Chris McGahan

Vitreous Humor Changes Expression of Iron-Handling Proteins in Lens Epithelial Cells

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(2).

Evaluation of the proliferative capacity of canine retinal pigment epithelial cells harvested from different regions of the fundus

Investigative Ophthalmology and Visual Science, 57(12).

Hypoxia alters the expression, movement, and secretion of APP in retinal pigmented epithelial (RPE) cells

Investigative Ophthalmology and Visual Science, 57(12).

Hypoxia controls iron metabolism and glutamate secretion in retinal pigmented epithelial cells

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1840(10), 3138–3144.

Hypoxia induced changes in expression of proteins involved in iron uptake and storage in cultured lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 125, 135–141.

Hydrogen peroxide and extracellular signal-related kinase 1/2 pathway regulate ferritin levels in retinal pigmented and lens epithelial cells

Molecular Vision, 19, 2106–2112.

Ceruloplasmin alters intracellular iron regulated proteins and pathways: Ferritin, transferrin receptor, glutamate and hypoxia-inducible factor-1α

Experimental Eye Research, 97(1), 90–97.

Altered Ferritin Subunit Composition: Change in Iron Metabolism in Lens Epithelial Cells and Downstream Effects on Glutathione Levels and VEGF Secretion

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(9), 4437–4446.

Changes in Ferritin H- and L-Chains in Canine Lenses with Age-Related Nuclear Cataract

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 50(1), 305–310.

Distribution of ferritin chains in canine lenses with and without age-related nuclear cataracts

Molecular Vision, 15(256-59), 2404–2410.

Iron metabolism in the eye: A review

Experimental Eye Research, 88(2), 204–215.

Iron regulates L-cystine uptake and glutathione levels in lens epithelial and retinal pigment epithelial cells by its effect on cytosolic aconitase

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 49(1), 310–319.

Ferritin H- and L-chains in fiber cell canine and human lenses of different ages

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 48(9), 3968–3975.

Lens epithelial cells synthesize and secrete ceruloplasmin: Effects of ceruloplasmin and transferrin on iron efflux and intracellular iron dynamics

EXPERIMENTAL EYE RESEARCH, 83(4), 721–727.

Differential degradation of ferritin H- and L-chains: Accumulation of L-chain-rich ferritin in lens epithelial cells

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 46(10), 3521–3529.

Iron alters glutamate secretion by regulating cytosolic aconitase activity

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 288(5), C1117–C1124.

Alpha lipoic acid changes iron uptake and storage in lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 76(2), 241–248.

Identification of a mechanism by which lens epithelial cells limit accumulation of overexpressed ferritin H-chain

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(44), 42920–42926.

The effect of UVB irradiation on ferritin subunit synthesis, ferritin assembly and Fe metabolism in cultured canine lens epithelial cells

The Journal of Biological Chemistry, 278, 42920–42926.

The effect of UVB irradiation on ferritin subunit synthesis, ferritin assembly and Fe metabolism in cultured canine lens epithelial cells

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 77(4), 440–445.

Overexpression of H- and L-ferritin subunits in lens epithelial cells: Fe metabolism and cellular response to UVB irradiation

Investigative Ophthalmology and Visual Science, 42(8), 1721–1727.

Effect of surgical technique on in vitro posterior capsule opacification

Davidson, M. G., Morgan, D. K., & McGahan, M. C. (2000, October). JOURNAL OF CATARACT AND REFRACTIVE SURGERY, Vol. 26, pp. 1550–1554.

Ex vivo canine lens capsular sac explants

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 238(8), 708–714.

Histologic and immunohistochemical characterization of lens capsular plaques in dogs with cataracts

AMERICAN JOURNAL OF VETERINARY RESEARCH, 61(2), 139–143.

Rabbit pigmented ciliary epithelium produces interleukin-6 in response to inflammatory cytokines

EXPERIMENTAL EYE RESEARCH, 70(3), 271–279.

The effects of Tempol on ferritin synthesis and Fe metabolism in lens epithelial cells

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1497(1), 51–60.

Telomerase activity in lens epithelial cells of normal and cataractous lenses

EXPERIMENTAL EYE RESEARCH, 69(6), 641–649.

Characterization of canine MDR1 mRNA: Its abundance in drug resistant cell lines and in vivo

Anticancer Research, 18(1A), 393–400.

The effect of ascorbic acid and ferric ammonium citrate on iron uptake and storage in lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 66(6), 687–697.

The lens influences aqueous humor levels of transforming growth factor-beta 2

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 236(4), 305–311.

Transferrin in after-cataract and as a survival factor for lens epithelium

EXPERIMENTAL EYE RESEARCH, 66(2), 207–215.

Mechanisms by which ascorbic acid increases ferritin levels in cultured lens epithelial cells

EXPERIMENTAL EYE RESEARCH, 64(3), 413–421.

Nitric oxide in ocular inflammation

In Advances in ocular toxicology (pp. 121–131).

