Madhavi Latha Kakumanu

Works (15)

Updated: December 8th, 2025 13:40

2025 article

Data from: Group recognition in a subsocial extreme omnivore is based on fecal odor preference that is modulated by coprophagy, diet, and learning

Wada-Katsumata, A., Hamilton, J., Kakumanu, M., & Schal, C. (2025, November 25). DRYAD.

By: A. Wada-Katsumata n , J. Hamilton n, M. Kakumanu n & C. Schal n

topics (OpenAlex):
Sources: NC State University Libraries, NC State University Libraries
Added: December 7, 2025

2022 article

Effects of Wolbachia elimination and B-vitamin supplementation on bed bug development and reproduction

Hickin, M. L., Kakumanu, M. L., & Schal, C. (2022, June 17). Scientific Reports, Vol. 6.

By: M. Hickin n, M. Kakumanu n & C. Schal n 

MeSH headings : Animals; Bedbugs; Dietary Supplements; Female; Nymph; Reproduction; Vitamin B Complex / pharmacology; Wolbachia
topics (OpenAlex): Insect symbiosis and bacterial influences; Insects and Parasite Interactions; Insect and Pesticide Research
TL;DR: In aposymbiotic bed bugs that were fed B-vitamins-supplemented blood, nymph development time, adult survivorship and hatch rate recovered to control levels, but adult size and egg number only partially recovered. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 18, 2022

2022 article

Multiple Mechanisms Confer Fipronil Resistance in the German Cockroach: Enhanced Detoxification and Rdl Mutation

González-Morales, M. A., DeVries, Z. C., Santangelo, R. G., Kakumanu, M. L., & Schal, C. (2022, August 9). (W. Booth, Ed.). Journal of Medical Entomology, Vol. 8.

By: M. González-Morales  n, Z. DeVries  n, R. Santangelo n, M. Kakumanu n & C. Schal n 

Ed(s): W. Booth

author keywords: urban IPM; German cockroach; Blattella germanica; fipronil; insecticide resistance; Rdl; target site insensitivity
MeSH headings : Animals; Blattellidae / genetics; Insecticide Resistance / genetics; Insecticides / pharmacology; Mutation; Pyrazoles
topics (OpenAlex): Insects and Parasite Interactions; Insect and Pesticide Research; Insect and Arachnid Ecology and Behavior
TL;DR: Evaluated five populations of German cockroaches and found that all field-collected strains are homozygous for a mutation that substitutes serine for an alanine in Rdl, and confers low resistance to fipronil, indicating little change in fipronsil resistance over the past 20 yr. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 10, 2022

2021 article

Resistance to Fipronil in the Common Bed Bug (Hemiptera: Cimicidae)

González-Morales, M. A., DeVries, Z., Sierras, A., Santangelo, R. G., Kakumanu, M. L., & Schal, C. (2021, April 2). (L. Hribar, Ed.). Journal of Medical Entomology, Vol. 58, pp. 1798–1807.

By: M. González-Morales n, Z. DeVries n, A. Sierras n, R. Santangelo n, M. Kakumanu n & C. Schal n 

Ed(s): L. Hribar

author keywords: bed bugs; Cimex lectularius; fipronil; insecticide resistance; synergist
MeSH headings : Animals; Bedbugs / drug effects; Bedbugs / genetics; Insect Proteins / genetics; Insecticide Resistance / genetics; Insecticides / pharmacology; Mutation; Pyrazoles / pharmacology; Pyrethrins / pharmacology; Receptors, GABA-A / genetics
topics (OpenAlex): Dermatological diseases and infestations; Insects and Parasite Interactions; Insect and Pesticide Research
TL;DR: Investigating the potential of fipronil resistance in bed bugs found that highly resistant populations were also highly resistant to deltamethrin, suggesting that metabolic enzymes that are responsible for pyrethroid detoxification might also metabolize fipronsil. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 7, 2021

2021 article

Sphingobacterium phlebotomi sp. nov., a new member of family Sphingobacteriaceae isolated from sand fly rearing substrate

Kakumanu, M. L., Marayati, B. F., Wada-Katsumata, A., Wasserberg, G., Schal, C., Apperson, C. S., & Ponnusamy, L. (2021, May 6). INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol. 71.

