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Works (48)
Updated: April 5th, 2024 00:49
2022 journal article
Modeling the influence of cell-cell contact and TGF-beta signaling on the epithelial mesenchymal transition in MCF7 breast carcinoma cells
JOURNAL OF THEORETICAL BIOLOGY, 546.
author keywords: Epithelial mesenchymal transition; Bistable switch; TGF-beta; Cell-cell contact; Breast carcinoma
MeSH headings : Breast Neoplasms / metabolism; Cadherins / metabolism; Cell Line, Tumor; Epithelial Cells / metabolism; Epithelial-Mesenchymal Transition; Female; Humans; MCF-7 Cells; Transforming Growth Factor beta / metabolism
TL;DR:
A simple mathematical model that examines the relationship between E-cadherin and Slug in response to pro-epithelial and pro-mesenchymal factors, cell-cell contact and TGF-β shows that acquiring and retaining invasive behavior by cells with high levels of cell- cell contact is not impossible but, instead, depends on the cooperation between the two switches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 15, 2022
2021 article
International Guidelines for Veterinary Tumor Pathology: A Call to Action
Meuten, D. J., Moore, F. M., Donovan, T. A., Bertram, C. A., Klopfleisch, R., Foster, R. A., … Whitley, D. (2021, July 20). VETERINARY PATHOLOGY.
author keywords: standardization; oncology; guidelines; protocols; validation
MeSH headings : Animals; Neoplasms / diagnosis; Neoplasms / veterinary; Pathology, Veterinary; Reproducibility of Results
TL;DR:
This initiative is a continuation of efforts published in this journal in 2011 and it is hoped that this initiative will facilitate collaboration and reproducibility between pathologists and institutions, increase case numbers, and strengthen clinical research findings, thus ensuring continued progress in veterinary oncologic pathology and improving patient care.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 2, 2021
2019 journal article
Incidence and risk factors associated with development of clinical cardiotoxicity in dogs receiving doxorubicin
Journal of Veterinary Internal Medicine, 33(2), 783–791.
author keywords: canine; cardiology; cardiomyopathy; chemotherapy; echocardiography; oncology
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / adverse effects; Antibiotics, Antineoplastic / therapeutic use; Body Weight; Cardiomyopathy, Dilated / veterinary; Cardiotoxicity / veterinary; Dog Diseases / drug therapy; Dogs; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Doxorubicin / therapeutic use; Female; Heart Diseases / chemically induced; Heart Diseases / veterinary; Incidence; Male; Neoplasms / drug therapy; Neoplasms / veterinary; Retrospective Studies; Risk Factors
TL;DR:
Overall, the incidence of clinical DOX‐induced cardiotoxicity is low, but Boxers and other breeds at high risk for dilated cardiomyopathy may be at an increased risk.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: April 22, 2019
2018 journal article
The role of cellular contact and TGF-beta signaling in the activation of the epithelial mesenchymal transition (EMT)
CELL ADHESION & MIGRATION, 13(1), 63–75.
author keywords: EMT; TGF-; cellular adhesion; epithelial; mesenchymal; breast carcinoma; colon carcinoma
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Cell Adhesion; Cell Movement; Colorectal Neoplasms / metabolism; Colorectal Neoplasms / pathology; Epithelial-Mesenchymal Transition / drug effects; Female; Humans; Signal Transduction; Transforming Growth Factor beta / pharmacology; Tumor Cells, Cultured
TL;DR:
Examination of the dual influence of the TGF-β pathway and intercellular contact on the activation of EMT in colon (SW480) and breast (MCF7) carcinoma cells highlights that, while EMT is induced by the synergy of multiple signals, this activation varies across cell types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2019
2017 journal article
A Theoretical Model of the Wnt Signaling Pathway in the Epithelial Mesenchymal Transition
THEORETICAL BIOLOGY AND MEDICAL MODELLING, 14.
