Chris McGahan

Works (79)

Updated: April 23rd, 2025 19:14

2017 article

Vitreous Humor Changes Expression of Iron-Handling Proteins in Lens Epithelial Cells

Goralska, M., Fleisher, L. N., & McGahan, M. C. (2017, February 28). Investigative Ophthalmology & Visual Science.

By: M. Goralska n, L. Fleisher n & M. McGahan n

author keywords: iron; oxidative damage; ferritin; transferrin receptor; vitreous humor
MeSH headings : Animals; Aquaporins / metabolism; Blotting, Western; Cells, Cultured; Disease Models, Animal; Dogs; Epithelial Cells / metabolism; Eye Proteins / metabolism; Ferritins / metabolism; Immunohistochemistry; Lens, Crystalline / metabolism; Receptors, Transferrin / metabolism; Vitreous Body / physiology
topics (OpenAlex): Connexins and lens biology; Iron Metabolism and Disorders; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: Virreous humor may significantly limit iron uptake by transferrin/transferrin receptor pathway, and by increasing ferritin levels could profoundly increase the iron-storage capacity of ferrit in lens cells. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

Evaluation of the proliferative capacity of canine retinal pigment epithelial cells harvested from different regions of the fundus

Investigative Ophthalmology and Visual Science, 57(12).

By: F. Mowat, J. Hash, P. Mzyk, J. Harned, S. Nagar & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Hypoxia alters the expression, movement, and secretion of APP in retinal pigmented epithelial (RPE) cells

Investigative Ophthalmology and Visual Science, 57(12).

By: P. Mzyk & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

2014 article

Hypoxia controls iron metabolism and glutamate secretion in retinal pigmented epithelial cells

Harned, J., Nagar, S., & McGahan, M. C. (2014, June 24). Biochimica Et Biophysica Acta (BBA) - General Subjects.

By: J. Harned n, S. Nagar n & M. McGahan n

author keywords: Iron transport; Glutamate; Hypoxia; Blood-ocular barriers
MeSH headings : Animals; Cell Hypoxia; Cells, Cultured; Dogs; Epithelial Cells / metabolism; Epithelial Cells / pathology; Glutamic Acid / metabolism; Humans; Iron / metabolism; Oxidation-Reduction; Retinal Pigment Epithelium / metabolism; Retinal Pigment Epithelium / pathology; Stroke / metabolism; Stroke / pathology
topics (OpenAlex): Iron Metabolism and Disorders; Hemoglobinopathies and Related Disorders; Trace Elements in Health
TL;DR: Iron, a key catalyst of free radical generation, is removed from RPE under hypoxic conditions which may help protect RPE from oxidative stress and indicate the importance of using polarized tight junctional cells as more physiologically relevant models for blood-barrier-like systems. (via Semantic Scholar)
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2014 article

Hypoxia induced changes in expression of proteins involved in iron uptake and storage in cultured lens epithelial cells

Goralska, M., Fleisher, L. N., & McGahan, M. C. (2014, May 27). Experimental Eye Research.

By: M. Goralska n, L. Fleisher n & M. McGahan n

author keywords: lens; iron; iron proteins; hypoxia
MeSH headings : Animals; Cell Hypoxia / physiology; Cells, Cultured; Dogs; Epithelial Cells / metabolism; Ferritins / metabolism; Gene Expression Regulation; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Oxidative Stress / physiology; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction; Receptors, Transferrin / metabolism; Transferrin / metabolism
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Connexins and lens biology; Aldose Reductase and Taurine
TL;DR: Changes in expression of ferritin and Tf/TfR1 in LEC cultured under hypoxic conditions are examined to better protect LEC against oxidative stress by limiting iron-catalyzed ROS formation in the low oxygen environment in which the lens resides. (via Semantic Scholar)
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2013 journal article

Hydrogen peroxide and extracellular signal-related kinase 1/2 pathway regulate ferritin levels in retinal pigmented and lens epithelial cells

Molecular Vision, 19, 2106–2112.

By: M. Lall, J. Harned & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Ceruloplasmin alters intracellular iron regulated proteins and pathways: Ferritin, transferrin receptor, glutamate and hypoxia-inducible factor-1α

Experimental Eye Research, 97(1), 90–97.

By: J. Harned n, J. Ferrell n, S. Nagar n, M. Goralska n, L. Fleisher n & M. McGahan n

author keywords: ceruloplasmin; iron; lens epithelial cells; retinal pigmented epithelial cells glutamate; hypoxia-inducible factor; transferrin receptor; ferritin
MeSH headings : Animals; Cells, Cultured; Ceruloplasmin / metabolism; Ceruloplasmin / pharmacology; Dogs; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Fluorescent Antibody Technique, Indirect; Glutamic Acid / metabolism; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Iron Chelating Agents / pharmacology; Lens, Crystalline / cytology; Oxalates / pharmacology; Receptors, Transferrin / metabolism; Retinal Pigment Epithelium / drug effects; Retinal Pigment Epithelium / metabolism
topics (OpenAlex): Trace Elements in Health; Connexins and lens biology; Iron Metabolism and Disorders
TL;DR: The Cp increased production and secretion of the neurotransmitter, glutamate, is a substantive finding of clinical relevance because of the neural and retinal degeneration found in aceruloplasminemia patients. (via Semantic Scholar)
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Sources: Crossref, Web Of Science
Added: August 6, 2018

2010 article

Altered Ferritin Subunit Composition: Change in Iron Metabolism in Lens Epithelial Cells and Downstream Effects on Glutathione Levels and VEGF Secretion

Harned, J., Ferrell, J., Lall, M. M., Fleisher, L. N., Nagar, S., Goralska, M., & McGahan, M. C. (2010, August 30). Investigative Ophthalmology & Visual Science.

By: J. Harned n, J. Ferrell n, M. Lall n, L. Fleisher n, S. Nagar n, M. Goralska n, M. McGahan n

MeSH headings : Animals; Apoferritins / genetics; Apoferritins / metabolism; Cell Nucleus / metabolism; Cells, Cultured; Culture Media, Conditioned / pharmacology; Cystine / pharmacokinetics; Dogs; Epithelial Cells / cytology; Epithelial Cells / metabolism; Glutathione / metabolism; Homeostasis / physiology; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Iron / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Oxidative Stress / physiology; Protein Subunits / genetics; Protein Subunits / metabolism; RNA, Small Interfering; Transfection; Vascular Endothelial Growth Factor A / metabolism
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Connexins and lens biology
TL;DR: Iron storage in ferritin was greatly reduced by FHsiRNA, resulting in increased iron availability, as noted by a decrease in transferrin receptor levels and iron uptake from transferrin, and profound effects clearly demonstrate that maintenance of a specific H:L ratio is part of a basic cellular homeostatic mechanism. (via Semantic Scholar)
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2009 article

Changes in Ferritin H- and L-Chains in Canine Lenses with Age-Related Nuclear Cataract

Goralska, M., Nagar, S., Colitz, C. M. H., Fleisher, L. N., & McGahan, M. C. (2009, January 1). Investigative Ophthalmology & Visual Science.

By: M. Goralska n, S. Nagar n, C. Colitz n, L. Fleisher n & M. McGahan n

MeSH headings : Aging; Animals; Apoferritins / metabolism; Cataract / metabolism; Cataract / veterinary; Dog Diseases / metabolism; Dogs; Electrophoresis, Polyacrylamide Gel / veterinary; Enzyme-Linked Immunosorbent Assay / veterinary; Fluorescent Antibody Technique, Indirect / veterinary; Lens, Crystalline / metabolism; Microscopy, Fluorescence / veterinary
topics (OpenAlex): Connexins and lens biology; Iron Metabolism and Disorders; Trace Elements in Health
TL;DR: There are significant differences in the characteristics of ferritin H-chain and its distribution in canine cataractous lenses compared with noncataractsous lenses, which allows this molecule to sequester more iron. (via Semantic Scholar)
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2009 journal article

Distribution of ferritin chains in canine lenses with and without age-related nuclear cataracts

Molecular Vision, 15(256-59), 2404–2410.

By: M. Goralska, S. Nagar, L. Fleisher & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

2008 article

Iron Regulates L-Cystine Uptake and Glutathione Levels in Lens Epithelial and Retinal Pigment Epithelial Cells by Its Effect on Cytosolic Aconitase

Lall, M. M., Ferrell, J., Nagar, S., Fleisher, L. N., & McGahan, M. C. (2008, January 1). Investigative Ophthalmology & Visual Science.

By: M. Lall n, J. Ferrell*, S. Nagar*, L. Fleisher* & M. McGahan*

MeSH headings : 2,2'-Dipyridyl / pharmacology; Aconitate Hydratase / antagonists & inhibitors; Aconitate Hydratase / metabolism; Amino Acid Transport System y+ / genetics; Amino Acid Transport System y+ / metabolism; Animals; Cells, Cultured; Chelating Agents / pharmacology; Cystine / metabolism; Cytosol; Dogs; Enzyme Inhibitors / pharmacology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Fluorescent Antibody Technique, Indirect; Gene Expression; Glutathione / metabolism; Immunoblotting; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Oxalates / pharmacology; Pigment Epithelium of Eye / metabolism; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transferrin / pharmacology
topics (OpenAlex): Biomedical Research and Pathophysiology; Amino Acid Enzymes and Metabolism; Connexins and lens biology
TL;DR: The authors found that the iron-induced increase in L-glutamate availability increased L-cystine uptake, with subsequent increases in GSH levels, demonstrating for the first time that iron regulates L-cycline uptake and the downstream production of GSH in two mammalian cell types. (via Semantic Scholar)
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2008 journal article

Iron metabolism in the eye: A review

Experimental Eye Research, 88(2), 204–215.