By: M. Kakumanu n, B. Marayati*, A. Wada-Katsumata n , G. Wasserberg *, C. Schal n , C. Apperson n, L. Ponnusamy n 

Contributors: M. Kakumanu n, B. Marayati*, A. Wada-Katsumata n , G. Wasserberg *, C. Schal n , C. Apperson n, L. Ponnusamy n 

author keywords: 16S rRNA gene; Polyphasic analysis; Sphingobacterium phlebotomi sp. nov.
MeSH headings : Animals; Bacterial Typing Techniques; Base Composition; DNA, Bacterial / genetics; Fatty Acids / chemistry; Fatty Acids / metabolism; Phlebotomus / microbiology; Phosphatidylethanolamines / metabolism; Phylogeny; RNA, Ribosomal, 16S / genetics; Sequence Analysis, DNA; Sphingobacterium / classification; Sphingobacterium / genetics; Sphingobacterium / isolation & purification; Sphingobacterium / metabolism
topics (OpenAlex): Genomics and Phylogenetic Studies; Plant Pathogenic Bacteria Studies; Insect symbiosis and bacterial influences
TL;DR: On the basis of the results of this polyphasic taxonomic analysis, the bacterial isolate represents a novel species within the genus Sphingobacterium, for which the name SphingOBacterium phlebotomi sp. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 7, 2021

2020 article

Oviposition-Site Selection of Phlebotomus papatasi (Diptera: Psychodidae) Sand Flies: Attraction to Bacterial Isolates From an Attractive Rearing Medium

Kakumanu, M. L., Marayati, B. F., Schal, C., Apperson, C. S., Wasserberg, G., & Ponnusamy, L. (2020, December 5). (R. Johnson, Ed.). Journal of Medical Entomology, Vol. 58, pp. 518–527.

By: M. Kakumanu n, B. Marayati*, C. Schal n , C. Apperson n, G. Wasserberg * & L. Ponnusamy n 

Ed(s): R. Johnson

author keywords: Phlebotomus papatasi; sand flies; leishmaniasis; dose-response bioassay; semiochemical
MeSH headings : Animals; Appetitive Behavior / drug effects; Bacteria / chemistry; Bacteria / isolation & purification; Culture Media; Female; Microbiota; Oviposition; Phlebotomus; Volatile Organic Compounds / pharmacology
topics (OpenAlex): Research on Leishmaniasis Studies; Insect and Pesticide Research; Insect symbiosis and bacterial influences
TL;DR: This study confirms the important role of saprophytic bacteria, gut bacteria, or both, in guiding the oviposition-site selection behavior of sand flies and identifies the specific attractive semiochemical cues that they produce that could lead to development of an attractive lure for surveillance and control ofSand flies. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 6, 2020

2019 article

Diversity and structure of the bacterial microbiome of the American dog tick, Dermacentor variabilis, is dominated by the endosymbiont Francisella

Travanty, N. V., Ponnusamy, L., Kakumanu, M. L., Nicholson, W. L., & Apperson, C. S. (2019, August 19). Symbiosis, Vol. 79, pp. 239–250.

By: N. Travanty n, L. Ponnusamy n , M. Kakumanu n, W. Nicholson* & C. Apperson n

author keywords: Dermacentor variabilis; American dog tick; Microbiome; 16S rDNA; QIIME 2 analysis; Francisella endosymbiont
topics (OpenAlex): Vector-borne infectious diseases; Insect symbiosis and bacterial influences; Plant and Fungal Interactions Research
TL;DR: The high-throughput amplicon sequencing of the 16S rRNA gene revealed that most Francisella were similar to Francisella-like endosymbionts of D. variabilis, which sets the foundation for further studies to determine the influence of microbiota on vector susceptibility to pathogens. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: February 27, 2020

2019 article

Drought-induced soil microbial amino acid and polysaccharide change and their implications for C-N cycles in a climate change world

Kakumanu, M. L., Ma, L., & Williams, M. A. (2019, July 29). Scientific Reports.

By: M. Kakumanu n, L. Ma * & M. Williams *

MeSH headings : Amino Acids / analysis; Bacteria / metabolism; Carbon / analysis; Carbon Cycle; Climate Change; Droughts; Nitrogen / analysis; Nitrogen Cycle; Polysaccharides, Bacterial / analysis; Soil / chemistry; Soil Microbiology
topics (OpenAlex): Soil Carbon and Nitrogen Dynamics; Legume Nitrogen Fixing Symbiosis; Isotope Analysis in Ecology
TL;DR: Overall major pools of C and N based microbial metabolites are dynamic to drying (drought), and thus have implications for earth’s biogeochemical fluxes ofC and N, perhaps costing 4–7% of forest fixed photosynthetic C input during a single drying (Drought) period. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 12, 2019

2019 journal article

Pervasive Resistance to Pyrethroids in German Cockroaches (Blattodea: Ectobiidae) Related to Lack of Efficacy of Total Release Foggers

Journal of Economic Entomology, 112(5), 2295–2301.