author keywords: Epithelial Mesenchymal Transition (EMT); Wnt; Bistable
TL;DR:
This model predicts that following activation of the Wnt pathway, an epithelial cell in the primary carcinoma must attain a threshold level of membrane-bound Dvl to convert to the mesenchymal-like phenotype and maintain that phenotype once it has migrated away from the primary tumor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Ezrin and moesin expression in canine and feline osteosarcoma
Histology and Histopathology, 32(8), 805–816.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Oral melphalan for the treatment of relapsed canine lymphoma
Veterinary and Comparative Oncology, 16(1), E123–E129.
author keywords: canine; chemotherapy; lymphoma; melphalan; rescue
MeSH headings : Administration, Oral; Animals; Antineoplastic Agents, Alkylating / administration & dosage; Antineoplastic Agents, Alkylating / adverse effects; Antineoplastic Agents, Alkylating / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Lymphoma / drug therapy; Lymphoma / veterinary; Male; Melphalan / administration & dosage; Melphalan / adverse effects; Melphalan / therapeutic use; Recurrence; Retrospective Studies
TL;DR:
Although treatment resulted in limited clinical benefit and non-durable responses, oral melphalan was well-tolerated and may be a reasonable rescue option in cases where minimal effective agents remain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2017 journal article
Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 80(2), 421–431.
author keywords: Manganese porphyrin; Canine; Lymph node; Lymphoma
MeSH headings : Anaphylaxis / chemically induced; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Dog Diseases / drug therapy; Dogs; Half-Life; Kidney / metabolism; Liver / metabolism; Lymph Nodes / metabolism; Lymphoma / drug therapy; Lymphoma / veterinary; Male; Maximum Tolerated Dose; Metalloporphyrins / administration & dosage; Metalloporphyrins / pharmacokinetics; Metalloporphyrins / toxicity; Species Specificity; Tachycardia / chemically induced; Tissue Distribution
TL;DR:
With MnBuOE lymph node accumulation, reduction in the dose and/or administration frequency could be possible, leading to reduced toxicity, and important implications for the utility of adjuvant MnBuoe to treat lymphoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Alternative Lengthening of Telomeres Does Exist in Various Canine Sarcomas
MOLECULAR CARCINOGENESIS, 56(3), 923–935.
author keywords: telomerase-independent; non-determined TMM; telomere length; dog; comparative; cancer
MeSH headings : Animals; Cell Line, Tumor; DNA Helicases / genetics; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Gene Expression Regulation, Neoplastic; Humans; Neuroblastoma / genetics; Neuroblastoma / pathology; Nuclear Proteins / genetics; Sarcoma / genetics; Sarcoma / pathology; Sarcoma / veterinary; Telomere / genetics; Telomere Homeostasis; Tumor Suppressor Protein p53 / genetics; X-linked Nuclear Protein
TL;DR:
It is demonstrated that canine sarcomas use alternative lengthening of telomeres (ALT), a telomere maintenance mechanism found in some human tumors such as sarcoma, which seems to share many similarities with their human counterparts and appear an attractive model for comparativeTelomere research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Canine acute leukaemia: 50 cases (1989-2014)
Veterinary and Comparative Oncology, 15(3), 1101–1114.
author keywords: acute leukaemia; canine; chemotherapy; CHOP; immunophenotype
MeSH headings : Acute Disease; Animals; Antineoplastic Agents / adverse effects; Antineoplastic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / mortality; Dogs; Leukemia / drug therapy; Leukemia / mortality; Leukemia / veterinary; Retrospective Studies; Survival Analysis; Treatment Outcome
TL;DR:
Most dogs developed chemoresistance within weeks of initiating treatment, and consequently, survival times for AL remain disappointingly short.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Serum 25-hydroxyvitamin D concentrations in dogs with osteosarcoma do not differ from those of age- and weight-matched control dogs
VETERINARY JOURNAL, 217, 132–133.
