Mary H Grace

natural products, structure elucidation, bioactive compounds, phytochemistry

PhD in pharmacognosy, phytochemistry, structural elucidation of natural products, health-related activities of fruits & vegetables

Works (139)

Updated: April 15th, 2024 05:03

2024 chapter

Polyphenols and food-grade protein-polyphenol complexes for attenuation of food allergy

In Encyclopedia of Food Allergy. Elsevier Publishers.

Contributors: M. Grace n

Source: ORCID
Added: February 2, 2024

2024 journal article

Spray dried insect protein-polyphenol particles deliver health-relevant value-added food ingredients

FUTURE FOODS, 9.

By: E. Silva n, J. Xiong n, F. Medeiros n, M. Grace n, M. Moncada n, M. Lila n, R. Hoskin n

author keywords: Alternative protein; Cricket; Food ingredients; Revalorization
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 journal article

Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach

ANTIOXIDANTS, 12(7).

By: R. Hoskin n, M. Grace n, A. Guiotto n, A. Pecorelli n, G. Valacchi n & M. Lila n

author keywords: sustainability; value-added; repurposing; skin health; cosmeceuticals
TL;DR: It is demonstrated that protein-polyphenol complexation is a synergistic strategy to stabilize and deliver residual fruit/algae phytoactives into cosmeceutical products for skin health applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 17, 2023

2023 journal article

Evaluation of saffron extract bioactivities relevant to skin resilience

JOURNAL OF HERBAL MEDICINE, 37.

By: J. Xiong n, M. Grace n, H. Kobayashi* & M. Lila n

author keywords: Tyrosinase; Collagenase; Collagen; Hyaluronic acid; Antioxidant activity; Crocus sativus
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 14, 2023

2023 journal article

Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease

ANTIOXIDANTS, 12(7).

By: M. Tambe*, A. Jacquet*, K. Strathearn*, J. Hensel*, B. Colon*, A. Chandran*, G. Yousef n, M. Grace n ...

author keywords: anthocyanin; Nrf2; paraquat; Parkinson's disease; polyphenols; rotenone
TL;DR: It is suggested that extracts enriched with certain combinations of ANC, PAC, stilbenes, and other polyphenols could potentially slow neurodegeneration in the brains of individuals exposed to PQ or rotenone by activating cellular antioxidant mechanisms and/or alleviating mitochondrial dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 25, 2023

2023 article

Spray-drying microencapsulation of blackcurrant and cocoa polyphenols using underexplored plant-based protein sources

Hoskin, R. T., Grace, M. H. H., Xiong, J., & Lila, M. A. (2023, May 9). JOURNAL OF FOOD SCIENCE, Vol. 5.

By: R. Hoskin n, M. Grace n, J. Xiong n & M. Lila n

author keywords: buckwheat; chia; pea; protein; carriers; revalorization
MeSH headings : Polyphenols / chemistry; Plant Proteins / chemistry; Antioxidants / chemistry; Anthocyanins; Chocolate; Pea Proteins; Plant Extracts / chemistry; Cacao / chemistry; Phytochemicals
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 11, 2023

2022 article

Boosting the Bioaccessibility of Dietary Bioactives by Delivery as Protein-Polyphenol Aggregate Particles

Lila, M. A., Hoskin, R. T., Grace, M. H., Xiong, J., Strauch, R., Ferruzzi, M., … Kay, C. (2022, April 8). JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Vol. 4.

By: M. Lila n, R. Hoskin n, M. Grace n, J. Xiong n, R. Strauch n, M. Ferruzzi*, M. Iorizzo n, C. Kay n

author keywords: bioavailability; digestion; absorption; circulation; uptake; matrix
MeSH headings : Humans; Polyphenols / analysis; Fruit / chemistry; Protein Aggregates; Dietary Proteins; Biological Availability; Food Ingredients
TL;DR: Evidence to date suggests that complexation of phy toactive polyphenolics effectively enhances their health-relevant impacts, specifically because the phytoactives are protected in the protein matrix during transit in the GIT, allowing intact, non-degraded molecules to reach the colon for catabolism at the gut microbiome level. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 14, 2022

2022 journal article

Dissecting the genetic basis of bioactive metabolites and fruit quality traits in blueberries (Vaccinium corymbosum L.)

FRONTIERS IN PLANT SCIENCE, 13.

By: M. Mengist n, M. Grace n, T. Mackey*, B. Munoz n, B. Pucker*, N. Bassil*, C. Luby*, M. Ferruzzi n, M. Lila n, M. Iorizzo n

author keywords: blueberry; anthocyanin; acylation; glycosylation; QTL mapping; candidate genes; fruit quality; chlorogenic acid
TL;DR: The study provides the first insights into the genetic basis controlling anthocyanins accumulation and composition, chlorogenic acid and fruit quality traits, and establishes a framework to advance genetic studies and molecular breeding for anthcyanins in blueberry. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022

2022 journal article

Spray-dried and freeze-dried protein-spinach particles; effect of drying technique and protein type on the bioaccessibility of carotenoids, chlorophylls, and phenolics

FOOD CHEMISTRY, 388.

By: M. Grace n, R. Hoskin n, M. Hayes n, M. Iorizzo n, C. Kay n, M. Ferruzzi n, M. Lila n

author keywords: Spinach phytochemicals; Whey protein; Soy protein; Drying; In vitro digestion; Dried ingredients
MeSH headings : Carotenoids / metabolism; Chlorophyll / metabolism; Digestion; Excipients / metabolism; Flavonoids / metabolism; Freeze Drying; Phenols / metabolism; Spinacia oleracea / metabolism
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022

2021 journal article

Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage

COSMETICS, 8(4).

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n, M. Grace n, J. Therrien n, M. Lila n, G. Valacchi n

author keywords: cosmeceuticals; environmental stressor; oxidation; inflammation; antioxidant; OxInflammation; phytochemicals
TL;DR: It is observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 2, 2021

2021 journal article

Efficacy of Pecan Husk and Shell Phenolic Extracts Against Phytophthora Blight in Chile Pepper

PLANT HEALTH PROGRESS, 22(3), 342–347.

By: P. Lujan*, S. Dura*, I. Guzman*, M. Grace n, M. Lila n, R. Steiner*, S. Sanogo*

author keywords: Phytophthora capsici; Capsicum annuum; induced resistance; elicitors; proanthocyanidins; soilborne pathogens
TL;DR: Pecan byproducts may be used as additional options for management of Phytophthora blight and the phenolic content in the extracts was largely made up of proanthocyanidins also known as condensed tannins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 18, 2022

2021 article

Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models

Jacquet, A. de R., Ambaw, A., Tambe, M. A., Ma, S. Y., Timmers, M., Grace, M. H., … Rochet, J.-C. (2021, July 16). FOOD & FUNCTION, Vol. 7.

By: A. Jacquet*, A. Ambaw*, M. Tambe*, S. Ma n, M. Timmers n, M. Grace, Q. Wu*, J. Simon* ...

MeSH headings : Animals; Astrocytes / drug effects; Cells, Cultured; Dietary Supplements; Dopaminergic Neurons / drug effects; Female; Humans; Isoflavones / pharmacology; Male; Models, Biological; Neuroprotective Agents / pharmacology; Parkinson Disease / metabolism; Phytochemicals / pharmacology; Rats; Rats, Sprague-Dawley; Soybeans / chemistry; Trifolium / chemistry
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 10, 2021

2021 journal article

Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

MOLECULES, 26(13).

By: R. Hoskin n, E. Pambianchi n, A. Pecorelli n, M. Grace n, J. Therrien*, G. Valacchi n, M. Lila n

author keywords: cosmeceuticals; pollution; phytochemicals; herbs
MeSH headings : Antioxidants / chemistry; Antioxidants / pharmacology; Cells, Cultured; Chlorella / chemistry; Cinnamates / chemistry; Depsides / chemistry; Environmental Exposure / adverse effects; Filaggrin Proteins; Humans; Rosmarinus / chemistry; Skin / injuries; Skin / metabolism; Skin / pathology; Skin Aging / drug effects
TL;DR: The ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts and active matrix metalloproteinase-9 (MMP-9) by limiting the loss of filaggrin induced by DEE exposure. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 23, 2021

2021 journal article

Phytoecdysteroids Do Not Have Anabolic Effects in Skeletal Muscle in Sedentary Aging Mice

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(2).

By: M. Lawrence*, K. Zwetsloot*, S. Arthur*, C. Sherman*, J. Huot*, V. Badmaev*, M. Grace n, M. Lila n, D. Nieman*, R. Shanely*

author keywords: skeletal muscle; hypertrophy; Akt; atrogenes; 20-hydroxyecdysone
MeSH headings : Aging; Anabolic Agents; Animals; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Rats
TL;DR: Data indicate that phytoecdysteroid treatment does not alter muscle mass or fiber type, nor does it activate protein synthesis signaling in the skeletal muscle of sedentary aging mice. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 7, 2021

2021 journal article

The same anthocyanins served four different ways: Insights into anthocyanin structure-function relationships from the wintergreen orchid, Tipularia discolor

PLANT SCIENCE, 303.

By: N. Hughes*, M. Connors*, M. Grace n, M. Lila n, B. Willans* & A. Wommack*

author keywords: Abaxial/adaxial anthocyanins; Acylated cyanidin; 3,7,3 '-Triglucoside; Camouflage; Chemotaxonomy; Leaf color evolution; Herbivory defense
MeSH headings : Anthocyanins / chemistry; Anthocyanins / isolation & purification; Anthocyanins / physiology; Chromatography, High Pressure Liquid; Color; Gas Chromatography-Mass Spectrometry; Microscopy; Orchidaceae / metabolism; Orchidaceae / ultrastructure; Plant Leaves / metabolism; Plant Leaves / ultrastructure; Structure-Activity Relationship
TL;DR: The results showed that the same three cyanidin 3,7,3'-triglucosides, in similar concentrations and proportions, accounted for coloration in each of these cases, and served as a reminder that plants may employ the same anthocyanins in different anatomical locations to achieve a broad range of colors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 11, 2020

2021 journal article

Whey and soy proteins as wall materials for spray drying rosemary: Effects on polyphenol composition, antioxidant activity, bioaccessibility after in vitro gastrointestinal digestion and stability during storage

LWT-FOOD SCIENCE AND TECHNOLOGY, 149.

By: M. Grace n, R. Hoskin n, J. Xiong n & M. Lila n

author keywords: Protein-polyphenol; Phenolic diterpenes; Bioaccessibility; Rosemary antioxidants; Spray-drying
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 16, 2021

2020 journal article

Diversity in Metabolites and Fruit Quality Traits in Blueberry Enables Ploidy and Species Differentiation and Establishes a Strategy for Future Genetic Studies

Frontiers in Plant Science, 11.

By: M. Mengist n, M. Grace n, J. Xiong n, C. Kay n, N. Bassil*, K. Hummer*, M. Ferruzzi n, M. Lila n, M. Iorizzo n

Contributors: M. Mengist n, M. Grace n, J. Xiong n, C. Kay n, N. Bassil*, K. Hummer*, M. Ferruzzi n, M. Lila n, M. Iorizzo n

author keywords: blueberry; health promoting phytochemicals; fruit size; ploidy; fruit quality; flavonoid pathway
Source: ORCID
Added: April 11, 2020

2020 journal article

Enhanced stability of berry pomace polyphenols delivered in protein-polyphenol aggregate particles to an in vitro gastrointestinal digestion model

Food Chemistry, 331, 127279.

By: J. Xiong n, Y. Chan n, T. Rathinasabapathy n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: J. Xiong n, Y. Chan n, T. Rathinasabapathy n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Food matrix; By-product; Stability; Antioxidant; Anti-inflammatory
MeSH headings : Animals; Anthocyanins / analysis; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antioxidants / analysis; Blueberry Plants / chemistry; Digestion; Food-Processing Industry; Fruit / chemistry; Mice; Plant Extracts / chemistry; Plant Extracts / pharmacokinetics; Plant Proteins, Dietary / chemistry; Polyphenols / pharmacokinetics; Proanthocyanidins / analysis; RAW 264.7 Cells; Vitis / chemistry
TL;DR: Protein-polyphenol particle digests retained 1.5 to 2-fold higher antioxidant capacity and suppressed the expression of pro-inflammatory cytokines, iNOS, IL6, and IL1β, compared to unmodified extract digests, which only suppressed IL6. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: June 19, 2020

2020 journal article

Hypoglycaemic, insulin releasing, and hepatoprotective effect of the aqueous extract of Aloe perryi Baker resin (Socotran Aloe) in streptozotocin-induced diabetic rats

Journal of Taibah University for Science, 14(1), 1671–1685.

author keywords: Aloe perryi; polyphenols; anti-diabetic; anti-hyperlipidemia; ALT; AST
TL;DR: In conclusion, AP extract exerts hypoglycaemic, insulin-releasing, and hepatic antioxidant potentials in diabetic rats. (via Semantic Scholar)
Source: ORCID
Added: December 13, 2020

2020 journal article

In Vitro Evaluation of a Novel Synthetic Bilirubin Analog as an Antioxidant and Cytoprotective Agent for Pancreatic Islet Transplantation

Cell Transplantation, 29, 096368972090641.

