Malcolm C. Roberts

Works (25)

Updated: February 10th, 2025 16:14

2013 journal article

Polyomavirus-Associated Nephritis in 2 Horses

Veterinary Pathology, 50(5), 769–774.

By: S. Jennings n, A. Wise*, V. Nickeleit *, R. Maes*, R. Cianciolo *, F. Piero*, J. Law n, Y. Kim n ...

author keywords: kidney; horse; myocarditis; nephritis; polyomavirus
MeSH headings : Animals; Blood Chemical Analysis / veterinary; Capsid Proteins / genetics; DNA Primers / genetics; Fatal Outcome; Female; Horse Diseases / immunology; Horse Diseases / pathology; Horse Diseases / virology; Horses; Immunocompromised Host / immunology; Immunoglobulin G / blood; Immunohistochemistry / veterinary; Kidney Cortex Necrosis / pathology; Kidney Cortex Necrosis / veterinary; Kidney Cortex Necrosis / virology; Male; Nephritis, Interstitial / pathology; Nephritis, Interstitial / veterinary; Nephritis, Interstitial / virology; Phylogeny; Polyomavirus / genetics; Polyomavirus Infections / pathology; Polyomavirus Infections / veterinary
TL;DR: 2 Standardbred horses with tubular necrosis and tubulointerstitial nephritis associated with productive equine polyomvirus infection that resembles BK polyomavirus nephropathy in immunocompromised humans are described. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2008 article

Equine lymphoma: What are the prospects for cellular differentiation, early diagnosis and intervention strategies?

Roberts, M. C. (2008, September). EQUINE VETERINARY EDUCATION, Vol. 20, pp. 464–466.

By: M. Roberts n

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4. Quality Education (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Evaluation of a point-of-care immunodot assay for predicting results of allergen-specific intradermal and immunoglobulin E serological tests

VETERINARY DERMATOLOGY, 16(2), 117–120.

By: T. Olivry* , H. Jackson*, K. Murphy*, K. Tater* & M. Roberts n

Contributors: T. Olivry* , H. Jackson*, K. Murphy*, K. Tater* & M. Roberts n

MeSH headings : Allergens / immunology; Animals; Dermatitis, Atopic / diagnosis; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dog Diseases / diagnosis; Dog Diseases / immunology; Dogs; Female; Immunoblotting / standards; Immunoblotting / veterinary; Immunoglobulin E / analysis; Immunoglobulin E / immunology; Intradermal Tests / standards; Intradermal Tests / veterinary; Male; Predictive Value of Tests; Sensitivity and Specificity; Serologic Tests / methods
TL;DR: In this population of dogs with AD, results of the E-Screen point-of-care immunodot assay was found to often agree with those of allergen-specific intradermal or Allercept tests for selected allerGEN groups. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 article

Effects of continuous rate intravenous infusion of butorphanol on physiologic and outcome variables in horses after celiotomy

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 18, pp. 555–563.

By: D. Sellon*, M. Roberts n, A. Blikslager n , C. Ulibarri* & M. Papich n 

author keywords: behavior; colic; cortisol; pain management; stress
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Constipation, laxative use, and colon cancer in a North Carolina population

AMERICAN JOURNAL OF GASTROENTEROLOGY, 98(4), 857–864.

By: M. Roberts*, R. Millikan, J. Galanko, C. Martin & R. Sandler

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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Identification of potential physiological and behavioral indicators of postoperative pain in horses after exploratory celiotomy for colic

APPLIED ANIMAL BEHAVIOUR SCIENCE, 80(1), 31–43.

By: L. Pritchett*, C. Ulibarri*, M. Roberts n, R. Schneider* & D. Sellon *

author keywords: postoperative pain; behavior; horse
TL;DR: It is concluded that reduced locomotion, elevated plasma cortisol concentration, and elevated heart rate are potential indicators of postoperative pain in horses. (via Semantic Scholar)
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13. Climate Action (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Prostaglandin E-2 and reactive oxygen metabolite damage in the cecum in a pony model of acute colitis

Canadian Journal of Veterinary Research, 66(1), 50–54.

By: R. McConnico, R. Argenzio & M. Roberts

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

A multicenter, matched case-control study of risk factors for equine laminitis

PREVENTIVE VETERINARY MEDICINE, 49(3-4), 209–222.

By: P. Alford *, S. Geller*, B. Richardson, M. Slater*, C. Honnas*, J. Foreman *, J. Robinson*, M. Messer * ...

author keywords: laminitis; horse; age influence; breed influence; gender
MeSH headings : Acute Disease; Age Factors; Animals; Breeding; Case-Control Studies; Chronic Disease; Female; Foot Diseases / epidemiology; Foot Diseases / veterinary; Hoof and Claw; Horse Diseases / epidemiology; Horses; Incidence; Inflammation / epidemiology; Inflammation / veterinary; Lameness, Animal / epidemiology; Logistic Models; Male; Odds Ratio; Prospective Studies; Risk Factors; Sex Factors
TL;DR: Risk factors for equine laminitis were examined in a prospective case-control study of the 258 cases seen at six collaborating veterinary teaching hospitals over a 32-month period, and mares - but not stallions - were more likely than geldings to develop acute laminationitis. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 journal article

Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses

AMERICAN JOURNAL OF VETERINARY RESEARCH, 62(2), 183–189.

