Works (23)
Updated: July 27th, 2023 21:17
2021 journal article
A modified silent substitution electroretinography protocol to separate photoreceptor subclass function in lightly sedated dogs
VETERINARY OPHTHALMOLOGY, 24(1), 103–107.
author keywords: electroretinography; L/M-cone; photoreceptor; rod; S-cone; silent substitution
MeSH headings : Analgesics, Opioid / administration & dosage; Animals; Butorphanol / administration & dosage; Dexmedetomidine / administration & dosage; Dogs / anatomy & histology; Dogs / physiology; Electroretinography / methods; Electroretinography / veterinary; Female; Hypnotics and Sedatives / administration & dosage; Male; Photoreceptor Cells, Vertebrate / classification; Photoreceptor Cells, Vertebrate / physiology
TL;DR:
A clinically applicable method to consistently isolate rod and cone subclass function in sedated dogs may allow detailed evaluation of photoreceptor function in clinical patients with rod or cone subclass deficits without the need for general anesthesia or protracted adaptation times.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 11, 2020
2021 journal article
Retinal cone photoreceptor distribution in the American black bear (Ursus americanus)
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 304(3), 662–672.
author keywords: black bear; cone; photoreceptor; retina; topography
MeSH headings : Animals; Retina / metabolism; Retinal Cone Photoreceptor Cells / metabolism; Ursidae; Vision, Ocular / physiology
TL;DR:
Examining the subtype and topography of cones in American black bear retinas confirmed that American black bears are predicted to have a dichromatic vision with high acuity indicated by the presence of a dorsotemporally located area centralis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: July 13, 2020
2021 journal article
Training with Multiple Structurally Related Odorants Fails to Improve Generalization of Ammonium Nitrate Detection in Domesticated Dogs (Canis familiaris)
ANIMALS, 11(1).
author keywords: canine; scent detection; improvised explosive device; categorical formation
TL;DR:
The results suggest the use of authentic explosive materials, without the added complication of including category-learning methods, likely remains a cost-effective and efficient way to train explosive scent detection dogs.
(via Semantic Scholar)
res.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 15, 2021
2020 journal article
Detection of circulating anti-retinal antibodies in dogs with sudden acquired retinal degeneration syndrome using indirect immunofluorescence: A case control study
EXPERIMENTAL EYE RESEARCH, 193.
author keywords: SARDS; Dog; Retina; Immune-mediated; IgG; IgM
MeSH headings : Animals; Autoantibodies / immunology; Blotting, Western; Case-Control Studies; Disease Models, Animal; Dogs; Fluorescent Antibody Technique, Indirect / methods; Retina / immunology; Retina / metabolism; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / immunology; Retinal Degeneration / metabolism; Syndrome
TL;DR:
Despite having decreased serum IgG compared with healthy controls, circulating IgG in dogs with SARDS binds photoreceptor outer segments to a greater extent than matched healthy controls.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020
2019 journal article
Circulating neurohormone imbalances in canine sudden acquired retinal degeneration syndrome and canine pituitary-dependent hypercortisolism
JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(6), 2587–2594.
author keywords: dog; dopamine; melatonin; PDH; retina; SARDS; serotonin
MeSH headings : Animals; Case-Control Studies; Dog Diseases / blood; Dog Diseases / metabolism; Dogs; Dopamine / blood; Melatonin / analogs & derivatives; Melatonin / blood; Melatonin / urine; Pituitary ACTH Hypersecretion / blood; Pituitary ACTH Hypersecretion / metabolism; Pituitary ACTH Hypersecretion / veterinary; Prospective Studies; Retinal Degeneration / blood; Retinal Degeneration / metabolism; Retinal Degeneration / veterinary; Serotonin / blood
TL;DR:
This study has identified neurohormone differences between dogs with SARDS and PDH, although the study was underpowered for detection of significant differences in serum serotonin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 11, 2019
2019 journal article
Diagnostic utility of clinical and laboratory test parameters for differentiating between sudden acquired retinal degeneration syndrome and pituitary‐dependent hyperadrenocorticism in dogs
Veterinary Ophthalmology, 22(6), 842–858.
