Melissa Christina Srougi
Also known as: Melissa S. Bentle
Works (23)
Updated: September 13th, 2023 05:00
2023 article
Innovating Life Sciences Laboratory Training: Molecular Biology Laboratory Education Modules (MBLEMs) as a Model for Advanced Training at Diverse Institutions
JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 299, pp. S260–S260.
doi.org (publisher)
Sources: Web Of Science, ORCID
Added: September 11, 2023
2021 journal article
Growth mindset interventions improve academic performance but not mindset in biochemistry
Biochemistry and Molecular Biology Education.
author keywords: academic performance; biochemistry; growth mindset; metacognition
MeSH headings : Academic Performance; Attitude; Humans; Learning; Students; Universities
Source: ORCID
Added: July 17, 2021
2021 journal article
Integrating Bioinformatics Tools into Inquiry-based Molecular Biology Laboratory Education Modules
Frontiers in Education, 6.
author keywords: bioinformatics; science education; molecular biotechnology; software tools; case studies
Sources: Web Of Science, ORCID
Added: August 23, 2021
2020 article
Using Metacognitive Strategies to Improve Academic Performance in Biochemistry
Miller, H. B., & Srougi, M. C. (2020, July 9). (Vol. 7). Vol. 7.
Source: ORCID
Added: June 25, 2021
2019 journal article
Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 10(152).
author keywords: Biochemistry; Issue 152; cell adhesion; cellular spreading; oxidative stress; fibronectin; epithelial cells; ATM inhibition; ruffles; stress fibers; cell circularity
MeSH headings : Animals; Cell Adhesion / drug effects; Cell Adhesion / physiology; Cell Count / methods; Cell Culture Techniques / methods; Cell Line; Cell Line, Transformed; Cells, Cultured; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Extracellular Matrix / drug effects; Extracellular Matrix / metabolism; Fibroblasts / drug effects; Fibroblasts / metabolism; Fibronectins / metabolism; Humans; Microscopy, Fluorescence / methods; Morpholines / pharmacology; Oxidative Stress / drug effects; Oxidative Stress / physiology; Pyrones / pharmacology
Sources: Web Of Science, ORCID
Added: November 18, 2019
2019 journal article
Loss of ATM positively regulates Rac1 activity and cellular migration through oxidative stress
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 508(4), 1155–1161.
author keywords: ATM; Rac1; Reactive oxygen species; Migration
MeSH headings : Animals; Ataxia Telangiectasia Mutated Proteins / metabolism; Cell Movement; Enzyme Activation; HeLa Cells; Humans; Oxidative Stress; Rats; Reactive Oxygen Species / metabolism; rac1 GTP-Binding Protein / metabolism
Sources: Web Of Science, ORCID
Added: April 20, 2020
2019 book
Molecular Biology Techniques 4th Edition
In Elsevier. https://www.elsevier.com/books/molecular-biology-techniques/carson/978-0-12-815774-9
Source: ORCID
Added: June 25, 2021
2018 journal article
Peer learning as a tool to strengthen math skills in introductory chemistry laboratories
Chemistry Education Research and Practice, 19(1), 319–330.
Source: ORCID
Added: June 25, 2021
2018 journal article
Student-Designed High-Throughput Assays to Assess Effects of Growth Insults in Budding Yeast.
Journal of Microbiology & Biology Education.
Source: ORCID
Added: June 25, 2021
2014 journal article
Making Heads or Tails: Planarian Stem Cells in the Classroom †
Journal of Microbiology & Biology Education, 15(1), 18–25.
Sources: ORCID, Crossref
Added: January 19, 2020
2014 journal article
Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.
Antioxidants & Redox Signaling.
MeSH headings : Animals; Bystander Effect / drug effects; Female; Humans; Mice; Mice, Nude; NAD(P)H Dehydrogenase (Quinone) / deficiency; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism; Naphthoquinones / pharmacology; Oxidation-Reduction / drug effects; Quinones / pharmacology; Radiation-Sensitizing Agents / pharmacology; Triple Negative Breast Neoplasms / drug therapy; Triple Negative Breast Neoplasms / metabolism; Triple Negative Breast Neoplasms / pathology; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
Source: ORCID
Added: June 25, 2021
2013 journal article
Assessment of a novel group-centered testing schema in an upper-level undergraduate molecular biotechnology course
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 41(4), 232–241.
author keywords: biotechnology; problem-based testing; collaborative learning; undergraduate
MeSH headings : Biotechnology / education; Curriculum; Educational Measurement / methods; Faculty; Humans; Learning; Students
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.