author keywords: Bone; Cancer; Canine; Osteosarcoma; Vitamin D
MeSH headings : 25-Hydroxyvitamin D 2 / blood; Age Factors; Animals; Body Weight; Bone Neoplasms / blood; Bone Neoplasms / etiology; Bone Neoplasms / veterinary; Calcifediol / blood; Case-Control Studies; Dog Diseases / blood; Dog Diseases / etiology; Dogs; Osteosarcoma / blood; Osteosarcoma / etiology; Osteosarcoma / veterinary; Vitamins / blood
TL;DR:
The mean 25-hydroxyvitamin D3 concentrations for dogs with osteosarcoma and matched-controls were 34.95 ng/mL and 33.85 NG/mL, respectively, suggesting that 25-Hydroxyv vitamin D insufficiency might not be important in the pathogenesis of canine osteosARcoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Telomere Transcripts Target Telomerase in Human Cancer Cells
GENES, 7(8).
author keywords: telomerase; enzyme inhibition; telomere; long non-coding transcript; viral expression systems; tumor cell lines; human; canine
TL;DR:
Bre recombinant TERRA transcripts were expressed in tumor cell lines with TA and with alternative lengthening of telomeres (ALT) to study effects on TMM and cell growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Canine and human sarcomas exhibit predominant FGFR1 expression and impaired viability after inhibition of signaling
MOLECULAR CARCINOGENESIS, 54(9), 841–852.
author keywords: fibroblast growth factor receptor; tyrosine kinase inhibitor; sarcoma; comparative analyses; dog; human
MeSH headings : Animals; Cell Line, Tumor; Dogs; Gene Expression Regulation, Neoplastic; Humans; Protein Isoforms / analysis; Protein Isoforms / genetics; Protein Structure, Tertiary; Protein-Tyrosine Kinases / pharmacology; Pyrimidines / pharmacology; Receptor, Fibroblast Growth Factor, Type 1 / analysis; Receptor, Fibroblast Growth Factor, Type 1 / antagonists & inhibitors; Receptor, Fibroblast Growth Factor, Type 1 / genetics; Sarcoma / drug therapy; Sarcoma / genetics; Sarcoma / pathology; Signal Transduction / drug effects; Urea / analogs & derivatives; Urea / pharmacology
TL;DR:
The important role FGFR1, especially splice variant IIIc, likely plays in sarcomas is emphasized and inhibitory small molecules could be of potential use for targeted therapy in aggressive sarcoma of both species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Comparative Pathology of Canine Soft Tissue Sarcomas: Possible Models of Human Non-rhabdomyosarcoma Soft Tissue Sarcomas
JOURNAL OF COMPARATIVE PATHOLOGY, 152(1), 22–27.
author keywords: comparative pathology; dog; man; soft tissue sarcoma
MeSH headings : Animals; Biomarkers, Tumor / analysis; Disease Models, Animal; Dogs; Humans; Immunohistochemistry; Sarcoma / pathology; Sarcoma / veterinary
TL;DR:
It is demonstrated that canine STSs display histological and immunohistochemical features similar to their human equivalents, a particular opportunity exists to understand the biology and treatment of human STS by potentially including dogs as clinical models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Thermal dose fractionation affects tumour physiological response
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 28(5), 431–440.
author keywords: thermal dosimetry; tumor oxygenation; microenvironment
MeSH headings : Animals; Antigens, Neoplasm / metabolism; Carbonic Anhydrases / metabolism; Caspase 3 / metabolism; Dogs; Hyperthermia, Induced; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Sarcoma / metabolism; Sarcoma / pathology; Sarcoma / therapy; Soft Tissue Neoplasms / metabolism; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / therapy; Tumor Burden; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
There was a greater reduction in tumour volume and water diffusion at the end of therapy in tumours receiving one hyperthermia fraction per week, and response data pointed to a one per week prescription being superior.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics
CLINICAL CANCER RESEARCH, 17(8), 2549–2560.