By: Z. DeVries n, R. Santangelo n, J. Crissman n, A. Suazo n, M. Kakumanu n & C. Schal n 

Ed(s): M. Rust

author keywords: cypermethrin; do-it-yourself pest control; kdr; topical application
MeSH headings : Animals; Biological Assay; Blattellidae; Cockroaches; Insecticide Resistance; Insecticides; Pyrethrins
topics (OpenAlex): Insects and Parasite Interactions; Insect and Arachnid Ecology and Behavior; Animal and Plant Science Education
TL;DR: Investigating insecticide resistance of apartment-collected cockroaches from homes where TRFs failed suggested pyrethroid resistance is a major factor contributing to the failure of TRFs, which were recently shown to be ineffective at reducing German cockroach infestations. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 21, 2019

2018 journal article

Overlapping Community Compositions of Gut and Fecal Microbiomes in Lab-Reared and Field-Collected German Cockroaches

Applied and Environmental Microbiology, 84(17), AEM.01037–01018.

By: M. Kakumanu n, J. Maritz *, J. Carlton * & C. Schal n 

Ed(s): E. Stabb

author keywords: German cockroach; Blattella microbiota; microbiome; gut; feces; fecal microbiota; indoor microbiome
MeSH headings : Animals; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Cockroaches / microbiology; Cockroaches / parasitology; Feces / microbiology; Feces / parasitology; Female; Gastrointestinal Microbiome / physiology; High-Throughput Nucleotide Sequencing; Male; Parasites / classification; Parasites / genetics; Parasites / isolation & purification; RNA, Ribosomal, 16S / genetics; RNA, Ribosomal, 18S / genetics
topics (OpenAlex): Insects and Parasite Interactions; Insect and Arachnid Ecology and Behavior; Animal and Plant Science Education
TL;DR: It is demonstrated that cockroaches disseminate their gut microbiome in their feces, and this work underscores the important contribution of the cockroach fecal microbiome to the microbial diversity of cockroach-infested homes. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 19, 2018

2018 article

Prevalence of Rickettsia Species (Rickettsiales: Rickettsiaceae) in Dermacentor variabilis Ticks (Acari: Ixodidae) in North Carolina

Kakumanu, M. L., Ponnusamy, L., Sutton, H., Meshnick, S. R., Nicholson, W. L., & Apperson, C. S. (2018, May 16). Journal of Medical Entomology.

By: M. Kakumanu n, L. Ponnusamy n , H. Sutton n, S. Meshnick*, W. Nicholson * & C. Apperson n

author keywords: Dermacentor variabilis; spotted fever group rickettsiae; Rickettsia; reverse line blot hybridization; intergenic spacer
MeSH headings : Animals; Dermacentor / microbiology; North Carolina; Phylogeny; Polymerase Chain Reaction / methods; Rickettsia / genetics; Rickettsia / isolation & purification
topics (OpenAlex): Vector-borne infectious diseases; Viral Infections and Vectors; Mosquito-borne diseases and control
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Sources: Web Of Science, ORCID
Added: February 4, 2019

2016 article

Development and Validation of an Improved PCR Method Using the 23S-5S Intergenic Spacer for Detection of Rickettsiae in Dermacentor variabilis Ticks and Tissue Samples from Humans and Laboratory Animals

Kakumanu, M. L., Ponnusamy, L., Sutton, H. T., Meshnick, S. R., Nicholson, W. L., & Apperson, C. S. (2016, January 28). Journal of Clinical Microbiology.

By: M. Kakumanu n, L. Ponnusamy n , H. Sutton n, S. Meshnick*, W. Nicholson * & C. Apperson n

MeSH headings : Animals; Animals, Laboratory; DNA Primers / genetics; DNA, Intergenic / chemistry; DNA, Intergenic / genetics; Dermacentor / microbiology; Humans; Nucleic Acid Hybridization; Oligonucleotide Probes / genetics; Polymerase Chain Reaction / methods; RNA, Ribosomal, 23S / genetics; RNA, Ribosomal, 5S; Rickettsiaceae Infections / diagnosis; Rickettsiaceae Infections / microbiology; Rickettsieae / classification; Rickettsieae / genetics; Rickettsieae / isolation & purification; Sensitivity and Specificity
topics (OpenAlex): Vector-borne infectious diseases; Viral Infections and Vectors; Vector-Borne Animal Diseases
TL;DR: The novel nested PCR assay was sensitive enough to detect one copy of a cloned 23S-5S IGS fragment from “Candidatus Rickettsia amblyommii,” and validated using clinical samples from humans and laboratory animals that were known to be infected with pathogenic species ofRickettsia. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 article

Incident Tick-Borne Infections in a Cohort of North Carolina Outdoor Workers

Wallace, J. W., Nicholson, W. L., Perniciaro, J. L., Vaughn, M. F., Funkhouser, S., Juliano, J. J., … Meshnick, S. R. (2016, March 23). Vector-Borne and Zoonotic Diseases.