By: M. Goralska n, J. Ferrell n, J. Harned n, M. Lall n, S. Nagar n, L. Fleisher n, M. McGahan n

author keywords: iron; ferritin; transferrin; lens; retinal pigmented epithelium; retina
MeSH headings : Animals; Eye / metabolism; Eye Diseases / metabolism; Homeostasis; Humans; Iron / metabolism; Oxidative Stress; Signal Transduction / physiology
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Iron Metabolism and Disorders; Neonatal Health and Biochemistry
TL;DR: This review article covers all aspects of iron metabolism, which include studies of iron levels within the eye and the processes used to maintain normal levels of iron in ocular tissues. (via Semantic Scholar)
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2007 article

Ferritin H- and L-Chains in Fiber Cell Canine and Human Lenses of Different Ages

Goralska, M., Fleisher, L. N., & McGahan, M. C. (2007, August 27). Investigative Ophthalmology & Visual Science.

By: M. Goralska n, L. Fleisher n & M. McGahan n

MeSH headings : Adolescent; Adult; Aged; Aging / physiology; Animals; Apoferritins / metabolism; Blotting, Western; Dogs; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Ferritins / metabolism; Humans; Iron Radioisotopes / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Middle Aged
topics (OpenAlex): Connexins and lens biology; RNA regulation and disease; Heat shock proteins research
TL;DR: Lens fiber cells, particularly from older lenses, may have limited ability to protect themselves against iron-catalyzed oxidative damage and are not likely to form functional ferritin capable of storing iron. (via Semantic Scholar)
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2006 article

Lens epithelial cells synthesize and secrete ceruloplasmin: Effects of ceruloplasmin and transferrin on iron efflux and intracellular iron dynamics

Harned, J., Fleisher, L. N., & McGahan, M. C. (2006, June 24). Experimental Eye Research.

By: J. Harned*, L. Fleisher n & M. McGahan n

author keywords: lens; ceruloplasmin; iron; ferritin; transferrin; labile iron pool
MeSH headings : Animals; Ceruloplasmin / biosynthesis; Ceruloplasmin / pharmacology; Ceruloplasmin / physiology; Culture Media, Conditioned; Cytosol / metabolism; Dogs; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Iron / metabolism; Lens Capsule, Crystalline / cytology; Lens Capsule, Crystalline / drug effects; Lens Capsule, Crystalline / metabolism; Tissue Culture Techniques; Transferrin / biosynthesis; Transferrin / pharmacology; Transferrin / physiology
topics (OpenAlex): Connexins and lens biology; Trace Elements in Health; Yersinia bacterium, plague, ectoparasites research
TL;DR: An important role for ceruloplasmin and transferrin in iron metabolism in the lens is indicated, with results consistent with increased efflux of iron. (via Semantic Scholar)
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2005 article

Differential Degradation of Ferritin H- and L-Chains: Accumulation of L-Chain-Rich Ferritin in Lens Epithelial Cells

Goralska, M., Nagar, S., Fleisher, L. N., & McGahan, M. C. (2005, September 26). Investigative Ophthalmology & Visual Science.

By: M. Goralska n, S. Nagar*, L. Fleisher* & M. McGahan*

MeSH headings : Aging / physiology; Animals; Apoferritins; Cells, Cultured; Cysteine Proteinase Inhibitors / pharmacology; Dogs; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Iron / metabolism; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Lysosomes / metabolism; Methionine / metabolism; Plasmids; Transfection
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Connexins and lens biology
TL;DR: The formation of inclusion bodies in older lens epithelial cells, as demonstrated in the current investigation, is intriguing and could point to possible involvement of cytoplasmic L-chain-enriched ferritin aggregates in the formation of age-related cataract. (via Semantic Scholar)
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2004 article

Iron alters glutamate secretion by regulating cytosolic aconitase activity

McGahan, M. C., Harned, J., Mukunnemkeril, M., Goralska, M., Fleisher, L., & Ferrell, J. B. (2004, December 22). American Journal of Physiology-Cell Physiology.

By: M. McGahan n, J. Harned n, M. Mukunnemkeril n, M. Goralska n, L. Fleisher n & J. Ferrell n

author keywords: retinal pigment epithelial cells; lens epithelial cells
MeSH headings : Aconitate Hydratase / antagonists & inhibitors; Aconitate Hydratase / metabolism; Animals; Cells, Cultured; Citric Acid / metabolism; Cytosol / metabolism; Dogs; Enzyme Activation / drug effects; Glutamates / metabolism; Iron / metabolism; Isocitrates / metabolism; Membrane Transport Proteins / metabolism; Oxalates / pharmacology; Pigment Epithelium of Eye / drug effects; Pigment Epithelium of Eye / enzymology; Riluzole / pharmacology; Vesicular Glutamate Transport Protein 1
topics (OpenAlex): Neuroscience and Neuropharmacology Research; Retinal Development and Disorders; Connexins and lens biology
TL;DR: The results are the first to provide a functional link between these two physiologically important substances by demonstrating a significant role for iron in the regulation of glutamate production and secretion in mammalian cells resulting from iron regulation of aconitase activity. (via Semantic Scholar)
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2003 article

Alpha lipoic acid changes iron uptake and storage in lens epithelial cells

Goralska, M., Dackor, R., Holley, B., & McGahan, M. C. (2003, February 1). Experimental Eye Research.

By: M. Goralska n, R. Dackor n, B. Holley n & M. McGahan n

author keywords: alpha lipoic acid (LA); Fe; ferritin; oxidative damage; calcein; labile Fe pool
MeSH headings : Animals; Antioxidants / pharmacology; Ascorbic Acid / pharmacology; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / biosynthesis; Ferritins / metabolism; Hydrogen Peroxide / antagonists & inhibitors; Hydrogen Peroxide / pharmacology; Iron / pharmacokinetics; Lens Capsule, Crystalline / cytology; Lens Capsule, Crystalline / drug effects; Lens Capsule, Crystalline / metabolism; Oxidative Stress / drug effects; Thioctic Acid / pharmacology
topics (OpenAlex): Biochemical Acid Research Studies; Aldose Reductase and Taurine; Alcoholism and Thiamine Deficiency
TL;DR: In vivo effects of lipoic acid treatment on Fe metabolism in cultured lens epithelial cells are examined, and it is found that LA decreases Fe uptake from transferrin, increases Fe deposition into ferritin and increases the concentration of this protein. (via Semantic Scholar)
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2003 article

Identification of a Mechanism by Which Lens Epithelial Cells Limit Accumulation of Overexpressed Ferritin H-chain

Goralska, M., Holley, B. L., & McGahan, M. C. (2003, October 1). Journal of Biological Chemistry.

By: M. Goralska n, B. Holley n & M. McGahan n

MeSH headings : Animals; Apoferritins; Blotting, Western; Cataract / metabolism; Cytosol / metabolism; DNA, Complementary / metabolism; Dogs; Electrophoresis, Polyacrylamide Gel; Epithelial Cells / metabolism; Eye Diseases, Hereditary / metabolism; Ferritins / biosynthesis; Ferritins / chemistry; Ferritins / metabolism; Humans; Iron Metabolism Disorders; Lens, Crystalline / metabolism; Mutation; Peptides / chemistry; Plasmids / metabolism; Precipitin Tests; RNA, Messenger / metabolism; Recombinant Proteins / metabolism; Time Factors; Transfection
topics (OpenAlex): Iron Metabolism and Disorders; Connexins and lens biology; Trace Elements in Health
TL;DR: It is concluded that lens epithelial cells differentially regulate concentration of both ferritin chains in the cytosol, which indicates that the inability of cells to more strictly control cytosolic levels of L-chain may augment its accumulation in lenses of humans with hereditary hyperferritinemia cataract syndrome. (via Semantic Scholar)
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2003 article

The Effect of UVB Irradiation on Ferritin Subunit Synthesis, Ferritin Assembly and Fe Metabolism in Cultured Canine Lens Epithelial Cells¶

Harned, J., Grimes, A. M., & McGahan, M. C. (2003, January 1). Photochemistry and Photobiology.

By: J. Harned n, A. Grimes n & M. McGahan n

topics (OpenAlex): Iron Metabolism and Disorders; Connexins and lens biology; Trace Elements in Health
TL;DR: It was hypothesized and then determined that newly synthesized chains did not assemble into functional holoferritin, and this study provides a cautionary note regarding the conclusions of such studies in the absence of data indicating assembly of functional ferritin molecules. (via Semantic Scholar)
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2003 journal article

The effect of UVB irradiation on ferritin subunit synthesis, ferritin assembly and Fe metabolism in cultured canine lens epithelial cells

The Journal of Biological Chemistry, 278, 42920–42926.

By: M. Goralska, B. Holley & M. McGahan

Source: NC State University Libraries
Added: September 9, 2019

2001 journal article

Overexpression of H- and L-ferritin subunits in lens epithelial cells: Fe metabolism and cellular response to UVB irradiation

Investigative Ophthalmology and Visual Science, 42(8), 1721–1727.

