Works (1)
Updated: July 5th, 2023 15:36
2017 journal article
A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis
BIOPHYSICAL JOURNAL, 113(1), 185–194.
MeSH headings : Animals; Cell Membrane / metabolism; Chemotaxis / physiology; Diffusion; Feedback, Physiological / physiology; Fibroblasts / enzymology; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Biological; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C / metabolism; Signal Transduction / physiology; Type C Phospholipases / metabolism
TL;DR:
A reaction-diffusion model of phospholipase C/protein kinase C (PKC) signaling is developed and it is shown that phosphorylation of myristoylated alanine-rich C kinase substrate by membrane-localized PKC constitutes a positive feedback that is sufficient for local pathway amplification.
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