By: E. Luckring n, P. Parker n, H. Hani*, M. Grace n, M. Lila n, J. Pierce n, C. Adin*

Contributors: E. Luckring n, P. Parker n, H. Hani*, M. Grace n, M. Lila n, J. Pierce n, C. Adin*

MeSH headings : Animals; Antioxidants / chemical synthesis; Antioxidants / chemistry; Bilirubin / analogs & derivatives; Bilirubin / chemical synthesis; Bilirubin / chemistry; Cell Survival / physiology; Fluorescence Recovery After Photobleaching; Islets of Langerhans Transplantation / methods; Molecular Structure; Swine
TL;DR: Two bilirubin analogs are synthesized that can be produced without the use of animal-derived products and have promising antioxidant and cytoprotective effects, limiting islet cell death in a model of islet transplantation hypoxic stress. (via Semantic Scholar)
Source: ORCID
Added: July 9, 2020

2020 journal article

LC-MS characterization of bioactive metabolites from two Yemeni Aloe spp. with antioxidant and antidiabetic properties

ARABIAN JOURNAL OF CHEMISTRY, 13(4), 5040–5049.

By: T. Aldayel*, M. Grace n, M. Lila n, M. Yahya*, U. Omar* & G. Alshammary*

Contributors: T. Aldayel*, M. Grace n, M. Lila n, M. Yahya*, U. Omar* & G. Alshammary*

author keywords: LC-ESI-IT-TOF; Aloe; Phenolics; alpha-Glucosidase inhibition; Antioxidant activity
TL;DR: Findings highlight the phytochemical profile, antioxidant and potential antidiabetic activity of the Yemeni Aloe species and draw attention to their potential application in food, medicine and cosmetic products. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 20, 2020

2020 journal article

Phenolic content, anti-inflammatory properties, and dermal wound repair properties of industrially processed and non-processed acai from the Brazilian Amazon

Food &Amp; Function, 11(6), 4903–4914.

By: J. Xiong n, F. Matta*, M. Grace n, M. Lila n, N. Ward*, M. Felipe-Sotelo*, D. Esposito n

Contributors: J. Xiong n, F. Matta*, M. Grace n, M. Lila n, N. Ward*, M. Felipe-Sotelo*, D. Esposito n

MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Arecaceae; Brazil; Food Industry; Fruit; Humans; Mice; Phytotherapy; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / chemistry; RAW 264.7 Cells / drug effects; Wound Healing / drug effects
TL;DR: The anti-inflammatory effect was diminished but wound healing effect was retained after pulp processing, suggesting the processing technology needs to be improved to maintain biological properties of acai fruit. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: June 5, 2020

2019 journal article

Alaskan Berry Extracts Promote Dermal Wound Repair Through Modulation of Bioenergetics and Integrin Signaling

FRONTIERS IN PHARMACOLOGY, 10(SEP).

By: D. Esposito n, J. Overall n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: D. Esposito n, J. Overall n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: skin regeneration; wound healing; Alaskan berries; integrins; proanthocyanidins; epicatechins
TL;DR: Targeting cellular bioenergetics and integrin-mediated cell–ECM signaling with bioactives from Alaskan wild berries shows considerable therapeutic promise to treat chronic skin wounds and inflammatory skin disorders, as well as more generally to support regenerative healing responses and restore function in a variety of tissue and organ settings after injury or aging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 14, 2019

2019 journal article

Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits

FOOD RESEARCH INTERNATIONAL, 121, 453–462.

By: F. Velde*, D. Esposito n, M. Grace n, M. Pirovani* & M. Lila n

Contributors: F. Velde*, D. Esposito n, M. Grace n, M. Pirovani* & M. Lila n

author keywords: Fragaria ananassa; Rubus fruticosus; Anthocyanins; Proanthocyanidins; Cyclooxygenase-2; Interleukin-6; Skin cell migration
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Fragaria / chemistry; Fruit / chemistry; Mice; Phytochemicals / analysis; Phytochemicals / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; Polyphenols / analysis; Polyphenols / pharmacology; Proanthocyanidins / analysis; Proanthocyanidins / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Rubus / chemistry; Wound Healing / drug effects
TL;DR: Results obtained in this work highlight the anti-inflammatory properties of berry polyphenolics, especially due to proanthocyanidins, and promising results were obtained about the effects of bberry anthocyanins on wound healing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2019

2019 journal article

Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits

Food Research International.

By: V. Velde*, D. Franco, M. Grace n, M. Pirovani* & M. Lila n

Source: ORCID
Added: January 14, 2020

2019 journal article

Changes due to high oxygen and high carbon dioxide atmospheres on the general quality and the polyphenolic profile of strawberries

Postharvest Biology and Technology, 148, 49–57.

By: F. Van de Velde*, M. Méndez-Galarraga*, M. Grace n, C. Fenoglio*, M. Lila n & M. Pirovani*

Contributors: F. Velde*, M. Méndez-Galarraga*, M. Grace n, C. Fenoglio*, M. Lila n & M. Pirovani*

author keywords: Modified atmosphere packaging; Abiotic stress; Anthocyanins; Phenolic acids; Ellagitannins; Vitamin C
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019

2019 journal article

Changes in the bioactive properties of strawberries caused by the storage in oxygen- and carbon dioxide-enriched atmospheres

FOOD SCIENCE & NUTRITION, 7(8), 2527–2536.

By: F. Velde*, D. Esposito n, J. Overall n, M. Mendez-Galarraga*, M. Grace n, M. Piroyani, M. Lila n

Contributors: F. Velde*, D. Esposito n, J. Overall n, M. Méndez-Galarraga*, M. Grace n, M. Élida Pirovani*, M. Lila n

author keywords: 2; 2-diphenyl-1-picrylhydrazil; cyclooxygenase-2; ferric reducing antioxidant power; human dermal fibroblast migration; interleukin-6; modified atmosphere storage
TL;DR: Evidence suggests that strawberry storage in 90% O2 + 10% CO2 can be a promissory alternative to offer fruits with enhanced bioactivity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 5, 2019

2019 journal article

Investigation of Secondary Metabolites and Cytotoxicity of Jacquemontia pentantha (Jacq.)

Pharmacognosy Journal, 11(4), 718–723.

By: D. Eskander, E. El-Khrisy, M. Grace*, M. Nabil, M. Nassar & M. Mounier

Contributors: D. Eskander, E. El-Khrisy, M. Grace*, M. Nabil, M. Nassar & M. Mounier

TL;DR: The chemical constituents (sterols and terpenes) of Jacquemontia pentantha aerial parts are characterized for the first time from this plant to support the possibility of its uses as a natural resource in therapeutics and to demonstrate the cytotoxic activity of the extract and phytol, which hasn't been investigated before for this plant. (via Semantic Scholar)
Source: ORCID
Added: January 14, 2020

2019 journal article

Photosynthetic Profiles of Green, Purple, and Spotted-Leaf Morphotypes of Tipularia discolor (Orchidaceae)

SOUTHEASTERN NATURALIST, 18(4), 641–658.

By: N. Hughes*, G. Gigantino*, M. Grace n, K. Hoffman*, M. Lila n, B. Willans*, A. Wommack*

Contributors: N. Hughes*, G. Gigantino*, M. Grace n, K. Hoffman*, M. Lila n, B. Willans*, A. Wommack*

TL;DR: It is concluded that leaf purpling and spotting in Cranefly Orchid are most likely not related to physiological stress, and are more likely genetic in nature, perhaps representing alternative phenotypic adaptations related to herbivory defense. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 6, 2020

2019 journal article

Simultaneous LC-MS quantification of anthocyanins and non-anthocyanin phenolics from blueberries with widely divergent profiles and biological activities

Food Chemistry, 277, 336–346.

By: M. Grace n, J. Xiong n, D. Esposito n, M. Ehlenfeldt* & M. Lila n

Contributors: M. Grace n, J. Xiong n, D. Esposito n, M. Ehlenfeldt* & M. Lila n

author keywords: Pink-fruited; Blueberries; LC-IT-TOF-MS; Quantification; Antioxidant; Anti-inflammatory; PCA
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Anti-Inflammatory Agents / analysis; Anti-Inflammatory Agents / pharmacology; Antioxidants / analysis; Antioxidants / pharmacology; Biological Assay; Blueberry Plants / chemistry; Cell Survival / drug effects; Chromatography, Liquid; Color; Flavonoids / analysis; Flavonoids / pharmacology; Flavonols / analysis; Flavonols / pharmacology; Fruit / chemistry; Hydroxybenzoates / analysis; Hydroxybenzoates / pharmacology; Limit of Detection; Mass Spectrometry; Mice; Nitric Oxide / metabolism; Phenols / analysis; Phenols / pharmacology; Plant Extracts / analysis; Plant Extracts / pharmacology; RAW 264.7 Cells; Reactive Oxygen Species / metabolism; Reproducibility of Results; Resveratrol / analysis; Resveratrol / pharmacology
TL;DR: A sensitive and straightforward LC-IT-TOF-MS method was validated for the profiling and simultaneous quantification of anthocyanins, flavan-3-ols, flavonols, phenolic acids, and resveratrol in blueberry genotypes with fruit color ranging from deep purple to various shades of pink. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 17, 2018

2019 journal article

Two Triterpenoid Saponins with α-glucosidase Inhibitory Activity from Harpullia pendula Seed Extract

Pharmacognosy Journal, 11(6), 1386–1390.

By: M. Nabil, N. Ghaly, I. Kassem, M. Grace* & F. Melek

Contributors: M. Nabil, N. Ghaly, I. Kassem, M. Grace* & F. Melek

UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: January 14, 2020

2018 journal article

Correction: In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse [BMC Plant Biol., 18, (2018) (122)] DOI: 10.1186/s12870-018-1345-y

BMC Plant Biology, 18(1).

By: R. El-Hawaz*, M. Grace n, A. Janbey n, M. Lila n & J. Adelberg*

Contributors: R. El-Hawaz*, M. Grace n, A. Janbey n, M. Lila n & J. Adelberg*

TL;DR: Following publication of the original article [1], the author reported a formatting error and an error in the figure caption. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
15. Life on Land (Web of Science)
Source: ORCID
Added: July 9, 2020

2018 journal article

In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse

BMC Plant Biology, 18(1).

By: R. El-Hawaz*, M. Grace n, A. Janbey n, M. Lila n & J. Adelberg*

Contributors: R. El-Hawaz*, M. Grace n, A. Janbey n, M. Lila n & J. Adelberg*

author keywords: Bioreactor; Sesquiterpenes; GC-MS; Curcuma longa rhizome; Response surface methods; Fed-batch technique
MeSH headings : Bioreactors; Calcium / metabolism; Curcuma / drug effects; Curcuma / metabolism; Fertilizers; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Magnesium / metabolism; Minerals / pharmacology; Nitrates / metabolism; Phosphates / metabolism; Potassium Compounds / metabolism; Rhizome / drug effects; Rhizome / metabolism; Volatile Organic Compounds / metabolism
TL;DR: Mining in the in vitro bioreactor medium during rhizome development affected biosynthesis of turmeric volatile components after transfer to the greenhouse six months later, and the varied phytochemical profiles were maintained with integrity during the greenhouse growth in high fertility conditions. (via Semantic Scholar)
Sources: ORCID, NC State University Libraries
Added: November 12, 2019

2018 journal article

In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse

BMC Plant Biology, 18.

