@article{jones_berube_cuchiara_grieger_hubal_karikó_strader_theriault_2024, title={Positioning nanotechnology to address climate change}, volume={44}, ISSN={2194-5403 2194-5411}, url={http://dx.doi.org/10.1007/s10669-024-09991-w}, DOI={10.1007/s10669-024-09991-w}, abstractNote={One of society's most pressing challenges in the twenty-first century is that of climate change. In fact, climate change is seen as the most defining issue of our time as we are witness to an anthropogenic perturbation in geology and earth sciences of global scale. To move forward in this new era, solutions will be sought to both mitigate the effects of climate change (e.g., reduce greenhouse gasses) as well as adapt and build resilience (e.g., improve infrastructure and agriculture to resist damage from extreme weather or floods). The immediacy of the needed solutions dictates that the response must use the full force of society's current knowledge base, science, technology, and innovation. Nanotechnology, an enabling technology that has matured over the past few decades and now considered for general-purpose and mass use, is ideal for addressing climate change and its impacts. To position nanotechnology to address such complex challenges, this Perspective integrates collective insights from a broad range of viewpoints and presents recommendations for how research can be motivated and scoped, organized, and implemented to achieve beneficial outcomes and innovations in the most efficient ways. While this Perspective was created with a focus on the research landscape within the United States, the findings are also relevant in other international contexts. Research that can effectively advance nanotechnology solutions will be use-inspired basic research, incorporate systems-level thinking, apply a convergence research approach, engage stakeholders, and require advanced nanotechnology infrastructure. By illuminating this compelling and complex research topic, this Perspective aims to direct, inform, and accelerate needed actions in the research community to advance nanotechnology solutions for addressing climate change.}, number={4}, journal={Environment Systems and Decisions}, publisher={Springer Science and Business Media LLC}, author={Jones, Jacob L. and Berube, David M. and Cuchiara, Maude and Grieger, Khara and Hubal, Elaine A. Cohen and Karikó, Sarah J. and Strader, Phillip and Theriault, Yves}, year={2024}, month={Oct}, pages={1039–1053} }
 @article{deviney_bhadha_crane_cuchiara_delanthamajalu_gatiboni_guzman_hendren_marshall_morrison_et al._2024, title={Triple Bottom Line Scenario Sites as Boundary Objects for Integrating Diverse Disciplines in Convergent Research}, volume={16}, ISSN={["2071-1050"]}, url={https://doi.org/10.3390/su162310429}, DOI={10.3390/su162310429}, abstractNote={Today’s challenges with sustainability are driven by complexity, lack necessary information, resist straightforward solutions, span multiple scales, and encompass diverse or sometimes conflicting perspectives. To tackle these issues effectively, research organizations need tools that support and accelerate the integration of disciplinary knowledge across both natural and social sciences so that they can explore and execute workable solutions. Boundary objects are tools that can bring diverse perspectives together through a shared point of focus that is meaningful across different groups and perspectives, enhancing communication between them. Here, we introduce a framework to develop Triple Bottom Line Scenario Sites (TBL Sites) as “convergence” boundary objects and intervention testbeds to support a holistic approach to sustainability research within multidisciplinary and multi-institutional organizations. We describe four key criteria used to identify a potential TBL Site: (1) proximity to researchers, (2) a bounded geographic location encompassing a particular ecosystem, (3) an integrated stakeholder network, and (4) access to existing resources. We explain how TBL Sites may be used to assess research impacts on environmental, economic, and social sustainability goals. Finally, we provide examples of aquatic, agricultural, and urban TBL Sites used by the Science and Technologies for Phosphorus Sustainability (STEPS) Center, demonstrating how these boundary objects facilitate convergence across a large multidisciplinary research team to tackle sustainable phosphorus management.}, number={23}, journal={SUSTAINABILITY}, author={Deviney, Alison V. and Bhadha, Jehangir H. and Crane, Lucas and Cuchiara, Maude and Delanthamajalu, Shwetha and Gatiboni, Luciano and Guzman, Sandra M. and Hendren, Christine Ogilvie and Marshall, Anna-Maria and Morrison, Elise and et al.}, year={2024}, month={Dec} }