MeSH headings : Animals; Cluster Analysis; Combined Modality Therapy; Dogs; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomics / methods; Humans; Hyperthermia, Induced; Magnetic Resonance Imaging / methods; Oligonucleotide Array Sequence Analysis; Radiotherapy / methods; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma / genetics; Sarcoma / therapy
TL;DR:
This is one of the first successful attempts to link changes in gene expression and functional imaging to understand the response heterogeneity and identify compounds enhancing thermoradiotherapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos
CHEMISTRY & BIOLOGY, 18(2), 252–263.
MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
TL;DR:
A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Establishment and Characterization of a Canine Soft Tissue Sarcoma Cell Line
VETERINARY PATHOLOGY, 48(2), 482–485.
author keywords: dog; domestic mammals; species; immunohistochemistry; technology; cell culture; technology; oncology; disease process
MeSH headings : Animals; Cell Line, Tumor; Chromosomes, Mammalian / genetics; Dog Diseases / pathology; Dogs; Immunohistochemistry / veterinary; Male; Mice; Mice, Nude; Microscopy, Fluorescence / veterinary; Sarcoma / pathology; Sarcoma / veterinary
TL;DR:
The establishment of a new canine soft tissue sarcoma cell line (MBSa1) derived from a high-grade, metastatic neurofibrosarcoma resulting in a large number of in vitro passages coupled with solid tumor formation in athymic nude mice demonstrates that MBSa 1 has been immortalized and is tumorigenic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Feasibility of using gene expression analysis to study canine soft tissue sarcomas
MAMMALIAN GENOME, 21(11-12), 577–582.
MeSH headings : Animals; Chemotherapy, Adjuvant; Dogs; Feasibility Studies; Gene Expression Profiling; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis / methods; Prognosis; RNA, Neoplasm / genetics; RNA, Neoplasm / metabolism; Reverse Transcriptase Polymerase Chain Reaction / methods; Sarcoma / genetics; Sarcoma / metabolism; Software; Up-Regulation
TL;DR:
The results demonstrate that microarray and qRT-PCR are feasible methods for comparing gene signatures in canine STSs and are likely to identify genes that are important in the development of metastatic disease and improve the ability to prognosticate for individual patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
The role of hypoxia in canine cancer
VETERINARY AND COMPARATIVE ONCOLOGY, 6(4), 213–223.
author keywords: canine; hypoxia; resistance; tumour
MeSH headings : Animals; Cell Hypoxia / physiology; Dog Diseases / metabolism; Dogs; Fluorocarbons / metabolism; Hydrocarbons, Brominated; Neoplasms / metabolism; Neoplasms / veterinary
TL;DR:
The knowledge from the human literature of problematic nature of hypoxic tumours combined with the rapid growth of veterinary oncology has necessitated a better understanding of hypoxia in canine tumours.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas
MOLECULAR CANCER THERAPEUTICS, 6(1), 380–389.
MeSH headings : Adenoviridae; Animals; Cats; Cytomegalovirus / genetics; Feasibility Studies; Genetic Therapy / adverse effects; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Hyperthermia, Induced; Interleukin-12 / blood; Interleukin-12 / genetics; Interleukin-12 / therapeutic use; Liver / pathology; Mice; Promoter Regions, Genetic / genetics; Recombinant Proteins / adverse effects; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Recombinant Proteins / therapeutic use; Sarcoma / drug therapy; Sarcoma / genetics; Sarcoma / radiotherapy; Sarcoma / veterinary
TL;DR:
An adenoviral gene therapy vector with IL-12 controlled by a heat-inducible promoter (heat shock promoter 70B) was developed and tested in a phase I clinical trial in cats with spontaneously arising soft tissue sarcoma, finding it possible to localize gene expression and limit systemic toxicity of IL- 12 using the hyperthermia-induced gene therapy approach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Heritability and segregation analysis of osteosarcorna in the Scottish deerhound
GENOMICS, 90(3), 354–363.
author keywords: cancer; osteosarcoma; canine; segregation; heritability
MeSH headings : Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Dogs; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Humans; Male; Models, Genetic; Models, Theoretical; Osteosarcoma / genetics; Osteosarcoma / veterinary; Pedigree; Regression Analysis
TL;DR:
The hypothesis that a major gene with a dominant effect explains most of the osteosarcoma phenotype within the Scottish deerhound is supported, and gender and genotype are not significant predictors of disease outcome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral Doxil extravasation
CLINICAL CANCER RESEARCH, 12(22), 6800–6807.
