Mengyue Chen

College of Engineering

Works (20)

Updated: July 30th, 2024 08:31

2023 journal article

Flexible Ultrasonic Transducers for Wearable Biomedical Applications: A Review on Advanced Materials, Structural Designs, and Future Prospects

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 71(7), 786–810.

By: X. Xue n, H. Wu n, Q. Cai n, M. Chen n, S. Moon n, Z. Huang *, T. Kim *, C. Peng * ...

author keywords: Transducers; Ultrasonic imaging; Biomedical imaging; Sensors; Acoustics; Piezoelectric materials; Biomedical monitoring; biomedical sensing; biomedical therapy; flexible electronics; flexible ultrasound; ultrasound transducers
TL;DR: This article comprehensively reviews the application of flexible ultrasound transducers in the field of biomedical imaging, sensing, and therapy and highlights some promising preliminary data with recent applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 28, 2024

2023 journal article

Inertial Measurement Unit-Assisted Ultrasonic Tracking System for Ultrasound Probe Localization

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 70(9), 920–929.

By: Q. Cai n, J. Hu *, M. Chen n, J. Prieto *, A. Rosenbaum *, J. Stringer *, X. Jiang n

author keywords: Dynamic localization; inertial navigation; Kalman filters; motion measurement; ultrasonic tracking
TL;DR: The proposed IMU-assisted US tracking system achieved centimeter-level positional tracking accuracy with the mean absolute error (MAE) of 12 mm and the MAE of orientational tracking was less than 1°. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 2, 2023

2023 journal article

Intravascular Sono-Ablation for In-Stent Restenosis Relief: Transducer Development and the In-Vitro Demonstration

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 70(7), 2172–2180.

By: H. Kim n , H. Wu n, M. Chen n, X. Dai, R. Zhou * & X. Jiang n

author keywords: In stent restenosis; focused ultrasound; tissue ablation; interstitial transducer; small aperture
MeSH headings : Humans; Coronary Restenosis; Stents; Computer Simulation; Treatment Outcome
TL;DR: The developed device can be used for sonoablation of the remaining plaque, providing a novel approach to the treatment of ISR, suggesting it could be as a future ISR treatment modality. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 7, 2023

2023 article

Intravascular sonothrombolysis with nanobubbles : <i>in</i>-<i>vitro</i> study

2023 IEEE 23RD INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY, NANO, pp. 376–379.

By: H. Wu n, B. Kreager n, M. Chen n, B. Zhang n , E. Abenojar *, A. Exner *, X. Jiang n

Contributors: H. Wu n, B. Kreager n, M. Chen n, B. Zhang n , E. Abenojar *, A. Exner *, X. Jiang n

author keywords: Micro/Nano-bubble mixture; Sonothrombolysis
TL;DR: An innovative method utilizing a stacked transducer for intravascular sonothrombolysis for higher lysis efficiency, employing a mixture of nanobubbles (NB) and microbubbles (MB) serves to enhance cavitation and improve the breakdown of clot structures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 23, 2023

2023 article

Quantitative characterization of the ultrasound thermal strains in tissue mimicking phantoms with different oil concentrations

Sheng, Z., Wei, R., Chen, M., Zhang, B., Kim, H., Geng, X., … Kim, K. (2023, March). JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, Vol. 153.

By: Z. Sheng *, R. Wei *, M. Chen n, B. Zhang n , H. Kim  n, X. Geng *, X. Jiang n, K. Kim *

TL;DR: An ultrasound transducer that combines an acoustic heating array and an imaging array to achieve US-TSI with heating performed in a region of approximately 10 mm by 5 mm by 2 mm within a very short time period of about 50 ms compared both cardiac and breathing motions is developed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2022 article

Intracorporeal Sonoporation-Induced Drug/Gene Delivery Using a Catheter Ultrasound Transducer

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: M. Chen n, H. Kim  n, B. Zhang n , W. Yang n, T. Osada *, E. Crosby *, H. Lyerly *, X. Jiang n

Contributors: M. Chen n, H. Kim  n, B. Zhang n , W. Yang n, T. Osada *, E. Crosby *, H. Lyerly *, X. Jiang n

author keywords: cancer immunotherapy; drug delivery; gene delivery; intracorporeal sonoporation; catheter ultrasound transducer; intratumoral immunotherapy
TL;DR: The LUC assay demonstrated a significantly enhanced transfection, indicating the developed catheter transducer is promising for intracorporeal sonoporation-induced drug/gene delivery, such as intratumoral immunotherapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 6, 2023

2022 article

Millisecond-Level Transient Temperature Monitoring Using an Ultra-Fast Response Thermocouple for Ultrasound-Induced Thermal Strain Imaging