By: R. El-Hawaz, M. Grace, A. Janbey, M. Lila & J. Adelberg

Source: NC State University Libraries
Added: August 6, 2018

2018 article

In vitro mineral nutrition of Curcuma longa L. affects production of volatile compounds in rhizomes after transfer to the greenhouse (vol 18, 122, 2018)

BMC Plant Biology, Vol. 18.

By: R. El-Hawaz, M. Grace, A. Janbey, M. Lila & J. Adelberg

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Increased Plasma Levels of Gut-Derived Phenolics Linked to Walking and Running Following Two Weeks of Flavonoid Supplementation

Nutrients, 10(11).

By: D. Nieman*, C. Kay n, A. Rathore n, M. Grace n, R. Strauch n, E. Stephan*, C. Sakaguchi*, M. Lila n

Contributors: D. Nieman*, C. Kay n, A. Rathore n, M. Grace n, R. Strauch n, E. Stephan*, C. Sakaguchi*, M. Lila n

author keywords: exercise; polyphenol; metabolite; hippurate; intestinal tract; colon
TL;DR: Data indicate that acute exercise bouts (brisk walking, intensive running) are linked to an increased translocation of gut-derived phenolics into circulation, an effect that is amplified when combined with a two-week period of increased flavonoid intake or chronic training as a runner. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2017 journal article

Inter- and intra-seasonal changes in anthocyanin accumulation and global metabolite profiling of six blueberry genotypes

Journal of Food Composition and Analysis.

Mary Grace

Source: ORCID
Added: November 12, 2019

2017 chapter

Acillea millefolium: Re-Exploring herbal remides for combating malaria

Mary Grace

Source: ORCID
Added: November 12, 2019

2017 journal article

Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women

JOURNAL OF PROTEOME RESEARCH, 16(8), 2924–2935.

By: D. Nieman*, S. Ramamoorthy*, C. Kay n, C. Goodman*, C. Capps*, Z. Shue*, N. Heyl*, M. Grace n, M. Lila n

Contributors: D. Nieman*, S. Ramamoorthy*, C. Kay n, C. Goodman*, C. Capps*, Z. Shue*, N. Heyl*, M. Grace n, M. Lila n

author keywords: dietary supplement; metabolomics; polyphenol; obesity
MeSH headings : Adolescent; Adult; Aged; Dietary Supplements; Female; Flavonoids / administration & dosage; Flavonoids / pharmacology; Humans; Intestinal Mucosa / metabolism; Metabolome / drug effects; Metabolomics / methods; Middle Aged; Obesity / metabolism; Obesity / urine; Overweight / metabolism; Overweight / urine; Phenols / urine; Young Adult
TL;DR: It was shown that 12 weeks ingestion of a mixed flavonoid nutrient supplement was associated with a corresponding increase in urine total phenolics and gut-derived phenolic metabolites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Inter- and intra-seasonal changes in anthocyanin accumulation and global metabolite profiling of six blueberry genotypes

JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 59, 105–110.

By: M. Timmers n, M. Grace n, G. Yousef n & M. Lila n

Contributors: M. Timmers n, M. Grace n, G. Yousef n & M. Lila n

author keywords: Anthocyanin; HPLC; PCA; Blueberry; Metabolite profile; Genotype and seasonal variations; Food analysis; Food composition
TL;DR: Genotypes were easily distinguished from one another across each harvest season, indicating that each genotype had distinctly different metabolite profile, whereas each of the rabbiteye genotypes overlapped on the scores plot, indicating commonalities in metabolite profiles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Metabolic Effects of Berries with Structurally Diverse Anthocyanins

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2).

By: J. Overall n, S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n, D. Esposito n, M. Lila n, S. Komarnytsky n

Contributors: J. Overall n, S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n, D. Esposito n, M. Lila n, S. Komarnytsky n

author keywords: berry; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Anthocyanins / metabolism; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Supplements; Feces / chemistry; Fruit / metabolism; Gastrointestinal Microbiome; Glucose / metabolism; Humans; Insulin Resistance; Mice; Molecular Structure; Oxygen Consumption
TL;DR: Examination of effects of six berries with structurally diverse anthocyanin profiles on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocianins that could be explained by differences in their structure and metabolism in the gut. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Metabolic effects of berries with structurally diverse anthocyanins

International Journal of Molecular Sciences.

Mary Grace

MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Anthocyanins / metabolism; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Supplements; Feces / chemistry; Fruit / metabolism; Gastrointestinal Microbiome; Glucose / metabolism; Humans; Insulin Resistance; Mice; Molecular Structure; Oxygen Consumption
Source: ORCID
Added: November 12, 2019

2017 journal article

One-step isolation of carnosic acid and carnosol from rosemary by centrifugal partition chromatography

JOURNAL OF SEPARATION SCIENCE, 40(5), 1057–1062.

By: M. Grace n, Y. Qiang n, S. Sang* & M. Lila n

Contributors: M. Grace n, Y. Qiang n, S. Sang* & M. Lila n

author keywords: carnosic acid; carnosol; centrifugal partition chromatography; Rosmarinus officinalis
MeSH headings : Abietanes / isolation & purification; Chromatography; Plant Extracts / chemistry; Rosmarinus / chemistry
TL;DR: Carnosic acid and carnosol are the main bioactive components responsible for the significant antioxidant activity of Rosmarinus officinalis and were identified by mass spectrometry, tandem mass spectromaetry, and comparison with authentic standards. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

One-step isolation of carnosic acid and carnosol from rosemary by centrifugal partition chromatography

Journal of Separation Science.

Mary Grace

author keywords: carnosic acid; carnosol; centrifugal partition chromatography; Rosmarinus officinalis
Source: ORCID
Added: November 12, 2019

2017 journal article

Pendulaosides A and B. Two acylated triterpenoid saponins from Harpullia pendula seed extract

Phytochemistry Letters.

Mary Grace

Source: ORCID
Added: November 12, 2019

2017 journal article

Pendulaosides A and B. Two acylated triterpenoid saponins from Harpullia pendula seed extract

Phytochemistry Letters, 21, 278–282.

By: N. Ghaly*, M. Nabil*, M. Grace* & F. Melek*

Contributors: N. Ghaly*, M. Nabil*, M. Grace* & F. Melek*

author keywords: Harpullia pendula; Sapindaceae; Pendulaosides A and B; Triterpenoid saponins; Cytotoxicity
TL;DR: The two isolated saponins were assayed for their in-vitro cytotoxic activity against the three human tumor cell lines HepG2, MCF7 and PC3 and showed that pendulaoside A exhibited moderate activity on PC3 cell line with IC50value equal to 13.0 μM and weak activity on Hepg2 cell linewith IC50 value equal to 41.0-μM. (via Semantic Scholar)
Source: ORCID
Added: July 9, 2020

2017 journal article

Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities

Chinese Journal of Natural Medicines, 15(11), 816–824.

By: J. Xiong n, M. Grace n, D. Esposito n, S. Komarnytsky n, F. Wang* & M. Lila n

Contributors: J. Xiong n, M. Grace n, D. Esposito n, S. Komarnytsky n, F. Wang* & M. Lila n

author keywords: Acacia mearnsii; Proanthocyanidins; Anti-inflammatory; alpha-Amylase; alpha-Glucosidase
MeSH headings : Acacia / chemistry; Animals; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Carbohydrate Metabolism / drug effects; Glycoside Hydrolase Inhibitors / pharmacology; Inflammation / metabolism; Interleukin-1beta / metabolism; Lipopolysaccharides; Macrophages / drug effects; Mice; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Plant Bark / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Polyphenols / isolation & purification; Polyphenols / pharmacology; Proanthocyanidins / pharmacology; RAW 264.7 Cells; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
TL;DR: Polyphenols isolated from Acacia mearnsii bark crude extract and fractions obtained by high-speed counter-current chromatography and evaluated their anti-inflammatory and carbolytic enzymes (α-glucosidase and α-amylase) inhibitory activities showed significant activities against reactive oxygen species, nitric oxide production, and expression of pro-inflammatory genes interleukin-1β. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Wild blueberry polyphenol-protein food ingredients produced by three drying methods: Comparative physico-chemical properties, phytochemical content, and stability during storage

FOOD CHEMISTRY, 235, 76–85.

By: R. Correia n, M. Grace n, D. Esposito n & M. Lila n

Contributors: R. Correia n, M. Grace n, D. Esposito n & M. Lila n

author keywords: Soy protein isolate; By-products; Spray drying; Phenolics; Shelf life
MeSH headings : Anthocyanins / analysis; Antioxidants; Blueberry Plants / chemistry; Desiccation / methods; Food Handling / methods; Freeze Drying; Phytochemicals; Polyphenols
TL;DR: Overall, spray drying the blueberry extracts complexed with protein proved to be an environment-friendly strategy to produce stable functional ingredients with multiple applications for the food industry. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

alpha-Amylase and alpha-Glucosidase inhibitory activities of phenolic extracts from Eucalyptus grandis x E-urophylla Bark

Journal of Chemistry.

By: P. Jiang, J. Xiong, F. Wang, M. Grace, M. Lila & R. Xu

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

α-Amylase and α-Glucosidase Inhibitory Activities of Phenolic Extracts from Eucalyptus grandis × E. urophylla Bark

Journal of Chemistry, 2017, 1–7.

By: P. Jiang*, J. Xiong*, F. Wang*, M. Grace n, M. Lila n & R. Xu*

Contributors: P. Jiang*, J. Xiong*, F. Wang*, M. Grace n, M. Lila n & R. Xu*

Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019

2017 journal article

∝-amylase and ∝- glucosidase inhibitory activities of phenolic extracts from Eucalyptus grandis x E. urophylla bark

Journal of Chemistry.

Mary Grace

Source: ORCID
Added: November 12, 2019

2016 journal article

A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice

The Journal of Nutritional Biochemistry, 31, 150–165.

By: B. Collins*, J. Hoffman*, K. Martinez*, M. Grace*, M. Lila*, C. Cockrell*, A. Nadimpalli*, E. Chang* ...

Contributors: B. Collins*, J. Hoffman*, K. Martinez*, M. Grace*, M. Lila*, C. Cockrell*, A. Nadimpalli*, E. Chang* ...

author keywords: Grapes; Obesity; Steatosis; Inflammation; Intestines; Microbiota
MeSH headings : Adiposity / drug effects; Animals; Biomarkers / metabolism; Diet, High-Fat; Gastrointestinal Microbiome / drug effects; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Polyphenols / pharmacology; Vitis / chemistry
TL;DR: Data demonstrate that the polyphenol-rich, EP fraction from table grapes attenuated many of the adverse health consequences associated with consuming an HF diet. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019

2016 journal article

A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance, and markers of inflammation and impacts gut microbiota in high-fat fed mice

Journal of Nutritional Biochemistry.

Mary Grace

MeSH headings : Adiposity / drug effects; Animals; Biomarkers / metabolism; Diet, High-Fat; Gastrointestinal Microbiome / drug effects; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Polyphenols / pharmacology; Vitis / chemistry
Source: ORCID
Added: November 12, 2019

2016 journal article

Antioxidant activity of pomegranate juice and punicalagin

Natural Science.

Mary Grace

Source: ORCID
Added: November 12, 2019

2016 conference paper

Bioactive Components from Pistachios Reduce Adipogenesis and Suppress Inflammatory Gene Expression In Vitro. Experimental Biolgy Meeting, San Diego, CA.

(2016, April 2).

Mary Grace

Source: ORCID
Added: November 12, 2019

2016 journal article

Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts

Food Chemistry, 210, 85–95.

By: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

Contributors: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

author keywords: Anacardic acids; Triterpene acids; Carotenoids; Tocopherols; Polyphenols; Anti-inflammatory
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / isolation & purification; Antioxidants / pharmacology; Cell Line; Dose-Response Relationship, Drug; Macrophages / drug effects; Macrophages / metabolism; Mice; Pistacia; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Reactive Oxygen Species / antagonists & inhibitors; Reactive Oxygen Species / metabolism
TL;DR: The P extract significantly decreased the non-mitochondrial oxidative burst associated with inflammatory response in macrophages and significantly inhibited the release of nitric oxide and reactive oxygen species in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Impact of a new postharvest disinfection method based on peracetic acid fogging on the phenolic profile of strawberries

POSTHARVEST BIOLOGY AND TECHNOLOGY, 117, 197–205.

