Works (63)

Updated: April 4th, 2024 22:16

2014 journal article

Antiviral efficacy of nine nucleoside reverse transcriptase inhibitors against feline immunodeficiency virus in feline peripheral blood mononuclear cells

AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(3), 273–281.

By: A. Schwartz*, M. McCrackin, R. Schinazi, P. Hill, T. Vahlenkamp*, M. Tompkins*, K. Hartmann

MeSH headings : Animals; Antiviral Agents / pharmacology; Cats; Cell Line; Immunodeficiency Virus, Feline / drug effects; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / virology; Reverse Transcriptase Inhibitors / pharmacology
TL;DR: The evaluated NRTIs had low cytotoxicity against feline peripheral blood mononuclear cells and appeared to be safe options for further in vivo evaluation for the treatment of FIV-infected cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ / GARP-mediated mechanism

Virology Journal, 11(1), 7.

By: M. Miller n, C. Petty, M. Tompkins n & J. Fogle n

author keywords: FIV; HIV; AIDS; Lentivirus; Treg cells; mTGF beta; GARP
MeSH headings : Animals; CD4-Positive T-Lymphocytes / chemistry; CD4-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Interleukin-2 Receptor alpha Subunit / analysis; Membrane Proteins / metabolism; Signal Transduction; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / metabolism
TL;DR: Th to Treg conversion may initiate a cascade of events that contributes to the maintenance of virus reservoirs, progressive Th cell immunosuppression, and the development of immunodeficiency, all of which are central to the pathogenesis of AIDS lentivirus infections. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Lentivirus-Activated T Regulatory Cells Suppress T Helper Cell Interleukin-2 Production by Inhibiting Nuclear Factor of Activated T Cells 2 Binding to the Interleukin-2 Promoter

AIDS RESEARCH AND HUMAN RETROVIRUSES, 30(1), 58–66.

By: L. Meng n, M. Tompkins n, M. Miller n & J. Fogle n

MeSH headings : Amino Acid Sequence; Animals; Cats; Cell Proliferation; Cells, Cultured; Coculture Techniques; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / biosynthesis; Interleukin-2 / genetics; Lentivirus Infections / immunology; Lentivirus Infections / pathology; Lentivirus Infections / virology; Lymph Nodes / cytology; Lymph Nodes / virology; Lymphocyte Activation / immunology; Molecular Sequence Data; NFATC Transcription Factors / antagonists & inhibitors; NFATC Transcription Factors / genetics; Promoter Regions, Genetic / immunology; Protein Binding / immunology; RNA, Messenger / biosynthesis; Receptors, Transforming Growth Factor beta / biosynthesis; Sequence Alignment; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / virology; Transforming Growth Factor beta / biosynthesis; Transforming Growth Factor beta / pharmacology; Up-Regulation
TL;DR: Data suggest that TGF-β-mediated Treg cell suppression of IL-2 transcription is modulated through alterations in NFAT2 binding to the IL-1 promoter in suppressed Th cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Feline Glycoprotein A Repetitions Predominant Anchors Transforming Growth Factor Beta on the Surface of Activated CD4(+)CD25(+) Regulatory T Cells and Mediates AIDS Lentivirus-Induced T Cell Immunodeficiency

AIDS RESEARCH AND HUMAN RETROVIRUSES, 29(4), 641–651.

By: M. Miller n, J. Fogle n, P. Ross n & M. Tompkins n

MeSH headings : Amino Acid Sequence; Animals; Cats; Feline Acquired Immunodeficiency Syndrome / etiology; Feline Acquired Immunodeficiency Syndrome / immunology; Glycoproteins / genetics; Glycoproteins / immunology; Glycoproteins / metabolism; Humans; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / pathogenicity; Membrane Proteins / genetics; Membrane Proteins / immunology; Membrane Proteins / metabolism; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes / metabolism; Protein Conformation; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Homology, Amino Acid; Species Specificity; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / metabolism
TL;DR: It is demonstrated that the GARP(+) Treg cells from FIV-infected cats suppress T helper cells in vivo and that blocking GARP or TGFb eliminates this suppression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Infection with Feline Immunodeficiency Virus Directly Activates CD4+ CD25+ T Regulatory Cells

Journal of Virology, 87(16), 9373–9378.

By: M. Miller n, J. Fogle n & M. Tompkins n

MeSH headings : Animals; CD4-Positive T-Lymphocytes / chemistry; CD4-Positive T-Lymphocytes / immunology; Cats; Cells, Cultured; Gene Expression Profiling; Immunodeficiency Virus, Feline / immunology; Immunosuppression Therapy; Interleukin-2 Receptor alpha Subunit / analysis; T-Lymphocyte Subsets / chemistry; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology
TL;DR: In vitro feline immunodeficiency virus (FIV) infection, but not UV-inactivated virus, activates Treg cells as measured by immunosuppressive function and upregulation of GARP, FoxP3, and membrane-bound transforming growth factor β (TGF-β). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

Effects of stress associated with weaning on the adaptive immune system in pigs

JOURNAL OF ANIMAL SCIENCE, 90(2), 649–656.

By: A. Kick n, M. Tompkins n, W. Flowers n, C. Whisnant n & G. Almond n

author keywords: cortisol; immune cell; pig; weaning
MeSH headings : Adaptive Immunity / immunology; Animals; Animals, Suckling / blood; Animals, Suckling / immunology; B-Lymphocytes / immunology; Blood Cell Count / veterinary; Body Weight / immunology; Female; Flow Cytometry / veterinary; Hydrocortisone / blood; Least-Squares Analysis; Male; Neutrophils / immunology; Random Allocation; Swine / blood; Swine / immunology; T-Lymphocytes / immunology; Weaning
TL;DR: Early weaning did not negatively affect the adaptive immunological competence of pigs as determined by changes in populations of immune cells, and lymphocyte concentrations were less in weaned pigs on the day after weaning than in pigs remaining on the sow or weaned at a younger age. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Renal Disease in Cats Infected with Feline Immunodeficiency Virus

JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(2), 238–243.

By: K. Baxter, J. Levy*, C. Edinboro*, S. Vaden* & M. Tompkins n

author keywords: Azotemia; Glomerulonephropathy; Human immunodeficiency virus - associated nephropathy; Proteinuria
MeSH headings : Animals; Blood Urea Nitrogen; CD4-CD8 Ratio / veterinary; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cats; Creatinine / blood; Cross-Sectional Studies; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / complications; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Immunodeficiency Virus, Feline / isolation & purification; Kidney Diseases / blood; Kidney Diseases / immunology; Kidney Diseases / veterinary; Kidney Diseases / virology; Male; Prospective Studies; Proteinuria / veterinary; Retrospective Studies; Specific Pathogen-Free Organisms; Statistics, Nonparametric
TL;DR: Proteinuria but not azotemia was associated with natural FIV infection and neither neuter status nor health status were risk factors for proteinuria in FIV-infected cats, but UPC was positively correlated with the CD4+:CD8+ T lymphocyte ratio. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

BCR-ABL translocation in a dog with chronic monocytic leukemia

VETERINARY CLINICAL PATHOLOGY, 40(1), 40–47.