Molecular Cancer Therapeutics.
MeSH headings : Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Breast Neoplasms / pathology; Catalase / genetics; Catalase / metabolism; DNA Breaks, Single-Stranded / drug effects; DNA Damage / drug effects; Female; Gene Expression Regulation, Neoplastic / drug effects; Humans; Hydrogen Peroxide / metabolism; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism; Naphthoquinones / administration & dosage; Necrosis / genetics; Necrosis / pathology; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases / genetics; Reactive Oxygen Species / metabolism
Source: ORCID
Added: June 25, 2021
2013 journal article
Inquiry into chemotherapy-induced p53 activation in cancer cells as a model for teaching signal transduction
Biochemistry and Molecular Biology Education, 41(6), 419–432.
author keywords: cancer; laboratory; cell signaling; p53
MeSH headings : Antineoplastic Agents, Phytogenic / pharmacology; Biochemistry / education; Blotting, Western; Cell Line, Tumor; Cell Survival / drug effects; Drug Therapy / methods; Etoposide / pharmacology; Flow Cytometry; Humans; Medical Laboratory Personnel / education; Microscopy, Fluorescence; Neoplasms / metabolism; Neoplasms / pathology; Phosphorylation / drug effects; Problem-Based Learning / methods; Reproducibility of Results; Research / education; Research / instrumentation; Research Design / standards; Research Report / standards; Signal Transduction / drug effects; Students; Teaching / methods; Tumor Suppressor Protein p53 / metabolism; Universities
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2011 journal article
The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.
PloS One.
MeSH headings : Breast Neoplasms / genetics; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Carcinoma / genetics; Carcinoma / metabolism; Carcinoma / pathology; Cell Death / drug effects; Cell Death / genetics; Cell Line, Transformed; DNA Damage / drug effects; DNA Damage / genetics; Female; Gene Expression Regulation, Neoplastic / drug effects; Guanine Nucleotide Exchange Factors / antagonists & inhibitors; Guanine Nucleotide Exchange Factors / genetics; Guanine Nucleotide Exchange Factors / metabolism; Guanine Nucleotide Exchange Factors / physiology; HeLa Cells; Humans; Oncogene Proteins / antagonists & inhibitors; Oncogene Proteins / genetics; Oncogene Proteins / metabolism; Oncogene Proteins / physiology; Proto-Oncogene Proteins / antagonists & inhibitors; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins / physiology; RNA, Small Interfering / pharmacology; Tumor Cells, Cultured; rhoB GTP-Binding Protein / antagonists & inhibitors; rhoB GTP-Binding Protein / genetics; rhoB GTP-Binding Protein / metabolism; rhoB GTP-Binding Protein / physiology
Source: ORCID
Added: June 25, 2021
2011 journal article
The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals.
PloS One.
MeSH headings : Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cells, Cultured; DNA Damage / physiology; Guanine Nucleotide Exchange Factors / metabolism; HeLa Cells; Humans; Monomeric GTP-Binding Proteins / metabolism; Oncogene Proteins / antagonists & inhibitors; Oncogene Proteins / genetics; Oncogene Proteins / metabolism; Oncogene Proteins / physiology; Protein Transport / drug effects; RNA, Small Interfering / pharmacology; Signal Transduction / drug effects; Signal Transduction / physiology; Tissue Distribution / drug effects; rhoA GTP-Binding Protein / metabolism
Source: ORCID
Added: June 25, 2021
2009 journal article
Undressing a cellular corset: septins exposed.
Nature Cell Biology.
MeSH headings : Animals; Cell Movement / physiology; Cell Polarity / physiology; Cell Shape / physiology; Cell Surface Extensions / metabolism; Cell Surface Extensions / ultrastructure; Chemotaxis, Leukocyte / physiology; Cytoskeletal Proteins / metabolism; GTP Phosphohydrolases / metabolism; Humans; Septins; T-Lymphocytes / metabolism; T-Lymphocytes / ultrastructure
Source: ORCID
Added: June 25, 2021
2007 journal article
An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.
Proceedings of the National Academy of Sciences of the United States of America.
author keywords: DNA repair inhibitor; non-small-cell lung cancer; NQO1; apoptosis; mu-calpain cell death
MeSH headings : Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Apoptosis / physiology; Carcinoma, Non-Small-Cell Lung / drug therapy; Carcinoma, Non-Small-Cell Lung / enzymology; Carcinoma, Non-Small-Cell Lung / metabolism; Cell Line; Cell Line, Tumor; Humans; Lung Neoplasms / drug therapy; Lung Neoplasms / enzymology; Lung Neoplasms / metabolism; NAD(P)H Dehydrogenase (Quinone) / biosynthesis; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / physiology; Naphthoquinones / pharmacology; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Tumor Cells, Cultured
Source: ORCID
Added: June 25, 2021
2007 journal article
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Cancer Research.