By: M. Goralska, B. Holley & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Effect of surgical technique on in vitro posterior capsule opacification

Davidson, M. G., Morgan, D. K., & McGahan, C. M. (2000, October 1). Journal of Cataract & Refractive Surgery.

By: M. Davidson n, D. Morgan n & C. McGahan n

MeSH headings : Animals; Cataract / etiology; Cataract / pathology; Cataract / prevention & control; Cell Count; Cells, Cultured; Culture Media, Serum-Free; Dogs; Lens Capsule, Crystalline / pathology; Lens Capsule, Crystalline / surgery; Phacoemulsification / methods; Postoperative Complications / etiology; Postoperative Complications / pathology; Postoperative Complications / prevention & control
topics (OpenAlex): Intraocular Surgery and Lenses; Connexins and lens biology; Retinal and Macular Surgery
TL;DR: Phacoemulsification with and without anterior and equatorial capsular vacuuming led to less initial LEC density in the capsular bag than ECCE, however, because cell proliferation rates among the 3 groups were only marginally affected, near 100% removal of LEC at the time of cataract extraction may be necessary to prevent PCO. (via Semantic Scholar)
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2000 article

Ex vivo canine lens capsular sac explants

Davidson, M. G., Wormstone, M., Morgan, D., Malakof, R., Allen, J., & McGahan, M. C. (2000, August 23). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: M. Davidson n, M. Wormstone *, D. Morgan n, R. Malakof n, J. Allen n & M. McGahan n

MeSH headings : Actins / metabolism; Animals; Biomarkers; Cataract / metabolism; Cataract / pathology; Cell Division; Cells, Cultured; Dogs; Enzyme-Linked Immunosorbent Assay; Insulin-Like Growth Factor I / metabolism; Lens Capsule, Crystalline / cytology; Lens Capsule, Crystalline / growth & development; Lens Capsule, Crystalline / metabolism; Transferrin / metabolism; Transforming Growth Factor beta / metabolism; Transforming Growth Factor beta2; Vimentin / metabolism
topics (OpenAlex): Intraocular Surgery and Lenses; Ocular Surface and Contact Lens; Surgical Sutures and Adhesives
TL;DR: Canine lens sac explants appear to be a useful alternative tissue source for this model when human cadaver eyes are unavailable and may influence the proliferation and metaplasia of LEC during the development of PCO. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 article

Histologic and immunohistochemical characterization of lens capsular plaques in dogs with cataracts

Colitz, C. M. H., Malarkey, D., Dykstra, M. J., McGahan, M. C., & Davidson, M. G. (2000, February 1). American Journal of Veterinary Research.

By: C. Colitz n, D. Malarkey*, M. Dykstra*, M. McGahan* & M. Davidson*

MeSH headings : Actins / analysis; Animals; Cataract / pathology; Cataract / veterinary; Cataract Extraction / veterinary; Dog Diseases / pathology; Dogs; Fibronectins / analysis; Histocytochemistry; Humans; Immunohistochemistry / methods; Lens, Crystalline / pathology; Lens, Crystalline / ultrastructure; Tenascin / analysis; Transforming Growth Factor beta / analysis
topics (OpenAlex): Intraocular Surgery and Lenses; Connexins and lens biology; Corneal surgery and disorders
TL;DR: Canine lens capsular plaques are histologically and immunohistochemically similar to posterior capsule opacification and subcapsular cataracts in humans, which suggests that the canine condition, like the human conditions, is associated with fibrous metaplasia of lens epithelial cells. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 article

Rabbit Pigmented Ciliary Epithelium Produces Interleukin-6 in Response to Inflammatory Cytokines

FLEISHER, L. L. O. Y. D. N., McGAHAN, M. C. H. R. I. S. T. I. N. E., & FERRELL, J. E. N. N. Y. B. (2000, March 1). Experimental Eye Research.

By: L. Fleisher n, M. McGAHAN* & J. Ferrell*

author keywords: interleukin-6; pigmented ciliary epithelium; interleukin-1; tumor necrosis factor-alpha; adenosine 3 ',5 '-cyclic monophosphate
MeSH headings : Animals; Cell Culture Techniques; Ciliary Body / immunology; Ciliary Body / metabolism; Cyclic AMP / metabolism; Cytokines / immunology; Endotoxins / immunology; Interleukin-1 / immunology; Interleukin-6 / biosynthesis; Pigment Epithelium of Eye / immunology; Pigment Epithelium of Eye / metabolism; Rabbits; Tumor Necrosis Factor-alpha / immunology
topics (OpenAlex): Systemic Lupus Erythematosus Research; Cell Adhesion Molecules Research
TL;DR: The results indicate that the pigmented ciliary epithelium is one potential source of interleukin-6 and may contribute to the elevation in intraocular fluid interleucin- 6 levels observed during various intraocular inflammatory episodes. (via Semantic Scholar)
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2000 article

The effects of Tempol on ferritin synthesis and Fe metabolism in lens epithelial cells

Goralska, M., Holley, B., & McGahan, M. C. (2000, June 1). Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research.

By: M. Goralska n, B. Holley n & M. McGahan n

author keywords: ferritin; Fe metabolism; lens; cataract; lens epithelial cell; tempol; oxidative damage; peroxide; free radical
MeSH headings : Animals; Antioxidants / pharmacology; Cyclic N-Oxides / pharmacology; Dogs; Dose-Response Relationship, Drug; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Female; Ferritins / biosynthesis; Ferritins / drug effects; Iron / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Male; Spin Labels; Time Factors; tert-Butylhydroperoxide / pharmacology
topics (OpenAlex): Connexins and lens biology; Trace Elements in Health; Redox biology and oxidative stress
TL;DR: The redistribution of Fe within the cell after 20 h of Tempol treatment appears to render the cells more vulnerable to oxidative stress, likely due to its effects on Fe metabolism, perhaps by reducing the availability of Fe for incorporation into ferritin and Fe-dependent enzymes as well as enlarging a low molecular weight pool of Fe which may be capable of catalyzing damaging free radical reactions. (via Semantic Scholar)
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1999 article

Telomerase Activity in Lens Epithelial Cells of Normal and Cataractous Lenses

COLITZ, C. A. R. M. E. N. M. H., DAVIDSON, M. I. C. H. A. E. L. G., & McGAHAN, M. C. H. R. I. S. T. I. N. E. (1999, December 1). Experimental Eye Research.

By: C. Colitz n, M. Davidson* & M. McGAHAN*

author keywords: telomerase; telomere; lens epithelial cells; cataract; DNA; cell senescence; beta-galactosidase
MeSH headings : Animals; Blotting, Southern; Cataract / enzymology; Cats; Cell Differentiation; Cell Division; Cells, Cultured; Cellular Senescence; Cytological Techniques; Dogs; Epithelial Cells / enzymology; Lens, Crystalline / cytology; Lens, Crystalline / enzymology; Lens, Crystalline / ultrastructure; Mice; Rabbits; Telomerase / analysis; Telomerase / metabolism; Telomere / ultrastructure; beta-Galactosidase / metabolism
topics (OpenAlex): Telomeres, Telomerase, and Senescence; Connexins and lens biology; Corneal Surgery and Treatments
TL;DR: Telomerase activity is likely important in the germinative epithelium to maintain its proliferative potential and prevent cell senescence and may function in the quiescent, central lens to maintain telomeres damaged by oxidative stress and ultraviolet light exposure, thereby preventing accelerated loss of these elements which triggers cellsenescence. (via Semantic Scholar)
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1998 journal article

Characterization of canine MDR1 mRNA: Its abundance in drug resistant cell lines and in vivo

Anticancer Research, 18(1A), 393–400.

By: S. Steingold, N. Sharp, M. McGahan, C. Hughes, S. Dunn & R. Page

Source: NC State University Libraries
Added: August 6, 2018

1998 article

The Effect of Ascorbic Acid and Ferric Ammonium Citrate on Iron Uptake and Storage in Lens Epithelial Cells

GORALSKA, M., HARNED, J., FLEISHER, L. N., & McGAHAN, M. C. (1998, June 1). Experimental Eye Research.

