Melissa Jean Lewis

Works (9)

Updated: December 6th, 2023 05:02

2023 journal article

Adaptation of land treadmill scoring system for underwater treadmill in dogs with thoracolumbar intervertebral disc extrusion

VETERINARY JOURNAL, 300.

By: M. Lewis*, S. Thomovsky * & G. Moore *

author keywords: Canine; Gait; Herniation; Rehabilitation; Spinal cord injury
TL;DR: In dogs recovering from TL-IVDE, LT-based gait scoring was feasible in dogs walking on the UWTM and might complement other gait analysis methods, especially for non-ambulatory dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: December 4, 2023

2020 journal article

Influence of Duration of Injury on Diffusion Tensor Imaging in Acute Canine Spinal Cord Injury

JOURNAL OF NEUROTRAUMA, 37(21), 2261–2267.

By: M. Lewis*, P. Early n, C. Mariani n , K. Munana n  & N. Olby n 

author keywords: dog; fractional anisotropy; imaging biomarker; intervertebral disc herniation; mean diffusivity
MeSH headings : Animals; Diffusion Tensor Imaging / methods; Dogs; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / pathology; Intervertebral Disc Displacement / veterinary; Spinal Cord Injuries / diagnostic imaging; Spinal Cord Injuries / pathology; Spinal Cord Injuries / veterinary; Time Factors
TL;DR: Investigating the impact of duration of injury on DTI indices in dogs with acute, spontaneous SCI due to thoracolumbar intervertebral disc herniation and explore associations with clinical severity found MD might differentiate injury severity in the acute setting and be worthy of development as an imaging biomarker. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 31, 2020

2019 journal article

Cardiac Leiomyosarcoma in a Cat Presenting for Bilateral Renal Neoplasia

JOURNAL OF COMPARATIVE PATHOLOGY, 168, 19–24.

By: M. Schreeg n, B. Evans n, J. Allen n, M. Lewis n, E. Luckring n, M. Evola n, D. Richard, K. Piner* ...

author keywords: cardiac neoplasia; cat; immunohistochemistry; leiomyosarcoma
MeSH headings : Animals; Cat Diseases / pathology; Cats; Female; Heart Neoplasms / veterinary; Kidney Neoplasms / veterinary; Leiomyosarcoma / veterinary
TL;DR: A 10-year-old neutered female domestic longhair cat was presented to a tertiary care veterinary hospital for evaluation of a right renal mass that was identified incidentally on abdominal radiographs as a sarcoma based on fine needle aspiration cytology, and diagnosed with cardiac leiomyosarcoma with pulmonary and bilateral renal metastasis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 4, 2019

2019 journal article

Development of a Novel Gait Analysis Tool Measuring Center of Pressure for Evaluation of Canine Chronic Thoracolumbar Spinal Cord Injury

Journal of Neurotrauma, 36(21), 3018–3025.

By: M. Lewis*, K. Williams*, T. Langley*, L. Jarvis*, G. Sawicki* & N. Olby n 

author keywords: center of pressure; chronic spinal cord injury; dogs; locomotion; postural control
MeSH headings : Animals; Dogs; Gait Analysis / instrumentation; Lumbar Vertebrae; Postural Balance / physiology; Spinal Cord Injuries / veterinary; Thoracic Vertebrae
TL;DR: COP analysis and body weight support measurements offer information about post-injury locomotion and further development is needed before consideration as an outcome measure to complement validated gait analysis methods in dogs with SCI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 24, 2019

2019 journal article

Predictors of Response to 4-Aminopyridine in Chronic Canine Spinal Cord Injury

Journal of Neurotrauma, 36(9), 1428–1434.

By: M. Lewis*, E. Laber n & N. Olby n 

author keywords: canine; chronic SCI; motor neuron pool excitability; potassium channel antagonist; spasticity
MeSH headings : 4-Aminopyridine / pharmacology; Animals; Dogs; Evoked Potentials, Motor / physiology; Female; H-Reflex / physiology; Male; Motor Neurons / physiology; Muscle Spasticity / physiopathology; Potassium Channel Blockers / pharmacology; Spinal Cord Injuries / physiopathology
TL;DR: Comparing clinical, electrodiagnostic, gait, and imaging variables between dogs that do and do not respond to 4AP, to identify predictors of response suggested Severity of spasticity and H-reflex threshold might allow prediction of response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 31, 2018

2017 journal article

Magnetic resonance imaging features of dogs with incomplete recovery after acute, severe spinal cord injury

Spinal Cord, 56(2), 133–141.

By: M. Lewis n, E. Cohen n  & N. Olby n 

Contributors: M. Lewis n, E. Cohen n  & N. Olby n 

MeSH headings : Analysis of Variance; Animals; Dogs; Female; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Recovery of Function / physiology; Spinal Cord / diagnostic imaging; Spinal Cord Injuries / diagnostic imaging; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary
TL;DR: Findings demonstrate a spectrum of injury severity on MRI among severely affected dogs, which is related to functional status. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

The Relationship between Trans-Lesional Conduction, Motor Neuron Pool Excitability, and Motor Function in Dogs with Incomplete Recovery from Severe Spinal Cord Injury

Journal of Neurotrauma, 34(21), 2994–3002.

By: M. Lewis n, J. Howard* & N. Olby n 

author keywords: central pattern generator; disc extrusion; electrophysiology; motor evoked potentials
MeSH headings : Animals; Dogs; Evoked Potentials, Motor / physiology; Evoked Potentials, Somatosensory / physiology; Gait / physiology; H-Reflex / physiology; Locomotion / physiology; Motor Neurons / physiology; Recovery of Function / physiology; Spinal Cord Injuries / physiopathology; Transcranial Magnetic Stimulation
TL;DR: The association between pelvic limb MEPs and gait scores supports the importance of descending influence on regaining walking after severe TL-SCI in dogs rather than just activation of spinal walking and implies that increases in motor neuron pool excitability might also contribute to motor recovery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Clinical and Diagnostic Imaging Features of Brain Herniation in Dogs and Cats

Journal of Veterinary Internal Medicine, 30(5), 1672–1680.

By: M. Lewis n, N. Olby n , P. Early n, C. Mariani n , K. Muñana n , G. Seiler n, E. Griffith n

MeSH headings : Animals; Body Size; Brain / diagnostic imaging; Brain / pathology; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Magnetic Resonance Imaging / veterinary; Retrospective Studies
TL;DR: Brain herniation can be quantified on MRI and more severe CTH based on TTX is associated with a worse short‐term outcome, compared with more severe foramen magnum based on FMH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: NC State University Libraries, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2013 journal article

Long-Term Effect of Cervical Distraction and Stabilization on Neurological Status and Imaging Findings in Giant Breed Dogs With Cervical Stenotic Myelopathy

Veterinary Surgery, 42(6), 701–709.

By: M. Lewis n, N. Olby n , N. Sharp & P. Early n

MeSH headings : Animals; Body Size; Cervical Vertebrae / pathology; Cervical Vertebrae / surgery; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Female; Male; Retrospective Studies; Spinal Cord Compression / complications; Spinal Cord Compression / surgery; Spinal Cord Compression / veterinary; Spinal Stenosis / pathology; Spinal Stenosis / surgery; Spinal Stenosis / veterinary; Tomography, X-Ray Computed
TL;DR: Distraction and stabilization with PMMA plugs and bone grafts is a safe surgical option for giant breed dogs with CSM with a single site of lateral or dorsolateral compression and long-term recurrence was common among dogs with multiple sites of compression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

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