinery to accommodate the lower volume, high-cost polymers used for tissue engineering and implantable biomedical devices and has a fiber collection component that uses adaptable robotics to create scaffolds with predetermined geometries. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020

2020 journal article

Influence of barbed epitendinous suture combined with a core locking-loop sutures to repair experimental flexor tendon lacerations

VETERINARY SURGERY, 49(8), 1590–1599.

By: A. Eby n, D. Duffy n, Y. Chang n, L. Gaffney n, M. Fisher n & G. Moore *

MeSH headings : Animals; Cadaver; Dogs / injuries; Dogs / surgery; Lacerations / surgery; Lacerations / veterinary; Plastic Surgery Procedures / veterinary; Suture Techniques / veterinary; Sutures / veterinary; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / surgery; Tensile Strength
TL;DR: Investigating the influence of barbed epitendinous sutures on the biomechanical properties and gap formation of repaired canine tendons found Stratafix barbed suture performed better as an ES compared with other barbedSutures and similarly to monofilament suture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 28, 2020

2020 journal article

Joint laxity varies in response to partial and complete anterior cruciate ligament injuries throughout skeletal growth

JOURNAL OF BIOMECHANICS, 101.

By: S. Cone  n, E. Lambeth n, J. Piedrahita n, J. Spang* & M. Fisher n

author keywords: Anterior cruciate ligament; Pediatric; Injury; Joint mechanics; Animal model
MeSH headings : Animals; Anterior Cruciate Ligament Injuries / complications; Biomechanical Phenomena; Female; Joint Instability / complications; Joint Instability / physiopathology; Rotation; Stifle / growth & development; Stifle / physiopathology; Swine
TL;DR: At all ages, the medial collateral ligament and the medial meniscus combined to resist the majority of applied anterior tibial load following complete ACL transection, adding to the current understanding of age-specific functional properties of both healthy and injured knees during skeletal growth. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: March 23, 2020

2020 journal article

Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment

CONNECTIVE TISSUE RESEARCH, 61(2), 190–204.

By: P. Huebner  n, P. Warren n, D. Chester n, J. Spang*, A. Brown n, M. Fisher n, R. Shirwaiker n 

author keywords: 3D printing; atomic force microscopy; elastic modulus; tissue engineering; tissue scaffolds
MeSH headings : Animals; Bioprinting; Collagen / chemistry; Extracellular Matrix / chemistry; Male; Polyesters / chemistry; Printing, Three-Dimensional; Rats; Rats, Sprague-Dawley; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR: The findings demonstrate the significant effects of 3D-bioplotted scaffold microarchitectures in the organization and sub-tissue-level mechanical properties of ECM in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2019

2019 journal article

Biomechanical Function and Size of the Anteromedial and Posterolateral Bundles of the ACL Change Differently with Skeletal Growth in the Pig Model

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 477(9), 2161–2174.

By: S. Cone  n, E. Lambeth, H. Ru*, L. Fordham, J. Piedrahita*, J. Spang, M. Fisher*

MeSH headings : Aging / physiology; Animals; Anterior Cruciate Ligament / physiology; Biomechanical Phenomena; Cadaver; Models, Animal; Musculoskeletal Development / physiology; Range of Motion, Articular / physiology; Rotation; Swine; Tibia / physiology; Torque
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: February 17, 2020

2019 journal article

Effect of bite depth of an epitendinous suture on the biomechanical strength of repaired canine flexor tendons

AMERICAN JOURNAL OF VETERINARY RESEARCH, 80(11), 1043–1049.

By: D. Duffy n, Y. Chang n, L. Gaffney n, M. Fisher n & G. Moore *

MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Dogs / surgery; Suture Techniques / veterinary; Tendon Injuries; Tendons / surgery; Tensile Strength
TL;DR: Increasing bite depth of an epitendinous suture toward the center of the tendon substance increased repair site strength and decreased the incidence of gap formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 20, 2020

2019 journal article

In Situ Joint Stiffness Increases During Skeletal Growth but Decreases Following Partial and Complete Anterior Cruciate Ligament Injury

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 141(12).