By: M. Goralska n, J. Harned*, L. Fleisher* & M. McGAHAN*

author keywords: ascorbic acid; ferritin; lens; iron; ferric ammonium citrate; transferrin
MeSH headings : Animals; Apoferritins / biosynthesis; Ascorbic Acid / pharmacology; Cells, Cultured; Chlorides; Dogs; Epithelial Cells / metabolism; Ferric Compounds / metabolism; Ferric Compounds / pharmacology; Homeostasis; Humans; Infant, Newborn; Iron Radioisotopes / metabolism; Lens, Crystalline / metabolism; Quaternary Ammonium Compounds / pharmacology; Transferrin / metabolism
topics (OpenAlex): Connexins and lens biology; Iron Metabolism and Disorders; Trace Elements in Health
TL;DR: Iron homeostasis in lens epithelial cells is affected mainly by changes in apoferritin synthesis, which is greatly stimulated by ascorbic acid, rather than by altering the rate of protein degradation, which has been very slow in these cells under all circumstances. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 article

The lens influences aqueous humor levels of transforming growth factor-β2

Allen, J. B., Davidson, M. G., Nasisse, M. P., Fleisher, L. N., & McGahan, M. C. (1998, March 18). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: J. Allen*, M. Davidson n, M. Nasisse*, L. Fleisher* & M. McGahan*

MeSH headings : Animals; Aphakia / etiology; Aphakia / metabolism; Aphakia / pathology; Aqueous Humor / metabolism; Biological Assay; Cataract / etiology; Cataract / metabolism; Cataract / pathology; Cells, Cultured; Ciliary Body / cytology; Ciliary Body / metabolism; Disease Models, Animal; Dogs; Enzyme-Linked Immunosorbent Assay; Female; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Male; Pigment Epithelium of Eye / cytology; Pigment Epithelium of Eye / metabolism; Rabbits; Transforming Growth Factor beta / metabolism
topics (OpenAlex): Intraocular Surgery and Lenses; Glaucoma and retinal disorders; Retinal and Macular Surgery
TL;DR: Surprisingly, aqueous humor from aphakic rabbit eyes contained significantly higher levels of TGF-β2 than their contralateral phakic controls, and that the presence and status of the lens may influence IOF TGF -β2 levels. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1998 article

Transferrin in After-Cataract and as a Survival Factor for Lens Epithelium

DAVIDSON, M. G., HARNED, J., GRIMES, A. M., DUNCAN, G., WORMSTONE, I. M., & McGAHAN, M. C. (1998, February 1). Experimental Eye Research.

By: M. Davidson n, J. Harned n, A. Grimes n, G. Duncan*, I. Wormstone * & M. McGAHAN n

author keywords: transferrin; after-cataract; human; rabbit; lens; epithelial cells; growth factors
MeSH headings : Animals; Cataract / pathology; Cataract Extraction; Cell Division; Cell Survival; Cells, Cultured; Epithelial Cells / metabolism; Humans; Lens Capsule, Crystalline / metabolism; Lens Capsule, Crystalline / pathology; Lens, Crystalline / metabolism; Lens, Crystalline / pathology; Postoperative Period; Rabbits; Recurrence; Transferrin / biosynthesis; Transferrin / metabolism
topics (OpenAlex): Connexins and lens biology; Intraocular Surgery and Lenses; Blood Coagulation and Thrombosis Mechanisms
TL;DR: Tf acts as a survival factor for lens epithelia and its synthesis is up-regulated in after-cataract lens sacs, suggesting that Tf may play an important role in the pathogenesis of lens epithelial cell proliferation and after-Cataract formation following cataract surgery. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 article

Mechanisms by which Ascorbic Acid Increases Ferritin levels in Cultured Lens Epithelial Cells

GORALSKA, M., HARNED, J., GRIMES, A. M., FLEISHER, L. N., & McGAHAN, M. C. (1997, March 1). Experimental Eye Research.

By: M. Goralska n, J. Harned n, A. Grimes n, L. Fleisher n & M. McGAHAN n

author keywords: ascorbic acid; ferritin; lens; cataract
MeSH headings : Animals; Ascorbic Acid / metabolism; Ascorbic Acid / pharmacology; Base Sequence; Blotting, Northern; Cells, Cultured; DNA / metabolism; Deferoxamine / pharmacology; Dithiothreitol / pharmacology; Dogs; Epithelium / drug effects; Epithelium / metabolism; Ferric Compounds / metabolism; Ferritins / biosynthesis; Ferritins / drug effects; Ferritins / genetics; Hydrogen Peroxide / pharmacology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Molecular Sequence Data; Oxidation-Reduction; Protein Biosynthesis; Protein Synthesis Inhibitors / pharmacology; RNA, Messenger / drug effects; RNA, Messenger / metabolism
topics (OpenAlex): Connexins and lens biology
TL;DR: The ability of ascorbic acid to increase ferritin concentration in lens epithelial cells could provide an additional protective mechanism for this antioxidant vitamin. (via Semantic Scholar)
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1997 article

Nitric Oxide in Ocular Inflammation

Allen, J. B., McGahan, M. C., Fleisher, L. N., Jaffe, G. J., Keng, T., & Privalle, C. T. (1997, January 1).

By: J. Allen n, M. McGahan n, L. Fleisher n, G. Jaffe *, T. Keng & C. Privalle

Ed(s):

topics (OpenAlex): Nitric Oxide and Endothelin Effects; Eicosanoids and Hypertension Pharmacology; Neuropeptides and Animal Physiology
TL;DR: Differential competitive inhibition of isoforms of NOS by NG-substituted L-arginine analogues allows selective intervention to inhibit production of NO as well as to further determine its functions. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1996 article

Hemoglobin exacerbates the ocular inflammatory response to endotoxin

McGahan, M. C., Grimes, A. M., & Fleisher, L. N. (1996, October 1). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: M. McGahan n, A. Grimes n & L. Fleisher n

MeSH headings : Animals; Apoproteins / toxicity; Aqueous Humor / metabolism; Deferoxamine / toxicity; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Escherichia coli; Eye Proteins / metabolism; Hemoglobins / toxicity; Leukocytes / pathology; Lipopolysaccharides / toxicity; Rabbits; Random Allocation; Siderophores / toxicity; Transferrin / toxicity; Uveitis, Anterior / chemically induced; Uveitis, Anterior / pathology; Uveitis, Anterior / physiopathology; Vitreous Body / metabolism
topics (OpenAlex): Biochemical effects in animals; High Altitude and Hypoxia; Advanced Glycation End Products research
TL;DR: It is likely that hemoglobinic Fe is responsible for the increased infiltration of white cells caused by the co-injection of autologous hemaglobin and endotoxin, which was increased 15-fold. (via Semantic Scholar)
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1996 article

Interleukin-1β Increases Prostaglandin E2-Stimulated Adenosine 3′,5′-cyclic Monophosphate Production in Rabbit Pigmented Ciliary Epithelium

FLEISHER, L. L. O. Y. D. N., McGAHAN, C. H. R. I. S. T. I. N. E. M., FERRELL, J. E. N. N. Y. B., & PAGAN, I. N. E. S. (1996, July 1). Experimental Eye Research.

By: L. Fleisher n, C. McGAHAN n, J. Ferrell n & I. Pagan n

author keywords: ciliary epithelium; cyclic AMP, interleukin-1; prostaglandins; transforming growth factor-beta; pigmented ciliary epithelium
MeSH headings : Animals; Cells, Cultured; Colforsin / pharmacology; Cyclic AMP / biosynthesis; Cycloheximide / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Dinoprostone / pharmacology; Dose-Response Relationship, Drug; Indomethacin / pharmacology; Interleukin-1 / pharmacology; Isoproterenol / pharmacology; Kinetics; Lipopolysaccharides / pharmacology; Pigment Epithelium of Eye / drug effects; Pigment Epithelium of Eye / metabolism; Protein Synthesis Inhibitors / pharmacology; Rabbits; Stimulation, Chemical; Transforming Growth Factor beta / pharmacology; Tumor Necrosis Factor-alpha / pharmacology; Up-Regulation; Vasoactive Intestinal Peptide / pharmacology
topics (OpenAlex): Inflammatory mediators and NSAID effects; Adenosine and Purinergic Signaling; Corneal Surgery and Treatments
TL;DR: This is the first report of prostaglandin E2-induced stimulation of adenosine 3',5'-cyclic monophosphate production by pigmented ciliary epithelial cells and of the unique ability of interleukin-1 to increase this effect. (via Semantic Scholar)
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Added: August 6, 2018

1996 article

Intravitreal transforming growth factor-β2 decreases cellular infiltration in endotoxin-induced ocular inflammation in rabbits

Allen, J. B., McGahan, M. C., Ogawa, Y., Sellon, D. C., Clark, B. D., & Fleisher, L. N. (1996, January 1). Current Eye Research.

By: J. Allen*, M. McGahan n, Y. Ogawa, D. Sellon  n, B. Clark* & L. Fleisher n

author keywords: inflammation; in situ hybridization; rabbits; transforming growth factor-beta (TGF-beta); uveitis; endotoxin
MeSH headings : Animals; Anterior Eye Segment / pathology; Body Fluids / metabolism; Cell Movement / drug effects; Injections; Interleukin-1 / metabolism; Lipopolysaccharides; Male; Rabbits; Transforming Growth Factor beta / pharmacology; Uveitis / chemically induced; Uveitis / metabolism; Uveitis / pathology; Vitreous Body
topics (OpenAlex): Corneal Surgery and Treatments; Retinal Diseases and Treatments; Angiogenesis and VEGF in Cancer
TL;DR: In a rabbit model of LPS-induced uveitis, TGF-beta may interrupt the cascade of events leading to ocular inflammation, thereby suggesting therapeutic potential. (via Semantic Scholar)
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Added: August 6, 2018

1996 article

Nitric Oxide Synthase Inhibitors Exert Differential Time-Dependent Effects on LPS-Induced Uveitis

ALLEN, J. B., McGAHAN, M. C., FERRELL, J. B., ADLER, K. B., & FLEISHER, L. N. (1996, January 1). Experimental Eye Research.

