K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15
Begley, M. A., Solon, A. L., Davis, E. M., Sherrill, M. G., Ohi, R., & Elting, M. W. (2021, October 20). (C. Walczak, Ed.). Molecular Biology of the Cell, Vol. 32.
MeSH headings : Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; Cell Line; Humans; Kidney / cytology; Kinesins / antagonists & inhibitors; Kinesins / genetics; Kinesins / metabolism; Kinetochores; Microtubules / metabolism; Spindle Apparatus / physiology; Time-Lapse Imaging
topics (OpenAlex): Microtubule and mitosis dynamics; Cellular Mechanics and Interactions; Cellular transport and secretion; Nuclear Structure and Function
TL;DR:
The data suggest that forces holding k-fibers together are of similar magnitude to other spindle forces, and that Kif15, acting as a microtubule crosslinker, helps fortify and repair k-Fibers.
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