By: F. Velde*, M. Grace n, M. Elida Pirovani* & M. Lila n

Contributors: F. Velde*, M. Grace n, M. Pirovani* & M. Lila n

author keywords: Nebulization; Anthocyanins; Proanthocyanidins; Hydroxycinnamic acid derivatives; Ellagitannins
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Impact of a new postharvest disinfection method based on peracetic acid fogging on the phenolic profile of strawberries

Postharvest Biology and Technology.

Mary Grace

Source: ORCID
Added: November 12, 2019

2016 journal article

In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents

Food & Function, 7(10), 4285–4298.

By: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

Contributors: M. Grace n, D. Esposito n, M. Timmers n, J. Xiong n, G. Yousef n, S. Komarnytsky n, M. Lila n

MeSH headings : Animals; Antioxidants; Cell Survival / drug effects; Cooking; Macrophages / drug effects; Macrophages / metabolism; Mice; Phytochemicals; Pistacia / chemistry; RAW 264.7 Cells; Reactive Oxygen Species; Respiratory Burst; Seeds / chemistry
TL;DR: The SNP had the strongest effect in decreasing non-mitochondrial oxidative burst associated with inflammatory response in macrophages, and was the most potent to inhibit the expression of COX2. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 patent

Methods and compositions for attenuating allergenicity in protein products

Mary Grace

Source: ORCID
Added: November 12, 2019

2016 journal article

Phytochemical characterization and anti-inflammatory properties of Acacia mearnsii leaves

Natural Product Communications, 11(5), 649–653.

By: J. Xiong n, M. Grace n, D. Esposito n, F. Wang* & M. Lila n

Contributors: J. Xiong n, M. Grace n, D. Esposito n, F. Wang* & M. Lila n

TL;DR: Results indicate that A. mearnsii leaves, a forest waste product, could be a valuable natural source of anti-inflammatory and functional components related to human health. (via Semantic Scholar)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2016 journal article

Phytochemical characterization and antiinflammatory properties of Acacia mearnsii leaves

Natural Product Communications.

Mary Grace

Source: ORCID
Added: November 12, 2019

2016 journal article

Quantitative comparison of phytochemical profile, antioxidant, and anti-inflammatory properties of blackberry fruits adapted to Argentina

JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 47, 82–91.

By: F. Velde*, M. Grace n, D. Esposito n, M. Elida Pirovani* & M. Lila n

Contributors: F. Velde*, M. Grace n, D. Esposito n, M. Pirovani* & M. Lila n

author keywords: Bubo fruticosus; Polyphenols content; Vitamin C; Cyanidin-3-O-glucoside; Proanthocyanidins; Reactive oxygen species; Cyclooxygenase-2; Interleukin-6; Food analysis; Food composition
TL;DR: The potential of blackberries cultivars ‘Black Satin’ and ‘Jumbo’ to contribute to a healthy diet, based on their higher polyphenol content, providing higher antioxidant and anti-inflammatory properties is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Unraveling Anthocyanin Bioavailability for Human Health

Annual Review of Food Science and Technology, 7, 375–393.

By: M. Lila n, B. Burton-Freeman*, M. Grace n & W. Kalt*

Contributors: M. Lila n, B. Burton-Freeman*, M. Grace n & W. Kalt*

author keywords: anthocyanin metabolites; phenolic acid metabolites; bioaccessibility; gastrointestinal tract; enterohepatic recycling
MeSH headings : Anthocyanins / analysis; Anthocyanins / chemistry; Anthocyanins / pharmacokinetics; Biological Availability; Diet; Flavonoids / chemistry; Food; Gastrointestinal Microbiome / physiology; Gastrointestinal Tract / metabolism; Health Promotion; Humans; Intestinal Absorption; Intestinal Reabsorption; Liver / metabolism
TL;DR: It is argued that the persistence of anthocyanin metabolites suggests enterohepatic recycling, leading to prolonged residence time, and supports the notion that Anthocyanins are far more bioavailable than previously suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: ORCID
Added: November 12, 2019

2016 review

Unraveling anthocyanin bioavailability for human health

[Review of ]. Annual review of food science and technology, vol 7, 7, 375–393.

By: M. Lila, B. Burton-Freeman, M. Grace & W. Kalt

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

A new acylated flavonol triglycoside and bioactivities of Jacquemontia pentantha (Jacq.)

Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6(6), 677–686. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951799106&partnerID=MN8TOARS

By: M. Nassar, E. Aboutabl, D. Eskander, M. Grace, A. Abd El Aty, A. Sleem, E. Elkhrisy

Contributors: M. Nassar, E. Aboutabl, D. Eskander, M. Grace, A. Abd El Aty, A. Sleem, E. Elkhrisy

Source: ORCID
Added: November 12, 2019

2015 journal article

Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes

JOURNAL OF FUNCTIONAL FOODS, 15, 396–407.

By: J. Kellogg n, D. Esposito n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: J. Kellogg n, D. Esposito n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Seaweed; Phlorotannin; Monoglycosyldiacylglycerol; Inflammation; Insulin resistance; Fucus distichus
TL;DR: Overall, the Alaskan seaweed F. distichus inhibited proinflammatory responses and improved lipid metabolism, suggesting the potential for seaweed phytochemicals to attenuate inflammatory diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Anthelmintic Activity of Punicalagin from Anogeissus Leiocarpus

Universal Journal of Plant Science.

Mary Grace

Source: ORCID
Added: November 12, 2019

2015 journal article

Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(27), 6172–6180.

By: D. Esposito n, T. Damsud n, M. Wilson n, M. Grace n, R. Strauch n, X. Li n, M. Lila n, S. Komarnytsky n

Contributors: D. Esposito n, T. Damsud n, M. Wilson n, M. Grace n, R. Strauch n, X. Li n, M. Lila n, S. Komarnytsky n

author keywords: gastrointestinal tract; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animals; Anthocyanins / administration & dosage; Anthocyanins / chemistry; Fruit / chemistry; Gastrointestinal Microbiome / drug effects; Glucose / metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity / drug therapy; Obesity / metabolism; Obesity / microbiology; Obesity / physiopathology; Plant Extracts / administration & dosage; Plant Extracts / chemistry; Ribes / chemistry; Weight Gain / drug effects
TL;DR: The data clearly demonstrate that gut microbiome and the type of the anthocyanin aglycone moiety can alter the protective effect of Anthocyanins against obesity and associated insulin resistance. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Characterization of Phenolic Compounds and Antioxidant and Antiinflammatory Activities from Mamuyo (Styrax ramirezii Greenm.) Fruit

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(48), 10459–10465.

By: M. Timmers n, J. Guerrero-Medina n, D. Esposito n, M. Grace n, O. Paredes-Lopez*, P. Garcia-Saucedo*, M. Ann Lila n

Contributors: M. Timmers n, J. Guerrero-Medina n, D. Esposito n, M. Grace n, O. Paredes-López*, P. García-Saucedo*, M. Lila n

author keywords: LC-TOF-MS; Styrax ramirezii; antioxidant activity; anti-inflammatory activity; norneolignan
MeSH headings : Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Cyclooxygenase 2 / immunology; Fruit / chemistry; Humans; Interleukin-1beta / immunology; Nitric Oxide / immunology; Nitric Oxide Synthase Type II / immunology; Nitric Oxide Synthase Type II / metabolism; Phenols / chemistry; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Reactive Oxygen Species / metabolism; Styrax / chemistry
TL;DR: Egonol potently inhibited the production of NO and also significantly reduced the release of ROS, suggesting the potential of S. ramirezii Greenm. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Flavonoids and gastroprotective effect of matricaria chamomilla against indomethacin-induced ulcer in rats

Journal of Herbs, Spices and Medicinal Plants, 21(2), 111–117.

By: S. El Souda*, K. Ahmed*, M. Grace*, E. Elkherassy*, A. Farrag* & S. Abdelwahab*

Contributors: S. El Souda*, K. Ahmed*, M. Grace*, E. Elkherassy*, A. Farrag* & S. Abdelwahab*

TL;DR: The antiulcer effect of Matricaria chamomilla flower head extracts were investigated on indomethacin-induced ulcer models in rats and the highest percent of inhibition was shown by the ethyl acetate and chloroform fractions. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2015 journal article

Novel strategies for capturing health-protective mango phytochemicals in shelf stable food matrices

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 66(2), 175–185.

By: I. Guzman n, M. Grace n, G. Yousef n, I. Raskin* & M. Lila n

Contributors: I. Guzman n, M. Grace n, G. Yousef n, I. Raskin* & M. Lila n

author keywords: Carotenoids; fortified foods; polyphenols; protein-rich flour; vitamin A
MeSH headings : Africa; Arachis; Carbohydrates / analysis; Carotenoids / administration & dosage; Carotenoids / analysis; Diet; Dietary Proteins; Flour / analysis; Food Handling / methods; Food Preservation; Fruit / chemistry; Health; Helianthus; Humans; Malnutrition / prevention & control; Mangifera / chemistry; Phytochemicals / analysis; Plant Oils; Polyphenols / administration & dosage; Polyphenols / analysis; Rural Population; Soybeans; Sunflower Oil
TL;DR: Cost-effective methods for concentration and stabilization of otherwise perishable mango fruit phytoactives into shelf stable high protein ingredients were developed to combat stunting (malnutrition) in rural Africa and capture the benefits of Otherwise perishable seasonal resources by complexing healthful proteins together with phy toactive compounds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Novel value-added uses for sweet potato juice and flour in polyphenol- and protein-enriched functional food ingredients

FOOD SCIENCE & NUTRITION, 3(5), 415–424.

By: M. Grace n, A. Truong n, V. Truong, I. Raskin* & M. Lila n

Contributors: M. Grace n, A. Truong n, V. Truong, I. Raskin* & M. Lila n

author keywords: Anti-inflammatory; antioxidant; berries; polyphenols; stability; sweet potato
TL;DR: Sensory evaluation of the ingredient matrices suggested potential uses for a wide range of functional food products, and anti-inflammatory and antioxidant fruit polyphenols with sweet potato functional constituents correlated well with total phenolic content. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Novel value-added uses for sweet potato juice and flour in polyphenol- and protein-enriched functional food ingredients.

Food Science & Nutrition.

Mary Grace

Source: ORCID
Added: November 12, 2019

2015 conference paper

Phytochemical Characterization, Anti-inflammatory and Lipolytic Activities of Pistachio Hulls, Skins, and Kernels. Experimental Biolgy Meeting, Boston MA

Mary Grace

Source: ORCID
Added: November 12, 2019

2014 journal article

Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle

European Review for Medical and Pharmacological Sciences, 18(17), 2584–2592. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942278734&partnerID=MN8TOARS

By: S. Arthur, K. Zwetsloot, M. Lawrence, D. Nieman, M. Lila, M. Grace, R. Howden, I. Cooley ...

Contributors: S. Arthur, K. Zwetsloot, M. Lawrence, D. Nieman, M. Lila, M. Grace, R. Howden, I. Cooley ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Anthocyanin profiling of wild maqui berries (Aristotelia chilensis [Mol.] Stuntz) from different geographical regions in Chile

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 94(13), 2639–2648.

By: C. Fredes*, G. Yousef n, P. Robert*, M. Grace n, M. Lila n, M. Gomez*, M. Gebauer*, G. Montenegro*

Contributors: C. Fredes*, G. Yousef n, P. Robert*, M. Grace n, M. Lila n, M. Gómez*, M. Gebauer*, G. Montenegro*

author keywords: delphinidin-3; 5-diglucoside; delphinidin-3-glucoside; genetic diversity; maqui genotypes; ISSR-PCR
MeSH headings : Altitude; Anthocyanins / analysis; Anthocyanins / metabolism; Antioxidants / analysis; Antioxidants / metabolism; Chile; Chromatography, High Pressure Liquid; Climate; Elaeocarpaceae / chemistry; Elaeocarpaceae / genetics; Elaeocarpaceae / growth & development; Elaeocarpaceae / metabolism; Fruit / chemistry; Fruit / genetics; Fruit / growth & development; Fruit / metabolism; Genetic Markers; Genetic Variation; Limit of Detection; Phenols / analysis; Phenols / metabolism; Phylogeny; Spatio-Temporal Analysis; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Wilderness
TL;DR: Three maqui genotypes exhibited significantly higher anthocyanin content than the others, as measured by pH differential method and high-performance liquid chromatography-mass spectrometry and significant genetic diversity was noted within each ecological population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 conference paper

Application of NMR in Natural Product Research for Human Health Benefits. Invited Speaker: Practical Applications of NMR in Industry Conferance PANIC, Charlotte, NC

Mary Grace

Source: ORCID
Added: November 12, 2019

2014 journal article

Bioactive Capacity, Sensory Properties, and Nutritional Analysis of a Shelf Stable Protein-rich Functional Ingredient with Concentrated Fruit and Vegetable Phytoactives

PLANT FOODS FOR HUMAN NUTRITION, 69(4), 372–378.