By: S. Cone  n, J. Piedrahita n, J. Spang* & M. Fisher n

TL;DR: This work furthers the understanding of the interaction between joint biomechanics and ACL function throughout growth and the impact of ACL injury in the skeletally immature joint. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: January 27, 2020

2019 journal article

Mechanical Anisotropy Assessment in Kidney Cortex Using ARFI Peak Displacement: Preclinical Validation and Pilot In Vivo Clinical Results in Kidney Allografts

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 66(3), 551–562.

By: M. Hossain n, R. Detwiler*, E. Chang *, M. Caughey *, M. Fisher*, T. Nichols *, E. Merricks*, R. Raymer* ...

author keywords: Acoustic radiation force impulse (ARFI); anisotropy; chronic kidney disease (CKD); kidney transplant; renal rejection; shear wave elasticity imaging (SWEI); ultrasound
MeSH headings : Adult; Aged; Allografts / diagnostic imaging; Allografts / physiology; Animals; Anisotropy; Elastic Modulus / physiology; Elasticity Imaging Techniques / methods; Female; Humans; Kidney Cortex / diagnostic imaging; Kidney Cortex / physiology; Kidney Transplantation; Male; Middle Aged; Renal Insufficiency, Chronic / diagnostic imaging; Renal Insufficiency, Chronic / surgery; Swine
TL;DR: The results of this pilot clinical study suggest the feasibility of implementing symmetrical ARF to obviate mechanical anisotropy in the kidney cortex when anisOTropy is a confounding factor and implementing asymmetric ARF in the cortex of human kidney allografts to exploit mechanical an isotropy when mechanicalAnisotropic biomarker is a potentially relevant biomarker. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 2, 2019

2019 journal article

Parametric control of fiber morphology and tensile mechanics in scaffolds with high aspect ratio geometry produced via melt electrowriting for musculoskeletal soft tissue engineering

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 99, 153–160.

By: P. Warren n, Z. Davis n  & M. Fisher n

author keywords: Musculoskeletal soft tissue; Additive manufacturing; Scaffold geometry; Tissue engineering
MeSH headings : Anisotropy; Biomimetics; Collagen / chemistry; Electrochemistry; Extracellular Matrix / metabolism; Materials Testing; Temperature; Tensile Strength; Tissue Engineering / instrumentation; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR: The need to tailor MEW process parameters in scaffolds with high aspect ratio geometry in order to consistently generate specific structural and mechanical properties is highlighted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 30, 2019

2019 review

SIZE AND SHAPE OF THE HUMAN ANTERIOR CRUCIATE LIGAMENT AND THE IMPACT OF SEX AND SKELETAL GROWTH

[Review of ]. JBJS REVIEWS, 7(6).

By: S. Cone  n, D. Howe n & M. Fisher n

MeSH headings : Anterior Cruciate Ligament / anatomy & histology; Anterior Cruciate Ligament / physiology; Anterior Cruciate Ligament Injuries / surgery; Anterior Cruciate Ligament Reconstruction / methods; Bone Development / physiology; Decision Support Techniques; Evidence-Based Medicine / classification; Graft Survival; Humans; Qualitative Research; Sex Factors
TL;DR: The present study condenses measurements describing the geometry of the ACL, its individual bundles, and its insertion sites, accounting for common covariates when possible, to provide a resource to the clinical and scientific communities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: September 3, 2019

2019 journal article

Tissue-specific changes in size and shape of the ligaments and tendons of the porcine knee during post-natal growth

PLOS ONE, 14(10).

By: S. Cone  n, H. Piercy n, E. Lambeth n, H. Ru n, J. Piedrahita n, J. Spang*, L. Fordham*, M. Fisher n

MeSH headings : Animals; Anterior Cruciate Ligament / diagnostic imaging; Anterior Cruciate Ligament / growth & development; Female; Knee Joint / diagnostic imaging; Knee Joint / growth & development; Magnetic Resonance Imaging; Organ Specificity; Patellar Ligament / diagnostic imaging; Patellar Ligament / growth & development; Swine
TL;DR: The findings suggest that musculoskeletal soft tissue morphometry can vary within tissues of similar structure and within a single joint during post-natal growth. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: June 8, 2020

2017 journal article

Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model

TISSUE ENGINEERING PART C-METHODS, 23(11), 745–753.