author keywords: biomarker; dog; hyperadrenocorticism; retina; sudden acquired retinal degeneration syndrome
MeSH headings : Animals; Case-Control Studies; Dog Diseases / diagnosis; Dogs; Electroretinography / veterinary; Female; Male; Pituitary ACTH Hypersecretion / diagnosis; Pituitary ACTH Hypersecretion / veterinary; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / veterinary; Tomography, Optical Coherence / veterinary
TL;DR:
This work provides the basis for future studies that could identify and examine dogs with SARDS prior to vision loss, which may extend the potential therapeutic window for SARDS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 16, 2019
2019 journal article
In vivo electroretinographic differentiation of rod, short-wavelength and long/medium-wavelength cone responses in dogs using silent substitution stimuli
EXPERIMENTAL EYE RESEARCH, 185.
author keywords: dog; Silent substitution; S-Cone; L/M-cone; Rod; Photoreceptor; Electroretinogram; Congenital stationary night blindness
MeSH headings : Animals; Cone Opsins / metabolism; Dark Adaptation; Disease Models, Animal; Dogs; Electroretinography / methods; Eye Diseases, Hereditary / metabolism; Eye Diseases, Hereditary / physiopathology; Female; Genetic Diseases, X-Linked / metabolism; Genetic Diseases, X-Linked / physiopathology; Male; Myopia / metabolism; Myopia / physiopathology; Night Blindness / metabolism; Night Blindness / physiopathology; Retina / metabolism; Retina / physiopathology; Retinal Cone Photoreceptor Cells / physiology; Retinal Rod Photoreceptor Cells / physiology
TL;DR:
Methods to differentiate rod, S- and L/M-cone function in dogs using silent substitution methods have been developed and the influence of temporal frequency and mean luminance on the ERGs originating in each photoreceptor type can now be studied independently.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 16, 2019
2018 journal article
Clinical therapeutic efficacy of mycophenolate mofetil in the treatment of SARDS in dogs-a prospective open-label pilot study
VETERINARY OPHTHALMOLOGY, 21(6), 565–576.
author keywords: dog; mycophenolate mofetil; retina; sudden acquired retinal degeneration syndrome; treatment; vision
MeSH headings : Animals; Dog Diseases / drug therapy; Dogs; Female; Immunosuppressive Agents / therapeutic use; Male; Mycophenolic Acid / therapeutic use; Pilot Projects; Prospective Studies; Retinal Degeneration / drug therapy; Retinal Degeneration / veterinary; Vision Tests / veterinary
TL;DR:
The effect of sole-agent treatment with mycophenolate mofetil as a sole agent has no measureable positive effect on physical health, vision, or retinal structure following a 6-week trial period.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018
2018 article
Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study
Foster, M. L., Bartnikas, T. B., Maresca-Fichter, H. C., Mercadante, C., Dash, M., Miller, C., & Dorman, D. C. (2018, January). NEUROTOXICOLOGY, Vol. 64, pp. 291–299.
author keywords: Manganese; Neurotoxicity; Pharmacokinetics; Metabolism
MeSH headings : Animals; Animals, Newborn; Brain / drug effects; Brain / metabolism; Female; Liver / drug effects; Liver / metabolism; Male; Manganese / toxicity; Mice, Inbred C57BL; Mice, Knockout; Motor Activity / drug effects; Pilot Projects; Tissue Distribution; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism
TL;DR:
The results suggest that the Parkin gene defect did not increase the susceptibility of neonatal mice to adverse health effects associated with high‐dose Mn exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 article
Olfactory toxicity in rats following manganese chloride nasal instillation: A pilot study
Foster, M. L., Rao, D. B., Francher, T., Traver, S., & Dorman, D. C. (2018, January). NEUROTOXICOLOGY, Vol. 64, pp. 284–290.