MeSH headings : Animals; Antibiotics, Antineoplastic / pharmacokinetics; Antibiotics, Antineoplastic / therapeutic use; Combined Modality Therapy / methods; Diagnostic Imaging / methods; Dose-Response Relationship, Drug; Doxorubicin / pharmacokinetics; Doxorubicin / therapeutic use; Drug Carriers / administration & dosage; Feasibility Studies; Female; Fibrosarcoma / therapy; Hyperthermia, Induced / methods; Liposomes / administration & dosage; Liposomes / pharmacokinetics; Radioactive Tracers; Rats; Technetium Tc 99m Exametazime / administration & dosage; Thigh / radiation effects; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
TL;DR:
The use of a radiolabeled tracer has potential value to monitor drug delivery and estimate the effect of an intervention aimed to increase liposomal accumulation, such as local hyperthermia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors
CLINICAL CANCER RESEARCH, 12(13), 4004–4010.
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacokinetics; Carcinoma / therapy; Carcinoma / veterinary; Combined Modality Therapy; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Doxorubicin / pharmacokinetics; Drug Administration Schedule; Drug Delivery Systems; Female; Hyperthermia, Induced / methods; Liposomes; Male; Maximum Tolerated Dose; Microwaves / therapeutic use; Sarcoma / therapy; Sarcoma / veterinary; Temperature; Treatment Outcome
TL;DR:
LTSL-doxorubicin offers a novel approach to improving drug delivery to solid tumors and was well tolerated and resulted in favorable response profiles in these patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
A retrospective study of 87 cases of canine soft tissue sarcomas, 1986-2001
International Journal of Applied Research in Veterinary Medicine, 3(2), 81–87.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy
Clinical Cancer Research, 11(14), 5206–5214.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Chemotherapy followed by half-body radiation therapy for canine lymphoma
JOURNAL OF VETERINARY INTERNAL MEDICINE, 18(5), 703–709.
author keywords: cancer; dog; multimodality therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Enhanced tumour uptake of radiolabelled antibodies by hyperthermia. Part II: Application of the thermal equivalency equation
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 21(1), 13–27.
author keywords: hyperthermia; monoclonal antibody; thermal isodose; combined modality therapies; radioimmunotherapy
MeSH headings : Animals; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Neoplasm / pharmacology; Brain Neoplasms / therapy; Cell Line, Tumor; Combined Modality Therapy; Glioma / therapy; Humans; Hyperthermia, Induced / methods; Iodine Radioisotopes / pharmacology; Mice; Mice, Inbred BALB C; Mice, Nude; Radiation Dosage; Radioimmunotherapy / methods; Temperature; Xenograft Model Antitumor Assays
TL;DR:
Differences in absolute tumour and normal tissue uptake were seen, suggesting that the thermal isodose formula has limited usefulness in the design and comparison of hyperthermia protocols for enhancing the tumour uptake of radiolabelled mAbs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Enhanced tumour uptake of radiolabelled antibodies by hyperthermia: Part I: Timing of injection relative to hyperthermia
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 21(1), 1–11.