By: D. Sellon  n, V. Monroe*, M. Roberts* & M. Papich* 

MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / adverse effects; Analgesics, Opioid / pharmacokinetics; Animals; Behavior, Animal / drug effects; Butorphanol / administration & dosage; Butorphanol / adverse effects; Butorphanol / pharmacokinetics; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Gastrointestinal Transit / drug effects; Half-Life; Horses / metabolism; Infusions, Intravenous / veterinary; Injections, Intravenous / veterinary; Male
TL;DR: Continuous infusion of butorphanol may be a useful treatment to induce analgesia in horses after a single IV injection was associated with adverse behavioral and gastrointestinal tract effects. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Genistein augments prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum

Genistein augments prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 278(2), G207–G216.

By: A. Blikslager* , M. Roberts*, K. Young*, J. Rhoads * & R. Argenzio n

author keywords: mucosa; chloride secretion; transmucosal resistance; tyrosine kinase
MeSH headings : 8-Bromo Cyclic Adenosine Monophosphate / pharmacology; Animals; Chlorides / metabolism; Cyclic GMP / pharmacology; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Female; Genistein / pharmacology; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Male; Mannitol / metabolism; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Swine / physiology; Tetradecanoylphorbol Acetate / pharmacology; Tritium
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Sources: Web Of Science, Crossref
Added: August 6, 2018

2000 journal article

Small intestinal malabsorption in horses

Equine Veterinary Education, 12(4), 214–219.

By: M. Roberts n

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Glutamine and transforming growth factor-α stimulate extracellular regulated kinases and enhance recovery of villous surface area in porcine ischemic-injured intestine

Surgery, 125(2), 186–194.

By: A. Blikslager* , J. Rhoads, D. Bristol*, M. Roberts* & R. Argenzio*

Contributors: A. Blikslager* , J. Rhoads, D. Bristol*, M. Roberts* & R. Argenzio*

TL;DR: Glutamine plus TGF-alpha treatment restored mucosal architecture within 72 hours of severe ischemic injury associated with sustained elevations in ERK activity. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

1999 journal article

Myeloperoxidase activity of the large intestine in an equine model of acute colitis

American Journal of Veterinary Research, 60(7), 807–813.

By: R. McConnico, D. Weinstock, M. Poston & M. Roberts

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Prostaglandin-induced recovery of barrier function in porcine ileum is triggered by chloride secretion

American Journal of Physiology-Gastrointestinal and Liver Physiology, 276(1), G28–G36.

By: A. Blikslager* , M. Roberts* & R. Argenzio n

author keywords: tight junction; ischemia; mucosa
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Amiloride / pharmacology; Animals; Bumetanide / pharmacology; Chlorides / antagonists & inhibitors; Chlorides / metabolism; Cyclic GMP / analogs & derivatives; Cyclic GMP / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Electric Conductivity; Electric Impedance; Enzyme Inhibitors / pharmacology; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Ileum / drug effects; Ileum / metabolism; Ileum / physiology; Indomethacin / pharmacology; Male; Ouabain / pharmacology; Permeability / drug effects; Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors; Swine
TL;DR: PGs signal recovery of R via induction of Cl- secretion and inhibition of Na+ absorption, possibly by establishing a transmucosal osmotic gradient. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

1999 journal article

The characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine

EQUINE VETERINARY JOURNAL, 31(4), 331–335.

By: M. Gerard*, A. Blikslager n , M. Roberts n, L. Tate n & R. Argenzio n

author keywords: horse; intestine; ischaemia; myeloperoxidase; lipid peroxidation
MeSH headings : Anastomosis, Surgical / veterinary; Animals; Follow-Up Studies; Horse Diseases / etiology; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Obstruction / complications; Intestinal Obstruction / pathology; Intestinal Obstruction / surgery; Intestinal Obstruction / veterinary; Intestine, Small / metabolism; Intestine, Small / pathology; Intestine, Small / surgery; Lipid Peroxidation; Peroxidase / metabolism; Reperfusion Injury / etiology; Reperfusion Injury / pathology; Reperfusion Injury / veterinary
TL;DR: Evidence of serosal injury and neutrophil infiltration in the proximal jejunal resection margins may predispose horses to post operative adhesions. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

Pharmacokinetics of cisapride in horses after intravenous and rectal administration: Erratum

American Journal of Veterinary Research, 59(4), 396.

By: G. Cook, M. Papich , M. Roberts & K. Bowman

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

How important is intestinal reperfusion injury in horses?