 @book{ruzante_shumaker_holt_mayer_kokotovich_cuchiara_binder_kuzma_grieger_2022, title={Eliciting Stakeholder Perceptions Using a Novel Online Engagement Platform: A Case Study on Nano-Agrifoods}, url={http://dx.doi.org/10.3768/rtipress.2022.op.0071.2201}, DOI={10.3768/rtipress.2022.op.0071.2201}, abstractNote={Stakeholder engagement is an important component in developing policies on critical issues such as the use and development of novel methods and technologies, including biotechnologies and nanotechnologies. Understanding the perspectives, needs, and concerns of stakeholder groups can facilitate the development of transparent and trusted policy recommendations. Innovative online research platforms have been developed as alternatives to typical stakeholder engagement methods such as in-person focus groups, interviews, and online and paper surveys. These platforms facilitate the engagement of geographically and linguistically (i.e., individuals who speak different languages) diverse stakeholders using a wide range of methods, from virtual focus groups to surveys. Stakeholders can participate at their own leisure and anonymously, which can facilitate more open interactions on issues where viewpoints may differ. In this work, we used an online stakeholder engagement platform (OSEP) to engage stakeholders and capture their perceptions and views about the application of nanotechnology in food and agriculture (nano-agrifood) and the role of responsible innovation in the development of nano-agrifood products. The OSEP provided a reliable and interactive environment for stakeholders to share their views and exchange ideas. Such OSEPs should be further explored as novel tools for engaging stakeholders on a range of issues from emerging technologies to public health.}, institution={RTI Press}, author={Ruzante, Juliana M. and Shumaker, Ellen Thomas and Holt, Sidney and Mayer, Susan and Kokotovich, Adam and Cuchiara, Maude and Binder, Andrew R. and Kuzma, Jennifer and Grieger, Khara}, year={2022}, month={Jan} }
 @article{merck_grieger_cuchiara_kuzma_2022, title={What Role Does Regulation Play in Responsible Innovation of Nanotechnology in Food and Agriculture? Insights and Framings from U.S. Stakeholders}, volume={42}, ISSN={0270-4676 1552-4183}, url={http://dx.doi.org/10.1177/02704676221102066}, DOI={10.1177/02704676221102066}, abstractNote={Historically, market regulation has played an important role in shaping the trajectory of scientific and technological innovation in food and agriculture. However, regulators’ traditional focus on safety and efficacy may be insufficient to address more complex ethical, legal, and social implications (ELSI) of novel products, such as the use of nanotechnology and nanomaterials in food and agriculture (nano-agrifoods). One solution might be to implement the principles of responsible innovation (RI) to challenge innovators and policymakers to better anticipate risks further upstream and be responsive to societal desires and concerns, although substantial barriers to implementation persist. This paper presents stakeholder views on the relationship between regulation and RI in nano-agrifoods based on a broader U.S. stakeholder engagement study conducted in the fall of 2020. We found that participants raised key issues that incorporated all 4 pillars of RI (anticipation, inclusion, reflexivity, responsiveness). We also found that participants’ attitudes about the relationship between regulation and innovation informed their recommendations about the relationship between regulation and RI. These attitudes are represented in a spectrum of views, ranging from “regulation as barrier” to “regulation as driver” of innovation. We further identified implications for how each attitude might be used to operationalize RI in regulatory systems. Overall, these results suggest that just as regulation drove key innovations in the twentieth century, regulation may still have a role to play in helping to promote RI of nano-agrifoods in the twenty-first.}, number={3}, journal={Bulletin of Science, Technology & Society}, publisher={SAGE Publications}, author={Merck, Ashton W. and Grieger, Khara D. and Cuchiara, Maude and Kuzma, Jennifer}, year={2022}, month={Jun}, pages={85–103} }
