@article{pinho_pang_leriquier_gagnon_benito_freire_2026, title={Establishment of a sedation threshold score for orthopedic radiographs in dogs and evaluation of inter-rater reliability and accuracy of video-based assessment}, volume={67}, number={2}, journal={The Canadian Veterinary Journal}, author={Pinho, R.H. and Pang, D. and Leriquier, C. and Gagnon, D. and Benito, J. and Freire, M.}, year={2026}, month={Feb}, pages={180–187} }
 @article{solash_cheema_freire_benito_pang_2025, title={Use of a novel subcutaneous injection site in the region of acupuncture point GV20 for premedicating cats before general anesthesia}, volume={66}, number={5}, journal={The Canadian Veterinary Journal}, author={Solash, Bayley and Cheema, Jagijit and Freire, Mila and Benito, Javier and Pang, Daniel S.J.}, year={2025}, month={May}, pages={537–545} }
 @article{renaud_freire_o'toole_huneault_llido_ringwood_juette_gagnon_2024, title={Clinical findings and prognostic factors for immediate survival in 33 dogs undergoing surgery for biliary peritonitis}, volume={54}, ISSN={0161-3499 1532-950X}, url={http://dx.doi.org/10.1111/vsu.14189}, DOI={10.1111/vsu.14189}, abstractNote={Abstract Objective To report demographics, clinical signs, physical examination, diagnostic test results, surgical findings, and prognostic factors for in‐hospital postoperative mortality following biliary peritonitis surgery in dogs. Study design Retrospective, multi‐institutional cohort study. Animals Thirty‐three client‐owned dogs. Methods The medical records of dogs that underwent surgery for biliary peritonitis between 2015 and 2021 were reviewed. Dogs were included if they had a definitive diagnosis of biliary peritonitis and a surgery report. Information on demographics, clinical signs and duration, physical examination findings, laboratory and diagnostic imaging results, surgery, perioperative medical treatment, and complications for each patient was obtained. Statistical analyses were performed to identify risk factors that affected survival. Results Cholecystectomy was the procedure most frequently performed (31/33, 94%). The overall mortality rate was 36% (12/33). Survival was affected negatively by hyperbilirubinemia ( p = .049), administration of vasopressors ( p = .002), renal dysfunction ( p = .008), and number of postoperative complications ( p = .005). A mortality rate of 50% was observed in dogs with a total bilirubin level greater than 60.5 μmol/L. There was no difference in mortality rate between septic and nonseptic biliary effusions. Conclusion New prognostic factors associated with in‐hospital postoperative mortality in dogs treated surgically for biliary peritonitis were identified, while others that had been reported previously were confirmed. A preoperative bilirubin threshold value associated with a 50% mortality was identified. Clinical significance Additional information that could help to predict survival in dogs with biliary peritonitis has been provided. However, further research is warranted.}, number={2}, journal={Veterinary Surgery}, publisher={Wiley}, author={Renaud, Solène and Freire, Mila and O'Toole, Elizabeth and Huneault, Louis and Llido, Marie and Ringwood, Brendon and Juette, Tristan and Gagnon, Dominique}, year={2024}, month={Nov}, pages={276–286} }
 @article{llido_leriquier_juette_benito_freire_2024, title={Comparison of sedation with dexmedetomidine administered subcutaneously at 2 different locations on the head in dogs}, volume={65}, number={4}, journal={The Canadian Veterinary Journal}, author={Llido, Marie and Leriquier, Claire and Juette, Tristan and Benito, Javier and Freire, Mila}, year={2024}, month={Apr}, pages={351–358} }
 @article{porcel sánchez_gagnon_brisson_hoddinott_juette_freire_2024, title={Subclinical bacteriuria and surgical-site infection in 140 dogs with orthopedic and neurological conditions}, volume={65}, number={12}, journal={The Canadian Veterinary Journal}, author={Porcel Sánchez, MM.D. and Gagnon, D and Brisson, B.A. and Hoddinott, K and Juette, T. and Freire, M.}, year={2024}, month={Dec}, pages={1253–1259} }