By: J. Cardona, R. Milner*, A. Alleman, C. Williams n, W. Vernau*, M. Breen n, M. Tompkins n

author keywords: FISH; flow cytometry; monocytosis; myeloproliferative disorder
MeSH headings : Animals; Bone Marrow Cells / pathology; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Flow Cytometry / veterinary; Leukemia, Myeloid / diagnosis; Leukemia, Myeloid / genetics; Leukemia, Myeloid / pathology; Leukemia, Myeloid / veterinary; Translocation, Genetic / genetics
TL;DR: Clinical and laboratory findings and the protracted course supported a diagnosis of chronic monocytic leukemia (CMoL), the first case of CMoL with a BCR-ABL chromosomal abnormalitiy described in dogs, and may have clinical implications for treatment of dogs with chronic leukemias associated with particular genetic mutations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Fozivudine Tidoxil as Single-Agent Therapy Decreases Plasma and Cell-Associated Viremia during Acute Feline Immunodeficiency Virus Infection

JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(3), 413–418.

By: J. Fogle n, W. Tompkins n, B. Campbell*, D. Sumner* & M. Tompkins n

author keywords: Acquired immunodeficiency syndrome; Antiretroviral therapy; Lentivirus; Zidovudine
MeSH headings : Animals; Antiviral Agents / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / virology; Cats; Immunodeficiency Virus, Feline / drug effects; Lentivirus Infections / drug therapy; Lipids / therapeutic use; Male; Specific Pathogen-Free Organisms; Viremia / drug therapy; Viremia / veterinary; Zidovudine / analogs & derivatives; Zidovudine / therapeutic use
TL;DR: Treatment of cats with FZD during the acute stage of FIV infection decreased plasma and cell-associated viremia during the first 2 weeks of infection, but was not protective against FIV, as all cats were infected by 6 weeks. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

CD4(+)CD25(+) T Regulatory Cells Inhibit CD8(+) IFN-gamma Production During Acute and Chronic FIV Infection Utilizing a Membrane TGF-beta-Dependent Mechanism

AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(2), 201–216.

By: J. Fogle n, A. Mexas*, W. Tompkins n & M. Tompkins n

MeSH headings : Animals; CD4 Antigens / analysis; CD8-Positive T-Lymphocytes / immunology; Cat Diseases / immunology; Cat Diseases / virology; Cats; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Interferon-gamma / antagonists & inhibitors; Interleukin-2 Receptor alpha Subunit / analysis; Lentivirus Infections / veterinary; Lentivirus Infections / virology; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / immunology
TL;DR: The results demonstrate the suppressive effect CD4(+)CD25(+) Treg cells have on the CD8(+) immune response during the acute and chronic stages of FIV infection and suggest that the mechanism of suppression may be mediated by mTGF-beta. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

CD4(+)CD25(+) T regulatory cells from FIV+ cats induce a unique anergic profile in CD8(+) lymphocyte targets

RETROVIROLOGY, 7.

By: J. Fogle n, W. Tompkins n & M. Tompkins n

MeSH headings : Animals; CD4 Antigens / immunology; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / metabolism; Cats; Cell Cycle / immunology; Clonal Anergy; Coculture Techniques; Down-Regulation; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline; Interleukin-2 Receptor alpha Subunit / immunology; T-Lymphocytes, Regulatory / immunology
TL;DR: It is suggested that CD4+CD25+ Treg cells from FIV+ cats induce CD8+ anergy by disruption of normal G1 to S cell cycle progression. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

CD4(+)CD25(+) regulatory T cells are infected and activated during acute FIV infection

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 126(3-4), 263–272.

By: A. Mexas n, J. Fogle n, W. Tompkins n & M. Tompkins n

author keywords: FIV; HIV; Regulatory T cells; Acute infection
MeSH headings : Animals; Cat Diseases / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Forkhead Transcription Factors / metabolism; Gene Expression Regulation / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes, Regulatory / virology; Viremia / veterinary
TL;DR: The hypothesis that early activation of Treg immunosuppressor function may limit an effective anti-FIV response is supported, contributing to the establishment of chronic infection and the immunodeficiency caused by this virus. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Endothelial cell suppression of peripheral blood mononuclear cell trafficking in vitro during acute exposure to feline immunodeficiency virus

CELL AND TISSUE RESEARCH, 334(1), 55–65.

By: L. Hudson*, M. Tompkins n & R. Meeker*

author keywords: HIV; astrocytes; microglia; monocyte; T cell; feline
MeSH headings : Animals; Astrocytes / immunology; Astrocytes / virology; B-Lymphocytes / immunology; B-Lymphocytes / virology; Brain / cytology; Brain / immunology; Brain / virology; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cats; Cell Movement / immunology; Cells, Cultured; Endothelial Cells / immunology; Endothelial Cells / virology; Immunodeficiency Virus, Feline; Leukocytes, Mononuclear / immunology; Leukocytes, Mononuclear / virology; Microglia / immunology; Microglia / virology
TL;DR: Initial exposure of PBMCs to FIV is sufficient to induce a general increase in trafficking, whereas initial exposure of endothelial cells to Fiv tends to down-regulate this effect. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

In vivo depletion of CD4(+)CD25(+) regulatory T cells in cats

JOURNAL OF IMMUNOLOGICAL METHODS, 329(1-2), 81–91.

By: S. Smithberg n, J. Fogle n, A. Mexas n, S. Reckling n, S. Lankford n, M. Tompkins n, G. Dean n

author keywords: regulatory T cell; FOXP3; feline immunodeficiency virus; monoclonal antibody
MeSH headings : Animals; Antibodies, Monoclonal; Antibody Formation; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Cells, Cultured; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Products, gag / pharmacology; Immunoglobulin G / blood; Immunologic Memory; Interleukin-2 Receptor alpha Subunit / immunology; Interleukin-2 Receptor alpha Subunit / metabolism; Lymphocyte Activation; Lymphocyte Depletion / methods; RNA, Messenger / metabolism; Recombinant Proteins / pharmacology; T-Lymphocytes, Regulatory / drug effects; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Time Factors
TL;DR: It is concluded that despite alterations in CD25+ cell levels during depletion, the feline immune system remains functional and a model for the study of disease pathogenesis in the context of reduced numbers of immunosuppressive CD4+CD25+ Tregs throughout the f cat system is demonstrated. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 article

Lentivirus-induced immune dysregulation

Tompkins, M. B., & Tompkins, W. A. (2008, May 15). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 123, pp. 45–55.