 @article{nelson_cuchiara_hendren_jones_marshall_2021, title={Hazardous Spills at Retired Fertilizer Manufacturing Plants Will Continue to Occur in the Absence of Scientific Innovation and Regulatory Enforcement}, volume={55}, ISSN={0013-936X 1520-5851}, url={http://dx.doi.org/10.1021/acs.est.1c05311}, DOI={10.1021/acs.est.1c05311}, abstractNote={ADVERTISEMENT RETURN TO ISSUEViewpointNEXTHazardous Spills at Retired Fertilizer Manufacturing Plants Will Continue to Occur in the Absence of Scientific Innovation and Regulatory EnforcementNatalie G. Nelson*Natalie G. NelsonBiological and Agricultural Engineering, North Carolina State University, Raleigh 27695, North Carolina, United StatesCenter for Geospatial Analytics, North Carolina State University, Raleigh 27695, North Carolina, United States*Phone: 919-515-6741; email: [email protected]More by Natalie G. NelsonView Biographyhttps://orcid.org/0000-0002-3258-7622, Maude L. CuchiaraMaude L. CuchiaraMaterials Science and Engineering, North Carolina State University, Raleigh 27695, North Carolina, United StatesMore by Maude L. Cuchiarahttps://orcid.org/0000-0001-8493-6620, Christine Ogilvie HendrenChristine Ogilvie HendrenResearch Institute for Environment, Energy and Economics, Appalachian State University, Boone 28608-2067, North Carolina, United StatesGeological and Environmental Science, Appalachian State University, Boone 28608-2067, North Carolina, United StatesMore by Christine Ogilvie Hendrenhttps://orcid.org/0000-0002-9546-6545, Jacob L. JonesJacob L. JonesMaterials Science and Engineering, North Carolina State University, Raleigh 27695, North Carolina, United StatesMore by Jacob L. Joneshttps://orcid.org/0000-0002-9182-0957, and Anna-Maria MarshallAnna-Maria MarshallSociology, University of Illinois Urbana−Champaign, Urbana 61801, United StatesMore by Anna-Maria MarshallCite this: Environ. Sci. Technol. 2021, 55, 24, 16267–16269Publication Date (Web):November 29, 2021Publication History Received6 August 2021Published online29 November 2021Published inissue 21 December 2021https://pubs.acs.org/doi/10.1021/acs.est.1c05311https://doi.org/10.1021/acs.est.1c05311article-commentaryACS PublicationsCopyright © 2021 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0. License Summary*You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below:Creative Commons (CC): This is a Creative Commons license.Attribution (BY): Credit must be given to the creator.View full license*DisclaimerThis summary highlights only some of the key features and terms of the actual license. It is not a license and has no legal value. Carefully review the actual license before using these materials. This publication is Open Access under the license indicated. Learn MoreArticle Views2392Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Byproducts,Manufacturing,Phosphorus,Separation science,Wastewater Get e-Alerts}, number={24}, journal={Environmental Science & Technology}, publisher={American Chemical Society (ACS)}, author={Nelson, Natalie G. and Cuchiara, Maude L. and Hendren, Christine Ogilvie and Jones, Jacob L. and Marshall, Anna-Maria}, year={2021}, month={Nov}, pages={16267–16269} }
 @article{grieger_merck_cuchiara_binder_kokotovich_cummings_kuzma_2021, title={Responsible innovation of nano-agrifoods: Insights and views from U.S. stakeholders}, volume={24}, ISSN={2452-0748}, url={http://dx.doi.org/10.1016/j.impact.2021.100365}, DOI={10.1016/j.impact.2021.100365}, abstractNote={To date, there has been little published work that has elicited diverse stakeholder views of nano-agrifoods and of how nano-agrifoods align with the goals of responsible innovation. This paper aims to fill this research gap by investigating views of nano-agrifoods, how well their development adheres to principles of responsible innovation, and potential challenges for achieving responsible nano-agrifood innovation. Using an online engagement platform, we find that U.S. stakeholder views of responsible innovation were dominated by environmental, health, and safety (EHS) contexts, considerations of societal impacts, opportunities for stakeholder engagement, and responding to societal needs. These views overlap with scholarly definitions of responsible innovation, albeit stakeholders were more focused on impacts of products, while the field of responsible innovation strives for more "upstream" considerations of the process of innovation. We also find that views of nano-agrifoods differed across applications with dietary supplements and improved whitening of infant formula viewed least favorably, and environmental health or food safety applications viewed most favorably. These findings align with the larger body of literature, whereby stakeholders are expected to be more supportive of nanotechnology used in agricultural applications compared to directly within food and food supplements. Overall, participants indicated they held relatively neutral views on research and innovation for nano-agrifoods being conducted responsibly, and they identified key challenges to ensuring their responsible innovation that were related to uncertainties in EHS studies, the need for public understanding and acceptance, and adequate regulation. In light of these results, we recommend future research efforts on EHS impacts and risk-benefit frameworks for nano-agrifoods, better understanding stakeholder views on what constitutes effective regulation, and addressing challenges with effective regulation and responsible innovation practices.}, journal={NanoImpact}, publisher={Elsevier BV}, author={Grieger, Khara D. and Merck, Ashton W. and Cuchiara, Maude and Binder, Andrew R. and Kokotovich, Adam and Cummings, Christopher L. and Kuzma, Jennifer}, year={2021}, month={Oct}, pages={100365} }