By: C. Pfeifer *, M. Fisher*, V. Saxena*, M. Kim*, E. Henning*, D. Steinberg*, G. Dodge *, R. Mauck *

author keywords: subchondral bone; cartilage; microfracture; skeletal maturity
MeSH headings : Aging / physiology; Animals; Bone Remodeling; Cartilage, Articular / diagnostic imaging; Cartilage, Articular / pathology; Cartilage, Articular / surgery; Collagen Type II / metabolism; Disease Models, Animal; Fluoroscopy; Immunohistochemistry; Male; Proteoglycans / metabolism; Swine; Swine, Miniature; Wound Healing; X-Ray Microtomography
TL;DR: The significant impact of skeletal maturity on the propensity of subchondral bone to remodel as a result of chondral injury is shown to improve selection criteria for animal models for studying cartilage injury, repair, and treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Biphasic Finite Element Modeling Reconciles Mechanical Properties of Tissue-Engineered Cartilage Constructs Across Testing Platforms

TISSUE ENGINEERING PART A, 23(13-14), 663–674.

By: G. Meloni*, M. Fisher n, B. Stoeckl *, G. Dodge * & R. Mauck *

author keywords: mechanical evaluation; mesenchymal stem cells; cartilage tissue engineering
MeSH headings : Animals; Cartilage / chemistry; Cartilage / cytology; Cartilage / metabolism; Cattle; Finite Element Analysis; Tissue Engineering
TL;DR: Finite element (FE) models (using FEBio) of unconfined compression and indentation testing, modalities commonly used for in vitro grown samples, showed significant changes in material properties during the maturation of engineered cartilage tissue, capturing dynamic changes in functional tissue mechanics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Engineering 3D-Bioplotted scaffolds to induce aligned extracellular matrix deposition for musculoskeletal soft tissue replacement

CONNECTIVE TISSUE RESEARCH, 58(3-4), 342–354.

By: P. Warren n, P. Huebner  n, J. Spang*, R. Shirwaiker n  & M. Fisher n

Contributors: P. Warren n, P. Huebner  n, J. Spang*, R. Shirwaiker n  & M. Fisher n

author keywords: Biofabrication; meniscus; tissue engineering; scaffold; 3D printing
MeSH headings : Animals; Cell Count; Cell Shape; Collagen / metabolism; Extracellular Matrix / metabolism; Imaging, Three-Dimensional; Male; Musculoskeletal Physiological Phenomena; Rats, Sprague-Dawley; Regeneration / physiology; Sus scrofa; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR: The ability to use interstrand spacing as a means of controlling the formation of aligned collagen in vivo was demonstrated, which helps establish a design space for scaffold-based meniscus tissue engineering. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Macrophages' role in tissue disease and regeneration

Macrophages: Origin, Functions and Biointervention, 62, 245–271.

By: L. Gaffney, P. Warren, E. Wrona, M. Fisher & D. Freytes

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Orientation changes in the cruciate ligaments of the knee during skeletal growth: A porcine model

Journal of Orthopaedic Research, 35(12), 2725–2732.

By: S. Cone  n, S. Simpson n, J. Piedrahita n, L. Fordham*, J. Spang* & M. Fisher n

author keywords: anterior cruciate ligament; posterior cruciate ligament; adolescent; porcine; MRI
MeSH headings : Animals; Anterior Cruciate Ligament / diagnostic imaging; Anterior Cruciate Ligament / growth & development; Female; Magnetic Resonance Imaging; Posterior Cruciate Ligament / diagnostic imaging; Posterior Cruciate Ligament / growth & development; Swine
TL;DR: The age‐dependent properties of the ACL and PCL in the female pig mirrored results found in female human patients, suggesting that the porcine model may provide a pre‐clinical platform to study the cruciate ligaments during skeletal growth. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 review

Rise of the Pigs: Utilization of the Porcine Model to Study Musculoskeletal Biomechanics and Tissue Engineering During Skeletal Growth

[Review of ]. TISSUE ENGINEERING PART C-METHODS, 23(11), 763–780.