By: M. Tompkins n & W. Tompkins n

author keywords: FIV; AIDS; immune suppression; immune regulation
MeSH headings : Animals; Antibody Formation / immunology; Apoptosis / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunity, Cellular / immunology; Immunodeficiency Virus, Feline / immunology
TL;DR: FIV infection of cats provides a number of advantages over other lentivirus infections as a model to study this immune dysregulation, including polyclonal B cell responses, gradual replacement of naïve CD4 (+) and CD8(+) T cell phenotypes with activation phenotypes, and the chronic activation of CD4(+)CD25(-) Treg cells. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Transforming growth factor-beta/transforming growth factor-beta RII signaling may regulate CD4(+)CD25(+) T-regulatory cell homeostasis and suppressor function in feline AIDS lentivirus infection

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 47(2), 148–160.

By: C. Petty n, M. Tompkins n & W. Tompkins n

author keywords: AIDS; immunodeficiency diseases; other animals; T lymphocytes
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Cats; Cells, Cultured; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry; Gene Expression Regulation; Homeostasis; Interleukin-2 Receptor alpha Subunit / analysis; Leukocytes, Mononuclear / immunology; Protein Serine-Threonine Kinases / immunology; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta / immunology; Reverse Transcriptase Polymerase Chain Reaction; Specific Pathogen-Free Organisms; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / immunology
TL;DR: The data suggest that the recruitment of Treg cells from the Th pool and suppressor function of T Reg cells are dependent on the TGFβ/TGFβ-RII signaling pathway and that this pathway is constitutively upregulated in asymptomatic chronically FIV-infected cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery

JOURNAL OF NEUROVIROLOGY, 12(4), 294–306.

By: P. Liu n, L. Hudson n, M. Tompkins n, T. Vahlenkamp n, B. Colby n, C. Rundle*, R. Meeker*

author keywords: dementia; HIV; macrophages; T cells; viremia
MeSH headings : Animals; Brain Diseases / cerebrospinal fluid; Brain Diseases / immunology; Brain Diseases / virology; Cats; DNA, Viral / isolation & purification; Feline Acquired Immunodeficiency Syndrome / cerebrospinal fluid; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / isolation & purification; Lymphocyte Subsets / immunology; Macrophages / immunology; Macrophages / virology; RNA, Viral / blood; RNA, Viral / cerebrospinal fluid; Viral Load
TL;DR: Results indicate that free FIV circulating in the CSF promotes infection of the CNS and provides a highly efficient pathway for the transfer of infectious virus to the periphery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Compartmentalization and evolution of feline immunodeficiency virus between the central nervous system and periphery following intracerebroventricular or systemic inoculation

JOURNAL OF NEUROVIROLOGY, 12(4), 307–321.

By: P. Liu n, L. Hudson n, M. Tompkins n, T. Vahlenkamp n & R. Meeker*

author keywords: brain; cerebrospinal fluid; dementia; evolution; heteroduplex tracking assay; HIV
MeSH headings : Animals; Brain / virology; Cats; Central Nervous System Diseases / blood; Central Nervous System Diseases / cerebrospinal fluid; Central Nervous System Diseases / virology; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / cerebrospinal fluid; Feline Acquired Immunodeficiency Syndrome / virology; Genes, env; Heteroduplex Analysis; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / metabolism; Leukocytes, Mononuclear / virology; Peripheral Nervous System Diseases / blood; Peripheral Nervous System Diseases / cerebrospinal fluid; Peripheral Nervous System Diseases / virology; RNA, Viral / blood; RNA, Viral / cerebrospinal fluid
TL;DR: Early changes in virus evolution and compartmentalization between peripheral tissues and the central nervous system (CNS) after intracerebroventricular or intraperitoneal inoculation of animals with cell-free feline immunodeficiency virus (FIV) were tracked. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Astrocytes and microglia differentially regulate trafficking of lymphocyte subsets across brain endothelial cells

BRAIN RESEARCH, 1058(1-2), 148–160.

By: L. Hudson n, D. Bragg*, M. Tompkins n & R. Meeker*

author keywords: HIV; FIV; CD4 T cell; CD8 T cell; B cell; monocyte
MeSH headings : Animals; Astrocytes / cytology; Astrocytes / physiology; B-Lymphocytes / cytology; B-Lymphocytes / immunology; Blood-Brain Barrier / cytology; Blood-Brain Barrier / immunology; Blood-Brain Barrier / virology; Brain / blood supply; Brain / immunology; Brain / virology; Cats; Cell Communication / immunology; Cells, Cultured; Cerebral Arteries / cytology; Cerebral Arteries / immunology; Cerebral Arteries / virology; Chemotaxis, Leukocyte / immunology; Coculture Techniques; Endothelial Cells / cytology; Endothelial Cells / physiology; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / physiopathology; Immune Tolerance / immunology; Immunodeficiency Virus, Feline / immunology; Lymphocytes / cytology; Lymphocytes / immunology; Microglia / cytology; Microglia / physiology; Monocytes / cytology; Monocytes / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology
TL;DR: Interaction between the triad of endothelial cells, astrocytes, and microglia played an important, but varying, role in the trafficking of different PBMC subsets, with astroCytes having a positive effect on trafficking of PBMCs, whilemicroglia had a suppressive effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Different thresholds of T cell activation regulate FIV infection of CD4(+)CD25(+) and CD4(+)CD25(-) cells

VIROLOGY, 335(2), 212–221.

By: A. Joshi n, H. Garg n, M. Tompkins n & W. Tompkins n

author keywords: treg cells; latency; activation; reservoirs; HIV; FIV; IL-2
MeSH headings : Animals; Apoptosis; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD4-Positive T-Lymphocytes / virology; Cats; Cell Proliferation / drug effects; Cells, Cultured; Concanavalin A / pharmacology; Dose-Response Relationship, Drug; Immunodeficiency Virus, Feline / drug effects; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Interleukin-2 / pharmacology; Lymphocyte Activation / drug effects; Lymphocyte Activation / immunology; Mitogens / pharmacology; Receptors, Interleukin-2 / genetics; Receptors, Interleukin-2 / immunology; Receptors, Interleukin-2 / metabolism; Up-Regulation / drug effects; Virus Latency / drug effects; Virus Replication / drug effects
TL;DR: The results suggest that CD4(+)CD25(+) and CD4 (+)CD 25(+) T cells have different activation requirements which can be modulated by both viral and cytokine stimuli to reach threshold activation levels in order to harbor a productive FIV infection. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Preferential feline immunodeficiency virus (FIV) infection of CD4(+) CD25(+) T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors

JOURNAL OF VIROLOGY, 79(8), 4965–4976.