By: M. Grace n, G. Yousef n, D. Esposito n, I. Raskin* & M. Lila n

Contributors: M. Grace n, G. Yousef n, D. Esposito n, I. Raskin* & M. Lila n

author keywords: Muscadine; Kale; Protein isolate; Inflammatory biomarkers
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Brassica / chemistry; Cannabis; Carotenoids / pharmacology; Carotenoids / therapeutic use; Chemokine CCL2 / metabolism; Diet; Dietary Proteins / analysis; Fruit / chemistry; Functional Food / analysis; Glucosinolates / pharmacokinetics; Glucosinolates / pharmacology; Humans; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-6 / metabolism; Mice; Nutritive Value; Plant Preparations / pharmacology; Plant Preparations / therapeutic use; Polyphenols / pharmacology; Polyphenols / therapeutic use; Soybean Proteins; Taste; Vegetables / chemistry; Vitis / chemistry
TL;DR: Proximate analyses determined that fortification of the soy protein isolate with muscadine or kale bioactives resulted in elevated dietary fibers, total carbohydrates, and free sugars, but did not increase calories/100 g dry matrix compared to unfortified SPI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(18), 4007–4017.

By: M. Grace n, D. Esposito n, K. Dunlap* & M. Lila n

Contributors: M. Grace n, D. Esposito n, K. Dunlap* & M. Lila n

author keywords: Vaccinium vitis-idaea; V. uliginosum; V. macrocarpon; V. angustifolium; phenolics; antioxidant; anti-inflammatory
MeSH headings : Alaska; Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Antioxidants / chemistry; Antioxidants / pharmacology; Chromatography, High Pressure Liquid; Fruit / chemistry; Macrophages / drug effects; Macrophages / immunology; Mass Spectrometry; Mice; Phenols / chemistry; Plant Extracts / chemistry; Plant Extracts / pharmacology; Vaccinium / chemistry
TL;DR: A polyphenol-rich fraction from lowbush cranberry exhibited dose-dependent inhibition of LPS-elicited induction of IL-1β in RAW 2647 cells, indicative of strong anti-inflammatory activity, corroborate the historic use of wild Alaskan berries as medicinally important foods in Alaska Native communities. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Concentrating Immunoprotective Phytoactive Compounds from Fruits and Vegetables into Shelf-stable Protein-rich Ingredients

PLANT FOODS FOR HUMAN NUTRITION, 69(4), 317–324.

By: G. Yousef n, M. Grace n, J. Medina n, S. Neff n, I. Guzman n, A. Brown n, I. Raskin*, M. Lila n

Contributors: G. Yousef n, M. Grace n, J. Medina n, S. Neff n, I. Guzman n, A. Brown n, I. Raskin*, M. Lila n

author keywords: Muscadine; Kale; Polyphenolics; Carotenoids; Glucosinolates; Protein isolate
MeSH headings : Brassica / chemistry; Carotenoids / analysis; Diet; Dietary Proteins; Food Handling; Fruit / chemistry; Functional Food; Glucosinolates / analysis; Humans; Immunologic Factors; Plant Extracts / chemistry; Polyphenols / analysis; Vegetables / chemistry; Vitis / chemistry
TL;DR: Neither total phenolics nor glucosinolates were significantly diminished even after long term storage at 4, 20, or 37 °C, whereas carotenoids degraded over time, particularly at higher temperatures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Cytotoxic Effects of Ellagitannins Isolated from Walnuts in Human Cancer Cells

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 66(8), 1304–1314.

By: V. Le*, D. Esposito n, M. Grace n, D. Ha*, A. Pham*, A. Bortolazzo*, Z. Bevens*, J. Kim* ...

Contributors: V. Le*, D. Esposito n, M. Grace n, D. Ha*, A. Pham*, A. Bortolazzo*, Z. Bevens*, J. Kim* ...

MeSH headings : 3T3 Cells; Animals; Apoptosis / drug effects; Cell Line, Tumor; Cyclin B1 / metabolism; Cytochromes c / metabolism; Diet; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydrolyzable Tannins / pharmacology; Juglans / chemistry; MCF-7 Cells; Mice; Mice, Nude; Mitochondria / drug effects; Nuts / chemistry; Plant Extracts / pharmacology
TL;DR: The results suggest impairment of mitochondrial function and apoptosis as relevant mechanism of anticancer effects of the walnut extract as well as antimitogenic effects of walnuts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)

FOOD CHEMISTRY, 142, 349–357.

By: D. Ribnicky*, D. Roopchand*, A. Oren*, M. Grace n, A. Poulev*, M. Lila n, R. Havenaar, I. Raskin*

Contributors: D. Ribnicky*, D. Roopchand*, A. Oren*, M. Grace n, A. Poulev*, M. Lila n, R. Havenaar, I. Raskin*

author keywords: Blueberry; Anthocyanins; Bioavailability; Bioaccessibility; Gastrointestinal model; TIM-1; Soybean flour; Nutrition
MeSH headings : Anthocyanins / metabolism; Anthocyanins / pharmacokinetics; Biological Availability; Blueberry Plants / metabolism; Cell Line; Dietary Fats / analysis; Dietary Fats / metabolism; Digestion; Fruit / metabolism; Gastrointestinal Tract / metabolism; Humans; Intestinal Absorption; Models, Biological; Soybean Proteins / chemistry; Soybean Proteins / metabolism
TL;DR: The TNO intestinal model (TIM-1) of the human upper gastrointestinal tract was used to compare intestinal absorption/bioaccessibility of blueberry anthocyanins under different digestive conditions, suggesting lipid-rich matrices selectively effect Anthocyanin bioaccessibility. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Efficient preparative isolation and identification of walnut bioactive components using high-speed counter-current chromatography and LC-ESI-IT-TOF-MS

FOOD CHEMISTRY, 158, 229–238.

By: M. Grace n, C. Warlick n, S. Neff n & M. Lila n

Contributors: M. Grace n, C. Warlick n, S. Neff n & M. Lila n

author keywords: Walnut; Jug Ions regia; Ellagitannins; High-speed counter-current; chromatography; ESI-MS/MS
MeSH headings : Chromatography, High Pressure Liquid / methods; Countercurrent Distribution / methods; Juglans / chemistry; Tandem Mass Spectrometry / methods
TL;DR: These results provided a foundation for in depth characterisation of walnut compounds and offered an efficient strategy for isolation of potentially health-relevant phytochemicals from walnuts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 patent

Hypoallergenic food-​grade protein matrices and uses thereof

Mary Grace

Source: ORCID
Added: November 12, 2019

2014 journal article

Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7022–7028.

By: D. Esposito n, A. Chen n, M. Grace n, S. Komarnytsky n & M. Lila n

Contributors: D. Esposito n, A. Chen n, M. Grace n, S. Komarnytsky n & M. Lila n

author keywords: Vaccinium angustifolium; lowbush blueberry; polyphenols; proanthocyanidins; chlorogenic acid
MeSH headings : Acute Disease; Animals; Anthocyanins / pharmacology; Base Sequence; Biomarkers / metabolism; Blueberry Plants / chemistry; Cell Line; Chromatography, High Pressure Liquid; Chronic Disease; DNA Primers; In Vitro Techniques; Inflammation / metabolism; Macrophages / drug effects; Macrophages / metabolism; Mice; Polymerase Chain Reaction
TL;DR: Among major polyphenols found in the wild blueberries, malvidin-3-glucoside was significantly more effective than epicatechin or chlorogenic acid in reducing the expression of pro-inflammatory genes in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum

PHARMACEUTICAL BIOLOGY, 52(3), 398–401.

By: P. Rojas-Silva*, R. Graziose*, B. Vesely*, A. Poulev*, F. Mbeunkui n, M. Grace n, D. Kyle*, M. Lila n, I. Raskin*

Contributors: P. Rojas-Silva*, R. Graziose*, B. Vesely*, A. Poulev*, F. Mbeunkui n, M. Grace n, D. Kyle*, M. Lila n, I. Raskin*

author keywords: Apiaceae; bioassay guided fractionation; cytotoxicity; leishmaniasis; LC-MS; NMR; sesquiterpenoids
MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / isolation & purification; Antiprotozoal Agents / pharmacology; Cell Line; Chromatography / methods; Chromatography, High Pressure Liquid / methods; Eryngium / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmania donovani / drug effects; Magnetic Resonance Spectroscopy / methods; Mass Spectrometry / methods; Myoblasts / drug effects; Myoblasts / metabolism; Myoblasts, Skeletal / drug effects; Myoblasts, Skeletal / metabolism; Plant Components, Aerial; Rats; Sesquiterpenes / administration & dosage; Sesquiterpenes / isolation & purification; Sesquiterpenes / pharmacology; Toxicity Tests
TL;DR: The bioassay-guided fractionation with the leishmanicidal and cytotoxicity activities of two compounds isolated for the first time from an Eryngium species were presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease

Brain Research, 1555, 60–77.

By: K. Strathearn*, G. Yousef n, M. Grace n, S. Roy*, M. Tambe*, M. Ferruzzi*, Q. Wu*, J. Simon* ...

Contributors: K. Strathearn*, G. Yousef n, M. Grace n, S. Roy*, M. Tambe*, M. Ferruzzi*, Q. Wu*, J. Simon*, M. Lila n, J. Rochet*

author keywords: Anthocyanin; Microglial activation; Mitochondria; Parkinson's disease; Proanthocyanidin; Rotenone
MeSH headings : Animals; Anthocyanins / therapeutic use; Cells, Cultured; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Mice; Microglia / drug effects; Mitochondria / drug effects; Mitochondria / metabolism; Neuroprotective Agents / therapeutic use; Parkinson Disease / drug therapy; Parkinson Disease / metabolism; Phytotherapy; Plant Extracts / therapeutic use; Proanthocyanidins / therapeutic use; Rotenone / toxicity; Tyrosine 3-Monooxygenase / metabolism
TL;DR: It is suggested that anthocyanin- and proanthocyanidin-rich botanical extracts may alleviate neurodegeneration in PD via enhancement of mitochondrial function. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Novel Strategy To Create Hypoallergenic Peanut Protein-Polyphenol Edible Matrices for Oral Immunotherapy

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62(29), 7010–7021.

By: N. Plundrich n, M. Kulis*, B. White, M. Grace n, R. Guo*, A. Burks*, J. Davis, M. Lila n

Contributors: N. Plundrich n, M. Kulis*, B. White, M. Grace n, R. Guo*, A. Burks*, J. Davis, M. Lila n

author keywords: basophil; cranberry; mouse model; peanut allergy; polyphenols
MeSH headings : Administration, Oral; Arachis / immunology; Arachis / metabolism; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Immunotherapy; Peanut Hypersensitivity / prevention & control; Plant Proteins / administration & dosage; Plant Proteins / immunology; Polyphenols / administration & dosage; Polyphenols / immunology; Spectroscopy, Fourier Transform Infrared
TL;DR: Polyphenol fortification of peanut flour resulted in a hypoallergenic matrix with reduced IgE binding and degranulation capacity, likely due to changes in protein secondary structure or masking of epitopes, suggesting potential applications for oral immunotherapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Orthosiphol A from the aerial parts of Orthosiphon aristatus is putatively responsible for hypoglycemic effect via α-glucosidase inhibition

Natural Product Communications, 9(5), 639–641. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901606984&partnerID=MN8TOARS

By: T. Damsud, M. Grace, S. Adisakwattana & P. Phuwapraisirisan

Contributors: T. Damsud, M. Grace, S. Adisakwattana & P. Phuwapraisirisan

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Phlorotannins from Alaskan Seaweed Inhibit Carbolytic Enzyme Activity

MARINE DRUGS, 12(10), 5277–5294.

