Matthew K. Roach

Works (1)

Updated: July 5th, 2023 15:36

2017 article

Design, selection, and development of cyclic peptide ligands for human erythropoietin

Kish, W. S., Sachi, H., Naik, A. D., Roach, M. K., Bobay, B. G., Blackburn, R. K., … Carbonell, R. G. (2017, April 12). Journal of Chromatography A, Vol. 1500, pp. 105–120.

By: W. Kish n, H. Sachi*, A. Naik n, M. Roach n, B. Bobay n, R. Blackburn n, S. Menegatti n , R. Carbonell n

author keywords: Erythropoietin; Cyclic peptide ligands; Ligand screening; Affinity chromatography; Affinity maturation; In-silico docking
MeSH headings : Amino Acid Sequence; Amino Acids / chemistry; Erythropoietin / chemistry; Humans; Kinetics; Ligands; Molecular Sequence Data; Peptides, Cyclic / chemistry; Peptides, Cyclic / isolation & purification; Protein Binding
topics (OpenAlex): Protein purification and stability; Computational Drug Discovery Methods; Monoclonal and Polyclonal Antibodies Research
TL;DR: Mutagenesis studies performed on FSLLSH with natural and non-natural amino acid substitutions led to the identification of critical EPO-binding determinants, and the discovery of new peptide ligands that facilitate EPO recovery. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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