By: S. Cone  n, P. Warren n & M. Fisher n

author keywords: animal models; ligament and tendon; cartilage; bone; skeletal muscle
MeSH headings : Animals; Biomechanical Phenomena; Bone Development; Models, Animal; Musculoskeletal Physiological Phenomena; Regenerative Medicine; Sus scrofa; Tissue Engineering
TL;DR: This review explores the publication history of the use of pig models in biomechanics and TERM discuss interspecies comparative studies, highlight studies on the effect of skeletal growth and other biological considerations in the porcine model, and present challenges and emerging opportunities for using this model to study functional TERM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

3D-Bioprinting of Polylactic Acid (PLA) Nanofiber–Alginate Hydrogel Bioink Containing Human Adipose-Derived Stem Cells

ACS Biomaterials Science & Engineering, 2(10), 1732–1742.

By: L. Narayanan n, P. Huebner  n, M. Fisher n, J. Spang*, B. Starly n  & R. Shirwaiker n 

Contributors: L. Narayanan n, P. Huebner  n, M. Fisher n, J. Spang*, B. Starly n  & R. Shirwaiker n 

author keywords: bioprinting; knee meniscus; alginate; nanofibers; adipose-derived stem cells; musculoskeletal soft tissue
TL;DR: This study focuses on the development and proof-of-concept assessment of a fibrous bioink composed of alginate hydrogel, polylactic acid nanofibers, and human adipose-derived stem cells for bioprinting such tissue constructs and shows that the nanofiber-reinforced bioink allowed higher levels of cell proliferation within biopprinted strands. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model

CARTILAGE, 7(2), 174–184.

By: M. Fisher n, N. Belkin*, A. Milby*, E. Henning*, N. Soeegaard, M. Kim*, C. Pfeifer *, V. Saxena* ...

author keywords: cartilage; repair; mesenchymal stem cells; TGF-3; animal models
TL;DR: At this early healing time point, treatment with TGF-β3 promoted the formation of collagen type II within the defect, while allogeneic MSCs had little benefit. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Enhanced cellular infiltration of human adipose-derived stem cells in allograft menisci using a needle-punch method

Journal of Orthopaedic Surgery and Research, 11.

By: R. Nordberg, A. Charoenpanich, C. Vaughn, E. Griffith, M. Fisher, J. Cole, J. Spang, E. Loboa

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Engineering meniscus structure and function via multi-layered mesenchymal stem cell-seeded nanofibrous scaffolds

JOURNAL OF BIOMECHANICS, 48(8), 1412–1419.

By: M. Fisher n, E. Henning*, N. Soeegaard, M. Bostrom*, J. Esterhai* & R. Mauck *

author keywords: Tissue engineering; Meniscus; Nanofibrous scaffold; Electrospinning; Mechanical properties
MeSH headings : Animals; Cattle; Cells, Cultured; Collagen / metabolism; Elastic Modulus; Materials Testing; Menisci, Tibial / pathology; Mesenchymal Stem Cells / physiology; Nanofibers / chemistry; Polyesters / chemistry; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR: This study developed multi-lamellar mesenchymal stem cell-seeded nanofibrous constructs that may serve as functional substitutes for the meniscus as well as test beds to understand the complex mechanical principles that enable meniscUS function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Impact of guidance documents on translational large animal studies of cartilage repair

SCIENCE TRANSLATIONAL MEDICINE, 7(310).

By: C. Pfeifer *, M. Fisher n, J. Carey * & R. Mauck *

MeSH headings : Animals; Cartilage / physiopathology; Models, Animal; Translational Research, Biomedical; United States; United States Food and Drug Administration
TL;DR: A systematic review of large animal cartilage repair studies demonstrates that few investigators attend to guidance documents published by regulatory agencies, and the availability of the documents appears to have little effect on adherence by researchers to the recommendations therein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Meniscus mechanics and mechanobiology

Donahue, T. L. H., Fisher, M. B., & Maher, S. A. (2015, June 1). JOURNAL OF BIOMECHANICS, Vol. 48, pp. 1341–1342.

By: T. Donahue*, M. Fisher n & S. Maher*

UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Repair of dense connective tissues via biomaterial-mediated matrix reprogramming of the wound interface

Biomaterials, 39, 85–94.