By: A. Joshi n, H. Garg n, M. Tompkins n & W. Tompkins n

MeSH headings : Animals; Benzylamines; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; Cats; Cells, Cultured; Cyclams; Feline Acquired Immunodeficiency Syndrome / immunology; Heterocyclic Compounds / pharmacology; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Lymph Nodes / immunology; Lymph Nodes / virology; Receptors, CXCR4 / antagonists & inhibitors; Receptors, CXCR4 / genetics; Receptors, Interleukin-2 / immunology; T-Lymphocytes / immunology; T-Lymphocytes / virology; Virus Replication
TL;DR: This is the first report elucidating the mechanisms that allow for productive lentiviral infection of CD4+ CD25+ Treg cells and constitutive and IL-2-responsive transactivation of activating transcription factor, CAAT enhancer binding protein, and activating protein 1 transcription factors that are important for FIV replication. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 article

The role of CD4(+)CD25(+) regulatory T cells in viral infections

Vahlenkamp, T. W., Tompkins, M. B., & Tompkins, W. A. F. (2005, October 18). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 108, pp. 219–225.

By: T. Vahlenkamp*, M. Tompkins n & W. Tompkins n

author keywords: regulatory T cells; viral infection; immune regulation; immunosuppression
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Herpesviridae Infections / immunology; Immune Tolerance; Lymphocyte Activation; Mice; Picornaviridae Infections / immunology; Receptors, Interleukin-2 / metabolism; Retroviridae Infections / immunology; T-Lymphocyte Subsets / immunology; Virus Diseases / immunology
TL;DR: The findings that T reg cells influence the functional immunity during viral infections might indicate that, in some cases, virus-specific T reg Cells not only influence immune pathology or prevent pathogen elimination but also can promote a generalized state of immunosuppression in vivo such that the host is more susceptible to secondary infections with other pathogens or has reduced resistance to tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Antinuclear antibodies can be detected in dog sera reactive to Bartonella vinsonii subsp berkhoffii, Ehrlichia canis, or Leishmania infantum antigens

JOURNAL OF VETERINARY INTERNAL MEDICINE, 18(1), 47–51.

By: B. Smith, M. Tompkins* & E. Breitschwerdt*

author keywords: autoimmunity; systemic lupus erythematous
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

B7(+)CTLA4(+) T cells engage in T-T cell interactions that mediate apoptosis: a model for lentivirus-induced T cell depletion

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(3-4), 203–214.

By: T. Vahlenkamp n, M. Bull n, J. Dow n, E. Collisson*, B. Winslow, A. Phadke*, W. Tompkins n, M. Tompkins n

author keywords: FIV; apoptosis; 137 costimulatory molecules; CTLA4
MeSH headings : Animals; Antigens, CD / biosynthesis; Antigens, CD / immunology; Antigens, Differentiation / biosynthesis; Antigens, Differentiation / immunology; Apoptosis / immunology; B7-1 Antigen / biosynthesis; B7-1 Antigen / immunology; B7-2 Antigen; CTLA-4 Antigen; Cats; Cell Communication / immunology; Concanavalin A / immunology; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Immunodeficiency Virus, Feline / immunology; In Situ Nick-End Labeling / veterinary; Ionomycin / immunology; Lymphocyte Activation / immunology; Membrane Glycoproteins / biosynthesis; Membrane Glycoproteins / immunology; Specific Pathogen-Free Organisms; T-Lymphocytes / immunology; T-Lymphocytes / virology; Tetradecanoylphorbol Acetate / immunology
TL;DR: The hypothesis that the chronic expansion of B7+CTLA4+ LN T cells in infected cats allows for T-T cell interactions resulting in T cell depletion and eventually the development of AIDS is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Failure of FIV-infected cats to control Toxoplasma gondii correlates with reduced IL2, IL6, and IL12 and elevated IL10 expression by lymph node T cells

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 98(1-2), 101–111.

By: J. Levy*, Y. Liang n, J. Ritchey*, M. Davidson n, W. Tompkins n & M. Tompkins n

author keywords: FIV; cytokine; Toxoplasma gondii
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cat Diseases / genetics; Cat Diseases / immunology; Cats; Gene Expression; Immunodeficiency Virus, Feline; Interleukin-10 / genetics; Interleukin-12 / genetics; Interleukin-2 / genetics; Interleukin-6 / genetics; Interleukins / genetics; Lentivirus Infections / complications; Lentivirus Infections / genetics; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; RNA, Messenger / genetics; RNA, Messenger / metabolism; T-Lymphocytes / immunology; Toxoplasmosis, Animal / complications; Toxoplasmosis, Animal / genetics; Toxoplasmosis, Animal / immunology
TL;DR: Elevated IL10 may suppress a Th1 cytokine response to T. gondii challenge, and control and FIV-infected cats showed increased expression of IL2, IFNgamma, IL10, IL12, and IL6 mRNAs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4(+)CD25(+) T regulatory cells

JOURNAL OF IMMUNOLOGY, 172(8), 4752–4761.

By: T. Vahlenkamp n, M. Tompkins n & W. Tompkins n

MeSH headings : Animals; Antigens, CD / biosynthesis; Antigens, CD / metabolism; Antigens, Differentiation / biosynthesis; Antigens, Viral / biosynthesis; B7-1 Antigen / biosynthesis; B7-1 Antigen / metabolism; B7-2 Antigen; CTLA-4 Antigen; Cats; Cell Division / immunology; Cell Separation; Cells, Cultured; Chronic Disease; Coculture Techniques; Concanavalin A / pharmacology; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Immunophenotyping; Interleukin-2 / biosynthesis; Interleukin-2 / deficiency; Ligands; Lipopolysaccharides / pharmacology; Lymph Nodes / cytology; Lymph Nodes / immunology; Lymphocyte Activation / immunology; Lymphocyte Count; Membrane Glycoproteins / biosynthesis; Membrane Glycoproteins / metabolism; Receptors, Interleukin-2 / biosynthesis; Receptors, Interleukin-2 / blood; Receptors, Interleukin-2 / metabolism; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / metabolism; T-Lymphocyte Subsets / virology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; T-Lymphocytes, Regulatory / virology; Up-Regulation / immunology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Preferential replication of FIV in activated CD4(+)CD25(+)T cells independent of cellular proliferation

VIROLOGY, 321(2), 307–322.

By: A. Joshi n, T. Vahlenkamp n, H. Garg n, W. Tompkins n & M. Tompkins n

author keywords: FIV; HIV; AIDS; latency; stimulation; anergy; apoptosis; reservoir
MeSH headings : Animals; Apoptosis; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; Cats; Cell Division / immunology; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / physiology; Lymphocyte Activation; Receptors, Interleukin-2 / analysis; Virus Latency; Virus Replication
TL;DR: The ability of CD4(+)CD25(+) cells to replicate FIV efficiently in the presence of IL-2 but remain anergic and unresponsive to apoptotic signaling suggests that these cells may provide a reservoir of productive FIV infection. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Spontaneous T cell apoptosis in feline immunodeficiency virus (FIV)-infected cats is inhibited by IL2 and anti-B7.1 antibodies

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 99(1-2), 25–37.