Hemoglobin exacerbates the ocular inflammatory response to endotoxin

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 234(10), 643–647.

Interleukin-1 beta increases prostaglandin E(2)-stimulated adenosine 3',5'-cyclic monophosphate production in rabbit pigmented ciliary epithelium

EXPERIMENTAL EYE RESEARCH, 63(1), 91–104.

Intravitreal transforming growth factor-beta 2 decreases cellular infiltration in endotoxin-induced ocular inflammation in rabbits

CURRENT EYE RESEARCH, 15(1), 95–103.

Nitric oxide synthase inhibitors exert differential time-dependent effects on LPS-induced uveitis

EXPERIMENTAL EYE RESEARCH, 62(1), 21–28.

INFLAMMATION-INDUCED CHANGES IN ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE PRODUCTION BY CILIARY EPITHELIAL-CELL BILAYERS

EXPERIMENTAL EYE RESEARCH, 60(2), 165–171.

IRON UPTAKE BY CULTURED LENS EPITHELIAL-CELLS

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 233(6), 354–359.

MEDIATORS OF THE OCULAR INFLAMMATORY RESPONSE TO INTERLEUKIN-1-BETA PLUS TUMOR-NECROSIS-FACTOR-ALPHA

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 233(2), 94–100.

TRANSFERRIN SECRETION BY LENS EPITHELIAL-CELLS IN CULTURE

EXPERIMENTAL EYE RESEARCH, 60(6), 667–673.

INFLUENCE OF EXPOSURE TIME ON INFLAMMATORY RESPONSE TO NEODYMIUM - YAG CYCLOPHOTOCOAGULATION IN RABBITS

ARCHIVES OF OPHTHALMOLOGY, 112(7), 977–981.

REGULATION OF FERRITIN LEVELS IN CULTURED LENS EPITHELIAL-CELLS

EXPERIMENTAL EYE RESEARCH, 59(5), 551–555.

TRANSFERRIN INHIBITS THE OCULAR INFLAMMATORY RESPONSE

MCGAHAN, M. C., GRIMES, A. M., & FLEISHER, L. N. (1994, April).

CELLULAR-RESPONSE TO INTRAVITREAL INJECTION OF ENDOTOXIN AND XANTHINE-OXIDASE IN RABBITS

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 230(5), 463–467.

DOES THE LENS SERVE AS A SINK FOR IRON DURING OCULAR INFLAMMATION

EXPERIMENTAL EYE RESEARCH, 54(4), 525–530.

Effects of copper loading and depletion on rabbit superoxide dismutase activity

Trace Elements in Medicine, 9, 55–58.

Synergistic uveitic effects of tumor necrosis factor-alpha and interleukin-1 beta

Investigative Ophthalmology and Visual Science, 33, 2120–2127.

EFFECTS OF COPPER DEPLETION AND D-PENICILLAMINE TREATMENT ON THE OCULAR INFLAMMATORY RESPONSE

AGENTS AND ACTIONS, 34(3-4), 405–409.

Lipid mediators of TNF- induced uveitis

Investigative Ophthalmology and Visual Science, 32, 2393–2399.

SELENIUM CONCENTRATION IN OCULAR-TISSUES AND FLUIDS

OPHTHALMIC RESEARCH, 23(1), 45–50.

COPPER AND ASPIRIN TREATMENT INCREASE THE ANTIOXIDANT ACTIVITY OF PLASMA

AGENTS AND ACTIONS, 31(1-2), 59–64.

OCULAR INFLAMMATORY EFFECTS OF INTRAVITREALLY INJECTED TUMOR NECROSIS FACTOR-ALPHA AND ENDOTOXIN

INFLAMMATION, 14(3), 325–335.

CLINICAL SIGNS OF ACUTE OCULAR INFLAMMATORY RESPONSE TO ENDOTOXIN ARE NOT ALTERED BY INCREASING ANTIOXIDANT POTENCY OF INTRAOCULAR FLUIDS

INFLAMMATION, 13(4), 393–400.

DIMETHYLTHIOUREA INHIBITS THE INFLAMMATORY RESPONSE TO INTRAVITREALLY-INJECTED ENDOTOXIN

EXPERIMENTAL EYE RESEARCH, 48(4), 561–567.

Ferroxidase activity increases dramatically in the aqueous humor during the ocular inflammatory response

Ophthalmic Research, 21, 221–225.

Inflammation-induced changes in the concentration of iron and total-iron-binding capacity in the intraocular fluids of rabbits

Graefes Archive for Clinical and Experimental Ophthalmology, 226, 27–30.

CYSTEINE - AN EFFECTIVE MATRIX MODIFIER FOR DETERMINATION OF GOLD IN BIOLOGICAL SAMPLES BY ELECTROTHERMAL ATOMIC-ABSORPTION SPECTROPHOTOMETRY

SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, 42(7), 909–913.