By: F. Qu*, M. Pintauro*, J. Haughan *, E. Henning*, J. Esterhai*, T. Schaer *, R. Mauck *, M. Fisher*

author keywords: Connective tissue; Drug delivery; ECM (extracellular matrix); In vivo test; Scaffold; Wound healing
MeSH headings : Animals; Biocompatible Materials / chemistry; Connective Tissue / physiology; Microscopy, Atomic Force; Polyethylene Glycols / chemistry; Rats; Sheep; Tissue Scaffolds / chemistry; Wound Healing / physiology
TL;DR: Findings show that partial digestion of the wound interface improves repair by creating a more compliant and porous microenvironment that expedites cell migration to and/or proliferation at the wound margin. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2014 journal article

Functional properties of bone marrow-derived MSC-based engineered cartilage are unstable with very long-term in vitro culture

Journal of Biomechanics, 47(9), 2173–2182.

By: M. Farrell, M. Fisher*, A. Huang, J. Shin, K. Farrell & R. Mauck

author keywords: Mesenchymal stem cells; Chondrogenesis; Three-dimensional culture; Cartilage; Mechanical properties
MeSH headings : Animals; Bone Marrow Cells / cytology; Cartilage / cytology; Cartilage / metabolism; Cattle; Cell Survival; Cells, Cultured; Chondrocytes / cytology; Chondrogenesis; Femur; Glycosaminoglycans / metabolism; Hydrogels; Mesenchymal Stem Cells / cytology; Sepharose; Tissue Engineering / methods; Tissue Scaffolds
TL;DR: Data suggest that, even within a controlled in vitro environment that is conducive to chondrogenesis, there may be an innate instability in the MSC phenotype that is independent of scaffold composition, and may ultimately limit their application in functional cartilage repair. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2014 journal article

Maximizing cartilage formation and integration via a trajectory-based tissue engineering approach

Biomaterials, 35(7), 2140–2148.

By: M. Fisher*, E. Henning*, N. Söegaard*, G. Dodge *, D. Steinberg* & R. Mauck *

author keywords: Tissue engineering; Hyaluronic acid; Hydrogels; Cartilage; Integration; Maturation
MeSH headings : Animals; Cartilage / growth & development; Cattle; Tissue Engineering
TL;DR: It is shown that integration to cartilage in-vitro is not correlated to the maturation state of TE constructs, but rather their maturation rate, providing a proof-of-concept for the use of TB-TE to enhance treatment outcomes following cartilage injury. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2013 journal article

Biomaterial-mediated delivery of degradative enzymes to improve meniscus integration and repair

Acta Biomaterialia, 9(5), 6393–6402.

By: F. Qu*, J. Lin*, J. Esterhai*, M. Fisher* & R. Mauck *

author keywords: Drug delivery; Enzyme; Meniscus tear; Nanofibrous scaffold; Wound healing
MeSH headings : Animals; Biocompatible Materials; Cattle; Enzymes / administration & dosage; Enzymes / metabolism; Knee Joint / pathology; Microscopy, Electron, Scanning
TL;DR: An innovative approach to targeted enzyme delivery may aid the many patients that exhibit meniscal tears by promoting integration of the defect, thereby circumventing the pathologic consequences of partial meniscus removal, and may find widespread application in the treatment of injuries to a variety of dense connective tissues. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2013 journal article

Organized nanofibrous scaffolds that mimic the macroscopic and microscopic architecture of the knee meniscus

Acta Biomaterialia, 9(1), 4496–4504.

By: M. Fisher*, E. Henning*, N. Söegaard*, J. Esterhai* & R. Mauck *

author keywords: Tissue engineering; Meniscus; Nanofibrous scaffold; Electrospinning; Mechanical properties
MeSH headings : Materials Testing; Menisci, Tibial / anatomy & histology; Menisci, Tibial / ultrastructure; Microscopy, Electron, Scanning; Molecular Mimicry; Nanostructures; Tissue Engineering; Tissue Scaffolds
TL;DR: A novel electrospinning method to produce scaffolds composed of circumferentially aligned (CircAl) nanofibers, quantified their structure and mechanics, and compared them with traditional linearly aligned (LinAl) scaffolds will enable the formation of functional anatomic meniscus constructs. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2012 journal article

Potential of healing a transected anterior cruciate ligament with genetically modified extracellular matrix bioscaffolds in a goat model

Knee Surgery, Sports Traumatology, Arthroscopy, 20(7), 1357–1365.

