Works (22)
Updated: November 20th, 2024 08:20
2024 article
Gut Microbiome and Osteoarthritis: Insights From the Naturally Occurring Canine Model of Osteoarthritis
Stevens, C., Norris, S., Arbeeva, L., Carter, S., Enomoto, M., Nelson, A. E., & Lascelles, B. D. X. (2024, August 9). ARTHRITIS & RHEUMATOLOGY, Vol. 8.
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2024
2024 journal article
Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogs
SCIENTIFIC REPORTS, 14(1).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2024 journal article
Response to treatment with grapiprant as part of a standard multimodal regimen in young dogs with appendicular joint osteoarthritis associated pain
Frontiers.
Source: ORCID
Added: November 13, 2024
2023 article
An Exploration of Machine Learning Methods for Gait Analysis of Potential Guide Dogs
TENTH INTERNATIONAL CONFERENCE ON ANIMAL-COMPUTER INTERACTION, ACI 2023.
author keywords: Guide Dog; Canine Behavior Analysis; Canine Gait Analysis; IMU; Machine Learning
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 22, 2024
2022 journal article
A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: osteoarthritis; joint pain; TNF-alpha; force plate; limb use asymmetry test
TL;DR:
The IA injection of caTNFR-Fc fusion protein provided no benefit in terms of objective limb use and activity data in dogs with OA in this pilot study, and data indicate TNF-α may not be a good therapeutic target in canine OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 27, 2022
2022 journal article
Initial exploration of the discriminatory ability of the PetPace collar to detect differences in activity and physiological variables between healthy and osteoarthritic dogs
FRONTIERS IN PAIN RESEARCH, 3.
Contributors: J. Robertson n
author keywords: canine; physical activity monitor; osteoarthritis; mobility; pain; accelerometry
TL;DR:
The results of this study suggest that the PetPace collar can detect differences between healthy dogs and those with OA-pain, and that Oa-pain negatively impacts overall activity levels in dogs, and especially higher intensity activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2022
2022 article
Spatial and Temporal Analytic Pipeline for Evaluation of Potential Guide Dogs Using Location and Behavior Data
NINTH INTERNATIONAL CONFERENCE ON ANIMAL-COMPUTER INTERACTION, ACI 2022.
author keywords: Guide Dog; Canine Behavior Analysis; Feature Extraction; IMU; Machine Learning; Clustering
TL;DR:
A preliminary data analysis workflow is demonstrated that is able to provide detailed information about candidate guide dogs’ day to day physical exercise levels and gait activities using objective environmental and behavioral data collected from a wearable collar-based Internet of Things device.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 30, 2023
2021 journal article
Biological resurfacing in a canine model of hip osteoarthritis
SCIENCE ADVANCES, 7(38).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 16, 2021
2021 article
Defining the rate of, and factors influencing, radiographic progression of osteoarthritis of the canine hip joint
Enomoto, M., Baines, E. A., Roe, S. C., Marcellin-Little, D. J., & Lascelles, B. D. X. (2021, June 12). VETERINARY RECORD, Vol. 189.
MeSH headings : Animals; Arthroplasty, Replacement, Hip / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs; Female; Hip Joint / diagnostic imaging; Hip Joint / surgery; Osteoarthritis, Hip / diagnostic imaging; Osteoarthritis, Hip / surgery; Osteoarthritis, Hip / veterinary; Radiography
TL;DR:
The rate of progression of radiographically assessed coxofemoral OA varies greatly, but is faster in younger, spayed female dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 16, 2021
2021 article
Refinement of the Feline Musculoskeletal Pain Index (FMPI) and development of the short-form FMPI
Enomoto, M., Lascelles, B. D. X., Robertson, J. B., & Gruen, M. E. (2021, May 18). JOURNAL OF FELINE MEDICINE AND SURGERY, Vol. 24.