 @article{leriquier_freire_llido_beauchamp_montasell_gagnon_benito_2023, title={Comparison of sedation with dexmedetomidine/atipamezole administered subcutaneously at <scp>GV20</scp> acupuncture point with usual routes of administration in dogs presented for orthopaedic radiographs}, volume={64}, ISSN={0022-4510 1748-5827}, url={http://dx.doi.org/10.1111/jsap.13668}, DOI={10.1111/jsap.13668}, abstractNote={Objectives To evaluate the efficacy of subcutaneous administration of dexmedetomidine/atipamezole at the Governing Vessel 20 (GV20) acupuncture point compared with other administration routes (intramuscular and intravenous) in dogs presented for orthopaedic radiographs. Materials and Methods Prospective, randomised, blinded, controlled clinical study. Sixty‐four client‐owned dogs were randomly injected with 200 μg/m 2 of dexmedetomidine intramuscular (lumbar muscles) (n=20), intravenous (n=23) or subcutaneous at the GV20 point (n=21). Following radiographs, dogs received 2000 μg/m 2 of atipamezole intramuscular (n=31), or subcutaneous at the GV20 point (n=27). Degree and time to sedation and recovery were assessed using a sedation scale and a Dynamic and Interactive Visual Analog Scale (DIVAS). Clinical physiological variables and adverse events were used. Statistical linear mixed‐effect models (analysis of variance) and Cox models were performed. Significance was set at P‐value <0.05. Results Sedation was insufficient to perform orthopaedic radiographs in six dogs in the intramuscular group. The time to sedation was significantly longer, and sedation scale and DIVAS scores were significantly lower in the intramuscular group. The intravenous group had significantly higher sedation scale and DIVAS scores than the GV20 group. No significant differences were observed between the intramuscular and GV20 recovery groups, although the time effect was significantly more pronounced in the GV20 recovery group. Clinical Significance Subcutaneous administration of dexmedetomidine and atipamezole at GV20 provided effective sedation and recovery in dogs undergoing orthopaedic radiographic studies. GV20 administration provided a clinically similar level of sedation to the intravenous route, and greater and faster sedation and similar recovery to intramuscular.}, number={12}, journal={Journal of Small Animal Practice}, publisher={Wiley}, author={Leriquier, C. and Freire, M. and Llido, M. and Beauchamp, G. and Montasell, X. and Gagnon, D. and Benito, J.}, year={2023}, month={Aug}, pages={759–768} }
 @article{lahiani_freire_montasell_juette_gagnon_2023, title={Effects of Transfixation Pin Positioning on the Biomechanical Properties of Acrylic External Skeletal Fixators in a Fracture Gap Model}, volume={36}, ISSN={0932-0814 2567-6911}, url={http://dx.doi.org/10.1055/s-0043-1768990}, DOI={10.1055/s-0043-1768990}, abstractNote={Abstract Objective The aim of this study was to evaluate the biomechanical effects of transfixation pin positioning in acrylic columns of external skeletal fixators (ESF). Study Design Twenty-four type I acrylic ESF were built simulating a fracture gap-model. Transfixation pins were placed centric (n = 12) or eccentric at ¼ of the column diameter (n = 12) in the acrylic columns. Six constructs from each group were subjected to axial compression and four-point bending tests. Stiffness, yield load and mode of failure were recorded. Results Stiffness was not influenced by centring (p = 0.373), but it was higher in four-point bending than in axial compression (p < 0.001). Pin positioning had no influence on the yield (p = 0.535) and failure loads (p = 0.715) in axial compression, nor on the yield load in bending (p = 0.135). Eccentric pin positioning decreased failure loads by 28% in bending (p < 0.001). Conclusion Eccentric position of transfixation pins within the acrylic columns alters the biomechanical properties of type I ESF constructs. While acrylic offers several advantages, when forming the columns, frame strength will be optimized if pins are centrally located.}, number={06}, journal={Veterinary and Comparative Orthopaedics and Traumatology}, publisher={Georg Thieme Verlag KG}, author={Lahiani, Joachim and Freire, Mila and Montasell, Xavier and Juette, Tristan and Gagnon, Dominique}, year={2023}, month={Jun}, pages={273–278} }