author keywords: hyperthermia; monoclonal antibody; combined modality therapies; radioimmunotherapy
MeSH headings : Animals; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Neoplasm / pharmacology; Brain Neoplasms / therapy; Cell Line, Tumor; Combined Modality Therapy; Glioma / therapy; Humans; Hyperthermia, Induced / methods; Iodine Radioisotopes / pharmacology; Mice; Mice, Inbred BALB C; Mice, Nude; Radioimmunotherapy / methods; Tenascin / immunology; Xenograft Model Antitumor Assays
TL;DR:
Tumour targeting mAbs administered in combination with heat may be injected either prior to or immediately following hyperthermia treatment, with the expectation that levels of uptake in tumour will be relatively equivalent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
A retrospective analysis of 140 dogs with oral melanoma treated with external beam radiation
VETERINARY RADIOLOGY & ULTRASOUND, 44(3), 352–359.
author keywords: dog; oral malignant melanoma; radiation therapy; prognostic factors
MeSH headings : Animals; Disease-Free Survival; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Dose Fractionation, Radiation; Female; Male; Melanoma / mortality; Melanoma / veterinary; Mouth Neoplasms / mortality; Mouth Neoplasms / veterinary; Neoplasm Recurrence, Local / mortality; Neoplasm Recurrence, Local / veterinary; North Carolina / epidemiology; Records / veterinary; Retrospective Studies; Survival Analysis; Treatment Outcome
TL;DR:
External beam radiation therapy is effective in local disease control of canine oral malignant melanoma; however, the optimal fractionation scheme has yet to be determined and further investigation into novel therapies is warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2003 article
Carboplatin and doxorubicin combination chemotherapy for the treatment of appendicular osteosarcoma in the dog
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 17, pp. 199–205.
author keywords: bone cancer; summation dose intensity; tolerable-dose diagram
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Feline injection site sarcomas
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 33(3), 553-+.
MeSH headings : Animals; Cat Diseases / chemically induced; Cat Diseases / diagnosis; Cat Diseases / prevention & control; Cat Diseases / therapy; Cats; Practice Guidelines as Topic; Rabies Vaccines / adverse effects; Sarcoma / diagnosis; Sarcoma / therapy; Sarcoma / veterinary; Vaccination / veterinary
TL;DR:
The development of the current understanding of this tumor with regard to areas of research into the cause of injection site sarcomas, epidemiology, and the current standard of care for treatment of this iatrogenic disease is summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2003 chapter
Injection site sarcomas
In Veterinary clinics of North america--update in Medical Oncology (pp. 553–571).
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Preoperative radiotherapy for vaccine associated sarcoma in 92 cats
VETERINARY RADIOLOGY & ULTRASOUND, 43(5), 473–479.
author keywords: cat; vaccine-associated sarcoma; radiation therapy; preoperative irradiation
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Carboplatin / administration & dosage; Carboplatin / therapeutic use; Cat Diseases / chemically induced; Cat Diseases / drug therapy; Cat Diseases / radiotherapy; Cat Diseases / surgery; Cats; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease-Free Survival; Female; Male; Neoplasm Recurrence, Local / mortality; Neoplasm Recurrence, Local / prevention & control; Neoplasm Recurrence, Local / veterinary; North Carolina; Preoperative Care / veterinary; Records / veterinary; Retrospective Studies; Sarcoma / chemically induced; Sarcoma / mortality; Sarcoma / radiotherapy; Sarcoma / surgery; Sarcoma / veterinary; Soft Tissue Neoplasms / chemically induced; Soft Tissue Neoplasms / mortality; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / surgery; Soft Tissue Neoplasms / veterinary; Treatment Outcome; Vaccination / adverse effects; Vaccination / veterinary
TL;DR:
Preoperative irradiation is an effective treatment for cats with vaccine associated sarcoma, especially if complete excision can be accomplished following irradiation, and outcome in cats receiving carboplatin was better than all other treatment groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 article
Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 16, pp. 553–557.
author keywords: cardiomyopathy; congestive heart failure; doxorubicin-induced cardiotoxicity; neoplasia; skeletal muscle trauma
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 article
Retrospective analysis of axial skeleton osteosarcoma in 22 large-breed dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 15, pp. 120–124.