author keywords: Manganese; Olfactory toxicity; Olfactory discrimination; Pharmacokinetics
MeSH headings : Administration, Inhalation; Animals; Chlorides / administration & dosage; Chlorides / metabolism; Chlorides / toxicity; Discrimination, Psychological / drug effects; Male; Manganese Compounds / administration & dosage; Manganese Compounds / metabolism; Odorants; Olfactory Bulb / drug effects; Olfactory Bulb / metabolism; Olfactory Bulb / pathology; Olfactory Mucosa / drug effects; Olfactory Mucosa / metabolism; Olfactory Mucosa / pathology; Pilot Projects; Rats, Inbred F344
TL;DR:
The nasal instillation and OD procedures developed in this study are useful methods to assess manganese – induced olfactory deficits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Phenotypic characterization of complete CSNB in the inbred research beagle: how common is CSNB in research and companion dogs?
DOCUMENTA OPHTHALMOLOGICA, 137(2), 87–101.
author keywords: Congenital stationary night blindness; Dog; Electroretinography; Complete; Retina
MeSH headings : Adaptation, Ocular / physiology; Animals; Animals, Inbred Strains; Dark Adaptation / physiology; Dogs; Electroretinography; Eye Diseases, Hereditary / physiopathology; Genetic Diseases, X-Linked / physiopathology; Myopia / physiopathology; Night Blindness / physiopathology; Phenotype; Refraction, Ocular / physiology; Retina / physiopathology; Retinal Bipolar Cells / physiology; Retinal Rod Photoreceptor Cells / physiology; Retrospective Studies; Vision, Ocular / physiology
TL;DR:
CSNB appears to be a rare disorder in the wider beagle population, although its detection could confound studies that use retinal function as an outcome measure in research dogs, necessitating careful baseline studies to be performed prior to experimentation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018
2018 journal article
Toxicity associated with ingestion of a polyacrylic acid hydrogel dog pad
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 30(5), 708–714.
author keywords: Dogs; hydrogel; neurotoxicity; poisoning; sodium polyacrylate
MeSH headings : Acrylic Resins / poisoning; Acrylic Resins / toxicity; Animals; Dog Diseases / chemically induced; Dogs; Eating; Female; Hydrogels / poisoning; Hydrogels / toxicity; Male; North Carolina; Rats; Rats, Sprague-Dawley
TL;DR:
Results from an experimental study in rats support the conclusion that some pet pad hydrogel products can induce acute neurotoxicity in animals under high-dose exposure conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2017 journal article
Canine scent detection of canine cancer: A feasibility study
Veterinary Medicine-Research and Reports, 8, 1–7.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Effect of wearing a Telemetry jacket on behavioral and physiologic parameters of dogs in the open-field test
Journal of the American Association for Laboratory Animal Science, 56(4), 382–389.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats
BIOMETALS, 29(3), 417–422.
author keywords: Manganese; Copper; Iron; Zinc; Exposure
MeSH headings : Administration, Oral; Animals; Copper / metabolism; Diet; Homeostasis / drug effects; Iron / metabolism; Male; Manganese / administration & dosage; Manganese / analysis; Manganese / toxicity; Rats; Rats, Inbred F344; Zinc / metabolism
TL;DR:
While manganese exposure affected levels of all metals, particularly in the frontal cortex and liver, copper levels were most prominently affected and suggests an under-appreciated effect of manganae exposure on copper homeostasis which may contribute to the understanding of the pathophysiology of mangansese toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
A test for the evaluation of emotional reactivity in Labrador retrievers used for explosives detection
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 10(2), 94–102.
author keywords: emotional reactivity test; anxiety scores; selection criteria; behavioral screening; explosives detection dog
TL;DR:
It is concluded that the ERT is a useful pre-training screening test that can be used to identify dogs with a low threshold of emotional reactivity for rejection, anddogs with a high threshold of emotions for entry into the IDD training program.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Olfactory discrimination and generalization of ammonium nitrate and structurally related odorants in Labrador retrievers
Animal Cognition, 18(6), 1255–1265.