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: M. Chen n, B. Zhang n , H. Kim  n, Z. Sheng, Q. Chen *, K. Kim *, X. Geng *, X. Jiang n

author keywords: ultrasound-induced thermal strain imaging; ultra-fast response thermocouple; transient temperature monitoring
TL;DR: The proposed method is capable of monitoring transient temperature rise in biological tissue for US- TSI and obvious transient temperature rises within 50 ms can be observed for both laser tests and tissue tests. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 article

Numerical and experimental evaluation of low-intensity transcranial focused ultrasound wave propagation using human skulls for brain neuromodulation

Chen, M., Peng, C., Wu, H., Huang, C.-C., Kim, T., Traylor, Z., … Jiang, X. (2022, November 24). MEDICAL PHYSICS, Vol. 11.

By: M. Chen n, C. Peng  n, H. Wu n, C. Huang  n, T. Kim *, Z. Traylor n , M. Muller n , P. Chhatbar * ...

author keywords: human skull; transcranial focused ultrasound; ultrasonic neuromodulation; ultrasound transducer
MeSH headings : Humans; Skull / diagnostic imaging; Brain / diagnostic imaging; Ultrasonography / methods; Head; Transducers; Ultrasonic Waves
TL;DR: The findings have important implications to predict tFUS wave propagation for ultrasound neuromodulation in clinical applications, and guide researchers to develop advanced ultrasound transducers as neural interfaces. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 12, 2022

2022 review

Recent Advances in Tracking Devices for Biomedical Ultrasound Imaging Applications

[Review of ]. MICROMACHINES, 13(11).

By: C. Peng *, Q. Cai n, M. Chen n & X. Jiang n

author keywords: tracking; ultrasound imaging; optical tracking; electromagnetic tracking; 3D ultrasound imaging; ultrasound-guided interventions; ultrasound image fusion
TL;DR: The basic tracking principles, system components, performance analyses, as well as the main sources of error for popular tracking technologies that are utilized in ultrasound imaging are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 28, 2022

2021 review

Acoustics at the nanoscale (nanoacoustics): A comprehensive literature review. Part I: Materials, devices and selected applications

[Review of ]. SENSORS AND ACTUATORS A-PHYSICAL, 332.

By: C. Peng  n, M. Chen n, J. Spicer * & X. Jiang n

author keywords: Acoustics; Nanotechnology; Nanoacoustics; Nanomaterials; Nanostructures; Acoustic microscopy; Manipulation; Sensing
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 3, 2022

2021 review

Acoustics at the nanoscale (nanoacoustics): A comprehensive literature review. Part II: Nanoacoustics for biomedical imaging and therapy

[Review of ]. SENSORS AND ACTUATORS A-PHYSICAL, 332.

By: C. Peng n, M. Chen n, J. Spicer * & X. Jiang n

author keywords: Acoustics; Nanotechnology; Nanoacoustics; Nanomaterials; Biomedical applications; Imaging; Therapy; Photoacoustics; Laser ultrasound; Sonothrombolysis
TL;DR: Recent advancements of acoustics-associated nanomaterials/nanostructures and nanodevices for different applications are outlined in this comprehensive review of nanoacoustics in biomedical imaging and therapy applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 3, 2022

2021 article

Biosafety of Low-Intensity Pulsed Transcranial Focused Ultrasound Brain Stimulation - A Human Skull Study

HEALTH MONITORING OF STRUCTURAL AND BIOLOGICAL SYSTEMS XV, Vol. 11593.

By: M. Chen n, C. Peng  n, T. Kim *, P. Chhatbar *, M. Muller n , W. Feng *, X. Jiang n

author keywords: noninvasive brain stimulation; transcranial focused ultrasound; biosafety; low intensity; thermal effect
TL;DR: Biosafety of low-intensity pulsed tFUS using various sonication parameters was evaluated by measuring acoustic intensities and temperature variations across a piece of real human skull and showed that ISPTA above 480 mW/cm^2 is likely to induce an excessive temperature rise for a sonication duration of 160 seconds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022

2021 article

Design and Simulation of Heating Transducer Arrays for Ultrasound-Induced Thermal Strain Imaging

INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS 2021).