Journal of the American Veterinary Medical Association, 211(11), 1387–1389.

By: A. Blikslager , M. Roberts, M. Gerard & R. Argenzio

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia?

SURGERY, 121(5), 526–534.

By: A. Blikslager n , M. Roberts n, J. Rhoads n & R. Argenzio n

MeSH headings : Animals; Female; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Intestines / blood supply; Intestines / enzymology; Ischemia / complications; Ischemia / metabolism; Male; Peroxidases / metabolism; Reperfusion Injury / complications; Reperfusion Injury / metabolism; Swine; Xanthine Dehydrogenase / metabolism; Xanthine Oxidase / metabolism
TL;DR: Reperfusion injury may not play an important role in intestinal injury under conditions of complete mesenteric ischemia and low-flow states in the pig, which may result from low xanthine oxidase-xanthine dehydrogenase levels, which are similar to those found in the human being. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 journal article

Mechanisms of intestinal mucosal repair

Journal of the American Veterinary Medical Association, 211(11), 1437–1441.

By: A. Blikslager  & M. Roberts

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Pharmacokinetics of cisapride in horses after intravenous and rectal administration

American Journal of Veterinary Research, 58(12), 1427–1430.

By: G. Cook, M. Papich , M. Roberts & K. Bowman

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Prostaglandins I2 and E2 have a synergistic role in rescuing epithelial barrier function in porcine ileum.

Journal of Clinical Investigation, 100(8), 1928–1933.

By: A. Blikslager n , M. Roberts n, J. Rhoads* & R. Argenzio n

author keywords: intestinal mucosa; ischemia; cAMP; calcium; tight junctions
MeSH headings : Animals; Cytoprotection; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Epithelium / drug effects; Epithelium / metabolism; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Ileum / drug effects; Ileum / metabolism; In Vitro Techniques; Indomethacin / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Inulin / metabolism; Male; Permeability / drug effects; Reperfusion Injury / drug therapy; Swine
TL;DR: It is concluded that PGE2 and PGI2 have a synergistic role in restoration of intestinal barrier function by increasing intracellular cAMP and Ca2+, respectively, which in turn signal cytoskeletal-mediated tight junction closure. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

1994 journal article

Evaluation of factors associated with postoperative ileus in horses: 31 cases (1990-1992)

Journal of the American Veterinary Medical Association, 205(12), 1748–1752.

By: A. Blikslager , K. Bowman, J. Levine , D. Bristol & M. Roberts

Source: NC State University Libraries
Added: August 6, 2018

1989 journal article

Castor-oil induced diarrhoea in ponies: A model for acute colitis

Equine Veterinary Journal, 60.

By: M. Roberts n, L. Clarke  n & C. Johnson  n

MeSH headings : Acidosis / physiopathology; Acidosis / veterinary; Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Blood Cell Count / veterinary; Castor Oil / adverse effects; Castor Oil / pharmacology; Cathartics / adverse effects; Cathartics / pharmacology; Cecum / drug effects; Cecum / pathology; Cecum / ultrastructure; Clonixin / analogs & derivatives; Clonixin / pharmacology; Colitis / blood; Colitis / physiopathology; Colitis / veterinary; Colon / drug effects; Colon / pathology; Colon / ultrastructure; Diarrhea / chemically induced; Diarrhea / physiopathology; Diarrhea / veterinary; Disease Models, Animal; Dose-Response Relationship, Drug; Electrolytes / analysis; Electrolytes / blood; Enterobacter / isolation & purification; Epithelium / drug effects; Epithelium / pathology; Epithelium / ultrastructure; Escherichia coli / isolation & purification; Feces / chemistry; Feces / microbiology; Fever / physiopathology; Fever / veterinary; Horse Diseases / blood; Horse Diseases / chemically induced; Horse Diseases / physiopathology; Horses; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / ultrastructure; Microvilli / ultrastructure; Syndrome
TL;DR: The experimental induction of castor oil colitis showed many similarities to intestinal endotoxaemia and the secretory type diarrhoea encountered in naturally occurring acute colitis syndromes in horses, which could prove applicable in studying the pathophysiological mechanisms precipitating such life-threatening disorders. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

journal article

Nitric oxide and the intestinal epithelial barrier: does it protect or damage the gut?

Journal of Pediatric Gastroenterology and Nutrition, 25(4), 439–440.

By: A. Blikslager  & M. Roberts

Source: NC State University Libraries
Added: August 6, 2018

chapter

Role of duodenal reflux in nonglandular gastric ulcer disease of the mature horse

In P. D. R. T. S. Mair & A. M. Merritt (Eds.), Equine gastric ulceration (Equine veterinary journal supplement) (pp. 24–29). Suffolk, UK: British Equine Veterinary Association.

By: H. Berschneider, A. Blikslager  & M. Roberts

Ed(s): P. T. S. Mair & A. Merritt

Source: NC State University Libraries
Added: August 6, 2018

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