Marisa Koyo Ames

Works (12)

Updated: April 5th, 2024 07:54

2022 article

Prevalence of aldosterone breakthrough in dogs receiving renin-angiotensin system inhibitors for proteinuric chronic kidney disease

Ames, M. K., Vaden, S. L., Atkins, C. E., Palerme, J.-S., Langston, C. E., Grauer, G. F., … Webb, T. (2022, November 9). JOURNAL OF VETERINARY INTERNAL MEDICINE.

By: M. Ames*, S. Vaden n, C. Atkins n, J. Palerme*, C. Langston *, G. Grauer*, S. Shropshire *, C. Bove*, T. Webb *

author keywords: mineralocorticoid receptor antagonists; nephrology; renin-angiotensin-aldosterone system; urine aldosterone to creatinine ratio
MeSH headings : Dogs; Animals; Aldosterone; Renin-Angiotensin System / physiology; Creatinine / urine; Prospective Studies; Prevalence; Antihypertensive Agents / therapeutic use; Proteinuria / drug therapy; Proteinuria / veterinary; Renal Insufficiency, Chronic / drug therapy; Renal Insufficiency, Chronic / veterinary; Dog Diseases / drug therapy
TL;DR: Whether ABT occurs in dogs with CKDP and if it is associated with decreased efficacy in proteinuria reduction during RAS inhibitor treatment is investigated and its relationship with outcomes is evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 21, 2022

2020 journal article

Non-Arsenical heartworm adulticidal therapy using topical moxidectin-imidacloprid and doxycycline: A prospective case series

VETERINARY PARASITOLOGY, 282.

By: M. Ames*, P. VanVranken*, C. Evans* & C. Atkins n

author keywords: Dirofilaria immitis; Dog; Moxidectin; Doxycycline; Melarsomine dihydrochloride; Slow-kill
MeSH headings : Animals; Antinematodal Agents / therapeutic use; Dirofilaria immitis / drug effects; Dirofilariasis / drug therapy; Dog Diseases / drug therapy; Dogs; Doxycycline / therapeutic use; Drug Therapy, Combination / veterinary; Female; Macrolides / therapeutic use; Male; Neonicotinoids / therapeutic use; Nitro Compounds / therapeutic use; Prospective Studies
TL;DR: The MOXY protocol was tolerated and 96 % (21/22) of dogs converted to NAD, though 2 dogs required greater than 1 year to achieve this result, and exercise restriction should be considered when using a nonarsenical protocol. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 21, 2020

2020 journal article

Treatment of dogs with severe heartworm disease

VETERINARY PARASITOLOGY, 283.

By: M. Ames* & C. Atkins n

author keywords: Dirofilaria immitis; Pneumonitis; Hypersensitivity reaction; Pulmonary hypertension; Pulmonary thromboembolism; Heart failure; Caval syndrome
MeSH headings : Animals; Dirofilariasis / complications; Dirofilariasis / diagnosis; Dirofilariasis / drug therapy; Dirofilariasis / parasitology; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / parasitology; Dogs; Drug Hypersensitivity / etiology; Drug Hypersensitivity / veterinary; Filaricides / therapeutic use
TL;DR: Complications occurring with heartworm infection and during its treatment most often directly reflect the pulmonary vascular and parenchymal injury inflicted by Dirofilaria immitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 21, 2020

2019 review

The renin-angiotensin-aldosterone system and its suppression

[Review of ]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(2), 363–382.

By: M. Ames*, C. Atkins n & B. Pitt *

author keywords: angiotensin converting enzyme inhibitor; angiotensin receptor blocker; chronic kidney disease; heart failure; mineralocorticoid receptor blocker; proteinuric kidney disease; systemic hypertension
MeSH headings : Aldosterone / metabolism; Angiotensin II / metabolism; Angiotensin Receptor Antagonists / therapeutic use; Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Cat Diseases / drug therapy; Cat Diseases / physiopathology; Cats; Dog Diseases / drug therapy; Dog Diseases / physiopathology; Dogs; Heart Failure / veterinary; Hypertension / veterinary; Kidney Diseases / veterinary; Mineralocorticoid Receptor Antagonists / therapeutic use; Renin-Angiotensin System / drug effects; Renin-Angiotensin System / physiology
TL;DR: This review focuses on updates in the understanding of the RAAS and the pathophysiology of AngII and aldosterone excess, reviewing what is known about its suppression in cardiovascular and renal diseases, especially in the cat and dog. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 22, 2019

2017 journal article

Aldosterone breakthrough in dogs with naturally occurring myxomatous mitral valve disease

JOURNAL OF VETERINARY CARDIOLOGY, 19(3), 218–227.

By: M. Ames n, C. Atkins n, A. Eriksson  n & A. Hess *

author keywords: Angiotensin converting enzyme inhibitor; Mineralocorticoid receptor blacker; Heart failure; Renin angiotensin aldosterone system
MeSH headings : Aldosterone / urine; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Creatinine / urine; Dog Diseases / drug therapy; Dogs; Female; Furosemide; Heart Failure; Heart Valve Diseases / drug therapy; Heart Valve Diseases / veterinary; Humans; Male; Mitral Valve; Renin-Angiotensin System / drug effects; Renin-Angiotensin System / physiology
TL;DR: It appears that incomplete RAAS blockade is common in dogs with MMVD receiving an ACEI, and the proven existence of ABT in dogs offers the potential to improve the prognosis for MMVD with the addition of a mineralocorticoid receptor blocker to current therapeutic regimens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Effects of high doses of enalapril and benazepril on the pharmacologically activated renin-angiotensin-aldosterone system in clinically normal dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 76(12), 1041–1050.