 @article{freire_job_hassanpour_benito_pang_paquet_theoret_2022, title={A disposable, canister-free negative-pressure wound therapy device proves feasible, but of inferior efficacy to conventional therapies for treating cutaneous wounds in dogs}, volume={83}, ISSN={0002-9645}, url={http://dx.doi.org/10.2460/ajvr.22.02.0029}, DOI={10.2460/ajvr.22.02.0029}, abstractNote={Abstract OBJECTIVE To assess the feasibility of a canister-free negative-pressure wound therapy (NPWT) device (PICO™ 1.6, Smith & Nephew Medical Ltd) and evaluate its effect on early phases of wound healing in canine experimental cutaneous wounds. ANIMALS 5 adult spayed female research Beagles. PROCEDURES In a pilot experimental study, 1 full-thickness 2-cm X 2-cm cutaneous wound was surgically created on each hemithorax in each dog. Wounds were treated with either NPWT or a conventional wound dressing for 14 days. Bandage changes and wound evaluations were done at 7 time points. First macroscopic appearance of granulation tissue, smoothness of granulation tissue, and percentages of wound contraction and epithelialization were compared between treatments. Wounds were sampled at 3 time points for histopathologic analyses and semiquantitative scoring. RESULTS NPWT dressings were well tolerated by all dogs. Complete seal of the dressing required the application of adhesive spray, and maintenance of the vacuum lessened over time. Self-limiting skin irritations appeared in all dogs and hampered the attainment of negative pressure. Granulation tissue developed faster and was more abundant in control wounds. Wound contraction, epithelialization, and fibroblast proliferation were greater in control wounds at the end of the study. CLINICAL RELEVANCE This canister-free NPWT device is feasible but problematic in maintaining a vacuum, requiring frequent revisions of the dressing. Further studies are necessary to evaluate the effect of this device on early phases of wound healing. Its benefits in wound healing remain unknown.}, number={10}, journal={American Journal of Veterinary Research}, publisher={American Veterinary Medical Association (AVMA)}, author={Freire, Mila and Job, Chloé and Hassanpour, Ida and Benito, Javier and Pang, Daniel S. J. and Paquet, Marilène and Theoret, Christine L.}, year={2022}, month={Oct} }
 @article{freire_conversy_de lasalle_fontaine_rousseau‐blass_pang_2022, title={Surgical correction of left auricular aneurysm herniation through a pericardial defect in a dog with atrial fibrillation and mitral valve disease}, volume={10}, ISSN={2052-6121 2052-6121}, url={http://dx.doi.org/10.1002/vrc2.408}, DOI={10.1002/vrc2.408}, abstractNote={Abstract Pericardial defect is a rare condition, with risk of cardiac chamber strangulation or incarceration. Surgical correction is recommended when clinical signs are unmanageable and to decrease the risk of thromboemboli. A 15‐year‐old, 4.1‐kg, spayed female Shih Tzu dog presented to the hospital with a 6‐month history of weakness and syncope episodes. The dog had been diagnosed with degenerative mitral valve disease 9 years earlier. Thoracic radiographs, echocardiography and computed tomography indicated a left auricular herniation through a pericardial defect. Clinical signs were temporarily controlled with pimobendan, benazepril and clopidogrel, until the syncope episodes returned along with atrial fibrillation (unresponsive to oral digoxin). Surgical correction (auriculectomy and partial pericardiectomy) was performed via thoracotomy. Atrial fibrillation reverted to normal sinus rhythm following surgery and recovery was uneventful. The patient survived, arrhythmia‐free, for 25 months postoperatively. Syncope episodes never resolved.}, number={3}, journal={Veterinary Record Case Reports}, publisher={Wiley}, author={Freire, Mila and Conversy, Bérénice and De Lasalle, Julie and Fontaine, Pascal and Rousseau‐Blass, Frédérik and Pang, Daniel S. J.}, year={2022}, month={Jun} }
 @article{montasell_dunn_freire_2020, title={Uretero-Cutaneous Fistula and Renal Abscessation as a Complication of Ureteral Stenting in a Dog}, volume={56}, ISSN={0587-2871 1547-3317}, url={http://dx.doi.org/10.5326/JAAHA-MS-6942}, DOI={10.5326/jaaha-ms-6942}, abstractNote={ABSTRACT An 11 yr old female spayed shih tzu was referred for treatment of left ureterolithiasis with complete obstruction of the left ureter and pyonephrosis. A ureteral stent was placed surgically to relieve the obstruction and pyonephrosis was treated with antibiotics. Three and a half years following stent placement, the patient developed an abscess on the left flank with chronic purulent discharge. Diagnostic imaging confirmed the presence of a left uretero-cutaneous fistula and renal abscess. A left ureteronephrectomy was performed. The dog was euthanatized 4 mo later for cardiac insufficiency unresponsive to medical treatment. This is the first report of a uretero-cutaneous fistula and renal abscessation as a complication of ureteral stenting in a dog.}, number={3}, journal={Journal of the American Animal Hospital Association}, publisher={American Animal Hospital Association}, author={Montasell, Xavier and Dunn, Marilyn and Freire, Mila}, year={2020}, pages={e563–03} }
