Works (4)
Updated: July 5th, 2023 16:01
2005 journal article
A novel enzymatic technique for limiting drug mobility in a hydrogel matrix
JOURNAL OF CONTROLLED RELEASE, 104(1), 141–153.
author keywords: oral drug delivery; hydrogel; enzyme; diffusion; guar
MeSH headings : Aspergillus niger / enzymology; Cross-Linking Reagents / chemistry; Cyamopsis / enzymology; Delayed-Action Preparations / chemistry; Drug Carriers / chemistry; Fluorescein-5-isothiocyanate / chemistry; Galactans / chemistry; Galactose / analogs & derivatives; Hydrogels / chemistry; Kinetics; Mannans / chemistry; Molecular Weight; Plant Gums; Solubility; Titanium / chemistry; alpha-Galactosidase / chemistry; beta-Mannosidase / chemistry
TL;DR:
Degradation of the hydrogel by beta-mannanase results in a slow and controlled rate of FITC-guar oligomer diffusion, which generates an extended release profile for the model drug.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Rheology of protein gels synthesized through a combined enzymatic and heat treatment method
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 31(1-3), 37–44.
author keywords: whey protein; rheology; gels; enzyme; low pH
MeSH headings : Dose-Response Relationship, Drug; Enzymes / chemistry; Hot Temperature; Hydrogen-Ion Concentration; Plant Proteins / chemistry; Proteins / chemistry; Temperature; Time Factors; Transaminases / chemistry
TL;DR:
Dynamic rheological measurements reveal that the gel elastic modulus and yield stress increase substantially when heat treatment is supplemented with enzyme treatment, which leads to two types of gel microstructure at short and long enzyme treatment times, with the extent of enzyme diffusion modulating the structure at intermediate times.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Diffusion of macromolecules in polymer solutions and gels: A laser scanning confocal microscopy study
MACROMOLECULES, 33(20), 7500–7507.
TL;DR:
The effects of enzyme treatment on the diffusion of macromolecules in guar solutions and titanium-guar hydrogels are examined and α-galactosidase, a side chain cleaving enzyme, displays a unique behavior due to changes in the fine structure of guar.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Triggered enzymatic degradation of a water-soluble polymer solution using a novel inhibitor
BIOMACROMOLECULES, 1(4), 688–695.
MeSH headings : Aspergillus niger / enzymology; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / pharmacology; Galactans / chemistry; Galactose / analogs & derivatives; Hydrogen-Ion Concentration; Mannans / chemistry; Mannosidases / antagonists & inhibitors; Mannosidases / chemistry; Plant Gums; Rheology; Tromethamine / chemistry; Tromethamine / pharmacology; Viscosity; beta-Mannosidase
TL;DR:
This study uses viscometry to investigate the use of tris(hydroxymethyl)aminomethane (Tris) as a reversible, pH-dependent inhibitor to control the degradation of guar galactomannan by Aspergillus niger beta-mannanase.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018