By: M. Bull n, T. Vahlenkamp n, J. Dow n, E. Collisson*, B. Winslow, A. Phadke*, M. Tompkins n, W. Tompkins n

author keywords: FIV; apoptosis; IL2; B7 co-stimulatory molecules; CTLA4
MeSH headings : Animals; Antibodies, Blocking / immunology; Antigens, CD / immunology; Apoptosis / drug effects; Apoptosis / immunology; B7-2 Antigen; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / pathology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / virology; Cats; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; In Situ Nick-End Labeling / veterinary; Interleukin-2 / immunology; Interleukin-2 / pharmacology; Lymph Nodes / immunology; Lymphocyte Activation / immunology; Membrane Glycoproteins / antagonists & inhibitors; Membrane Glycoproteins / immunology; RNA, Viral / chemistry; RNA, Viral / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms
TL;DR: A role of B7 signaling in the increased spontaneous apoptosis observed in LN T cells from FIV-infected animals is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Analysis of constitutive cytokine expression by pigs infected in-utero with porcine reproductive and respiratory syndrome virus

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 94(1-2), 35–45.

By: W. Feng n, M. Tompkins n, J. Xu n, H. Zhang* & M. McCaw n

author keywords: porcine reproductive and respiratory syndrome virus; cytokine; delayed type hypersensitivity; peripheral blood mononuclear cells; RT-PCR
MeSH headings : Animals; Cytokines / genetics; Cytokines / immunology; Gene Expression Regulation; Hypersensitivity, Delayed / immunology; Leukocytes, Mononuclear / immunology; Leukocytes, Mononuclear / metabolism; Porcine Reproductive and Respiratory Syndrome / congenital; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine respiratory and reproductive syndrome virus / immunology; Porcine respiratory and reproductive syndrome virus / isolation & purification; RNA, Messenger / analysis; Swine / immunology; Swine / virology
TL;DR: It is concluded that in-utero infection with PRRSV results in significant alteration of cytokine mRNA expression that may cause transient immunomodulation, and at 10 weeks of age the pigs' immune responses seemed to recover. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Cerebrospinal fluid centesis at the cerebellomedullary cistern of kittens

Contemporary Topics in Laboratory Animal Science, 41(5), 30–32.

By: L. Hudson, T. Vahlenkamp, K. Howard, B. Colby, M. Tompkins & R. Meeker

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Choroid plexus macrophages proliferate and release toxic factors in response to feline immunodeficiency virus

JOURNAL OF NEUROVIROLOGY, 8(3), 225–239.

By: D. Bragg*, L. Hudson n, Y. Liang n, M. Tompkins n, A. Fernandes* & R. Meeker n

author keywords: human immunodeficiency virus; brain; AIDS; neural culture; neurotoxicity
MeSH headings : Animals; CD18 Antigens / analysis; CD40 Ligand / pharmacology; Cats; Cell Division / drug effects; Cell Division / immunology; Cells, Cultured; Cerebral Cortex / cytology; Choroid Plexus / cytology; Choroid Plexus / immunology; Choroid Plexus / virology; Culture Media, Conditioned / pharmacology; Cytotoxins / immunology; Cytotoxins / metabolism; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / immunology; In Vitro Techniques; Macrophages / chemistry; Macrophages / cytology; Macrophages / virology; Neurons / virology; Specific Pathogen-Free Organisms
TL;DR: The results suggest that lentiviral infection of the choroid plexus can induce a toxic inflammatory response that is fueled by local macrophage proliferation and may contribute to an inflammatory cascade in the brain that progresses independently of systemic and CSF viral load. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 article

Feline immunodeficiency virus infection is characterized by B7(+)CTLA4(+) T cell apoptosis

Tompkins, M. B., Bull, M. E., Dow, J. L., Ball, J. M., Collisson, E. W., Winslow, B. J., … Tompkins, W. A. (2002, April 15). JOURNAL OF INFECTIOUS DISEASES, Vol. 185, pp. 1077–1093.

By: M. Tompkins n, M. Bull*, J. Dow*, J. Ball, E. Collisson, B. Winslow, A. Phadke, T. Vahlenkamp*, W. Tompkins*

MeSH headings : Abatacept; Animals; Antigens, CD / analysis; Antigens, Differentiation / analysis; Apoptosis; B7-1 Antigen / analysis; B7-2 Antigen; CTLA-4 Antigen; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immunoconjugates; In Situ Nick-End Labeling; Membrane Glycoproteins / analysis; T-Lymphocytes / physiology
TL;DR: Data support the hypothesis that lymph node apoptosis and immune deterioration in FIV-infected cats results from chronic B7.1- and/or B.2-CTLA4-mediated T-T interactions. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Infection of the choroid plexus by feline immunodeficiency virus

JOURNAL OF NEUROVIROLOGY, 8(3), 211–224.

By: D. Bragg*, T. Childers n, M. Tompkins n, W. Tompkins n & R. Meeker n

author keywords: human immunodeficiency virus; macrophages; brain; AIDS; neural culture
MeSH headings : Animals; Cats; Cells, Cultured; Choroid Plexus / cytology; Choroid Plexus / virology; Coculture Techniques; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / isolation & purification; Immunodeficiency Virus, Feline / pathogenicity; Immunohistochemistry; Macrophages / cytology; Macrophages / virology; Neurons / cytology; Neurons / virology; Polymerase Chain Reaction; Proviruses / genetics; Proviruses / isolation & purification; Specific Pathogen-Free Organisms; T-Lymphocytes / cytology; T-Lymphocytes / virology; Virulence
TL;DR: The direct infection of choroid plexus macrophages with FIV, the efficient transfer of the infection to T cells indicate that the choroids plexu can be a highly efficient site of viral infection and perhaps trafficking of both macrophage- Tropic and T-cell-tropic viruses into the CNS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in utero infection with porcine reproductive and respiratory syndrome virus

VIROLOGY, 302(2), 363–372.

By: W. Feng n, M. Tompkins n, J. Xu n, T. Brown n, S. Laster n, H. Zhang*, M. McCaw n

author keywords: PRRSV; thymus; thymocyte; T lymphocyte
MeSH headings : Animals; Animals, Newborn; Female; Infectious Disease Transmission, Vertical; Leukocytes, Mononuclear / immunology; Lymphocyte Count; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / immunology; Pregnancy; Pregnancy, Animal; Swine; Swine Diseases / immunology; Swine Diseases / virology; T-Lymphocyte Subsets / immunology; Thymus Gland / cytology; Thymus Gland / immunology; Uterus / virology
TL;DR: It is shown that the number of thymocytes undergoing apoptosis was increased twofold in piglets infected with PRRSV and this results help explain the dramatic immunosuppression observed in neonatal animals infected in utero withPRRSV. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 conference paper

B7.1/B7.2 and CTLA4 expression on feline T cells in vitro correlates with apoptosis

Journal of Leukocyte Biology, (2001), 255.

By: T. Vahlenkamp, M. Bull, J. Dow, J. Anderson, M. Tompkins & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Constitutive expression of types 1 and 2 cytokines by alveolar macrophages from feline immunodeficiency virus-infected cats

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 79(1-2), 83–100.