 @article{freire_diaw_2019, title={Transvaginal uterine evisceration during labor in a Bengal queen}, volume={5}, ISSN={2055-1169 2055-1169}, url={http://dx.doi.org/10.1177/2055116919872301}, DOI={10.1177/2055116919872301}, abstractNote={Case summary A 2.5-year-old Bengal queen was admitted with a 12-h history of a mass protruding from the vulva during labor. At that time, three healthy kittens had already been delivered. Physical examination identified the mass as a portion of the uterus that was eviscerated without eversion of the mucosa. Exploratory laparotomy revealed a vaginal vault rupture with a large portion of the uterus herniated through the tear and eviscerated through the vulva. Ovariohysterectomy was performed, and a dead fetus was removed with the uterus. Reconstruction of the vaginal rupture required careful dissection and urethral catheterization. The queen recovered without complications. Relevance and novel information Uterine evisceration through a vaginal tear is a very rare condition that sometimes is erroneously referred to as ‘prolapse’. Uterine prolapse and uterine evisceration may have similar presenting signs; however, proper identification and surgical correction is key when the uterus is eviscerated. This case highlights the importance of differentiating these two conditions and of rapid identification and surgical intervention for successful patient survival.}, number={2}, journal={Journal of Feline Medicine and Surgery Open Reports}, publisher={SAGE Publications}, author={Freire, Mila and Diaw, Mouhamadou}, year={2019}, month={Jul} }
 @article{ashwell_freire_o’nan_benito_hash_mcculloch_lascelles_2019, title={Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain}, volume={243}, ISSN={1090-0233}, url={http://dx.doi.org/10.1016/j.tvjl.2018.11.008}, DOI={10.1016/j.tvjl.2018.11.008}, abstractNote={Degenerative joint disease (DJD) associated-pain is a clinically relevant and common condition affecting domesticated cats and other species including humans. Identification of the neurobiological signature of pain is well developed in rodent pain models, however such information is lacking from animals or humans with naturally occurring painful conditions. In this study, identification of housekeeping genes (HKG) for neuronal tissue and expression levels of genes considered associated with chronic pain in rodent models were explored in cats with naturally occurring osteoarthritic pain. Fourteen adult cats were evaluated — seven without clinical signs of osteoarthritic pain, and seven with hind limb radiographic DJD and pain. Expression of an investigator-selected set of pain signaling genes (including ASIC3, ATF3, COX2, CX3CL1, NAV1.7, NAV1.8, NAV1.9, NGF, NK1R, TNFα, TRKA) in lumbar spinal cord dorsal horn and lumbar dorsal root ganglia tissues from clinically healthy cats and cats with DJD were studied using quantitative RT-PCR (qPCR). HKG identified as the most stable across all tissue samples were many of the ribosomal protein genes, such as RPL30 and RPS19. qPCR results showed ATF3 and CX3CL1 up-regulated in DJD-affected dorsal root ganglia compared to clinically healthy controls. In spinal cord, CX3CL1 was up-regulated and NGF was down-regulated when DJD-affected samples were compared to healthy samples. Further work is needed to understand the neurobiology of pain in naturally occurring disease and what rodent models are predictive of these changes in more heterogeneous populations such as domestic cats.}, journal={The Veterinary Journal}, publisher={Elsevier BV}, author={Ashwell, M. and Freire, M. and O’Nan, A.T. and Benito, J. and Hash, J. and McCulloch, R.S. and Lascelles, B.D.X.}, year={2019}, month={Jan}, pages={42–47} }