author keywords: canine; metastasis; radiation therapy; retriever
TL;DR:
Prevalence of metastasis and median survival for large-breed dogs with axial skeleton OSA seems to be similar to that reported for large and purebred dogs with appendicular skeletons OSA, and definitive radiation therapy may have a role in the treatment of axialkeleton osteosarcoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia
STEM CELLS, 18(5), 360–365.
author keywords: thrombocytopenia; thrombopoietin; mimetic peptide; GW395058; canine; pharmacokinetics; pharmacodynamics
MeSH headings : Animals; Carboplatin / toxicity; Dogs; Female; Injections, Intravenous; Injections, Subcutaneous; Leukocyte Count / drug effects; Male; Metabolic Clearance Rate; Molecular Mimicry; Neoplasm Proteins; Neutrophils / drug effects; Peptides / blood; Peptides / pharmacokinetics; Peptides / pharmacology; Platelet Count / drug effects; Proto-Oncogene Proteins / agonists; Proto-Oncogene Proteins / physiology; Receptors, Cytokine; Receptors, Thrombopoietin; Thrombocytopenia / blood; Thrombocytopenia / chemically induced; Thrombocytopenia / therapy; Thrombopoietin / physiology
TL;DR:
The pharmacokinetics and pharmacodynamics of GW395058 were characterized using a randomized, crossover study in a large‐animal model (dog) of chemotherapy‐induced thrombocytopenia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Factors influencing survival after radiotherapy of nasal tumors in 130 dogs
VETERINARY RADIOLOGY & ULTRASOUND, 40(3), 312–317.
author keywords: dog; nasal tumor; radiation therapy; cobalt; predictive factors
MeSH headings : Animals; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Multivariate Analysis; Nose Neoplasms / mortality; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Prognosis; Radiotherapy Dosage; Survival Rate
TL;DR:
In a subset of dogs that received cobalt radiation, after adjusting for age, dogs treated with a boost technique had decreased survival and in general, local control of canine nasal tumors following aggressive radiation therapy is poor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 article
Palliative radiotherapy of appendicular osteosarcoma in 95 dogs
VETERINARY RADIOLOGY & ULTRASOUND, Vol. 40, pp. 517–522.
author keywords: canine; osteosarcoma; palliative radiotherapy
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / radiotherapy; Bone Neoplasms / veterinary; Dog Diseases / drug therapy; Dog Diseases / radiotherapy; Dogs; Dose-Response Relationship, Radiation; Female; Male; Multivariate Analysis; Osteosarcoma / drug therapy; Osteosarcoma / radiotherapy; Osteosarcoma / veterinary; Palliative Care; Probability
TL;DR:
Ninety-five dogs with either a presumptive or biopsy confirmed diagnosis of osteosarcoma received palliative radiotherapy using 60Co photons and seventy-three of the 95 dogs experienced pain relief following treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Cytotoxicity of alpha-particle emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia
BRITISH JOURNAL OF CANCER, 77(5), 753–759.
author keywords: monoclonal antibody; hyperthermia; spheroid; astatine-211; alpha-emitter
MeSH headings : Alpha Particles; Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / metabolism; Antibodies, Monoclonal / therapeutic use; Antibody Specificity; Astatine / therapeutic use; Biological Transport; Gliosarcoma / pathology; Humans; Hyperthermia, Induced; Immunoglobulin G / immunology; Immunoglobulin G / metabolism; Immunoglobulin G / therapeutic use; Mice; Organoids / immunology; Organoids / metabolism; Organoids / radiation effects; Radioimmunotherapy; Recombinant Fusion Proteins / immunology; Recombinant Fusion Proteins / metabolism; Recombinant Fusion Proteins / therapeutic use; Tenascin / immunology; Tumor Cells, Cultured / radiation effects
TL;DR:
Results and those from autoradiographs indicate that hyperthermia at 42 degrees C for 1 h had no significant effect on the uptake or distribution of this antitenascin MAb in D-247 MG spheroids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
The effects of local hyperthermia on the catabolism of a radioiodinated chimeric monoclonal antibody
Clinical Cancer Research, 4, 2071–2077.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 13(3), 307–316.