By: J. Ritchey n, J. Levy n, S. Bliss n, W. Tompkins n & M. Tompkins n

author keywords: FIV; macrophages; interleukins
MeSH headings : Animals; Bronchoalveolar Lavage / veterinary; Cat Diseases / metabolism; Cats; Feline Acquired Immunodeficiency Syndrome / metabolism; Gene Products, gag / biosynthesis; Immunodeficiency Virus, Feline; Interleukin-10 / biosynthesis; Interleukin-12 / biosynthesis; Interleukin-6 / biosynthesis; Macrophages, Alveolar / metabolism; Male; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Tumor Necrosis Factor-alpha / biosynthesis; Viral Envelope Proteins / biosynthesis
TL;DR: Pulmonary immune changes seen in FIV- Infected cats are similar to those seen in HIV-infected human patients, suggesting that the increased cytokine response by AM following infection of cats with FIV is an intrinsic characteristic of FIV -infected AM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Distribution of immune cells in the female reproductive tract in uninfected and FIV infected cats

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 83(1-2), 37–51.

By: J. Butterworth, R. English*, H. Jordan & M. Tompkins*

author keywords: feline immunodeficiency virus (FIV); immunohistochemistry; mucosal immunity
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cats; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Genitalia, Female / immunology; Genitalia, Female / pathology; Genitalia, Female / virology; Image Processing, Computer-Assisted; Immunity, Mucosal / immunology; Immunodeficiency Virus, Feline / immunology; Immunohistochemistry / veterinary; Mucous Membrane / immunology; Mucous Membrane / virology; Specific Pathogen-Free Organisms
TL;DR: It is indicated that similar to the peripheral immune system, FIV infection is associated with CD4+ cell loss and reduced CD4-:CD8+ ratios in the female reproductive mucosal tissue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 conference paper

Feline immunodeficiency virus (FIV) infection induces B7(+)CTLA4(+) T cell apoptosis: A model for T cell depletion and immunodeficiency

Journal of Leukocyte Biology, (2001), 254.

By: M. Tompkins, M. Bull, J. Dow & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Feline retrovirus testing and management

Compendium on Continuing Education for the Practicing Veterinarian, 23(7), 652-.

By: J. Levy, J. Richards, D. Edwards, T. Elston, K. Hartmann, I. Rodan, V. Thayer, M. Tompkins, A. Wolf

Source: NC State University Libraries
Added: August 6, 2018

2001 article

Immunopathology of Bartonella vinsonii (berkhoffii) in experimentally infected dogs

Pappalardo, B. L., Brown, T. T., Tompkins, M., & Breitschwerdt, E. B. (2001, December). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, Vol. 83, pp. 125–147.

By: B. Pappalardo n, T. Brown n, M. Tompkins n & E. Breitschwerdt n

author keywords: dog; Bartonella; immunosuppression
MeSH headings : Animals; Antigen Presentation / immunology; Apoptosis / immunology; Bartonella / genetics; Bartonella / growth & development; Bartonella Infections / immunology; Bartonella Infections / microbiology; Bartonella Infections / veterinary; CD4-CD8 Ratio; Cytokines / biosynthesis; Cytokines / blood; DNA, Bacterial / chemistry; DNA, Bacterial / isolation & purification; Dog Diseases / immunology; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Flow Cytometry / veterinary; Histocytochemistry; Lymph Nodes / immunology; Lymph Nodes / pathology; Lymphocytes / immunology; Phagocytosis / immunology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms; T-Lymphocyte Subsets / immunology
TL;DR: Results from this study indicate that B. vinsonii establishes chronic infection in dogs which may result in immune suppression characterized by defects in monocytic phagocytosis, an impaired subset of CD8+ T lymphocytes, and impaired antigen presentation within LN. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis type II

JOURNAL OF VIROLOGY, 75(10), 4889–4895.

By: W. Feng*, S. Laster*, M. Tompkins*, T. Brown*, J. Xu*, C. Altier*, W. Gomez n, D. Benfield*, M. McCaw*

MeSH headings : Animals; Cell Differentiation; Disease Susceptibility / immunology; Female; Infectious Disease Transmission, Vertical; Leukocyte Count; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / physiopathology; Porcine Reproductive and Respiratory Syndrome / transmission; Porcine respiratory and reproductive syndrome virus / immunology; Porcine respiratory and reproductive syndrome virus / isolation & purification; Pregnancy; Pregnancy, Animal; Streptococcal Infections / complications; Streptococcal Infections / immunology; Streptococcal Infections / microbiology; Streptococcal Infections / pathology; Streptococcus suis / immunology; Streptococcus suis / isolation & purification; Streptococcus suis / physiology; Swine; Uterus / virology
TL;DR: In utero infection by PRRSV makes piglets more susceptible to infection and disease following challenge by S. suis type II, and this model may provide a useful model to study the interaction betweenPRRSV and bacterial coinfections in piglets. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 patent

Nucleic acids obtained from the envelope coding region of feline immunodeficiency virus molecular clone designated JSY3

Washington, DC: U.S. Patent and Trademark Office.

By: W. Tompkins, M. Tompkins & J. Yang

Source: NC State University Libraries
Added: August 6, 2018

2001 conference paper

T cell apoptosis in FIV-infected cats is blocked by the addition of antibodies to B7.1 and B7.2

Journal of Leukocyte Biology, (2001), 256.

By: M. Bull, T. Vahlenkamp, M. Tompkins & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

T cells overexpressing interferon-gamma and interleukin-10 are found in both the thymus and secondary lymphoid tissues of feline immunodeficiency virus-infected cats

JOURNAL OF INFECTIOUS DISEASES, 181(2), 564–575.

By: Y. Liang n, L. Hudson n, J. Levy n, J. Ritchey n, W. Tompkins n & M. Tompkins n

MeSH headings : Animals; B-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Gene Products, gag / metabolism; Immunodeficiency Virus, Feline / immunology; Immunohistochemistry; In Situ Hybridization; Interferon-gamma / biosynthesis; Interferon-gamma / genetics; Interleukin-10 / biosynthesis; Interleukin-10 / genetics; Lymph Nodes / immunology; Lymph Nodes / pathology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocyte Subsets / immunology; Thymus Gland / immunology; Thymus Gland / pathology
TL;DR: In conclusion, overexpression of IFN-gamma and IL-10 is a feature of the thymus and secondary lymphoid tissues of FIV-infected cats and is likely to cause marked alteration in thymic lymphocyte subpopulations. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Vaccination with feline immunodeficiency virus induces CD4 epitope masking by soluble factors

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 73(3-4), 343–352.