By: J. Wallace*, W. Nicholson *, J. Perniciaro *, M. Vaughn*, S. Funkhouser*, J. Juliano *, S. Lee n, M. Kakumanu n ...

author keywords: Epidemiology; Rickettsia; Serology; Tick(s)
MeSH headings : Adult; Borrelia burgdorferi / isolation & purification; Ehrlichia chaffeensis / isolation & purification; Ehrlichiosis / epidemiology; Ehrlichiosis / transmission; Female; Humans; Incidence; Lyme Disease / epidemiology; Lyme Disease / transmission; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure; Rickettsia / classification; Rickettsia Infections / epidemiology; Rickettsia Infections / transmission; Tick Bites / epidemiology; Tick-Borne Diseases / epidemiology
topics (OpenAlex): Vector-borne infectious diseases; Viral Infections and Vectors; Vector-Borne Animal Diseases
TL;DR: Outdoor workers in North Carolina are at high risk of incident tick-borne infections, most of which appear to be asymptomatic. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Stable Transmission of Borrelia burgdorferi Sensu Stricto on the Outer Banks of North Carolina

Zoonoses and Public Health, 64(5), 337–354.

By: J. Levine n , C. Apperson n, M. Levin *, T. Kelly n, M. Kakumanu n, L. Ponnusamy n , H. Sutton n, S. Salger n, J. Caldwell n, A. Szempruch n

author keywords: Borrelia burgdorferi; Ixodes scapularis; Peromyscus leucopus; Oryzomys palustris; Sylvilagus palustris; Outer Banks; North Carolina
MeSH headings : Animals; Bacteriological Techniques; Borrelia burgdorferi / genetics; Borrelia burgdorferi / isolation & purification; DNA, Bacterial / genetics; Female; Ixodes / microbiology; Lyme Disease / epidemiology; Lyme Disease / microbiology; Lyme Disease / transmission; Lyme Disease / veterinary; Male; North Carolina / epidemiology; Phylogeny; Rabbits / microbiology; Reptiles / microbiology; Rodentia / microbiology
topics (OpenAlex): Vector-borne infectious diseases; Viral Infections and Vectors; Yersinia bacterium, plague, ectoparasites research
TL;DR: Two studies indicate that B. burgdorferi sensu stricto is endemic in questing I. scapularis and mammalian tick hosts on the Outer Banks of North Carolina. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2014 article

Prevalence of Rickettsiales in ticks removed from the skin of outdoor workers in North Carolina

Lee, S., Kakumanu, M. L., Ponnusamy, L., Vaughn, M., Funkhouser, S., Thornton, H., … Apperson, C. S. (2014, December 1). Parasites & Vectors.

By: S. Lee n, M. Kakumanu n, L. Ponnusamy n , M. Vaughn*, S. Funkhouser*, H. Thornton n, S. Meshnick*, C. Apperson n

author keywords: Ticks; Rickettsiales pathogens; Rickettsia; Ehrlichia; Reverse line blot hybridization
MeSH headings : Animals; Arachnid Vectors / microbiology; Base Sequence; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Ribosomal / chemistry; DNA, Ribosomal / genetics; Double-Blind Method; Female; Humans; Ixodidae / microbiology; Male; Molecular Sequence Data; North Carolina / epidemiology; Polymerase Chain Reaction; Prevalence; Rickettsia / genetics; Rickettsia / isolation & purification; Rickettsia Infections / epidemiology; Rickettsia Infections / microbiology; Sequence Analysis, DNA; Tick Infestations / epidemiology
topics (OpenAlex): Vector-borne infectious diseases; Viral Infections and Vectors; Vector-Borne Animal Diseases
TL;DR: It is concluded that in North Carolina, the most common rickettsial exposure is to R. amblyommii carried by A. americanum, and Rickettsiales bacteria, including novel species of Rickettsia, were less frequently detected in A.Americanum. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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