author keywords: interstitial fluid pressure; xenograft; hyperthermia
MeSH headings : Animals; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Monoclonal / therapeutic use; Biological Transport, Active; Combined Modality Therapy; Extracellular Space / physiology; Glioma / immunology; Glioma / physiopathology; Glioma / therapy; Humans; Hyperthermia, Induced / methods; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Pressure; Time Factors; Transplantation, Heterologous
TL;DR:
It is demonstrated that local hyperthermia (4 h, 41.8 degrees C) is capable of significantly enhancing the uptake of radiolabelled monoclonal antibodies (mAbs) in D-54 MG glioma xenografts grown subcutaneously in athymic mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model
Clinical Cancer Research, 3, 63–70.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Phase I evaluation of mitoxantrone alone and combined with whole body hyperthermia in dogs with lymphoma
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 12(3), 309–320.
author keywords: hyperthermia; mitoxanthrone; lymphoma; canine
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / toxicity; Blood Cell Count / veterinary; Dogs; Female; Fever / veterinary; Lymphoma / metabolism; Lymphoma / therapy; Lymphoma / veterinary; Male; Mitoxantrone / therapeutic use; Mitoxantrone / toxicity; Neutropenia / complications; Neutropenia / veterinary; Neutrophils / metabolism; Regression Analysis; Thrombocytopenia / complications; Thrombocytopenia / veterinary
TL;DR:
It is concluded that MX may be administered without dose reduction to dogs undergoing WBH and that MX should be evaluated more thoroughly in future thermochemotherapy studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
The effects of clinically relevant hyperthermic temperatures on the kinetic binding parameters of a monoclonal antibody
NUCLEAR MEDICINE AND BIOLOGY, 23(4), 551–557.
author keywords: monoclonal antibodies; hyperthermia; antibody binding kinetics; radiotherapy
MeSH headings : Animals; Antibodies, Monoclonal / metabolism; Antibodies, Monoclonal / pharmacokinetics; Dogs; Glioma / metabolism; Humans; Hyperthermia, Induced; Kinetics; Mice; Mice, Nude; Osteosarcoma / metabolism; Tumor Cells, Cultured
TL;DR:
The effects of clinically relevant levels of hyperthermia on the kinetic binding parameters were investigated for 81C6, an antibody undergoing Phase I/II clinical trials for the treatment of brain tumors and neoplastic meningitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1995 chapter
Enhancement of radiolabeled monoclonal antibody uptake in tumors with local hyperthermia
In Handbook of targeted delivery of imaging agents (pp. 333–359).
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
EFFECT OF WHOLE-BODY HYPERTHERMIA ON CARBOPLATIN DISPOSITION AND TOXICITY IN DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 10(6), 807–816.
MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Carboplatin / toxicity; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Female; Hematopoietic System / drug effects; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary
TL;DR:
A randomized phase II evaluation should be initiated to determine if a therapeutic gain can be achieved using combined CBDCA and WBH and further refinement of the CBDCA dose in such a trial should be based on both pharmacokinetic parameters and normal tissue response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1992 journal article
QUANTITATIVE ESTIMATION OF THE THERMAL DOSE-MODIFYING FACTOR FOR CIS-DIAMMINEDICHLOROPLATINUM (CDDP) IN TUMOR-BEARING DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 8(6), 761–769.
MeSH headings : Animals; Bone Marrow / drug effects; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Drug Tolerance; Female; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Kidney / drug effects; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary; Organoplatinum Compounds / administration & dosage; Organoplatinum Compounds / adverse effects
TL;DR:
A statistical method for estimating clinical toxicity was used to determine a theoretical isoeffect dose-modifying factor for dogs with disseminated or refractory neoplasia treated with cis-diammine dichloroplatinum (II) plus whole-body hyperthermia or CDDP alone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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