@misc{faridounnia_folkers_boelens_2018, title={Function and Interactions of ERCC1-XPF in DNA Damage Response}, volume={23}, ISSN={["1420-3049"]}, DOI={10.3390/molecules23123205}, abstractNote={Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particular involved in nucleotide excision repair (NER), but also in double strand break repair and interstrand cross-link repair pathways. Here we review the function of ERCC1-XPF in various DNA repair pathways and discuss human disorders associated with ERCC1-XPF deficiency. We also overview our molecular and structural understanding of XPF-ERCC1.}, number={12}, journal={MOLECULES}, author={Faridounnia, Maryam and Folkers, Gert E. and Boelens, Rolf}, year={2018}, month={Dec} }