By: J. Kellogg n, M. Grace n & M. Lila n

Contributors: J. Kellogg n, M. Grace n & M. Lila n

author keywords: Alaska; seaweed; diabetes; glucosidase; hyperglycemia; amylase; type 2 diabetes mellitus; phlorotannin; polyphenol; ethnopharmacology
MeSH headings : Animals; Biological Factors / metabolism; Biological Factors / pharmacology; Carbohydrates; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Fucus / metabolism; Kinetics; Saccharomyces cerevisiae / metabolism; Seaweed / metabolism; Swine / metabolism; Tannins / metabolism; Tannins / pharmacology; alpha-Amylases / antagonists & inhibitors; alpha-Glucosidases / metabolism
TL;DR: It is suggested that coastal Alaskan seaweeds are sources of α-glucosidase and α-amylase inhibitory phlorotannins, and thus have potential to limit the release of sugar from carbohydrates and thus alleviate postprandial hyperglycemia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Phytochemical changes in phenolics, anthocyanins, ascorbic acid, and carotenoids associated with sweetpotato storage and impacts on bioactive properties

FOOD CHEMISTRY, 145, 717–724.

By: M. Grace n, G. Yousef n, S. Gustafson n, V. Truong, G. Yencho n & M. Lila n

Contributors: M. Grace n, G. Yousef n, S. Gustafson n, V. Truong, G. Yencho n & M. Lila n

author keywords: Sweetpotato; Phenolics; Carotenoids; Antioxidant activity; Storage; Postharvest
MeSH headings : Anthocyanins / analysis; Anthocyanins / isolation & purification; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / isolation & purification; Antioxidants / chemistry; Antioxidants / isolation & purification; Ascorbic Acid / analysis; Ascorbic Acid / isolation & purification; Carotenoids / analysis; Carotenoids / isolation & purification; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Food Storage; Genotype; Humans; Ipomoea batatas / chemistry; Ipomoea batatas / genetics; Ipomoea batatas / metabolism; Lipopolysaccharides; Phenols / analysis; Phenols / isolation & purification; Plant Extracts / chemistry; Reactive Oxygen Species / metabolism; Temperature; Time Factors
TL;DR: Gradual changes in sweetpotato phytochemical content and antioxidant and anti-inflammatory capacity were noted during normal long-term storage, but the specific effects were genotype-dependent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties

FOOD CHEMISTRY, 163, 178–185.

By: B. Graf*, A. Poulev*, P. Kuhn*, M. Grace n, M. Lila n & I. Raskin*

Contributors: B. Graf*, A. Poulev*, P. Kuhn*, M. Grace n, M. Lila n & I. Raskin*

author keywords: Ecdysterone; Flavonoids; Metabolic syndrome; Nutraceutical; Phytoecdysteroids
MeSH headings : Animals; Chenopodium quinoa / chemistry; Chromatography, Liquid; Ecdysterone / isolation & purification; Ecdysterone / pharmacology; Hypoglycemic Agents / isolation & purification; Male; Mice; Mice, Inbred C57BL; Seeds / chemistry
TL;DR: Leaching effectively releases and concentrates bioactive phytochemicals from quinoa seeds, providing an efficient means to produce a food-grade mixture that may be useful for anti-diabetic applications. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Stressed for Success: How the Berry's Wild Origins Result in Multifaceted Health Protections

X INTERNATIONAL SYMPOSIUM ON VACCINIUM AND OTHER SUPERFRUITS, Vol. 1017, pp. 23–43.

By: M. Lila*, J. Kellogg*, M. Grace*, G. Yousef*, T. Kraft & R. Rogers

author keywords: elicitation; anthocyanins; proanthocyanidins; inflammation; metabolic syndrome
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 book

Stressed for success: How the berry's wild origins result in multifaceted health protections

In Acta Horticulturae (Vol. 1017, pp. 23–44). http://www.scopus.com/inward/record.url?eid=2-s2.0-84892711366&partnerID=MN8TOARS

By: M. Lila, J. Kellogg, M. Grace, G. Yousef, T. Kraft & R. Rogers

Contributors: M. Lila, J. Kellogg, M. Grace, G. Yousef, T. Kraft & R. Rogers

Source: ORCID
Added: November 12, 2019

2013 journal article

Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill

PHYTOCHEMISTRY, 87, 78–85.

By: R. Graziose, M. Grace*, T. Rathinasabapathy*, P. Rojas-Silva, C. Dekock, A. Poulev, M. Lila*, P. Smith, I. Raskin

Contributors: R. Graziose, M. Grace*, T. Rathinasabapathy*, P. Rojas-Silva, C. Dekock, A. Poulev, M. Lila*, P. Smith, I. Raskin

author keywords: Datisca glomerata; Cucurbitales; Datiscaceae; Durango root; Bioassay guided fractionation; Cucurbitacin; Antimalarial; Antileishmanial; Cytotoxicity
MeSH headings : Animals; Antimalarials / chemistry; Antimalarials / pharmacology; CHO Cells; Cell Line; Cricetinae; Glycosides / chemistry; Glycosides / pharmacology; Magnoliopsida / chemistry; Molecular Structure; Plants, Medicinal / chemistry; Plasmodium falciparum / drug effects; Rats; Triterpenes / chemistry; Triterpenes / pharmacology
TL;DR: The traditionally used antimalarial plant, Datisca glomerata (C. Presl) Baill, was subjected to antiplasmodial assay guided fractionation, which led to the isolation of seven cucurbitacin glycosides, datiscosides I-O, along with two known compounds from the aerial parts of D. glomersata, which displayed cytotoxicity against L6 but not CHO mammalian cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein-rich matrices for topical applications

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, 35(4), 394–401.

By: N. Plundrich n, M. Grace n, I. Raskin* & M. Lila n

Contributors: N. Plundrich n, M. Grace n, I. Raskin* & M. Ann Lila n

author keywords: antimicrobial; blackcurrant; muscadine grape; polyphenols; topical applications; tyrosinase
MeSH headings : Polyphenols / administration & dosage; Polyphenols / pharmacology; Proteins / drug effects; Ribes / chemistry; Vitis / chemistry
TL;DR: Natural botanical agents that are antimicrobial, or that modulate skin hyperpigmentation via tyrosinase inhibition, are increasingly sought in the cosmetic industry. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Efficient Quantification of the Health-Relevant Anthocyanin and Phenolic Acid Profiles in Commercial Cultivars and Breeding Selections of Blueberries (Vaccinium spp.)

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(20), 4806–4815.

By: G. Yousef n, A. Brown n, Y. Funakoshi n, F. Mbeunkui n, M. Grace n, J. Ballington n, A. Loraine*, M. Lila n

Contributors: G. Yousef n, A. Brown n, Y. Funakoshi n, F. Mbeunkui n, M. Grace n, J. Ballington n, A. Loraine*, M. Lila n

author keywords: anthocyanins; chlorogenic acid; blueberry; HPLC-DAD-MS; Vaccinium spp.; freeze-drying; health benefits
MeSH headings : Anthocyanins / analysis; Blueberry Plants / chemistry; Breeding; Chromatography, High Pressure Liquid / methods; Food, Preserved / analysis; Frozen Foods / analysis; Fruit / chemistry; Genotype; Glucosides / analysis; Health Promotion; Humans; Hydroxybenzoates / analysis; Plant Extracts / chemistry; Species Specificity; Tandem Mass Spectrometry / methods
TL;DR: An improved protocol was developed for the accurate, efficient, and rapid comparative screening for large blueberry sample sets and different genotypes frequently had comparable overall levels of total anthocyanins and phenolic acids, but differed dramatically in individual profiles of compounds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum

Pharmacognosy Research, 5(1), 17–21.

By: M. Nassar, E. Aboutabl, D. Eskander, M. Grace*, E. EL-Khrisy & A. Sleem

Contributors: M. Nassar, E. Aboutabl, D. Eskander, M. Grace*, . E.-D.A. EL-Khrisy & A. Sleem

author keywords: Amphilophium paniculatum; bignoniaceae; flavonoids; pharmacology
TL;DR: The 70% ethanol crud extract and its successive chloroform, ethyl acetate, and 100% ethanol extracts showed significant anti-inflammatory activity, analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2013 conference paper

HSCCC Isolation and Characterization of Walnut Polyphenols with Antioxidative and Lipolytic Activity

Mary Grace

Source: ORCID
Added: November 12, 2019

2013 journal article

Stable Binding of Alternative Protein-Enriched Food Matrices with Concentrated Cranberry Bioflavonoids for Functional Food Applications

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(28), 6856–6864.

By: M. Grace n, I. Guzman n, D. Roopchand*, K. Moskal*, D. Cheng*, N. Pogrebnyak*, I. Raskin*, A. Howell*, M. Lila n

Contributors: M. Grace n, I. Guzman n, D. Roopchand*, K. Moskal*, D. Cheng*, N. Pogrebnyak*, I. Raskin*, A. Howell*, M. Lila n

author keywords: A-type proanthocyanidins; polyphenols; Vaccinium macrocarpon; antiadhesion; antimicrobial; shelf stability
MeSH headings : Anthocyanins / analysis; Anti-Bacterial Agents / administration & dosage; Arachis / chemistry; Beverages / analysis; Cannabis / chemistry; Dietary Proteins / metabolism; Flavonoids / metabolism; Food, Fortified; Fruit / chemistry; Functional Food; Plant Proteins / metabolism; Polyphenols / metabolism; Proanthocyanidins / analysis; Soybean Proteins / metabolism; Urinary Tract Infections / prevention & control; Vaccinium macrocarpon / chemistry
TL;DR: Nutritional and sensory analyses indicated that the targeted CB-matrix combinations have high potential for incorporation in functional food formulations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Antiparasitic compounds from Cornus florida L. with activities against Plasmodium falciparum and Leishmania tarentolae

JOURNAL OF ETHNOPHARMACOLOGY, 142(2), 456–461.

By: R. Graziose*, P. Rojas-Silva*, T. Rathinasabapathy*, C. Dekock*, M. Grace n, A. Poulev*, M. Lila n, P. Smith*, I. Raskin*

Contributors: R. Graziose*, P. Rojas-Silva*, T. Rathinasabapathy*, C. Dekock*, M. Grace n, A. Poulev*, M. Ann Lila n, P. Smith*, I. Raskin*

author keywords: Cornus; Antiplasmodial; Antileishmanial; Malaria; Cytotoxicity; Triterpene; Betulinic acid
MeSH headings : Animals; Antimalarials / isolation & purification; Antimalarials / pharmacology; Cell Line; Cornus / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmaniasis / drug therapy; Muscle, Skeletal / drug effects; Myoblasts / drug effects; Phytotherapy; Plant Bark; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Plasmodium falciparum / drug effects; Rats; Trypanocidal Agents / isolation & purification; Trypanocidal Agents / pharmacology; Trypanocidal Agents / therapeutic use
TL;DR: The compounds isolated in this study, while displaying moderate in vitro antiplasmodial activity, do not fully support the historical importance of C. florida as an antimalarial remedy in North America. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Antiplasmodial activity of the ethnobotanical plant Cassia fistula

Natural Product Communications, 7(10), 1263–1266. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869831873&partnerID=MN8TOARS

By: M. Grace, C. Lategan, R. Graziose, P. Smith, I. Raskin & M. Lila

Contributors: M. Grace, C. Lategan, R. Graziose, P. Smith, I. Raskin & M. Lila

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2012 journal article

Comparison of Health-Relevant Flavonoids in Commonly Consumed Cranberry Products

JOURNAL OF FOOD SCIENCE, 77(8), H176–H183.

By: M. Grace n, A. Massey n, F. Mbeunkui n, G. Yousef n & M. Lila n

Contributors: M. Grace n, A. Massey n, F. Mbeunkui n, G. Yousef n & M. Lila n

author keywords: anthocyanins; cranberry; flavonoids; proanthocyanidins; processing
MeSH headings : Anthocyanins / analysis; Beverages; Biflavonoids / analysis; Catechin / analysis; Chromatography, High Pressure Liquid; Flavonoids / analysis; Food Handling / methods; Freeze Drying; Fruit / chemistry; Plant Extracts / analysis; Proanthocyanidins / analysis; Vaccinium macrocarpon / chemistry
TL;DR: As cranberry juices and other products are increasingly consumed for their recognized health benefits (including prophylaxis against urinary tract infection), it is relevant to consider how various degrees of commercial and home processing can alter innate levels of the biologically active flavonoids characteristic to the intact fruits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Complementary Approaches To Gauge the Bioavailability and Distribution of Ingested Berry Polyphenolics

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 60(23), 5763–5771.