By: J. Allen n, M. McGAHAN n, J. Ferrell n, K. Adler n & L. Fleisher n

author keywords: nitric oxide; uveitis; nitric oxide synthase; nitric oxide synthase inhibitors; inflammation
MeSH headings : Animals; Aqueous Humor / metabolism; Arginine / analogs & derivatives; Arginine / therapeutic use; Cell Count / drug effects; Dose-Response Relationship, Drug; Eye Proteins / drug effects; Guanidines / therapeutic use; Kinetics; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide / antagonists & inhibitors; Nitric Oxide / physiology; Nitric Oxide Synthase / antagonists & inhibitors; Rabbits; Uveitis, Anterior / etiology; Uveitis, Anterior / metabolism; Uveitis, Anterior / prevention & control
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Retinal and Optic Conditions
TL;DR: Investigation of the effects of NOS inhibitors with different NOS isoform specificities in the rabbit model of endotoxin-induced ocular inflammation suggests that cNOS may play a greater role in the earlier stages of this developing inflammatory response, and extends others' observations that NO is a key mediator in uveitis. (via Semantic Scholar)
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Added: August 6, 2018

1995 article

Inflammation induced changes in adenosine 3′,5′-cyclic monophosphate production by ciliary epithelial cell bilayers

Fleisher, L. N., Ferrell, J. B., & McGahan, M. C. (1995, February 1). Experimental Eye Research.

By: L. Fleisher n, J. Ferrell n & M. McGahan n

author keywords: ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE; INTERLEUKIN-1; TUMOR NECROSIS FACTOR; ANTERIOR UVEA; CILIARY EPITHELIUM; ENDOTOXIN; UVEITIS
MeSH headings : Animals; Ciliary Body / drug effects; Ciliary Body / metabolism; Colforsin / pharmacology; Culture Techniques; Cyclic AMP / biosynthesis; Epithelium / drug effects; Epithelium / metabolism; Interleukin-1 / pharmacology; Isoproterenol / pharmacology; Lipopolysaccharides / pharmacology; Male; Rabbits; Recombinant Proteins / pharmacology; Tumor Necrosis Factor-alpha / pharmacology; Uveitis, Anterior / etiology; Uveitis, Anterior / metabolism
topics (OpenAlex): Ocular Surface and Contact Lens; Neuroinflammation and Neurodegeneration Mechanisms; Glaucoma and retinal disorders
TL;DR: The inability of IL-1 beta, TNF alpha, or the low concentration of endotoxin to increase cAMP production by bilayers, in vitro, suggests that the enhanced cAMPProduction observed with inflamed bilayer, ex vivo, was not due to a direct action of these inflammatory agonists on the ciliary epithelial bilayer. (via Semantic Scholar)
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Added: August 6, 2018

1995 article

Iron uptake by cultured lens epithelial cells

McGahan, M. C., Grimes, A. M., Nasisse, M. P., & Fleisher, L. N. (1995, June 1). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: M. McGahan*, A. Grimes n, M. Nasisse n & L. Fleisher n

MeSH headings : 2,2'-Dipyridyl / pharmacology; Animals; Ascorbic Acid / pharmacology; Biological Transport / drug effects; Cataract / metabolism; Cataract / pathology; Cells, Cultured; Dogs; Epithelium / metabolism; Iron / metabolism; Iron Radioisotopes; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Receptors, Transferrin / metabolism; Transferrin / metabolism
topics (OpenAlex): Connexins and lens biology; Aldose Reductase and Taurine
TL;DR: The reduction of Fe uptake by the subcultured and cataract cell lines probably reflects a decrease in transferrin receptor expression and in the activity of an alternative pathway for Fe transferrin uptake occurring over time. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1995 article

Mediators of the ocular inflammatory response to interleukin-1β plus tumor necrosis factor-α

Fleisher, L., Ferrell, J., & McGahan, C. (1995, February 1). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: L. Fleisher n, J. Ferrell n & C. McGahan n

MeSH headings : Animals; Indomethacin / therapeutic use; Interleukin-1 / toxicity; Male; Platelet Activating Factor / antagonists & inhibitors; Platelet Activating Factor / metabolism; Rabbits; Tumor Necrosis Factor-alpha / toxicity; Uveitis, Anterior / immunology; Uveitis, Anterior / prevention & control; Uveitis, Posterior / immunology; Uveitis, Posterior / prevention & control
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Immune Response and Inflammation
TL;DR: The findings do not support an important role for PAF in TNFa/IL-1β-induced uveitis, and it cannot be ruled out that more intensive treatment with a specific and long-acting PAF-receptor antagonist might yield more positive results. (via Semantic Scholar)
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Added: August 6, 2018

1995 article

Transferrin secretion by lens epithelial cells in culture

McGahan, M. C., Harned, J., Goralska, M., Sherry, B., & Fleisher, L. N. (1995, June 1). Experimental Eye Research.

By: M. McGahan n, J. Harned n, M. Goralska n, B. Sherry n & L. Fleisher n

author keywords: TRANSFERRIN; LENS; ANTIOXIDANTS; GROWTH FACTORS; AQUEOUS HUMOR
MeSH headings : Animals; Aqueous Humor / chemistry; Blotting, Northern; Cells, Cultured; Ciliary Body / metabolism; Dogs; Epithelium / metabolism; Lens, Crystalline / metabolism; Rabbits; Secretory Rate; Time Factors; Transferrin / metabolism; Vitreous Body / chemistry
topics (OpenAlex): Connexins and lens biology; Intraocular Surgery and Lenses; Urinary Bladder and Prostate Research
TL;DR: This is the first experimental demonstration that an intraocular tissue can make and secrete Tf, and transferrin secretion by the lens may contribute significantly to the IOF content of this important intraocular protein. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1994 article

Influence of Exposure Time on Inflammatory Response to Neodymium:YAG Cyclophotocoagulation in Rabbits

Echelman, D. A. (1994, July 1). Archives of Ophthalmology.

By: D. Echelman*

MeSH headings : Animals; Aqueous Humor / metabolism; Ciliary Body / metabolism; Ciliary Body / pathology; Ciliary Body / surgery; Erythrocyte Count; Inflammation; Laser Coagulation / adverse effects; Leukocyte Count; Rabbits; Time Factors; Uveitis / etiology; Uveitis / metabolism; Uveitis / pathology
topics (OpenAlex): Glaucoma and retinal disorders; Intraocular Surgery and Lenses; Anorectal Disease Treatments and Outcomes
TL;DR: When energy is constant, a shorter duration of exposure with transscleral Nd:YAG cyclophotocoagulation in rabbits is associated with greater tissue disruption and inflammation. (via Semantic Scholar)
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Added: August 6, 2018

1994 article

Regulation of Ferritin Levels in Cultured Lens Epithelial Cells

McGahan, M. C., Harned, J., Grimes, A. M., & Fleisher, L. N. (1994, November 1). Experimental Eye Research.

By: M. McGahan n, J. Harned n, A. Grimes n & L. Fleisher n

author keywords: IRON; FERRITIN; LENS EPITHELIAL CELLS; PEROXIDE; FREE RADICALS; ASCORBIC ACID
MeSH headings : Animals; Cells, Cultured; Chelating Agents / pharmacology; Deferoxamine / pharmacology; Dogs; Enzyme-Linked Immunosorbent Assay; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Hemin / pharmacology; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism
topics (OpenAlex): Connexins and lens biology; Aldose Reductase and Taurine; Iron Metabolism and Disorders
TL;DR: Regulation of ferritin levels may represent a mechanism by which the lens epithelium is protected from oxidative damage, and in pathological circumstances, the iron content and redox state of the aqueous humor is dramatically altered and may affect the steady state levels of Ferritin within the lens. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1994 article

Transferrin Inhibits the Ocular Inflammatory Response

McGahan, M. C., Grimes, A. M., & Fleisher, L. N. (1994, April 1). Experimental Eye Research.

By: M. McGahan*, A. Grimes* & L. Fleisher*

MeSH headings : Animals; Eye Proteins / metabolism; Leukocyte Count / drug effects; Rats; Transferrin / therapeutic use; Uveitis / prevention & control; Xanthine Oxidase
topics (OpenAlex): Retinal Diseases and Treatments; Iron Metabolism and Disorders; Retinal Development and Disorders
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1992 article

Cellular response to intravitreal injection of endotoxin and xanthine oxidase in rabbits

McGahan, M. C., & Fleisher, L. N. (1992, August 1). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: M. McGahan* & L. Fleisher n

MeSH headings : Animals; Aqueous Humor / cytology; Endotoxins / administration & dosage; Endotoxins / pharmacology; Escherichia coli; Injections; Leukocyte Count / drug effects; Leukocytes; Lipopolysaccharides; Rabbits; Vitreous Body / cytology; Xanthine Oxidase / administration & dosage; Xanthine Oxidase / pharmacology
topics (OpenAlex): Connexins and lens biology; Glaucoma and retinal disorders; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: Myeloperoxidase (MPO) activity of the iris-ciliary body was increased only in those eyes with a large neutrophilic response and thus is not recommended for use as a definitive index of the ocular inflammatory response, but may be a useful adjunct for such studies. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1992 article

Does the lens serve as a ‘sink’ for iron during ocular inflammation?

McGahan, M. C. (1992, April 1). Experimental Eye Research.