 @article{chassang_langlois_loos_freire_o'toole_2018, title={Chylous ascites associated with abdominal trauma and intestinal resection-anastomosis in a pet ferret (Mustela putorius furo)}, volume={252}, ISSN={0003-1488}, url={http://dx.doi.org/10.2460/javma.252.10.1272}, DOI={10.2460/javma.252.10.1272}, abstractNote={Abstract CASE DESCRIPTION A 10-week-old 0.73-kg (1.6-lb) castrated male domestic ferret (Mustela putorius furo) was referred for exploratory laparotomy because of pneumoperitoneum and possible septic peritonitis after being bitten by the owner's dog. CLINICAL FINDINGS Abdominal exploration revealed a large laceration of the duodenum, tears of the jejunal mesentery, and 2 small tears in the abdominal wall. Chylous abdominal effusion developed 48 hours after surgery. TREATMENT AND OUTCOME Postoperative care included supportive treatment, analgesia, and antimicrobials. An abdominal drain was placed during the laparotomy and enabled monitoring of abdominal fluid production. Enteral feeding was provided through an esophagostomy tube. The chylous fluid production rapidly decreased after treatment with octreotide was initiated, and the ferret improved. Chyloabdomen resolved after 8 days of hospitalization and medical treatment. CLINICAL RELEVANCE Findings suggested that chylous ascites can potentially develop secondary to blunt abdominal trauma in ferrets. In this ferret, chyloabdomen was successfully treated with octreotide administration and abdominal drainage.}, number={10}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={Chassang, Lucile and Langlois, Isabelle and Loos, Pauline and Freire, Mila and O'Toole, Elizabeth}, year={2018}, month={May}, pages={1272–1278} }
 @article{freire_knazovicky_case_thomson_lascelles_2016, title={Comparison of thermal and mechanical quantitative sensory testing in client-owned dogs with chronic naturally occurring pain and normal dogs}, volume={210}, ISSN={1090-0233}, url={http://dx.doi.org/10.1016/j.tvjl.2016.01.005}, DOI={10.1016/j.tvjl.2016.01.005}, abstractNote={Detecting dogs with central sensitization (CS) secondary to chronic pain is hampered by the current inability to measure this condition. The current study aimed to use quantitative sensory testing (QST) to measure (CS) in normal dogs and dogs with painful degenerative joint disease (DJD). It was hypothesized that QST would differ between these two groups of animals. Mechanical and thermal sensory thresholds obtained in animals with DJD-associated pain on two time points 28 days apart were compared with those of normal dogs. Values of sensory thresholds in DJD dogs obtained 28 days after the first evaluation were significantly lower than the results on the first day of evaluation but no differences were found when these results were compared with those of normal dogs. In conclusion, whether QST is different between dogs with chronic pain and normal dogs needs further investigation using a larger group of animals and age, weight and sex matched groups.}, journal={The Veterinary Journal}, publisher={Elsevier BV}, author={Freire, Mila and Knazovicky, David and Case, Beth and Thomson, Andrea and Lascelles, B. Duncan X.}, year={2016}, month={Apr}, pages={95–97} }
 @article{lascelles_knazovicky_case_freire_innes_drew_gearing_2015, title={A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain}, volume={11}, ISSN={1746-6148}, url={http://dx.doi.org/10.1186/s12917-015-0413-x}, DOI={10.1186/s12917-015-0413-x}, abstractNote={These pilot data demonstrate a positive analgesic effect of anti-NGF antibody in dogs suffering from chronic pain. The magnitude of the effect appeared identical to that expected with an NSAID.}, number={1}, journal={BMC Veterinary Research}, publisher={Springer Science and Business Media LLC}, author={Lascelles, B Duncan X and Knazovicky, David and Case, Beth and Freire, Mila and Innes, John F and Drew, Alexander C and Gearing, David P}, year={2015}, month={Apr}, pages={101} }
 @article{freire_meuten_lascelles_2014, title={Pathology of Articular Cartilage and Synovial Membrane From Elbow Joints With and Without Degenerative Joint Disease in Domestic Cats}, volume={51}, ISSN={0300-9858 1544-2217}, url={http://dx.doi.org/10.1177/0300985813516648}, DOI={10.1177/0300985813516648}, abstractNote={The elbow joint is one of the feline appendicular joints most commonly and severely affected by degenerative joint disease. The macroscopic and histopathological lesions of the elbow joints of 30 adult cats were evaluated immediately after euthanasia. Macroscopic evidence of degenerative joint disease was found in 22 of 30 cats (39 elbow joints) (73.33% cats; 65% elbow joints), and macroscopic cartilage erosion ranged from mild fibrillation to complete ulceration of the hyaline cartilage with exposure of the subchondral bone. Distribution of the lesions in the