MeSH headings : Aluminum; Ammonium Compounds; Animals; Discrimination Learning; Discrimination, Psychological; Dogs; Explosive Agents; Fertilizers; Iraq; Nitrates; Odorants; Smell / physiology; Soil
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018
2015 journal article
Olfactory transport of manganese: Implications for neurotoxicity
Manganese in Health and Disease, 22, 119–132.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Pharmacokinetic Evaluation of the Equivalency of Gavage, Dietary, and Drinking Water Exposure to Manganese in F344 Rats
TOXICOLOGICAL SCIENCES, 145(2), 244–251.
author keywords: manganese; pharmacokinetics; oral exposure; dose rate
MeSH headings : Administration, Oral; Animals; Body Burden; Chlorides / administration & dosage; Chlorides / pharmacokinetics; Chlorides / toxicity; Diet; Food Contamination; Male; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Manganese Poisoning / etiology; Rats, Inbred F344; Risk Assessment; Tissue Distribution; Water Pollutants, Chemical / administration & dosage; Water Pollutants, Chemical / pharmacokinetics; Water Pollutants, Chemical / toxicity
TL;DR:
Increased femur, striatum, cerebellum, frontal cortex, and olfactory bulb manganese concentrations were also seen following gavage suggesting that dose rate is an important factor in the pharmacokinetics of oral mangansese.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
The use of an open-field model to assess sound-induced fear and anxiety-associated behaviors in Labrador retrievers
JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 10(4), 338–345.
author keywords: military working dogs; open-field test; fear; anxiety; thunderstorm; gunfire
TL;DR:
In general, candidate IED-detection Labrador retrievers responded to sound stimuli and recovered quickly, although dogs stratified in their response to sound stimulus, suggesting that dogs habituated to the open field arena.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Acquisition of a visual discrimination and reversal learning task by Labrador retrievers
ANIMAL COGNITION, 17(3), 787–792.
author keywords: Dog; Canine; Cognition; Visual discrimination
MeSH headings : Animals; Cognition; Discrimination Learning; Discrimination, Psychological; Dogs / psychology; Female; Male; Neuropsychological Tests; Pattern Recognition, Visual; Reversal Learning; Visual Perception
TL;DR:
The present study confirmed that the modified TGTA system is suitable for cognitive evaluations in Labrador retriever MWDs and can be used to further explore effects of sex, phenotype, age, and other factors in relation to canine cognition and learning, and may provide an additional screening tool for MWD selection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Assessment of geographical variation in the respiratory toxicity of desert dust particles
INHALATION TOXICOLOGY, 25(7), 405–416.
author keywords: Cytotoxicity; dust inhalation; in vitro; in vivo; particle toxicity; pulmonary toxicity; rat
MeSH headings : Administration, Inhalation; Afghanistan; Animals; Arsenic / analysis; Arsenic / toxicity; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Cell Count; Cell Line; Cell Survival / drug effects; Cytokines / metabolism; Dust / analysis; Endotoxins / analysis; Endotoxins / toxicity; Geography; Iraq; L-Lactate Dehydrogenase / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Male; Metals / analysis; Metals / toxicity; Rats; Silicon Dioxide / analysis; Silicon Dioxide / toxicity; United States
TL;DR:
The in vitro cytotoxicity assay results were partially predictive of in vivo responses and could be used to prioritize future particle inhalation studies or guide epidemiological study design.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Inhalation dosimetry of hexamethylene diisocyanate vapor in the rat and human respiratory tracts
INHALATION TOXICOLOGY, 25(3), 168–177.
author keywords: Computational fluid dynamics; dosimetry; hexamethylene diisocyanate; inhalation; lung; nose
MeSH headings : Air Pollutants, Occupational / pharmacokinetics; Air Pollutants, Occupational / toxicity; Animals; Cyanates / pharmacokinetics; Cyanates / toxicity; Dose-Response Relationship, Drug; Humans; Inhalation Exposure; Isocyanates; Lung / drug effects; Lung / metabolism; Lung / pathology; Male; Models, Biological; Rats; Rats, Inbred F344; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism; Species Specificity; Volatilization
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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