By: M. Fisher*, R. Liang *, H. Jung *, K. Kim*, G. Zamarra*, A. Almarza *, P. McMahon*, S. Woo*

MeSH headings : Animals; Anterior Cruciate Ligament / surgery; Anterior Cruciate Ligament Injuries; Anterior Cruciate Ligament Reconstruction / methods; Biomechanical Phenomena; Extracellular Matrix; Galactosyltransferases / deficiency; Goats; Guided Tissue Regeneration; Hydrogel, Polyethylene Glycol Dimethacrylate; Materials Testing; Models, Animal; Prostheses and Implants; Swine; Tissue Engineering; Tissue Scaffolds
TL;DR: The application of an ECM bioscaffold and hydrogel was found to accelerate the healing of a transected ACL following suture repair in the goat model with limited tissue hypertrophy and improvement in some of its biomechanical properties. (via Semantic Scholar)
Source: Crossref
Added: February 7, 2021

2011 journal article

Alpha1,3-galactosyltransferase knockout does not alter the properties of porcine extracellular matrix bioscaffolds

Acta Biomaterialia, 7(4), 1719–1727.

By: R. Liang *, M. Fisher*, G. Yang *, C. Hall* & S. Woo*

author keywords: Extracellular matrix; Bioscaffold; Growth factors; alpha Gal
MeSH headings : Animals; Anterior Cruciate Ligament / metabolism; Anterior Cruciate Ligament / pathology; Biomechanical Phenomena; Blotting, Western; Bromodeoxyuridine / metabolism; Cell Proliferation; Extracellular Matrix / metabolism; Extracellular Matrix / pathology; Fibroblast Growth Factor 2 / metabolism; Galactosyltransferases / deficiency; Galactosyltransferases / metabolism; Gene Knockout Techniques; Humans; Immunohistochemistry; Intestinal Mucosa / pathology; Reproducibility of Results; Sus scrofa; Tissue Scaffolds / chemistry; Transforming Growth Factor beta1 / metabolism; Urinary Bladder / pathology
TL;DR: The multidisciplinary results suggest that genetic modification to eliminate the αGal epitopes in the ECM bioscaffolds had not altered the properties of these ECMBioscaffolding and, as such, they should retain their performance in tissue engineering in humans. (via Semantic Scholar)
Source: Crossref
Added: February 7, 2021

2011 journal article

Suture augmentation following ACL injury to restore the function of the ACL, MCL, and medial meniscus in the goat stifle joint

Journal of Biomechanics, 44(8), 1530–1535.

By: M. Fisher*, H. Jung *, P. McMahon* & S. Woo*

author keywords: Anterior cruciate ligament (ACL); Suture augmentation; Biomechanics; Robotic/UFS testing system
MeSH headings : Animals; Anterior Cruciate Ligament / surgery; Anterior Cruciate Ligament Injuries; Biomechanical Phenomena; Goats; Humans; Knee Injuries / pathology; Knee Injuries / surgery; Medial Collateral Ligament, Knee / injuries; Medial Collateral Ligament, Knee / surgery; Menisci, Tibial / surgery; Models, Anatomic; Robotics; Suture Techniques; Sutures; Tibia / pathology; Tibial Meniscus Injuries
TL;DR: Suture augmentation may be helpful in combination with FTE approaches for ACL healing by providing the needed initial joint stability while lowering the loads on the MM. (via Semantic Scholar)
Source: Crossref
Added: February 7, 2021

2011 journal article

The effects of multiple freeze-thaw cycles on the biomechanical properties of the human bone-patellar tendon-bone allograft

Journal of Orthopaedic Research, 29(8), 1193–1198.

By: H. Jung *, G. Vangipuram*, M. Fisher*, G. Yang *, S. Hsu *, J. Bianchi, C. Ronholdt, S. Woo*

author keywords: anterior cruciate ligament reconstruction; bone-patellar tendon-bone allograft; multiple freeze-thaw cycles; biomechanics
MeSH headings : Adult; Aged; Biomechanical Phenomena; Bone-Patellar Tendon-Bone Grafting; Cryopreservation; Female; Freezing; Humans; Male; Middle Aged; Patellar Ligament
TL;DR: It is suggested that the BPTB allografts used for anterior cruciate ligament reconstruction could potentially be re‐frozen without a loss in their biomechanical properties, given appropriate storage and care. (via Semantic Scholar)
Source: Crossref
Added: February 7, 2021

2010 journal article

Biomechanical evaluation of using one hamstrings tendon for ACL reconstruction: a human cadaveric study

Knee Surgery, Sports Traumatology, Arthroscopy, 18(1), 11–19.