By: M. Lila n, D. Ribnicky*, L. Rojo*, P. Rojas-Silva*, A. Oren*, R. Havenaar*, E. Janle*, I. Raskin* ...

Contributors: M. Lila n, D. Ribnicky*, L. Rojo*, P. Rojas-Silva*, A. Oren*, R. Havenaar*, E. Janle*, I. Raskin*, G. Yousef n, M. Grace n

author keywords: bioavailability; bioaccessibility; radiolabeling; artificial gastrointestinal tract
MeSH headings : Absorption; Animals; Anthocyanins / analysis; Anthocyanins / pharmacokinetics; Biological Availability; Blueberry Plants / chemistry; Carbon Isotopes / analysis; Carbon Isotopes / pharmacokinetics; Cell Line; Computer Simulation; Fruit / chemistry; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / metabolism; Humans; Models, Biological; Phytochemicals / analysis; Phytochemicals / pharmacokinetics; Polyphenols / analysis; Polyphenols / pharmacokinetics; Rats; Vitis / chemistry
TL;DR: Two different strategies for investigating the likely fate, after ingestion, of natural, bioactive berry constituents (anthocyanins and other non-nutritive flavonoids) are compared. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 conference paper

Cucurbitacin glycosides from Datisca glomerata with antiplasmodial activity

Planta Medica, 78(11), 1245–1245.

By: R. Graziose, M. Grace, T. Rathinasabapathy, P. Rojas-Silva, C. Dekock, A. Poulev, M. Lila, P. Smith, I. Raskin

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Efficient sorption of polyphenols to soybean flour enables natural fortification of foods

Food Chemistry, 131(4), 1193–1200.

By: D. Roopchand*, M. Grace n, P. Kuhn*, D. Cheng*, N. Plundrich n, A. Poulev*, A. Howell*, B. Fridlender* ...

Contributors: D. Roopchand*, M. Grace n, P. Kuhn*, D. Cheng*, N. Plundrich n, A. Poulev*, A. Howell*, B. Fridlender*, M. Lila n, I. Raskin*

TL;DR: It is demonstrated that defatted soybean flour (DSF) can sorb polyphenols from blueberry and cranberry juices while separating them from sugars, providing a means to create protein-rich food ingredients containing concentrated plant bioactives without excess sugars, fats and water that can be incorporated in a variety of scientifically validated functional foods and dietary supplements. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis)

Food Chemistry, 131(2), 387–396.

By: L. Rojo*, D. Ribnicky*, S. Logendra*, A. Poulev*, P. Rojas-Silva*, P. Kuhn*, R. Dorn*, M. Grace n ...

Contributors: L. Rojo*, D. Ribnicky*, S. Logendra*, A. Poulev*, P. Rojas-Silva*, P. Kuhn*, R. Dorn*, M. Grace n, M. Lila n, I. Raskin*

author keywords: Dietary anthocyanins; Metabolic syndrome; Glucose metabolism; Maqui Berry
TL;DR: It is observed that oral administration of ANC improved fasting blood glucose levels and glucose tolerance in hyperglycaemic obese C57BL/6J mice fed a high fat diet and D3S5G also increased glucose uptake in L6 myotubes and is at least partially responsible for ANC's anti-diabetic properties. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

In vitro antiplasmodial activity of indole alkaloids from the stem bark of Geissospermum vellosii

JOURNAL OF ETHNOPHARMACOLOGY, 139(2), 471–477.

By: F. Mbeunkui n, M. Grace n, C. Lategan*, P. Smith*, I. Raskin* & M. Lila n

Contributors: F. Mbeunkui n, M. Grace n, C. Lategan*, P. Smith*, I. Raskin* & M. Lila n

author keywords: Geissospermum vellosii; Apocynaceae; Indole alkaloids; Antiplasmodial activity; Malaria
MeSH headings : Animals; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Antimalarials / toxicity; Apocynaceae / chemistry; CHO Cells; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Indole Alkaloids / chemistry; Indole Alkaloids / isolation & purification; Indole Alkaloids / pharmacology; Indole Alkaloids / toxicity; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Parasitic Sensitivity Tests; Plant Bark; Plants, Medicinal; Plasmodium falciparum / drug effects
TL;DR: Evidence is provided to support the use of Geissospermum vellosii as an antimalarial agent, as used by the native populations, as part of the ongoing investigations of new bioactive compounds with activity against malaria parasites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Isolation and characterization of flavonols from blackcurrant by high-performance counter-current chromatography and electrospray ionization tandem mass spectrometry

JOURNAL OF SEPARATION SCIENCE, 35(13), 1682–1689.

By: F. Mbeunkui*, M. Grace*, G. Yousef* & M. Lila n

Contributors: F. Mbeunkui*, M. Grace*, G. Yousef* & M. Ann Lila n

author keywords: Blackcurrant (Ribes nigrum); Flavonols; High-performance counter-current chromatography; Liquid chromatography with tandem mass spectrometry
MeSH headings : Countercurrent Distribution / methods; Flavonols / chemistry; Flavonols / isolation & purification; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Ribes / chemistry; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR: The results of these experiments demonstrated that high-performance counter-current chromatography along with ESI-MS(n) is a sensitive, selective, and effective technology for isolation and characterization of minor constituents from a complex mixture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Isolation and structural elucidation of indole alkaloids from Geissospermum vellosii by mass spectrometry

Journal of Chromatography B, 885-886, 83–89.

By: F. Mbeunkui n, M. Grace* & M. Lila*

Contributors: F. Mbeunkui n, M. Grace* & M. Lila*

author keywords: Electrospray ionization tandem mass spectrometry; High performance counter-current chromatography; Indole alkaloids; Structural elucidation
MeSH headings : Apocynaceae / chemistry; Chromatography, High Pressure Liquid / methods; Countercurrent Distribution / methods; Indole Alkaloids / chemistry; Indole Alkaloids / isolation & purification; Molecular Conformation; Plant Bark / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Tandem Mass Spectrometry / methods
TL;DR: The results of the experiments demonstrated that the combination of high performance counter current chromatography and ESI-MS(n) is a sensitive, selective and effective approach for rapid isolation and characterization of alkaloids from G. vellosii. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018

2012 conference paper

Seeking novel Leishmanicidal natural products from common medicinal plants, the example of Eryngium foetidum L

Planta Medica, 78(11), 1132–1132.

By: P. Rojas-Silva, R. Graziose, A. Poulev, F. Mbeunkui, M. Grace, M. Lila, I. Raskin

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L.

JOURNAL OF ETHNOPHARMACOLOGY, 133(1), 26–30.

By: R. Graziose*, T. Rathinasabapathy*, C. Lategan*, A. Poulev*, P. Smith*, M. Grace n, M. Lila n, I. Raskin*

Contributors: R. Graziose*, T. Rathinasabapathy*, C. Lategan*, A. Poulev*, P. Smith*, M. Grace n, M. Lila n, I. Raskin*

author keywords: Antimalarial; Aporphine alkaloids; Sesquiterpene lactones; Liriodendron tulipifera L.; Magnoliaceae; Cytotoxicity
MeSH headings : Alkaloids / chemistry; Alkaloids / isolation & purification; Alkaloids / pharmacology; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Aporphines / chemistry; Aporphines / isolation & purification; Aporphines / pharmacology; Lactones / chemistry; Lactones / isolation & purification; Lactones / pharmacology; Liriodendron / chemistry; Malaria / drug therapy; Phytotherapy; Plant Bark; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Plant Leaves; Sesquiterpenes / chemistry; Sesquiterpenes / isolation & purification; Sesquiterpenes / pharmacology; United States
TL;DR: This work supports the historical use of Liriodendron tulipifera as an antimalarial remedy of the United States and characterizes its antiplasmodial constituents. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Complementary approaches to gauge the bioavailability and distribution of ingested berry polyphenolics. Journal of Agricultural and Food Chemistry 60:5763-5771

Journal of Agricultural and Food Chemistry.

Mary Grace

author keywords: bioavailability; bioaccessibility; radiolabeling; artificial gastrointestinal tract
Source: ORCID
Added: November 12, 2019

2011 journal article

Isolation and identification of antiplasmodial N-alkylamides from Spilanthes acmella flowers using centrifugal partition chromatography and ESI-IT-TOF-MS

Journal of Chromatography B, 879(21), 1886–1892.

By: F. Mbeunkui n, M. Grace n, C. Lategan*, P. Smith*, I. Raskin* & M. Lila n

Contributors: F. Mbeunkui n, M. Grace n, C. Lategan*, P. Smith*, I. Raskin* & M. Lila n

author keywords: Centrifugal partition chromatography; N-alkylamides; Antiplasmodial activity
MeSH headings : Amides / chemistry; Amides / isolation & purification; Amides / pharmacology; Animals; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Asteraceae / chemistry; CHO Cells; Cell Survival / drug effects; Centrifugation; Chromatography, Liquid / methods; Cricetinae; Cricetulus; Flowers / chemistry; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum / drug effects; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR: A systematic approach for investigating a suitable centrifugal partition chromatography (CPC) solvent system for N-alkylamides separation was reported, and CPC fractions demonstrated significantly higher antiplasmodial activity compared to corresponding purified N-alkinglamides, thus suggesting that interactions between these N-alklamides may potentiate antiplAsmodial bioactivity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2011 conference paper

Variation of Resveratrol and Anthocyanins Contents in Blueberry Species and Cultivars and their Implications for Human Health. Berry Health Benifits Symposium, Westlake, CA ,

Mary Grace

Source: ORCID
Added: November 12, 2019

2010 journal article

Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana

Natural Product Communications, 5(12), 1869–1872. http://www.scopus.com/inward/record.url?eid=2-s2.0-78751538177&partnerID=MN8TOARS

By: M. Grace, C. Lategan, F. Mbeunkui, R. Graziose, P. Smith, I. Raskin, M. Lila

Contributors: M. Grace, C. Lategan, F. Mbeunkui, R. Graziose, P. Smith, I. Raskin, M. Lila

Source: ORCID
Added: November 12, 2019

2010 journal article

Tracking deposition of a <sup>14</sup>C-radiolabeled kudzu hairy root-derived isoflavone-rich fraction into bone

Experimental Biology and Medicine, 235(10), 1224–1235.

By: J. Mun*, M. Grannan*, P. Lachcik*, R. Rogers*, G. Yousef*, M. Grace*, E. Janle*, Q. Wu* ...

Contributors: J. Mun*, M. Grannan*, P. Lachcik*, R. Rogers*, G. Yousef*, M. Grace*, E. Janle*, Q. Wu* ...

author keywords: kudzu; isoflavones; puerarin; hairy roots; radiolabeling; pharmacokinetics; metabolic tracking
MeSH headings : Animals; Bone and Bones / drug effects; Bone and Bones / metabolism; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Isoflavones / administration & dosage; Isoflavones / isolation & purification; Isoflavones / pharmacokinetics; Male; Osteoporosis / prevention & control; Plant Extracts / administration & dosage; Plant Extracts / pharmacokinetics; Plant Roots / chemistry; Pueraria / chemistry; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tissue Distribution
TL;DR: It is demonstrated that kudzu isoflavones and metabolites are capable of reaching bone tissues, where they may contribute to the prevention of osteoporosis and the promotion of bone health. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: November 12, 2019

2009 journal article

Characteristic flavonoids from Acacia burkittii and A. acuminata heartwoods and their differential cytotoxicity to normal and leukemia cells

Natural Product Communications, 4(1), 69–76. http://www.scopus.com/inward/record.url?eid=2-s2.0-66849101227&partnerID=MN8TOARS

By: M. Grace, G. Wilson, F. Kandil, E. Dimitriadis & R. Coates

Contributors: M. Grace, G. Wilson, F. Kandil, E. Dimitriadis & R. Coates

Source: ORCID
Added: November 12, 2019

2009 journal article

Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton

Phytomedicine, 16(5), 406–415.