cartilage indicated the presence of medial compartment joint disease (most severe lesions located in the medial coronoid process of the ulna and medial humeral epicondyle). Synovitis scores were mild overall and correlated only weakly with macroscopic cartilage damage. Intra-articular osteochondral fragments either free or attached to the synovium were found in 10 joints. Macroscopic or histologic evidence of a fragmented coronoid process was not found even in those cases with intra-articular osteochondral fragments. Lesions observed in these animals are most consistent with synovial osteochondromatosis secondary to degenerative joint disease. The pathogenesis for the medial compartmentalization of these lesions has not been established, but a fragmented medial coronoid process or osteochondritis dissecans does not appear to play a role.}, number={5}, journal={Veterinary Pathology}, publisher={SAGE Publications}, author={Freire, M. and Meuten, D. and Lascelles, D.}, year={2014}, month={Jan}, pages={968–978} }
 @article{charlton_benito_simpson_freire_lascelles_2013, title={Evaluation of the clinical use of tepoxalin and meloxicam in cats}, volume={15}, ISSN={1098-612X 1532-2750}, url={http://dx.doi.org/10.1177/1098612X12473994}, DOI={10.1177/1098612x12473994}, abstractNote={Medical records where tepoxalin (Zubrin) or meloxicam (Metacam) were prescribed in cats were reviewed and data extracted. Comparisons were performed for exploring changes between pre- and post-non-steroidal anti-inflammatory drug course laboratory tests. Seventy-nine medical records fit the inclusion criteria (n = 57 and n = 22, tepoxalin and meloxicam, respectively). The median dosages administered were 13 and 0.029 mg/kg / day (tepoxalin and meloxicam, respectively). Median prescription durations were 11 (2–919) and 93 (4–1814) days for tepoxalin and meloxicam, respectively. Suspected adverse events were reported for tepoxalin (9%, 5/57 cats) and meloxicam (18%, 4/22 cats) a median of 774 and 448 days, respectively, after the prescription started. For cats prescribed meloxicam, there were several statistically significant changes for serum biochemistry and hematology parameters, but median values were within normal limits. These valuable clinical data suggest that tepoxalin and meloxicam are well tolerated in the clinical setting at the doses prescribed in this study.}, number={8}, journal={Journal of Feline Medicine and Surgery}, publisher={SAGE Publications}, author={Charlton, Anna N and Benito, Javier and Simpson, Wendy and Freire, Mila and Lascelles, B Duncan X}, year={2013}, month={Jan}, pages={678–690} }
 @article{briley_williams_freire_griffith_lascelles_2014, title={Feasibility and repeatability of cold and mechanical quantitative sensory testing in normal dogs}, volume={199}, ISSN={1090-0233}, url={http://dx.doi.org/10.1016/j.tvjl.2013.10.025}, DOI={10.1016/j.tvjl.2013.10.025}, abstractNote={Feasibility and inter-session repeatability of cold and mechanical quantitative sensory testing (QST) were assessed in 24 normal dogs. Cold thermal latencies were evaluated using a thermal probe (0°C) applied to three pelvic limb sites. Mechanical thresholds were measured using an electronic von Frey anesthesiometer (EVF) and a blunt-probed pressure algometer (PA) applied to the dorsal aspect of the metatarsus. All QST trials were performed with dogs in lateral recumbency. Collection of cold QST data was easy (feasible) in 19/24 (79%) dogs. However, only 18.4%, 18.9% and 13.2% of cold QST trials elicited a response at the medial tibia, third digital pad and plantar metatarsal regions, respectively. Collection of mechanical QST data was easy (feasible) in 20/24 (83%) dogs for both EVF and PA. At consecutive sampling times, approximately 2 weeks apart, the average EVF sensory thresholds were 414 ± 186 g and 379 ± 166 g, respectively, and the average PA sensory thresholds were 1089 ± 414 g and 1028 ± 331 g, respectively. There was no significant difference in inter-session or inter-limb threshold values for either mechanical QST device. The cold QST protocol in this study was achievable, but did not provide consistently quantifiable results. Both mechanical QST devices tested provided repeatable, reliable sensory threshold measurements in normal, client-owned dogs. These findings contribute to the validation of the EVF and PA as tools to obtain repeated QST data over time in dogs to assess somatosensory processing changes.}, number={2}, journal={The Veterinary Journal}, publisher={Elsevier BV}, author={Briley, Jessica D. and Williams, Morika D. and Freire, Mila and Griffith, Emily H. and Lascelles, B. Duncan X.}, year={2014}, month={Feb}, pages={245–250} }