By: G. Zamarra*, M. Fisher*, S. Woo* & G. Cerulli*

author keywords: ACL; ACL reconstruction; Semitendinosus tendon; Gracilis tendon; Knee kinematics; In situ forces in the ACL
MeSH headings : Adult; Anterior Cruciate Ligament / surgery; Anterior Cruciate Ligament Injuries; Biomechanical Phenomena; Cadaver; Humans; Knee Joint / physiology; Knee Joint / surgery; Middle Aged; Muscle, Skeletal / surgery; Orthopedic Procedures / methods; Range of Motion, Articular; Tendons / surgery; Tendons / transplantation; Transplantation, Autologous
TL;DR: The “All-inside” technique using either the semitendinosus or gracilis tendon for ACL reconstruction could satisfactorily restore time-zero knee kinematics and the in situ forces in either graft to those for the intact ACL, supporting clinical findings. (via Semantic Scholar)
Source: Crossref
Added: February 7, 2021

2010 journal article

Evaluation of bone tunnel placement for suture augmentation of an injured anterior cruciate ligament: Effects on joint stability in a goat model

Journal of Orthopaedic Research, 28(10), 1373–1379.

By: M. Fisher*, H. Jung *, P. McMahon* & S. Woo*

author keywords: anterior cruciate ligament (ACL); suture augmentation; biomechanics; robotic testing system
MeSH headings : Animals; Anterior Cruciate Ligament / physiopathology; Anterior Cruciate Ligament / surgery; Anterior Cruciate Ligament Injuries; Biomechanical Phenomena; Goats; Joint Instability / physiopathology; Joint Instability / surgery; Knee Joint / physiopathology; Knee Joint / surgery; Male; Models, Animal; Range of Motion, Articular / physiology; Suture Techniques; Treatment Outcome
TL;DR: Suture augmentation, when placed close to the ACL insertion, could be helpful in providing initial joint stability to aid ACL healing in the goat model. (via Semantic Scholar)
Source: Crossref
Added: February 7, 2021

2009 journal article

Future of Orthopaedic Sports Medicine and Soft Tissue Healing: The Important Role of Engineering

Cellular and Molecular Bioengineering, 2(3), 448–461.

By: S. Woo*, R. Liang * & M. Fisher*

author keywords: Orthopaedics; Ligaments; Tendons; Functional tissue engineering; Biomechanics
TL;DR: The history of fundamental work done to characterize their biomechanical properties is detailed and some recent advances using functional tissue engineering strategies, including the use of bioscaffolds, to improve the healing of medial collateral ligament, patellar tendon, and anterior cruciate ligament are highlighted. (via Semantic Scholar)
Source: Crossref
Added: February 7, 2021

2008 journal article

Low-Serum Media and Dynamic Deformational Loading in Tissue Engineering of Articular Cartilage

Annals of Biomedical Engineering, 36(5), 769–779.

By: T. Kelly *, M. Fisher*, E. Oswald*, T. Tai*, R. Mauck *, G. Ateshian *, C. Hung*

MeSH headings : Animals; Cartilage, Articular / cytology; Cartilage, Articular / growth & development; Cattle; Cell Culture Techniques / methods; Cells, Cultured; Chondrocytes / cytology; Chondrocytes / physiology; Chondrogenesis / physiology; Culture Media, Serum-Free / metabolism; Elasticity; Mechanotransduction, Cellular / physiology; Serum / metabolism; Stress, Mechanical; Tissue Engineering / methods
TL;DR: The results show that low serum/ITS supplementation does not support the same level of tissue formation as compared to high serum controls, and low-serum/ITS media produced significant enhancement in tissue properties compared to constructs grown continuously in 20%FBS. (via Semantic Scholar)
Source: Crossref
Added: February 7, 2021

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