author keywords: Osteoarthritis; pain; musculoskeletal disease; degenerative joint disease; behavioral change; outcome measure
MeSH headings : Analgesics; Animals; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cats; Musculoskeletal Pain / veterinary; Reproducibility of Results; Surveys and Questionnaires
TL;DR:
The proposed FMPI-sf may be able to better distinguish between placebo and analgesic effects in cats with DJD and its reliability was reassessed using the data sets described above.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 19, 2021
2020 journal article
Correlation of Artemin and GFRα3 With Osteoarthritis Pain: Early Evidence From Naturally Occurring Osteoarthritis-Associated Chronic Pain in Dogs
Frontiers in Neuroscience.
author keywords: osteoarthritis; pain; DRG; GDNF; artemin; GFR alpha 3; dogs; human
TL;DR:
The results using banked tissue from well-phenotyped dogs indicates that artemin/GFRα3 may play an important, and hitherto unrecognized, role in chronic OA-associated pain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: February 15, 2020
2020 journal article
Development of a checklist for the detection of degenerative joint disease-associated pain in cats
Journal of Feline Medicine and Surgery.
author keywords: Osteoarthritis; pain; checklist; musculoskeletal disease; degenerative joint disease; screening; behavioral change
MeSH headings : Animals; Cat Diseases / diagnosis; Cats; Checklist; Cross-Sectional Studies; Female; Joint Diseases / diagnosis; Joint Diseases / veterinary; Male; Pain / diagnosis; Pain Measurement / methods; Pain Measurement / veterinary; Sensitivity and Specificity
TL;DR:
An evidence-based, clinically expedient checklist to identify cats likely to have degenerative joint disease (DJD)-associated pain and the identified behaviors comprising the checklist may further provide a foundation for increasing awareness of DJD pain among cat owners.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: March 3, 2020
2019 journal article
Pet Dogs with Subclinical Acute Radiodermatitis Experience Widespread Somatosensory Sensitization
Radiation Research.
MeSH headings : Acute Disease; Animals; Dog Diseases / radiotherapy; Dogs; Pets; Radiodermatitis / etiology; Radiodermatitis / physiopathology; Radiotherapy Dosage; Sarcoma / radiotherapy; Sarcoma / veterinary; Sensory Thresholds / radiation effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: February 15, 2020
2019 journal article
Placebo-controlled pilot study of the effects of an eggshell membrane-based supplement on mobility and serum biomarkers in dogs with osteoarthritis
The Veterinary Journal, 253, 105379.
author keywords: Biomarkers; Inflammation; Mobility; Nutritional supplement; Osteoarthritis
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Biomarkers / blood; Dietary Supplements; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Egg Shell; Female; Male; Osteoarthritis / drug therapy; Osteoarthritis / veterinary; Pilot Projects; Range of Motion, Articular; Treatment Outcome
TL;DR:
The changes in biomarkers and LOAD scores were small, and do not provide definitive evidence of positive effects, but provide a rationale for performing a larger placebo-controlled study of the potential effects of the eggshell membrane-based nutritional supplement.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: December 3, 2019
2018 journal article
Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats
Vet Rec, 184(1), 14.
MeSH headings : Animals; Antibodies, Monoclonal / therapeutic use; Cat Diseases / therapy; Cats; Dog Diseases / therapy; Dogs; Nerve Growth Factors / antagonists & inhibitors; Osteoarthritis / complications; Osteoarthritis / therapy; Osteoarthritis / veterinary; Pain / etiology; Pain / veterinary; Pain Management / veterinary; Randomized Controlled Trials as Topic
TL;DR:
The mechanism of action of NGF, the role of N GF in osteoarthritis, research in rodent OA models and the current status of the development of anti-NGF mAbs in humans are outlined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 25, 2019
2018 journal article
Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis
PAIN, 159(11), 2318–2330.