By: M. McGahan n

author keywords: IRON; CRYSTALLINE LENS; OCULAR INFLAMMATION; TRANSFERRIN
MeSH headings : Animals; Copper / metabolism; Endotoxins; Iron / metabolism; Lens, Crystalline / metabolism; Rabbits; Time Factors; Uveitis / chemically induced; Uveitis / metabolism
topics (OpenAlex): Connexins and lens biology; Heme Oxygenase-1 and Carbon Monoxide; Advanced Glycation End Products research
TL;DR: There was a distinct relationship between the dose of endotoxin used and the amount of Fe accumulated by the lens, and there may be a specific Fe uptake mechanism in this ocular tissue. (via Semantic Scholar)
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1992 journal article

Effects of copper loading and depletion on rabbit superoxide dismutase activity

Trace Elements in Medicine, 9, 55–58.

By: J. Ferrell, L. Fleisher, M. Smith & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

1992 journal article

Synergistic uveitic effects of tumor necrosis factor-alpha and interleukin-1 beta

Investigative Ophthalmology and Visual Science, 33, 2120–2127.

By: L. Fleisher, J. Ferrell & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

1991 article

Effects of copper depletion andd-penicillamine treatment on the ocular inflammatory response

McGahan, M. C., Fleisher, L. N., & Grimes, A. M. (1991, November 1). Inflammation Research.

By: M. McGahan*, L. Fleisher n & A. Grimes n

MeSH headings : Animals; Antioxidants; Aqueous Humor / metabolism; Ceruloplasmin / metabolism; Copper / deficiency; Copper / metabolism; Endophthalmitis / metabolism; Endophthalmitis / pathology; Free Radicals; Penicillamine / pharmacology; Rabbits
topics (OpenAlex): Connexins and lens biology; Trace Elements in Health; Vanadium and Halogenation Chemistry
TL;DR: Rabbits placed on a copper (Cu)-deficient diet for four weeks had lower plasma Cu concentration, ferroxidase activity, and antioxidant activity than rabbits fed an identical Cu-adequate basel diet and it is likely that ceruloplasmin plays a protective role in the intraocular inflammatory response. (via Semantic Scholar)
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1991 journal article

Lipid mediators of TNF- induced uveitis

Investigative Ophthalmology and Visual Science, 32, 2393–2399.

By: L. Fleisher, J. Ferrell & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

1991 article

Selenium Concentration in Ocular Tissues and Fluids

McGahan, M. C., & Grimes, A. M. (1991, January 1). Ophthalmic Research.

By: M. McGahan n & A. Grimes*

author keywords: SELENIUM; AQUEOUS HUMOR; LENS; IRIS; RETINA; CORNEA
MeSH headings : Animals; Aqueous Humor / chemistry; Brain Chemistry; Eye / chemistry; Kidney / chemistry; Organ Size; Rabbits; Selenium / analysis; Selenium / blood; Spectrophotometry, Atomic
topics (OpenAlex): Selenium in Biological Systems; Mercury impact and mitigation studies; Protein Interaction Studies and Fluorescence Analysis
TL;DR: A simple, precise method for the analysis of selenium (Se) in ocular fluids and tissues using electrothermal atomic absorption spectroscopy is presented and it is likely that the difference in Se concentration between plasma and aqueous humor reflects the relative distribution of protein between these fluids. (via Semantic Scholar)
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1990 article

Copper and aspirin treatment increase the antioxidant activity of plasma

McGahan, M. C. (1990, August 1). Inflammation Research.

By: M. McGahan n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor / enzymology; Aqueous Humor / metabolism; Aspirin / pharmacology; Ceruloplasmin / metabolism; Copper / pharmacology; Endotoxins / toxicity; Eye Diseases / blood; Eye Diseases / chemically induced; Inflammation / blood; Inflammation / chemically induced; Lipid Peroxidation / drug effects; Molecular Weight; Oxidation-Reduction; Rabbits; Superoxide Dismutase / metabolism; Transferrin / metabolism
topics (OpenAlex): Advanced Glycation End Products research; Pharmacological Effects of Medicinal Plants; Drug-Induced Hepatotoxicity and Protection
TL;DR: A large increase in plasma antioxidant activity may have a protective effect in other models of inflammation and provide a mechanism for the proven increase in anti-inflammatory efficacy of Cu-chelates of many compounds. (via Semantic Scholar)
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1990 article

Ocular inflammatory effects of intravitreally injected tumor necrosis factor-alpha and endotoxin

Fleisher, L. N., Ferrell, J. B., & McGahan, M. C. (1990, June 1). Inflammation.

By: L. Fleisher*, J. Ferrell n & M. McGahan n

MeSH headings : Animals; Aqueous Humor / analysis; Drug Synergism; Endotoxins / administration & dosage; Endotoxins / toxicity; Inflammation; Injections; Male; Rabbits; Recombinant Proteins / administration & dosage; Recombinant Proteins / toxicity; Tumor Necrosis Factor-alpha / administration & dosage; Tumor Necrosis Factor-alpha / toxicity; Uveitis / chemically induced; Uveitis / pathology; Vitreous Body
topics (OpenAlex): Neuroinflammation and Neurodegeneration Mechanisms; Glaucoma and retinal disorders; Immune Response and Inflammation
TL;DR: Intravitreal injection of human recombinant tumor necrosis factor-alpha induced inflammation in the rabbit eye characterized by dilation of blood vessels in the iris, disruption of the blood-ocular barriers, infiltration of inflammatory cells into the anterior chamber, and accumulation of prostaglandin E in intraocular fluids differed from that reported for intravitreally injected endotoxin in terms of time course and the types ofinflammatory cells in the aqueous humor. (via Semantic Scholar)
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1989 article

Clinical signs of acute ocular inflammatory response to endotoxin are not altered by increasing antioxidant potency of intraocular fluids

Mcgahan, M. C., Fleisher, L. N., & Grimes, A. M. (1989, August 1). Inflammation.

By: M. Mcgahan*, L. Fleisher n & A. Grimes n

MeSH headings : Animals; Antioxidants; Aqueous Humor / metabolism; Ceruloplasmin / metabolism; Copper / blood; Copper / pharmacology; Endotoxins / toxicity; Rabbits; Transferrin / metabolism; Uveitis / physiopathology
topics (OpenAlex): Vanadium and Halogenation Chemistry; Connexins and lens biology; S100 Proteins and Annexins
TL;DR: Increased intraocular fluid antioxidant activity did not affect the acute anterior segment response to endotoxin, and it is possible that the time course and resolution of the response is altered by changes in extracellular fluid antioxidants activity. (via Semantic Scholar)
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1989 article

Dimethylthiourea inhibits the inflammatory response to intravitreally-injected endotoxin

Fleisher, L. N., Ferrell, J. B., Olson, N. C., & McGahan, M. C. (1989, April 1). Experimental Eye Research.

By: L. Fleisher n, J. Ferrell n, N. Olson n & M. McGahan n

MeSH headings : Animals; Endotoxins; Escherichia coli; Male; Rabbits; Thiourea / administration & dosage; Thiourea / analogs & derivatives; Thiourea / pharmacology; Uveitis, Anterior / chemically induced; Uveitis, Anterior / prevention & control; Vitreous Body
topics (OpenAlex): Inflammatory mediators and NSAID effects; Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Vanadium and Halogenation Chemistry
TL;DR: The ability of dimethylthiourea to significantly inhibit the inflammatory response to intravitreally-injected endotoxin suggests that toxic oxygen metabolites may play an important role in the initiation and/or propagation of this form of acute anterior uveitis. (via Semantic Scholar)
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1989 article

Ferroxidase Activity Increases in the Aqueous Humor during the Ocular Inflammatory Response

McGahan, C., Grimes, A. M., & Fleisher, L. N. (1989, January 1). Ophthalmic Research.

By: C. McGahan n, A. Grimes n & L. Fleisher n

MeSH headings : Animals; Aqueous Humor / enzymology; Ceruloplasmin / analysis; Ceruloplasmin / metabolism; Copper / analysis; Copper / blood; Endophthalmitis / enzymology; Endotoxins; Escherichia coli / metabolism; Proteins / analysis; Rabbits; Spectrophotometry, Atomic; Time Factors; Vitreous Body
topics (OpenAlex): Connexins and lens biology; Glaucoma and retinal disorders; Neutrophil, Myeloperoxidase and Oxidative Mechanisms
TL;DR: Plasma copper transport protein ceruloplasmin (plasma ferroxidase) entered the inflamed aqueous humor from plasma through disrupted blood ocular barriers and would facilitate the removal of potentially damaging, free radical generating Fe+2.2. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1988 article

Inflammation-induced changes in the iron concentration and total iron-binding capacity of the intraocular fluids of rabbits

McGahan, M. C., & Fleisher, L. N. (1988, January 1). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: M. McGahan n & L. Fleisher n

MeSH headings : Animals; Aqueous Humor / metabolism; Endophthalmitis / chemically induced; Endophthalmitis / metabolism; Eye / metabolism; Iron / analysis; Iron / blood; Iron / metabolism; Rabbits; Transferrin / metabolism; Vitreous Body / metabolism
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Connexins and lens biology; Barrier Structure and Function Studies
TL;DR: The influx of the partially saturated plasma protein transferrin through disrupted blood-ocular barriers most likely accounts for the increased TIBC in the inflamed eye and could provide some protection against the potentially harmful effects of Fe arising from tissue necrosis and hemolysis subsequent to hemorrhage. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

1987 article

Cysteine—an effective matrix modifier for determination of gold in biological samples by electrothermal atomic absorption spectrophotometry

Matthews, D. O., & McGahan, M. C. (1987, January 1). Spectrochimica Acta Part B Atomic Spectroscopy.