By: M. Chen n, Z. Sheng *, H. Kim  n, B. Zhang n , Q. Chen *, K. Kim *, X. Geng *, X. Jiang n

Contributors: M. Chen n, Z. Sheng *, H. Kim  n, B. Zhang n , Q. Chen *, K. Kim *, X. Geng *, X. Jiang n

author keywords: ultrasound-induced thermal strain imaging; atherosclerosis plaque; dual 1.5D heating arrays; dual-focus beamforming
TL;DR: The acoustic and thermal simulation results demonstrated that the designed dual heating arrays can induce a 2.1 °C temperature rise within 50 ms in a volume of 2 × 10 × 10 mm3(in terms of full width at half maximum, FWHM). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 15, 2022

2021 review

Direct Communication Between Brains: A Systematic PRISMA Review of Brain-To-Brain Interface

[Review of ]. FRONTIERS IN NEUROROBOTICS, 15.

By: C. Nam n , Z. Traylor n , M. Chen n, X. Jiang n, W. Feng * & P. Chhatbar *

author keywords: brain-to-brain interface; brain-computer interface; computer-brain interface; brain communication; neuroergonomics
TL;DR: These studies show B2BI can offer advances in human communication and collaboration, but more design and experiments are needed to prove potential, as the CBI method varied greatly between studies indicating no agreed upon neurostimulatory method for transmitting information. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 10, 2021

2021 review

Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review

[Review of ]. FRONTIERS IN NEUROSCIENCE, 15.

By: T. Kim *, C. Park *, P. Chhatbar *, J. Feld *, B. Mac Grory *, C. Nam n , P. Wang *, M. Chen n, X. Jiang n, W. Feng *

author keywords: ultrasound; low intensity transcranial ultrasound stimulation; non-invasive brain stimulation; neuromodulation; human; animal
TL;DR: LI-TUS appears to be capable of targeting both superficial and deep cerebral structures to modulate cognitive or motor behavior in both animals and humans and its potential for translation as a therapeutic tool in humans is identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

2021 journal article

Implication of auditory confounding in interpreting somatosensory and motor responses in low-intensity focused transcranial ultrasound stimulation

JOURNAL OF NEUROPHYSIOLOGY, 125(6), 2356–2360.

By: C. Park *, M. Chen n & T. Kim *

author keywords: auditory confounding; low intensity; noninvasive brain stimulation; transcranial ultrasound
MeSH headings : Animals; Auditory Pathways; Humans; Somatosensory Cortex; Ultrasonography
TL;DR: The implications and interpretations of auditory confounding in the context of neuromodulation are discussed and direct stimulation of the peripheral auditory pathway could confound the somatosensory and motor responses observed with LI-tFUS stimulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 6, 2021

2021 journal article

Under-Display Ultrasonic Fingerprint Recognition With Finger Vessel Imaging

IEEE SENSORS JOURNAL, 21(6), 7412–7419.

By: C. Peng n, M. Chen n & X. Jiang n

author keywords: Fingerprint recognition; ultrasonic; under-display; mobile devices
TL;DR: Under-display ultrasonic fingerprint recognition (UDUFR) was investigated for the first time via imaging a finger vessel underneath the fingerprint and the results reported open up new avenues for the next generation of robust and secure UDUFR technology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 29, 2021

2020 journal article

Broadband Piezoelectric Transducers for Under-Display Ultrasonic Fingerprint Sensing Applications

IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS, 68(5), 4426–4434.

By: C. Peng n, M. Chen n, H. Wang, J. Shen & X. Jiang n

author keywords: Fingerprint recognition; Acoustics; Imaging; Smart phones; Impedance; Sensitivity; Optical sensors; Fingerprint sensor; ultrasound; ultrasonic transducer; under-display
TL;DR: The fingerprint-mimicking phantom imaging results suggest that the 20 MHz broadband PZT-based multilayer structure holds great potential for under-display ultrasonic fingerprint sensor applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: March 15, 2021

2020 journal article

Noninvasive and Nonocclusive Blood Pressure Monitoring via a Flexible Piezo-Composite Ultrasonic Sensor

IEEE SENSORS JOURNAL, 21(3), 2642–2650.

By: C. Peng n, M. Chen n, H. Sim n, Y. Zhu n & X. Jiang n

author keywords: Blood pressure monitoring; flexible sensor; ultrasound; noninvasive; nonocclusive
TL;DR: The results obtained in this study demonstrated the capability of the proposed flexible sensor to continuously monitor blood pressure waveforms during cardiac cycles and provides a promising solution for noninvasive, nonocclusive and calibration-free blood pressure monitoring. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 22, 2021

2020 journal article

P(VDF-TrFE) Thin-Film-Based Transducer for Under-Display Ultrasonic Fingerprint Sensing Applications

IEEE SENSORS JOURNAL, 20(19), 11221–11228.

By: C. Peng n, M. Chen n, H. Wang, J. Shen & X. Jiang n

author keywords: Fingerprint sensing; under-display sensing; ultrasonic transducer; P(VDF-TrFE)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 16, 2020

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