author keywords: Central sensitisation; Diffuse noxious inhibitory controls; Dog; Nociceptive withdrawal reflex; Osteoarthritis
MeSH headings : Acepromazine / pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Case-Control Studies; Central Nervous System Sensitization / drug effects; Central Nervous System Sensitization / physiology; Dogs; Dopamine Antagonists / pharmacology; Electromyography; Electrophysiological Phenomena / physiology; Evoked Potentials, Motor / drug effects; Evoked Potentials, Motor / physiology; Musculoskeletal Abnormalities / diagnosis; Musculoskeletal Abnormalities / etiology; Osteoarthritis / drug therapy; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain Threshold / drug effects; Pain Threshold / physiology; Reflex / drug effects; X-Rays
TL;DR:
Evidence of neurophysiological changes consistent with CS is provided in dogs with spontaneous OA and it is demonstrated that canine OA is associated with reduced DNIC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 10, 2018
2018 journal article
Initial evaluation of PetPace activity monitor
Vet J, 237, 63–68.
author keywords: Activity; Accelerometer; Dog; Monitor; Osteoarthritis
MeSH headings : Accelerometry / instrumentation; Accelerometry / methods; Accelerometry / standards; Accelerometry / veterinary; Actigraphy / instrumentation; Actigraphy / methods; Actigraphy / standards; Actigraphy / veterinary; Animals; Back; Dogs / physiology; Humans; Monitoring, Physiologic / methods; Monitoring, Physiologic / veterinary; Motor Activity / physiology; Quality of Life; Veterinarians
TL;DR:
PetPace has a moderate correlation with the most validated activity monitor that has been used in veterinary medicine, and its real-time data acquisition, user friendly interface for owners and cost make this device an attractive tool for monitoring activity in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 25, 2019
2018 journal article
Randomized Pilot Trial of the Effects of an Egg-Shell Membrane-Based Supplement (Movoflextm) on Mobility and Serum Biomarkers of Inflammation in Dogs with Osteoarthritis
Veterinary and Comparative Orthopaedics and Traumatology, 31(S 02), A1–A25.
Sources: ORCID, Crossref, NC State University Libraries
Added: December 3, 2019
2017 journal article
Defining local nerve blocks for feline distal pelvic limb surgery: a cadaveric study
JOURNAL OF FELINE MEDICINE AND SURGERY, 19(12), 1215–1223.
MeSH headings : Anesthetics, Local / administration & dosage; Animals; Cadaver; Cats / anatomy & histology; Female; Hindlimb / innervation; Hindlimb / surgery; Male; Methylene Blue / analogs & derivatives; Nerve Block / methods; Nerve Block / veterinary; Peroneal Nerve / anatomy & histology
TL;DR:
These two, three-point injection methods may be an effective perioperative analgesia technique for feline distal pelvic limb procedures.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product
BMC Veterinary Research, 13.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product
BMC Veterinary Research, 13(1).
author keywords: Buprenorphine; Extended release; Pressure sensitive walkway; Landing; Cat; Kinetic
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / therapeutic use; Animals; Buprenorphine / administration & dosage; Buprenorphine / therapeutic use; Cats / surgery; Delayed-Action Preparations; Female; Hoof and Claw / surgery; Male; Motor Activity; Orthopedic Procedures / veterinary; Pain Measurement / methods; Pain Measurement / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Pilot Projects
TL;DR:
This study demonstrates that SC administration of ER-Bup may be an effective analgesic for a 72 h period postoperatively, and landing onto a PSW from an elevated perch may be a useful and efficient way to assess analgesics in cats using a unilateral model of limb pain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: December 3, 2019
2015 journal article
Defining the local nerve blocks for feline distal thoracic limb surgery: a cadaveric study
JOURNAL OF FELINE MEDICINE AND SURGERY, 18(10), 838–845.
MeSH headings : Animals; Cadaver; Cats / anatomy & histology; Female; Forelimb / innervation; Forelimb / surgery; Male; Median Nerve / anatomy & histology; Nerve Block / veterinary; Radial Nerve / anatomy & histology; Ulnar Nerve / anatomy & histology
TL;DR:
A four-point injection method based on cadaveric dissections and tested using dye injections may be an effective perioperative analgesia technique for feline distal thoracic limb procedures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
Employment
Updated: September 25th, 2018 15:24
2014 - present
North Carolina State University College of Veterinary Medicine Raleigh, NC, US
Clinical Sciences
Education
Updated: September 25th, 2018 15:25
2004 - 2010
Azabu University Sagamihara, JP
BVSc
Veterinary Science
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