By: D. Matthews n & M. McGahan n

topics (OpenAlex): Electrochemical Analysis and Applications; Trace Elements in Health
TL;DR: Addition of plasma proteins and amino acids as matrix modifiers increased both the absorbance signal of the standard and the recovery of gold added to intraocular fluids and tissue digests. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1987 article

The determination of platinum in biological materials by electrothermal atomic absorption spectroscopy

McGahan, M. C., & Tyczkowska, K. (1987, January 1). Spectrochimica Acta Part B Atomic Spectroscopy.

By: M. McGahan n & K. Tyczkowska n

topics (OpenAlex): Analytical chemistry methods development; Electrochemical Analysis and Applications
TL;DR: The wet ashing technique is fast and convenient and requires minimal sample treatment, and there was complete recovery of platinum added to the tissues when the tissues were wet ashed. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1986 article

A micromethod for the determination of iron and total iron-binding capacity in intraocular fluids and plasma using electrothermal atomic absorption spectroscopy

McGahan, M. C., & Fleisher, L. N. (1986, August 1). Analytical Biochemistry.

By: M. McGahan n & L. Fleisher n

MeSH headings : Animals; Aqueous Humor / metabolism; Cats; Dogs; Electrochemistry; Eye / metabolism; Horses; Indicators and Reagents; Iron / analysis; Iron / blood; Iron / metabolism; Rabbits; Species Specificity; Spectrophotometry, Atomic; Swine; Temperature; Vitreous Body / metabolism
topics (OpenAlex): Intraocular Surgery and Lenses; Glaucoma and retinal disorders; Retinal Diseases and Treatments
TL;DR: Using this method considerably less species variation in IOF Fe concentration was found as compared to previous studies, and some possible methodological reasons for this difference are discussed. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1986 article

Antioxidant activity of aqueous and vitreous humor from the inflamed rabbit eye

McGahan, M. C., & Fleisher, L. N. (1986, January 1). Current Eye Research.

By: M. McGahan n & L. Fleisher n

MeSH headings : Animals; Antioxidants / metabolism; Aqueous Humor / metabolism; Brain / metabolism; Endophthalmitis / metabolism; Eye Proteins / metabolism; Male; Malondialdehyde / biosynthesis; Oxidation-Reduction; Rabbits; Time Factors; Vitreous Body / metabolism
topics (OpenAlex): Glaucoma and retinal disorders; Connexins and lens biology; Traumatic Brain Injury and Neurovascular Disturbances
TL;DR: Entry of plasma proteins through disrupted blood ocular barriers may function in protecting ocular tissues against the increased oxidation which occurs during inflammation. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1986 article

Copper concentration in cornea, iris, normal, and cataractous lenses and intraocular fluids of vertebrates

Cook, C. S., & Mcgahan, M. C. (1986, January 1). Current Eye Research.

By: C. Cook n & M. Mcgahan n

MeSH headings : Age Factors; Animals; Aqueous Humor / analysis; Bufo marinus; Cataract / metabolism; Cats; Copper / analysis; Cornea / analysis; Dogs; Horses; Iris / analysis; Lens, Crystalline / analysis; Rabbits; Vitreous Body / analysis
topics (OpenAlex): Trace Elements in Health; Connexins and lens biology; Mercury impact and mitigation studies
TL;DR: A method using electrothermal atomic absorption spectroscopy was developed for the determination of copper (Cu) concentration in the cornea, iris, and lens of a variety of species, including dog, cat, rabbit, horse, and toad. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1986 article

Effects of melittin on a model renal epithelium, the toad urinary bladder

McGahan, M. C., Matthews, D. O., & Bentley, P. J. (1986, February 1). Biochimica Et Biophysica Acta (BBA) - Biomembranes.

By: M. McGahan n, D. Matthews n & P. Bentley n

MeSH headings : Amiloride / pharmacology; Animals; Bee Venoms / pharmacology; Bufo marinus; Epithelium / drug effects; Kidney / cytology; Lanthanum / pharmacology; Meclofenamic Acid / pharmacology; Melitten / pharmacology; Membrane Potentials / drug effects; Models, Biological; Urinary Bladder / cytology; Urinary Bladder / drug effects
topics (OpenAlex): Healthcare and Venom Research; Bee Products Chemical Analysis; Insect and Pesticide Research
TL;DR: The bee venom melittin, 10(-6) M, on the mucosal (urinary) side of the toad urinary bladder (in vitro), markedly decreased transepithelial potential difference, short-circuit current (Isc, sodium-dependent) and resistance. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1986 article

The pathophysiology of the ocular microenvironment. II. Copper-induced ocular inflammation and hypotony

McGahan, M. C., Bito, L. Z., & Myers, B. M. (1986, June 1). Experimental Eye Research.

By: M. McGahan*, L. Bito* & B. Myers *

MeSH headings : Animals; Anterior Chamber / metabolism; Ascorbic Acid / metabolism; Copper / metabolism; Copper / toxicity; Copper Sulfate; Dose-Response Relationship, Drug; Eye Diseases / chemically induced; Eye Proteins / metabolism; Female; Inflammation / chemically induced; Intraocular Pressure / drug effects; Muscle Hypotonia / chemically induced; Rabbits; Time Factors; Vitreous Body / metabolism
topics (OpenAlex): Intraocular Surgery and Lenses; Retinal and Optic Conditions
TL;DR: The ocular effects of intravitreally injected copper sulfate solutions were studied in New Zealand white rabbits and resulted in uveitis characterized by prolonged ocular hypotony, increased protein concentrations and decreased ascorbic acid concentrations, and an apparent decrease in the transport function of the anterior uvea. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1986 article

Time course for prostaglandin synthesis by rabbit lens during endotoxin-induced ocular inflammation

Fleisher, L. N., & McGahan, M. C. (1986, January 1). Current Eye Research.

By: L. Fleisher n & M. McGahan n

MeSH headings : Animals; Body Fluids / metabolism; Dinoprost; Dinoprostone; Endophthalmitis / chemically induced; Endophthalmitis / metabolism; Endophthalmitis / pathology; Endotoxins / pharmacology; Escherichia coli; Lens, Crystalline / metabolism; Male; Prostaglandins E / biosynthesis; Prostaglandins F / biosynthesis; Rabbits
topics (OpenAlex): Inflammatory mediators and NSAID effects; Glaucoma and retinal disorders; Immune Response and Inflammation
TL;DR: The results suggest that during ocular inflammation, aqueous humor PGE2 may be derived, at least in part, from the lens and leukocytes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1985 article

Ascorbic acid levels in aqueous and vitreous humors of the rabbit: Effects of inflammation and ceruloplasmin

McGahan, M. C. (1985, January 1). Experimental Eye Research.

By: M. McGahan n

MeSH headings : Animals; Aqueous Humor / drug effects; Aqueous Humor / metabolism; Ascorbic Acid / metabolism; Ceruloplasmin / pharmacology; Copper / metabolism; Dehydroascorbic Acid / metabolism; Endophthalmitis / etiology; Endophthalmitis / metabolism; Endotoxins; Eye Proteins / metabolism; Rabbits; Vitreous Body / drug effects; Vitreous Body / metabolism
topics (OpenAlex): Glaucoma and retinal disorders; Intraocular Surgery and Lenses; Corneal surgery and disorders
TL;DR: A HPLC method for determination of ascorbic acid and dehydroascorbic acid in plasma and aqueous and vitreous humors of rabbits is described and indicates that the aqueously humor is not the source of vitreal ascorBic acid. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1985 article

Endotoxin-induced ocular inflammation increases prostaglandin E2 synthesis by rabbit lens

Fleisher, L. N., & McGahan, M. C. (1985, May 1). Experimental Eye Research.

By: L. Fleisher n & M. McGahan n

MeSH headings : Animals; Aqueous Humor / metabolism; Dinoprostone; Endotoxins / pharmacology; Escherichia coli; Eye / drug effects; Eye / pathology; Inflammation / metabolism; Lens, Crystalline / metabolism; Male; Prostaglandins E / biosynthesis; Rabbits
topics (OpenAlex): Biochemical effects in animals; Inflammatory mediators and NSAID effects; Aldose Reductase and Taurine
TL;DR: Twenty-four hours after the intravitreal injection of 0.1-100 ng of Escherichia coli endotoxin into one eye of the New Zealand white rabbit, lenses from the inflamed eyes synthesized significantly more prostaglandin E2 (PGE2) than their contralateral lenses at all doses of endotoxin. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1985 article

Melittin-induced changes in Na and Cl movements across the skin and cornea (in vitro) of the toad Bufo marinus

McGahan, M. C., Hazard, R. L., & Bentley, P. J. (1985, January 1). Comparative Biochemistry and Physiology Part C Comparative Pharmacology.