By: C. Leutenegger, E. Holznagel, R. Hofmann-Lehmann, A. Aubert, M. Tompkins* & H. Lutz

author keywords: soluble factors; feline immunodeficiency virus; CD4 receptor; IL-16; vaccination; masking
MeSH headings : Animals; Antibodies, Monoclonal; Apoptosis; CD4 Antigens / analysis; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cats; Epitopes, T-Lymphocyte / immunology; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / prevention & control; Female; Flow Cytometry / veterinary; Immunodeficiency Virus, Feline / immunology; Immunophenotyping / veterinary; Lymphocyte Count / veterinary; Male; Vaccination / veterinary; Vaccines, Synthetic / administration & dosage; Viral Vaccines / administration & dosage
TL;DR: Findings will be discussed based on the current knowledge of CD8(+) T-cell antiviral factors and their involvement in lentiviral infection and/or replication. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Microglial proliferation in cortical neural cultures exposed to feline immunodeficiency virus

JOURNAL OF NEUROIMMUNOLOGY, 101(1), 15–26.

By: R. Meeker*, Y. Azuma n, D. Bragg*, R. English n & M. Tompkins n

author keywords: feline immunodeficiency virus; microglia; astrocytes; AIDS; dementia; HIV
MeSH headings : AIDS Dementia Complex / etiology; Animals; Astrocytes / physiology; Bromodeoxyuridine / metabolism; Cats; Cell Division; Cells, Cultured; Cerebral Cortex / cytology; Female; Immunodeficiency Virus, Feline / physiology; Microglia / cytology; Pregnancy; Tumor Necrosis Factor-alpha / physiology
TL;DR: Using feline immunodeficiency virus and cat neural cultures, a dramatic increase in the accumulation of microglia is observed from a basal rate of 5-7% day−1 to 25-126% day(-1). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Neurotoxicity of FIV and FIV envelope protein in feline cortical cultures

BRAIN RESEARCH, 816(2), 431–437.

By: D. Bragg*, R. Meeker*, B. Duff*, R. English n & M. Tompkins n

author keywords: feline immunodeficiency virus; gp120; neurotoxicity; glutamate
MeSH headings : Animals; Cats; Cells, Cultured; Cerebral Cortex / cytology; Cerebral Cortex / drug effects; Cerebral Cortex / virology; Immunodeficiency Virus, Feline / pathogenicity; Neurons / drug effects; Neurons / virology; Neurotoxins / toxicity; Viral Envelope Proteins / toxicity; Virulence
TL;DR: A concentration-effect curve showed that FIV-PPR protein produced maximal toxicity at 200 pM protein and decreased toxicity at higher concentrations, which is consistent with previous reports of the HIV-1 surface glycoprotein, gp120. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats

JOURNAL OF INFECTIOUS DISEASES, 180(5), 1503–1513.

By: D. Gebhard n, J. Dow n, T. Childers n, J. Alvelo n, M. Tompkins n & W. Tompkins n

MeSH headings : Animals; CD8-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / immunology; Immunophenotyping; Integrins / metabolism; L-Selectin / analysis; Leukocytes, Mononuclear / immunology; Lymph Nodes / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Regulatory / immunology
TL;DR: The progressive expansion of the CD8alpha+betaloCD62L- effector subset cells in FIV-infected cats parallels that seen in human immunodeficiency virus (HIV)-infected patients, suggesting that failure in homeostatic mechanisms regulating lymphocyte activation or trafficking (or both) may be a consequence of both HIV and FIV infections. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Toward a canine model of atopic dermatitis: amplification of cytokine-gene transcripts in the skin of atopic dogs

EXPERIMENTAL DERMATOLOGY, 8(3), 204–211.

By: T. Olivry*, G. Dean n, M. Tompkins n, J. Dow n & P. Moore*

author keywords: skin; atopic dermatitis; dogs; canine; cytokine; interleukin; interferon
MeSH headings : Animals; Biopsy; Cytokines / genetics; Dermatitis, Atopic / genetics; Dermatitis, Atopic / pathology; Disease Models, Animal; Dogs; Interferon-gamma / genetics; Interleukin-12 / genetics; Interleukin-2 / genetics; Interleukin-4 / genetics; Interleukin-5 / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin / metabolism; Skin / pathology; Transcription, Genetic
TL;DR: The transcription of type‐2 cytokine‐genes in the skin of dogs with AD is established for the first time, to confirm whether or not canine AD could be considered an immunological model for a human disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 article

Elevated interleukin-10-to-interleukin-12 ratio in feline immunodeficiency virus-infected cats predicts loss of type 1 immunity to Toxoplasma gondii

Levy, J. K., Ritchey, J. W., Rottman, J. B., Davidson, M. G., Liang, Y. H., Jordan, H. L., … Tompkins, M. B. (1998, August). JOURNAL OF INFECTIOUS DISEASES, Vol. 178, pp. 503–511.

By: J. Levy n, J. Ritchey n, J. Rottman n, M. Davidson n, Y. Liang n, H. Jordan n, W. Tompkins n, M. Tompkins n

MeSH headings : Animals; Bronchi / immunology; Cats; Cytokines / biosynthesis; Cytokines / genetics; Disease Models, Animal; Immunity; Immunodeficiency Virus, Feline / immunology; Interleukin-10 / biosynthesis; Interleukin-10 / genetics; Interleukin-10 / immunology; Interleukin-12 / biosynthesis; Interleukin-12 / genetics; Interleukin-12 / immunology; Lentivirus Infections / complications; Lentivirus Infections / immunology; Lymph Nodes / immunology; Male; RNA, Messenger; Toxoplasmosis / complications; Toxoplasmosis / immunology
TL;DR: Results indicate that FIV immunodeficiency may derive from a failure to generate an IL-12-dependent type 1 response and that an elevated level of IL-10 mRNA expression is a predictor of lentivirus immunodficiency. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Horizontal transmission of feline immunodeficiency virus with semen from seropositive cats

Journal of Reproductive Immunology, 41(1-2), 341–357.

By: H. Jordan*, J. Howard*, J. Bucci n, J. Butterworth n, R. English n, S. Kennedy-Stoskopf n, M. Tompkins n, W. Tompkins n

MeSH headings : Animals; Cats; Disease Transmission, Infectious; Female; Genitalia, Female / virology; Immunodeficiency Virus, Feline / physiology; Insemination, Artificial / adverse effects; Lentivirus Infections / transmission; Proviruses; Semen / virology; Vagina / virology; Virus Replication
TL;DR: Experiments indicate that FIV infection in domestic cats may provide a unique small animal model of sexual transmission of HIV-1. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Lessons from the cat: Feline immunodeficiency virus as a tool to develop intervention strategies against human immunodeficiency virus type 1

AIDS RESEARCH AND HUMAN RETROVIRUSES, 14(9), 797–801.

By: J. Elder*, G. Dean*, E. Hoover*, J. Hoxie*, M. Malim*, L. Mathes*, J. Neil*, T. North* ...