THE DETERMINATION OF PLATINUM IN BIOLOGICAL-MATERIALS BY ELECTROTHERMAL ATOMIC-ABSORPTION SPECTROSCOPY

SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, 42(5), 665–668.

A MICROMETHOD FOR THE DETERMINATION OF IRON AND TOTAL IRON-BINDING-CAPACITY IN INTRAOCULAR FLUIDS AND PLASMA USING ELECTROTHERMAL ATOMIC-ABSORPTION SPECTROSCOPY

ANALYTICAL BIOCHEMISTRY, 156(2), 397–402.

ANTIOXIDANT ACTIVITY OF AQUEOUS AND VITREOUS-HUMOR FROM THE INFLAMED RABBIT EYE

CURRENT EYE RESEARCH, 5(9), 641–645.

COPPER CONCENTRATION IN CORNEA, IRIS, NORMAL, AND CATARACTOUS LENSES AND INTRAOCULAR FLUIDS OF VERTEBRATES

CURRENT EYE RESEARCH, 5(1), 69–76.

Effects of melittin on a model renal epithelium, the toad urinary bladder

Biochimica Et Biophysica Acta, 855, 63–67.

THE PATHOPHYSIOLOGY OF THE OCULAR MICROENVIRONMENT .2. COPPER-INDUCED OCULAR INFLAMMATION AND HYPOTONY

EXPERIMENTAL EYE RESEARCH, 42(6), 595–605.

TIME COURSE FOR PROSTAGLANDIN SYNTHESIS BY RABBIT LENS DURING ENDOTOXIN-INDUCED OCULAR INFLAMMATION

CURRENT EYE RESEARCH, 5(9), 629–634.

ASCORBIC-ACID LEVELS IN AQUEOUS AND VITREOUS HUMORS OF THE RABBIT - EFFECTS OF INFLAMMATION AND CERULOPLASMIN

EXPERIMENTAL EYE RESEARCH, 41(3), 291–298.

ENDOTOXIN-INDUCED OCULAR INFLAMMATION INCREASES PROSTAGLANDIN-E2 SYNTHESIS BY RABBIT LENS

EXPERIMENTAL EYE RESEARCH, 40(5), 711–719.

Melittin-induced changes in Na and Cl movements across toad's skin and cornea (in vitro) of the toad, Bufo marinus

Comparative Biochemistry and Physiology, 291–296.

CALCIUM-METABOLISM OF THE RABBIT LENS

EXPERIMENTAL EYE RESEARCH, 36(1), 57–66.

DETERMINATION OF COPPER CONCENTRATION IN BLOOD-PLASMA AND IN OCULAR AND CEREBROSPINAL FLUIDS USING GRAPHITE-FURNACE ATOMIC-ABSORPTION SPECTROSCOPY

ANALYTICAL BIOCHEMISTRY, 135(1), 186–192.

SOME OBSERVATIONS ON THE MAGNESIUM-METABOLISM OF THE RABBIT LENS

EXPERIMENTAL EYE RESEARCH, 36(1), 67–73.

THE PATHO-PHYSIOLOGY OF THE OCULAR MICROENVIRONMENT .1. PRELIMINARY-REPORT ON THE POSSIBLE INVOLVEMENT OF COPPER IN OCULAR INFLAMMATION

CURRENT EYE RESEARCH, 2(12), 883–885.

A PHARMACOLOGICAL ANALYSIS OF CHLORIDE TRANSPORT ACROSS THE AMPHIBIAN CORNEA

JOURNAL OF PHYSIOLOGY-LONDON, 325(APR), 481–492.

STIMULATION OF TRANS-EPITHELIAL SODIUM AND CHLORIDE TRANSPORT BY ASCORBIC-ACID - INDUCTION OF NA+ CHANNELS IS INHIBITED BY AMILORIDE

BIOCHIMICA ET BIOPHYSICA ACTA, 689(2), 385–392.

ALPHA-AMINOISOBUTYRIC-ACID EFFLUX FROM THE CORNEA OF THE TOAD, BUFO-MARINUS

JOURNAL OF PHYSIOLOGY-LONDON, 315(JUN), 253–266.

Alpha-aminoisobutyric acid transport in the amphibian crystalline lens

Journal of Physiology (London), 34, 49–56.

INHIBITION OF ALPHA-AMINOISOBUTYRIC-ACID UPTAKE BY DIISOTHIOCYANOSTILBENEDISULPHONIC ACID IN THE AMPHIBIAN CORNEA

BIOCHIMICA ET BIOPHYSICA ACTA, 643(1), 261–264.

INHIBITORY-ACTION OF DIDS ON CHLORIDE TRANSPORT ACROSS THE AMPHIBIAN CORNEA

JOURNAL OF PHYSIOLOGY-LONDON, 304(JUL), 519–527.

The mode of action of bumetanide: inhibition of chloride transport across the amphibian cornea

Journal of Pharmacology and Experimental Therapeutics, 203, 97–102.