MeSH headings : Antineoplastic Agents / pharmacology; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Breaks; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Humans; Models, Biological; Naphthoquinones / pharmacology; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases / metabolism; Reverse Transcriptase Inhibitors / pharmacology; Time Factors
Source: ORCID
Added: June 25, 2021
2006 journal article
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair.
The Journal of Biological Chemistry.
MeSH headings : Adenosine Triphosphate / metabolism; Calcium / metabolism; Cell Death / drug effects; Chelating Agents / pharmacology; DNA / genetics; DNA Damage / genetics; DNA Repair / genetics; Egtazic Acid / analogs & derivatives; Egtazic Acid / pharmacology; Enzyme Activation / drug effects; Humans; Hydrogen Peroxide / pharmacology; NAD / metabolism; Naphthoquinones / pharmacology; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases / genetics; Poly(ADP-ribose) Polymerases / metabolism; Time Factors
Source: ORCID
Added: June 25, 2021
2006 journal article
Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses.
Journal of Cellular Physiology.
MeSH headings : Apoptosis / drug effects; Cell Cycle / drug effects; Cell Cycle / physiology; Cell Death / drug effects; Cell Physiological Phenomena; Clusterin / genetics; Clusterin / metabolism; DNA Mismatch Repair; Feedback, Physiological / physiology; Humans; Naphthoquinones / pharmacology; Naphthoquinones / therapeutic use; Neoplasms / drug therapy; Radiation-Sensitizing Agents / pharmacology; Radiation-Sensitizing Agents / therapeutic use
Source: ORCID
Added: June 25, 2021
2006 journal article
New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors.
Journal of Molecular Histology.
author keywords: DNA repair inhibitors; carcinogenesis; beta-lapachone; DNA repair; NQ01; poly(ADP-ribose) polymerase-1; DNA damage; cancer therapy; cancer prevention
MeSH headings : Anticarcinogenic Agents / pharmacology; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Repair; Humans; Models, Biological; Naphthoquinones / pharmacology; Naphthoquinones / toxicity; Neoplasms / drug therapy; Neoplasms / enzymology; Neoplasms / genetics; Neoplasms / prevention & control; Poly(ADP-ribose) Polymerases / genetics
Source: ORCID
Added: June 25, 2021
2005 journal article
Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research.
MeSH headings : Cell Division / drug effects; Cell Line, Tumor; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Magnetic Resonance Spectroscopy; NAD(P)H Dehydrogenase (Quinone) / metabolism; Naphthoquinones / chemistry; Naphthoquinones / pharmacology; Neoplasms / drug therapy; Neoplasms / enzymology; Neoplasms / pathology; Prodrugs / chemical synthesis; Prodrugs / chemistry; Prodrugs / pharmacology; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Structure-Activity Relationship
Source: ORCID
Added: June 25, 2021
Employment
Updated: July 11th, 2023 16:02
2023 - present
North Carolina State University Raleigh, North Carolina, US
Associate Professor
Molecular Biomedical Sciences
2019 - 2023
NC State University Raleigh, NC, US
Assistant Professor
Molecular Biomedical Sciences
2014 - 2019
High Point University High Point, NC, US
Assistant Professor of Biochemistry
Chemistry
2011 - 2014
North Carolina State University Raleigh, NC, US
Teaching Associate
Biotechnology Program
2007 - 2011
University of North Carolina at Chapel Hill Chapel Hill, NC, US
Postdoctoral Research Associate
Lineberger Comprehensive Cancer Center
Education
Updated: October 25th, 2017 08:35
2001 - 2007
Case Western Reserve University Cleveland, OH, US
PhD
Pharmacology
1997 - 2001
University of Toledo Toledo, OH, US
BS
Biological Sciences
Funding History
Funding history based on the linked ORCID record. Updated: July 11th, 2023 16:03
grant
February 1, 2024 - January 31, 2027
REU Site: Modeling the Dynamics of Biological Systems
Directorate for Biological Sciences
grant
January 1, 2022 - January 1, 2024
Educating the Current and Future Bioindustrial Workforce: Molecular Biotechnology, Bioprocessing Fundamentals and Responsible Innovation
Department of Defense
grant
July 1, 2019 - June 30, 2022
MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Support Undergraduate Research at High Point University
Directorate for Mathematical & Physical Sciences