MeSH headings : AIDS Vaccines; Animals; Anti-HIV Agents / therapeutic use; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Feline Acquired Immunodeficiency Syndrome / therapy; Feline Acquired Immunodeficiency Syndrome / transmission; Feline Acquired Immunodeficiency Syndrome / virology; Genome, Viral; HIV Infections / prevention & control; HIV Infections / therapy; HIV Infections / transmission; HIV Infections / virology; HIV-1 / chemistry; Humans; Immunodeficiency Virus, Feline / chemistry; Immunodeficiency Virus, Feline / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 article

Mucosally transmitted feline immunodeficiency virus induces a CD8(+) antiviral response that correlates with reduction of cell-associated virus

Bucci, J. G., English, R. V., Jordan, H. L., Childers, T. A., Tompkins, M. B., & Tompkins, W. A. F. (1998, January). JOURNAL OF INFECTIOUS DISEASES, Vol. 177, pp. 18–25.

By: J. Bucci n, R. English n, H. Jordan n, T. Childers n, M. Tompkins n & W. Tompkins n

MeSH headings : Animals; Antibodies, Viral / analysis; CD8-Positive T-Lymphocytes / immunology; Cats; Cells, Cultured; Coculture Techniques; Female; Immunodeficiency Virus, Feline; Lentivirus Infections / immunology; Lentivirus Infections / transmission; Lentivirus Infections / virology; Leukocytes, Mononuclear / virology; Longitudinal Studies; Specific Pathogen-Free Organisms; Vagina / virology; Viremia / immunology; Virus Replication / immunology
TL;DR: CD8+ immunity may play a major role in eliminating virus during primary transmucosal FIV infection and may down-regulate viral replication during asymptomatic infection. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

The CD8(+) cell phenotype mediating antiviral activity in feline immunodeficiency virus-infected cats is characterized by reduced surface expression of the CD8 beta chain

JOURNAL OF INFECTIOUS DISEASES, 178(4), 968–977.

By: J. Bucci n, D. Gebhard n, T. Childers n, R. English n, M. Tompkins n & W. Tompkins n

MeSH headings : Acute Disease; Animals; Antibody Specificity; CD8 Antigens / biosynthesis; CD8 Antigens / immunology; CD8-Positive T-Lymphocytes / immunology; Carrier State; Cats; Down-Regulation; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry; Immunity, Cellular; Immunodeficiency Virus, Feline / isolation & purification; Phenotype
TL;DR: Flow cytometric analysis of peripheral blood mononuclear cells with anti-CD8 beta chain monoclonal antibody 117 revealed that the CD8 alpha + beta lo phenotype expanded throughout the asymptomatic infection, constituting 80%-90% of the CD 8 beta + cells in long-term-infected cats. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Cortical cell loss in asymptomatic cats experimentally infected with feline immunodeficiency virus

AIDS RESEARCH AND HUMAN RETROVIRUSES, 13(13), 1131–1140.

By: R. Meeker*, B. Thiede, C. Hall, R. English & M. Tompkins*

MeSH headings : Animals; Astrocytes / pathology; CD4-CD8 Ratio; Cats; Cerebral Cortex / pathology; Corpus Striatum / pathology; Disease Progression; Feline Acquired Immunodeficiency Syndrome / pathology; Frontal Lobe / pathology; Immunohistochemistry; Microglia / pathology; Neurons / pathology; Parietal Lobe / pathology; Presynaptic Terminals / pathology; Synaptophysin / isolation & purification; Time Factors
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 patent

Feline immunodeficiency virus isolate NCSU.sub.1

Washington, DC: U.S. Patent and Trademark Office.

By: W. Tompkins & M. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Immunophenotypic characterization of canine lymphoproliferative disorders

In Vivo (Athens, Greece), 11(2), 169–172.

By: D. Ruslander, D. Gebhard, M. Tompkins, C. Grindem & R. Page

Source: NC State University Libraries
Added: August 6, 2018

1995 patent

Feline immunodeficiency virus isolate NCSU.sub.1Lb

Washington, DC: U.S. Patent and Trademark Office.

By: W. Tompkins & M. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1993 journal article

Diagnosis of feline retroviral infections

Veterinary Technician, 14(4), 205.

By: M. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

1991 journal article

Early events in the immunopathogenesis of feline retrovirus infections

Journal of the American Veterinary Medical Association, 199(10), 1311.

By: M. Tompkins, P. Nelson, R. English & C. Novotney

Source: NC State University Libraries
Added: August 6, 2018

1990 journal article

CHARACTERIZATION OF MONOCLONAL-ANTIBODIES TO FELINE LYMPHOCYTES-T AND THEIR USE IN THE ANALYSIS OF LYMPHOCYTE TISSUE DISTRIBUTION IN THE CAT

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 26(4), 305–317.

By: M. Tompkins n, D. Gebhard n, H. Bingham*, M. Hamilton*, W. Davis* & W. Tompkins n

MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / isolation & purification; Antigens, Surface / immunology; Cats / immunology; Electrophoresis, Polyacrylamide Gel; Epitopes / immunology; Flow Cytometry; Hybridomas / immunology; Lymph Nodes / cytology; Lymph Nodes / immunology; Mice; Precipitin Tests; Specific Pathogen-Free Organisms; Spleen / cytology; Spleen / immunology; T-Lymphocyte Subsets / immunology; Thymus Gland / cytology; Thymus Gland / immunology
TL;DR: Analysis of PBL profiles of 35 normal cats using the three monoclonal antibodies indicates that the distribution of feline PBL subpopulations is similar to man, including the CAT30A:3.357 ratio, which is identical to reported CD4:CD8 ratios in man. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1990 journal article

HUMAN RECOMBINANT INTERLEUKIN-2 INDUCES MATURATION AND ACTIVATION SIGNALS FOR FELINE EOSINOPHILS INVIVO

JOURNAL OF LEUKOCYTE BIOLOGY, 48(6), 531–540.

By: M. Tompkins n, C. Novotney n, C. Grindem n, R. Page n, R. English n, P. Nelson n, W. Tompkins n

MeSH headings : Animals; Bone Marrow Cells; Cats; Cell Survival / drug effects; Eosinophilia / chemically induced; Eosinophils / drug effects; Eosinophils / physiology; Female; Hematopoietic Stem Cells / drug effects; Humans; Interleukin-2 / pharmacology; Killer Cells, Lymphokine-Activated / drug effects; Leukocyte Count; Male; Recombinant Proteins / pharmacology; Time Factors
TL;DR: In addition to a maturation signal, rHulL‐2 induces a potent activation signal for eosinophils as measured by a decrease in density and an increase in longevity in culture, suggesting that an enhanced maturation response of BM eOSinophil precursors is a major contributor to the rHU‐2‐induced blood eosInophilia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1989 journal article

Interleukin-2 suppression in cats naturally infected with feline leukemia virus

Journal of Biological Response Modifiers, 8(1), 86.

By: M. Tompkins, G. Ogilvie, A. Gast, R. Franklin, R. Weigel & W. Tompkins

Source: NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.