By: M. Grace*, D. Ribnicky*, P. Kuhn*, A. Poulev*, S. Logendra*, G. Yousef*, I. Raskin*, M. Lila*

Contributors: M. Grace*, D. Ribnicky*, P. Kuhn*, A. Poulev*, S. Logendra*, G. Yousef*, I. Raskin*, M. Lila*

author keywords: Blueberry; Vaccinium angustifolium; Anthocyanins; Malvidin; Diabetes; Hyperglycemia; Hypoglycemia; Labrasol
MeSH headings : Animals; Anthocyanins / analysis; Anthocyanins / pharmacology; Blood Glucose / drug effects; Blueberry Plants; Drug Delivery Systems; Drug Therapy, Combination; Glucosides / analysis; Glucosides / pharmacology; Glycerides; Hypoglycemic Agents / chemistry; Hypoglycemic Agents / pharmacology; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Organic Chemicals / administration & dosage; Organic Chemicals / pharmacology; Phenols / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology
TL;DR: It is demonstrated that anthocyanins from blueberry have the potency to alleviate symptoms of hyperglycemia in diabetic C57b1/6J mice and their bio-enhancing effect, most likely due to increasing the bioavailability of the administered preparations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019

2009 journal article

Phytochemical characterization of an adaptogenic preparation from Rhodiola heterodonta

Natural Product Communications, 4(8), 1053–1058. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949106585&partnerID=MN8TOARS

By: M. Grace, G. Yousef, A. Kurmukov, I. Raskin & M. Lila

Contributors: M. Grace, G. Yousef, A. Kurmukov, I. Raskin & M. Lila

Source: ORCID
Added: November 12, 2019

2008 journal article

In vitro production of metabolism-enhancing phytoecdysteroids from Ajuga turkestanica

Plant Cell, Tissue and Organ Culture, 93(1), 73–83.

By: D. Cheng*, G. Yousef*, M. Grace*, R. Rogers*, J. Gorelick-Feldman*, I. Raskin*, M. Lila*

Contributors: D. Cheng*, G. Yousef*, M. Grace*, R. Rogers*, J. Gorelick-Feldman*, I. Raskin*, M. Lila*

author keywords: 20-Hydroxyecdysone; cell suspension culture; cyasterone; hairy root; methyl jasmonate; mevalonic acid; turkesterone
TL;DR: The results suggest that sustainable production of metabolically active phytoecdysteroid can be achieved through hairy root culture systems. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019

2008 journal article

Neo-clerodane diterpenes from Ajuga turkestanica

Phytochemistry Letters, 1(2), 81–84.

By: M. Grace*, D. Cheng*, I. Raskin* & M. Lila*

Contributors: M. Grace*, D. Cheng*, I. Raskin* & M. Lila*

author keywords: Ajuga turkestanica; Labiatae; Neo-clerodane diterpenes; 14,15-Dihydroajugachin B; 14-Hydro-15-methoxyajugachin B
TL;DR: The ethyl acetate extract of the aerial parts of Ajuga turkestanica afforded 6 neo-clerodane diterpenes, including two novel compounds, 14, 15-dihydroajugachin B and 14-hydro-15-methoxyajugaches B and chamaepitin, which were elucidated through exhaustive NMR spectroscopic analysis and chemical transformation. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019

2007 journal article

ent-Beyerane diterpenoids from the heartwood of Excoecaria parvifolia

Phytochemistry, 68(4), 546–553.

By: M. Grace*, J. Faraldos*, M. Lila* & R. Coates*

Contributors: M. Grace*, J. Faraldos*, M. Lila* & R. Coates*

MeSH headings : Diterpenes / chemistry; Diterpenes / isolation & purification; Euphorbiaceae / chemistry; Models, Molecular; Molecular Structure; Plant Oils / chemistry; Wood
TL;DR: Diosphenol 2 and nor-lactone 5 exhibited significant potency in bioassays for cytotoxic activity against leukemia cells (L1210). (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019

2006 journal article

Chemopreventive potential of flavonoid extracts from plantation-bred and wild Aronia melanocarpa (black chokeberry) fruits

Journal of Food Science, 71(8).

By: L. Sueiro*, G. Yousef*, D. Seigler*, E. De Mejia*, M. Grace* & M. Lila*

Contributors: L. Sueiro*, G. Yousef*, D. Seigler*, E. De Mejia*, M. Grace* & M. Lila*

author keywords: Aronia; chokeberry; flavonoids; human DNA catalytic topoisomerase II assay; L1210 murine leukemia cell assay; proanthocyanidins
TL;DR: Both cultivated and wild genotypes exhibited promise toward chemoprevention, but differed in levels of activity in the assays used to determine chemoprotective potential. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2006 journal article

Comparative phytochemical characterization of three Rhodiola species

Phytochemistry, 67(21), 2380–2391.

By: G. Yousef*, M. Grace*, D. Cheng*, I. Belolipov*, I. Raskin* & M. Lila*

Contributors: G. Yousef*, M. Grace*, D. Cheng*, I. Belolipov*, I. Raskin* & M. Lila*

author keywords: Rhodiola heterodonta; Rhodiola semenovii; Rhodiola rosea; Crassulaceae; heterodontoside; phenylethanoid glycosides; cyanogenic glucosides; proanthocyanidins; prodelphinidins; EGCG; EGC; HPLC-ESI-MS
MeSH headings : Glucosides / chemistry; Glycosides / chemistry; Molecular Structure; Phenols / chemistry; Proanthocyanidins / chemistry; Rhodiola / chemistry; Rhodiola / classification; Rhodiola / metabolism; Species Specificity
TL;DR: This study resulted in the identification and isolation of phytochemical constituents for direct cross-comparison between three Rhodiola species of medicinal and pharmacological value. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 12, 2019

2006 journal article

Cytotoxic investigation of Cynara sibthorpiana

Asian Journal of Chemistry, 18(1), 423–431. http://www.scopus.com/inward/record.url?eid=2-s2.0-29244450216&partnerID=MN8TOARS

By: A. Khatab, E. Haggag & M. Grace

Contributors: A. Khatab, E. Haggag & M. Grace

Source: ORCID
Added: November 12, 2019

2006 journal article

Structures, biogenetic relationships, and cytotoxicity of pimarane-derived diterpenes from Petalostigma pubescens

Phytochemistry, 67(16), 1708–1715.

By: M. Grace*, Y. Jin*, G. Wilson* & R. Coates*

Contributors: M. Grace*, Y. Jin*, G. Wilson* & R. Coates*

author keywords: Petalostigma pubescens; Euphorbiaceae; heartwood; diterpene; rosane; erythroxylane; nor diterpene; cleistanthane; biogenetic pathways
MeSH headings : Abietanes / chemistry; Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Crystallography, X-Ray; Diterpenes / chemistry; Diterpenes / pharmacology; Drug Screening Assays, Antitumor; Leukemia L1210 / pathology; Magnetic Resonance Spectroscopy; Malpighiaceae / chemistry; Malpighiaceae / genetics; Mice; Models, Molecular; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet
TL;DR: Biogenetic schemes originating from a common ent-copalyl diphosphate intermediate are presented to rationalize the structures of these natural products and a novel ring contraction-ring expansion mechanism is suggested to account for the 7-membered B ring of pubescenone. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2004 journal article

Polyphenolics in Rhizophora mangle L. leaves and their changes during leaf development and senescence

Trees - Structure and Function, 18(5), 518–528.

By: F. Kandil*, M. Grace*, D. Seigler* & J. Cheeseman*

Contributors: F. Kandil*, M. Grace*, D. Seigler* & J. Cheeseman*

author keywords: flavonoids; quercetin glycosides; condensed tannins; proanthocyanidin glycosides; 5,4 '-dimethoxy-7,3 ',5 '-trihydroxyflavone
TL;DR: The overall pools of plant phenolics in R. mangle leaves are quantified, identify the major constituents of these pools and document their changes during leaf maturation and senescence, where polyphenolic pools become simplified. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2002 journal article

Chemical composition and biological activity of the volatiles of Anthemis melampodina and Pluchea dioscoridis

Phytotherapy Research, 16(2), 183–185.

By: M. Grace*

Contributors: M. Grace*

author keywords: Anthemis melampodina; Pluchea dioscoridis; Asteraceae; volatile oils; mosquito larvicidal activity
MeSH headings : Animals; Asteraceae; Biological Assay; Culicidae / drug effects; Gas Chromatography-Mass Spectrometry; Larva / drug effects; Lethal Dose 50; Oils, Volatile / chemistry; Oils, Volatile / isolation & purification; Oils, Volatile / pharmacology; Plant Leaves / chemistry; Plant Leaves / metabolism; Pyrethrins / pharmacology; Sesquiterpenes / analysis
TL;DR: The volatile fractions obtained by hydrodistillation of the fresh leaves of Anthemis melampodina and Pluchea dioscoridis were analysed by GC‐MS technique and showed a marked mosquito larvicidal activity against Culex pipiens. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2001 journal article

A new eudesmanolide from Crataegus flava fruits

Fitoterapia, 72(7), 756–759.

By: A. Ahmed*, A. Khattab*, M. Grace* & M. Sahl*

Contributors: A. Ahmed*, A. Khattab*, M. Grace* & M. Sahl*

author keywords: Crataegus flava; sesquiterpene lactones; 1 beta,9 alpha-dihydroxyeudesm-3-en-5 beta,6 alpha,7 alpha,11 alpha H-12,6-olide
MeSH headings : Crataegus; Fruit; Humans; Lactones / chemistry; Magnetic Resonance Spectroscopy; Phytotherapy; Plant Extracts / chemistry; Sesquiterpenes / chemistry; Sesquiterpenes, Eudesmane
TL;DR: A new eudesmanolide, 1beta,9alpha-dihydroxyeudesm-3-en-5beta,6alpha,7alpha,11alphaH-12,6-olide was isolated from Crataegus flava fruits and its structure was determined by spectroscopic methods. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

2001 journal article

A new flavone derivative from Ehretia ovalifolia leaves

Pharmazie, 56(8), 661–662. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034886882&partnerID=MN8TOARS

By: A. Khattab, M. Grace & E. El-Khrisy

Contributors: A. Khattab, M. Grace & E. El-Khrisy

Source: ORCID
Added: November 12, 2019

2001 journal article

Flavonoids and pharmacological activity of Vernonia galamensis ssp. galamensis var. petitiana (A. Rich) M. Gilbert. 40(2), 117-128.

Egyptian Journal of Pharmaceutical Sciences.

Mary Grace

Source: ORCID
Added: November 12, 2019

2001 journal article

Pharmaco-​chemical investigations of Plantago ovata aerial parts. 39(1), 345-352.

Bulletin of the Faculty of Pharmacy (Cairo University).

Mary Grace

Source: ORCID
Added: November 12, 2019

2001 journal article

Polyphenols from Cornulaca monacantha

Phytochemistry, 58(4), 611–613.

By: F. Kandil* & M. Grace*

Contributors: F. Kandil* & M. Grace*

author keywords: Cornulaca monacantha; Chenopodiaceae; quercetin-4 '-O-beta-D-galactoside; gallotannins; monacanthin A and B; tannins
TL;DR: The aerial parts of the Egyptian herb Cornulaca monacantha have yielded two new galloyltannin analogs characterized by protoctechuoyl moiety at C-6, and also a new flavonol glycoside, quercetin-4'-O-beta-D-galactoside. (via Semantic Scholar)
Source: ORCID
Added: November 12, 2019

1999 journal article

Chemical constituents and molluscicidal activity of Senecio cineraria D.C. 39(1-3), 253-266.

Egyptian Journal of Pharmaceutical Sciences.

Mary Grace

Source: ORCID
Added: November 12, 2019

1999 journal article

Flavonoids of Carduncellus eriocephalus. 39(4-6), 409-416

Egyptian Journal of Pharmaceutical Sciences.

Mary Grace

Source: ORCID
Added: November 12, 2019

1996 journal article

Hepato-protective effect of daturaolone isolated from Solanum arundo

Pharmazie, 51(8), 593–595. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029790303&partnerID=MN8TOARS

By: M. Grace & M. Saleh

Contributors: M. Grace & M. Saleh

Source: ORCID
Added: November 12, 2019

1996 journal article

Volatile oil of Egyptian sweet fennel (Foeniculum vulgare, var. dulce, Alef.) and its effects on isolated smooth muscles

Pharmaceutical and Pharmacological Letters, 6(1), 5–7. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029941777&partnerID=MN8TOARS

By: M. Saleh, F. Hashem & M. Grace

Contributors: M. Saleh, F. Hashem & M. Grace

Source: ORCID
Added: November 12, 2019

Education

Updated: September 13th, 2019 14:33

1991 - 1994

Cairo University Faculty of Pharmacy Cairo, EG
PhD Pharmacognosy

Cairo University Faculty of Pharmacy Cairo, EG
Master degree Pharmacognosy

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