Mary Frances Wang

College of Sciences

Works (5)

Updated: January 27th, 2026 07:10

2026 article

Spatially resolved lipids in a mouse brain model of globoid cell leukodystrophy via IR-MALDESI MSI and parallel reaction monitoring MSI

Hunter, S. N., Wang, M. F., Thomas, B. N., Filiano, A. J., & Muddiman, D. C. (2026, January 23). Analytical and Bioanalytical Chemistry, Vol. 1.

By: S. Hunter n, M. Wang n, B. Thomas *, A. Filiano * & D. Muddiman n 

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Lysosomal Storage Disorders Research; Metabolomics and Mass Spectrometry Studies
Sources: NC State University Libraries, NC State University Libraries
Added: January 26, 2026

2025 article

Application and Characterization of Novel Mid-IR Glucoloop Laser for Mass Spectrometry Imaging and Small Molecule Screening

Eisenberg, S. M., Bruce, E. R., Ashbacher, S. M., Wang, M. F., Sawicki, J. W., Radosevich, A. J., … Muddiman, D. C. (2025, November 17). Analytical Chemistry.

By: S. Eisenberg n, E. Bruce n, S. Ashbacher n , M. Wang n, J. Sawicki *, A. Radosevich *, J. Williams *, G. Spühler, A. Selivanau, D. Muddiman  n

topics (OpenAlex): Spectroscopy and Laser Applications; Spectroscopy Techniques in Biomedical and Chemical Research; Atmospheric and Environmental Gas Dynamics
Sources: NC State University Libraries, NC State University Libraries
Added: November 18, 2025

2024 article

Optimizing neurotransmitter pathway detection by IR-MALDESI-MSI in mouse brain

Wang, M. F., Ouyang, Y., Segura, T., & Muddiman, D. C. (2024, June 1). Analytical and Bioanalytical Chemistry, Vol. 6.

By: M. Wang n, Y. Ouyang *, T. Segura * & D. Muddiman n 

author keywords: IR-MALDESI; Mass spectrometry imaging; Sucrose; PFA; Neurotransmitter
MeSH headings : Animals; Neurotransmitter Agents / analysis; Neurotransmitter Agents / metabolism; Mice; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Brain / metabolism; Mice, Inbred C57BL; Brain Chemistry
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
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Sources: Web Of Science, NC State University Libraries
Added: June 11, 2024

2023 article

Comparative analysis of sucrose-embedding for whole-body zebrafish MSI by IR-MALDESI

Wang, M. F., Ritter, M. M., Kullman, S. W., & Muddiman, D. C. (2023, August 29). Analytical and Bioanalytical Chemistry, Vol. 8.

By: M. Wang n, M. Ritter  n, S. Kullman n  & D. Muddiman n 

author keywords: IR-MALDESI; Mass spectrometry imaging; Sucrose; PFA; Zebrafish
MeSH headings : Animals; Zebrafish; Sucrose / analysis; Sucrose / metabolism; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Tissue Embedding / methods; Lipids / analysis; Lipids / chemistry
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Physiological and biochemical adaptations
TL;DR: Danio rerio, or zebrafish, are model organisms for various disease states and can be imaged as a multi-organ sample to analyze morphological and metabolomic preservation as a result of sample preparation to compare sucrose-embedding with paraformaldehyde fixation against conventional fresh-frozen sample preparation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 25, 2023

2023 article

Lipidomic Analysis of Mouse Brain to Evaluate the Efficacy and Preservation of Different Tissue Preparatory Techniques by IR-MALDESI-MSI

Wang, M. F., Sohn, A. L., Samal, J., Erning, K., Segura, T., & Muddiman, D. C. (2023, March 29). Journal of the American Society for Mass Spectrometry, Vol. 3.

By: M. Wang n, A. Sohn n, J. Samal *, K. Erning *, T. Segura * & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging; sucrose; PFA
MeSH headings : Mice; Animals; Spectrometry, Mass, Electrospray Ionization / methods; Lipidomics; Ice; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ions / chemistry; Lipids / analysis; Brain
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Analytical Chemistry and Chromatography
TL;DR: Evidence from these investigations supports sucrose-embedding without ice matrix as an alternative preparatory technique for IR-MALDESI-MSI, and demonstrates improved spatial distribution of ions resulting from the cryo-protective property of sucrose and paraformaldehyde fixation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 24, 2023

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