By: M. Ames*, C. Atkins*, S. Lee, A. Lantis* & J. zumBrunnen

MeSH headings : Aldosterone / blood; Aldosterone / urine; Angiotensin-Converting Enzyme Inhibitors / administration & dosage; Animals; Benzazepines / administration & dosage; Blood Pressure / drug effects; Body Weight / drug effects; Dogs / physiology; Enalapril / administration & dosage; Female; Furosemide / administration & dosage; Heart Rate / drug effects; Male; Peptidyl-Dipeptidase A / blood; Renin-Angiotensin System / drug effects; Time Factors
TL;DR: Administration of high doses of enalapril and benazepril significantly inhibited ACE activity, yet did not prevent increases in mean urine and serum aldosterone concentrations resulting from furosemide activation of RAAS, suggesting that ald testosterone breakthrough from ACE inhibition was a dose-independent effect of ACE inhibitors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

The effect of enalapril on furosemide-activated renin-angiotensin-aldosterone system in healthy dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(5), 513–517.

By: A. Lantis*, M. Ames n, S. Werre * & C. Atkins n

TL;DR: It appears that failure to suppress aldosterone suppression with furosemide stimulation may be a drug class effect, and the discrepancy between the current data and the documented benefits of enalapril likely reflects the efficacy of this ACE inhibitor in suppressing tissue RAAS, variable population responsiveness to ACE-inhibition, and/or providing additional survival benefits, possibly through as yet unknown mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Aldosterone breakthrough with benazepril in furosemide-activated renin-angiotensin-aldosterone system in normal dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(1), 65–73.

By: A. Lantis n, M. Ames n, C. Atkins n, T. Defrancesco n , B. Keene n & S. Werre  n

MeSH headings : Aldosterone / metabolism; Aldosterone / urine; Angiotensin-Converting Enzyme Inhibitors / administration & dosage; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Benzazepines / administration & dosage; Benzazepines / pharmacology; Diuretics / administration & dosage; Diuretics / pharmacology; Dogs / physiology; Dogs / urine; Drug Therapy, Combination; Furosemide / administration & dosage; Furosemide / pharmacology; Peptidyl-Dipeptidase A; Renin-Angiotensin System / drug effects; Renin-Angiotensin System / physiology
TL;DR: Benazepril decreased plasma ACE activity but did not prevent furosemide-induced RAAS activation, indicating aldosterone breakthrough (escape), particularly noteworthy in that breakthrough is observed at the time of initiation of RAAS suppression, as opposed to developing after months of therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(5), 534–539.

By: Y. Reina-Doreste n, J. Stern* , B. Keene n, S. Tou n, C. Atkins n, T. DeFrancesco n , M. Ames n, T. Hodge n, K. Meurs n 

MeSH headings : Animals; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cardiotonic Agents / therapeutic use; Case-Control Studies; Cat Diseases / drug therapy; Cat Diseases / mortality; Cats; Female; Heart Failure / drug therapy; Heart Failure / mortality; Heart Failure / veterinary; Male; Pyridazines / therapeutic use; Retrospective Studies
TL;DR: The addition of pimobendan to traditional treatment for CHF may provide a substantial clinical benefit in survival time for HCM-affected cats with CHF and possibly HOCM- affected cats withCHF. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Recovery of normal esophageal function in a kitten with diffuse megaesophagus and an occult lower esophageal stricture

JOURNAL OF FELINE MEDICINE AND SURGERY, 17(6), 557–561.

By: J. Schneider n, M. Ames n, M. DiCicco  n, M. Savage n, C. Atkins n, M. Wood n, J. Gookin n 

MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / therapy; Catheterization / veterinary; Cats; Endoscopy / veterinary; Esophageal Achalasia / complications; Esophageal Achalasia / veterinary; Esophageal Stenosis / complications; Esophageal Stenosis / veterinary; Male; Recovery of Function
TL;DR: Management of kittens with radiographic findings suggestive of congenital megaesophagus by means of gastrostomy tube feeding may be associated with a return of normal esophageal motility and widening of the esophagal stricture, and facilitate subsequent success of interventional dilation of the EsophageAL stricture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(6), 1437–1440.

By: K. Meurs n , J. Stern n , D. Sisson*, M. Kittleson *, S. Cunningham *, M. Ames n, C. Atkins n, T. DeFrancesco n  ...

author keywords: Boxer; Dilated cardiomyopathy; Mutation; Striatin
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / veterinary; Case-Control Studies; Confidence Intervals; DNA / chemistry; DNA / genetics; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Female; Genotype; Male; Membrane Proteins / genetics; Polymerase Chain Reaction / veterinary; Sequence Deletion / genetics
TL;DR: This study demonstrates an association between DCM in the Boxer dog and the striatin mutation, particularly with the homozygous genotype, and suggests that there is at least 1 other cause of DCm in the boxer dog. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Effect of furosemide and high-dosage pimobendan administration on the renin-angiotensin-aldosterone system in dogs

American Journal of Veterinary Research, 74(8), 1084–1090.

By: M. Ames n, C. Atkins*, A. Lantis* & S. Were

MeSH headings : Animals; Cardiotonic Agents / pharmacology; Diuretics / pharmacology; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Furosemide / pharmacology; Male; Pyridazines / pharmacology; Renin-Angiotensin System / drug effects; Renin-Angiotensin System / physiology
TL;DR: High-dosage pimobendan administration neither substantially suppressed nor potentiated the RAAS when administered with furosemide in healthy dogs, and this effect was significant only for dogs that received both drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

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