 @article{lascelles_henry_brown_robertson_sumrell_simpson_wheeler_hansen_zamprogno_freire_et al._2010, title={Cross-Sectional Study of the Prevalence of Radiographic Degenerative Joint Disease in Domesticated Cats}, volume={39}, ISSN={0161-3499 1532-950X}, url={http://dx.doi.org/10.1111/j.1532-950X.2010.00708.x}, DOI={10.1111/j.1532-950x.2010.00708.x}, abstractNote={DJD is a common disease of domesticated cats that requires further investigation of its associated clinical signs.}, number={5}, journal={Veterinary Surgery}, publisher={Wiley}, author={Lascelles, B. Duncan X. and Henry, John B., III and Brown, James and Robertson, Ian and Sumrell, Andrea Thomson and Simpson, Wendy and Wheeler, Simon and Hansen, Bernie D. and Zamprogno, Helia and Freire, Mila and et al.}, year={2010}, month={Jun}, pages={535–544} }
 @article{freire_brown_robertson_pease_hash_hunter_simpson_thomson sumrell_lascelles_2010, title={Meniscal Mineralization in Domestic Cats}, volume={39}, ISSN={0161-3499 1532-950X}, url={http://dx.doi.org/10.1111/j.1532-950X.2010.00648.x}, DOI={10.1111/j.1532-950x.2010.00648.x}, abstractNote={Clinical significance of meniscal mineralization is uncertain. Further work is needed to determine if the meniscal mineralization is a cause, or a consequence of joint degeneration.}, number={5}, journal={Veterinary Surgery}, publisher={Wiley}, author={Freire, Mila and Brown, James and Robertson, Ian D. and Pease, Anthony P. and Hash, Jonathan and Hunter, Stuart and Simpson, Wendy and Thomson Sumrell, Andrea and Lascelles, B. Duncan X.}, year={2010}, month={Mar}, pages={545–552} }
 @article{benito-de-la-víbora_lascelles_garcía-fernández_freire_gómez de segura_2008, title={Efficacy of tolfenamic acid and meloxicam in the control of postoperative pain following ovariohysterectomy in the cat}, volume={35}, ISSN={1467-2987}, url={http://dx.doi.org/10.1111/j.1467-2995.2008.00407.x}, DOI={10.1111/j.1467-2995.2008.00407.x}, abstractNote={The hypothesis was that Visual Analog Scale (VAS) scores would be lower, and mechanical wound thresholds (MWT) higher, in cats receiving tolfenamic acid compared to those receiving placebo in the postoperative period following elective ovariohysterectomy.Sixty-nine client-owned cats.A prospective, randomized, blinded and placebo-controlled study was performed in cats which underwent ovariohysterectomy following preoperative tolfenamic acid, meloxicam, or placebo. A second dose of the same analgesic was administered 24 hours postoperatively. Assessments were made 1-hour before induction and 1, 2, 4, 6, 22, and 25 hours postoperatively. Pain was assessed by a blinded observer using Numerical Rating (NRS) and VAS scales. The MWT were measured using a force-measuring device. Group comparison was performed by using one-way ANOVA and chi-squared test for qualitative and quantitative data, respectively, and a mixed model for repeated measurements (p < 0.05).Sixty-five cats were included in the study. There were no differences between groups at baseline. There was a treatment effect on the NRS scores at 6, 22 and 25 hours. The meloxicam group was less painful than controls at 6 and 22 hours; both treatment groups were less painful than controls at 25 hours. There were no differences between groups in VAS for pain or sedation. The number of animals receiving rescue analgesia did not differ between groups. There was a treatment effect on MWT; thresholds in both treatment groups were significantly higher than that observed in controls at all time points.Preoperative tolfenamic acid or meloxicam reduced wound sensitivity following ovariohysterectomy in the cat.Tolfenamic acid and meloxicam administered preoperatively provided a similar analgesic effect in the postoperative period lasting 24 hours. Mechanical thresholds may be a better way of evaluating postoperative analgesia provided by nonsteroidal anti-inflammatory drugs in cats.}, number={6}, journal={Veterinary Anaesthesia and Analgesia}, publisher={Elsevier BV}, author={Benito-de-la-Víbora, Javier and Lascelles, B Duncan X and García-Fernández, Paloma and Freire, Milagros and Gómez de Segura, Ignacio A}, year={2008}, month={Nov}, pages={501–510} }