By: M. McGahan n, R. Hazard n & P. Bentley n

MeSH headings : Amphotericin B / pharmacology; Animals; Bee Venoms / pharmacology; Biological Transport, Active / drug effects; Bufo marinus; Bumetanide / pharmacology; Chlorides / metabolism; Cornea / drug effects; Cornea / metabolism; Meclofenamic Acid / pharmacology; Melitten / pharmacology; Quinacrine / pharmacology; Skin / drug effects; Skin / metabolism; Sodium / metabolism; Trifluoperazine / pharmacology; Vasopressins / pharmacology
topics (OpenAlex): Healthcare and Venom Research; Bee Products Chemical Analysis; Insect and Pesticide Research
TL;DR: Melittin apparently has two types of effects, one mediated by prostaglandins while the other is more direct, as shown in corneas with melittin on the inside and on the tear side of the cornea. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1983 article

Calcium metabolism of the rabbit lens

McGahan, M. C., Chin, B., & Bentley, P. J. (1983, January 1). Experimental Eye Research.

By: M. McGahan*, B. Chin* & P. Bentley*

MeSH headings : Animals; Calcium / metabolism; Calcium-Binding Proteins / metabolism; Hydrogen-Ion Concentration; In Vitro Techniques; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Male; Osmolar Concentration; Rabbits
topics (OpenAlex): Retinal and Macular Surgery; Intraocular Surgery and Lenses; Retinal Diseases and Treatments
TL;DR: Efflux of Ca from the lens was unchanged, under experimental conditions, by metabolic inhibitors, by EGTA, verapamil, TFP and vanadate, and in the presence of metabolic inhibitors (iodoacetate plus cyanide) lenticular Ca rises. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1983 article

Determination of copper concentration in blood plasma and in ocular and cerebrospinal fluids using graphite furnace atomic absorption spectroscopy

McGahan, M. C., & Bito, L. Z. (1983, November 1). Analytical Biochemistry.

By: M. McGahan n & L. Bito*

MeSH headings : Animals; Aqueous Humor / analysis; Bufo marinus; Cats; Copper / analysis; Copper / blood; Copper / cerebrospinal fluid; Female; Graphite; Male; Rabbits; Species Specificity; Spectrophotometry, Atomic / methods; Vitreous Body / analysis
topics (OpenAlex): Trace Elements in Health; Heavy Metal Exposure and Toxicity; Electrochemical Analysis and Applications
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Source: Web Of Science
Added: August 6, 2018

1983 article

Some observations on the magnesium metabolism of the rabbit lens

McGahan, M. C., Chin, B., & Bentley, P. J. (1983, January 1). Experimental Eye Research.

By: M. McGahan*, B. Chin* & P. Bentley*

MeSH headings : Animals; Calcimycin / pharmacology; In Vitro Techniques; Lens Cortex, Crystalline / drug effects; Lens Nucleus, Crystalline / drug effects; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Magnesium / metabolism; Male; Osmolar Concentration; Rabbits
topics (OpenAlex): Magnesium in Health and Disease; Biomedical Research and Pathophysiology; Information Technology and Learning
TL;DR: Incubation of lenses in solutions containing EDTA or following freezing and thawing suggested that much of the Mg is present in a bound form, and adjustment of the external Mg level in the presence of A-23187 indicated that the internal 'free' Mg concentration was about 3 mM, suggesting that about 35% of the lenticular magnesium is bound. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1982 article

A pharmacological analysis of chloride transport across the amphibian cornea.

Bentley, P. J., & McGahan, M. C. (1982, April 1). The Journal of Physiology.

By: P. Bentley* & M. McGahan*

MeSH headings : 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / analogs & derivatives; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / pharmacology; Animals; Biological Transport, Active / drug effects; Bucladesine / pharmacology; Bufo marinus; Bumetanide / pharmacology; Calcimycin / pharmacology; Chlorides / metabolism; Cornea / metabolism; Dinoprostone; Epinephrine / pharmacology; In Vitro Techniques; Meclofenamic Acid / pharmacology; Models, Biological; Prostaglandins E / pharmacology; Quinacrine / pharmacology; Trifluoperazine / pharmacology
topics (OpenAlex): Glaucoma and retinal disorders; Molecular Sensors and Ion Detection; Inflammatory mediators and NSAID effects
TL;DR: Active Cl, but not Na, transport across the toad cornea was inhibited by mepacrine, which is a phospholipase A2 inhibitor; trifluoperazine, which blocks the action of calmodulin; and meclofenamic acid, which inhibits synthesis of prostaglandins. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1982 article

Stimulation of transepithelial sodium and chloride transport by ascorbic acid. Induction of Na+ channels is inhibited by amiloride

McGahan, M. C., & Bentley, P. J. (1982, July 1). Biochimica Et Biophysica Acta (BBA) - Biomembranes.

By: M. McGahan* & P. Bentley*

MeSH headings : Amiloride / pharmacology; Animals; Ascorbic Acid / pharmacology; Biological Transport, Active / drug effects; Bufo marinus; Chlorides / metabolism; Cornea / metabolism; Epithelium / drug effects; Epithelium / metabolism; Ion Channels / drug effects; Ion Channels / metabolism; Kinetics; Pyrazines / pharmacology; Sodium / metabolism
topics (OpenAlex): Ion Transport and Channel Regulation
TL;DR: The effect of ascorbic acid on Isc when it was on the aqueous humor side of the cornea could be blocked by bumetanide but that due to the vitamin's presence on the tear side was unchanged, and these effects were additive. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1982 article

The pathophysiology of the ocular microenvironment. I. Preliminary report on the possible involvement of copper in ocular inflammation

McGahan, M. C., & Bito, L. Z. (1982, January 1). Current Eye Research.

By: M. McGahan* & L. Bito*

MeSH headings : Animals; Aqueous Humor / analysis; Copper / adverse effects; Copper / analysis; Copper Sulfate; Disease Models, Animal; Eye Proteins / analysis; Inflammation / chemically induced; Mechlorethamine / adverse effects; Rabbits; Uveitis / chemically induced; Uveitis / physiopathology; Vitreous Body / analysis
topics (OpenAlex): Trace Elements in Health; Drug-Induced Hepatotoxicity and Protection; Vanadium and Halogenation Chemistry
TL;DR: A better understanding of trace element metabolism is clearly required to further elucidate the mechanism of ocular inflammation and associated tissue damage. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1981 journal article

Alpha-aminoisobutyric acid transport in the amphibian crystalline lens

Journal of Physiology (London), 34, 49–56.

By: M. McGahan & P. Bentley

Source: NC State University Libraries
Added: August 6, 2018

1981 article

Alpha‐aminoisobutyric acid efflux from the cornea of the toad, Bufo marinus.

McGahan, M. C. (1981, June 1). The Journal of Physiology.

By: M. McGahan*

MeSH headings : Aminoisobutyric Acids / metabolism; Animals; Biological Transport / drug effects; Bufo marinus; Cornea / metabolism; Endothelium / metabolism; Epithelium / metabolism; Hydrogen-Ion Concentration; In Vitro Techniques; Sodium / pharmacology
topics (OpenAlex): Neurobiology and Insect Physiology Research; Enzyme function and inhibition; Physiological and biochemical adaptations
TL;DR: Although the largest amount of AIB accumulated by the cornea was present in the epithelium, evidence is presented that the endothelium and stromal keratocytes may also concentrate and retain amino acids. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1981 article

Inhibition of α-aminoisobutyric acid uptake by diisothiocyanostilbenedisulphonic acid in the amphibian cornea

McGahan, M. C., & Bentley, P. J. (1981, April 1). Biochimica Et Biophysica Acta (BBA) - Biomembranes.

By: M. McGahan* & P. Bentley*

MeSH headings : 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / analogs & derivatives; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / analogs & derivatives; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / pharmacology; Alanine / metabolism; Aminoisobutyric Acids / metabolism; Animals; Biological Transport / drug effects; Bufo marinus; Cornea / metabolism; Hydrogen-Ion Concentration; Kinetics; Lens, Crystalline / metabolism; Stilbenes / pharmacology
topics (OpenAlex): Lipid Membrane Structure and Behavior; Antimicrobial Peptides and Activities; Healthcare and Venom Research
TL;DR: The inhibitory effect of diisothiocyanostilbenedisulphonic acid on aminoisobutyric acid accumulation appears to reflect a direct action on membrane mechanisms that mediate its influx. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1980 article

Inhibitory action of DIDS on chloride transport across the amphibian cornea.

Bentley, P. J., & McGahan, M. C. (1980, July 1). The Journal of Physiology.

By: P. Bentley* & M. McGahan*

MeSH headings : 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / analogs & derivatives; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / pharmacology; Animals; Biological Transport, Active / drug effects; Bufo marinus; Bumetanide / pharmacology; Chlorides / metabolism; Cornea / drug effects; Cornea / metabolism; In Vitro Techniques; Membrane Potentials / drug effects; Sodium / metabolism; Stilbenes / pharmacology
topics (OpenAlex): Corneal surgery and disorders; Ocular Surface and Contact Lens; Corneal Surgery and Treatments
TL;DR: The results are consistent with the role of a Cl‐/anion exchange mechanism in active Cl transport across the cornea and a hypothesis regarding the interactions and site of action of bumetanide in relation to that of DIDS, and the Cl transport process is proposed. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1977 journal article

The mode of action of bumetanide: inhibition of chloride transport across the amphibian cornea

Journal of Pharmacology and Experimental Therapeutics, 203, 97–102.

By: M. McGahan, T. Yorio & P. Bentley

Source: NC State University Libraries
Added: August 6, 2018

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