 @article{hahn_taite_moon_rowland_ruffino_west_2006, title={Photolithographic patterning of polyethylene glycol hydrogels}, volume={27}, url={http://dx.doi.org/10.1016/j.biomaterials.2005.11.045}, DOI={10.1016/j.biomaterials.2005.11.045}, number={12}, journal={Biomaterials}, publisher={Elsevier BV}, author={HAHN, M and TAITE, L and MOON, J and ROWLAND, M and RUFFINO, K and WEST, J}, year={2006}, month={Apr}, pages={2519–2524} }
 @article{tseng_puperi_kim_ayoub_shah_cuchiara_west_grande-allen, title={Anisotropic Poly(Ethylene Glycol)/Polycaprolactone Hydrogel-Fiber
   Composites for Heart Valve Tissue Engineering}, volume={20}, DOI={{10.1089/ten.tea.2013.0397}}, number={19-20}, journal={TISSUE ENGINEERING PART A}, author={Tseng, Hubert and Puperi, Daniel S. and Kim, Eric J. and Ayoub, Salma and Shah, Jay V. and Cuchiara, Maude L. and West, Jennifer L. and Grande-Allen, K. Jane}, pages={{2634–2645}} }
 @article{grieger_bossa_levis_borries_strader_cuchiara_hendren_hansen_jones, title={Application and testing of risk screening tools for nanomaterial risk
   analysis}, volume={5}, DOI={{10.1039/c8en00518d}}, number={8}, journal={ENVIRONMENTAL SCIENCE-NANO}, author={Grieger, Khara and Bossa, Nathan and Levis, James W. and Borries, Kerstin Johanna Felicitas and Strader, Phillip and Cuchiara, Maude and Hendren, Christine Ogilvie and Hansen, Steffen Foss and Jones, Jacob L.}, pages={{1844–1858}} }
 @article{taite_rowland_ruffino_smith_lawrence_west, title={Bioactive hydrogel substrates: Probing leukocyte receptor-ligand
   interactions in parallel plate flow chamber studies}, volume={34}, DOI={{10.1007/s10439-006-9173-x}}, number={11}, journal={ANNALS OF BIOMEDICAL ENGINEERING}, author={Taite, Lakeshia J. and Rowland, Maude L. and Ruffino, Katie A. and Smith, Bryan R. E. and Lawrence, Michael B. and West, Jennifer L.}, pages={{1705–1711}} }
 @article{cuchiara_coskun_banda_horter_hirschi_west, title={Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche
   and facilitate HSC expansion in culture}, volume={113}, DOI={{10.1002/bit.25848}}, number={4}, journal={BIOTECHNOLOGY AND BIOENGINEERING}, author={Cuchiara, Maude L. and Coskun, Sueleyman and Banda, Omar A. and Horter, Kelsey L. and Hirschi, Karen K. and West, Jennifer L.}, pages={{870–881}} }
 @article{cuchiara_horter_banda_west, title={Covalent immobilization of stem cell factor and stromal derived factor 1
   alpha for in vitro culture of hematopoietic progenitor cells}, volume={9}, DOI={{10.1016/j.actbio.2013.08.012}}, number={12}, journal={ACTA BIOMATERIALIA}, author={Cuchiara, Maude L. and Horter, Kelsey L. and Banda, Omar A. and West, Jennifer L.}, pages={{9258–9269}} }
 @article{cuchiara_davies_matthews, title={Defining ``Research'' in the US and EU: Contrast of Sherley v.
   Sebelius and Brustle v. Greenpeace Rulings}, volume={9}, DOI={{10.1007/s12015-013-9462-3}}, number={6}, journal={STEM CELL REVIEWS AND REPORTS}, author={Cuchiara, Maude L. and Davies, James Lawford and Matthews, Kirstin R. W.}, pages={{743–751}} }
 @article{alvarez-urena_davis_sonnet_henslee_gugala_strecker_linscheid_cuchiara_west_davis_et al., title={Encapsulation of Adenovirus BMP2-Transduced Cells with PEGDA Hydrogels
   Allows Bone Formation in the Presence of Immune Response}, volume={23}, DOI={{10.1089/ten.tea.2016.0277}}, number={5-6}, journal={TISSUE ENGINEERING PART A}, author={Alvarez-Urena, Pedro and Davis, Eleanor and Sonnet, Corinne and Henslee, Gabrielle and Gugala, Zbigniew and Strecker, Edward V. and Linscheid, Laura J. and Cuchiara, Maude and West, Jennifer and Davis, Alan and et al.}, pages={{177–184}} }
 @article{tseng_cuchiara_durst_cuchiara_lin_west_grande-allen, title={Fabrication and Mechanical Evaluation of Anatomically-Inspired
   Quasilaminate Hydrogel Structures with Layer-Specific Formulations}, volume={41}, DOI={{10.1007/s10439-012-0666-5}}, number={2}, journal={ANNALS OF BIOMEDICAL ENGINEERING}, author={Tseng, Hubert and Cuchiara, Maude L. and Durst, Christopher A. and Cuchiara, Michael P. and Lin, Chris J. and West, Jennifer L. and Grande-Allen, K. Jane}, pages={{398–407}} }
 @article{matthews_cuchiara, title={Gene patents, patenting life and the impact of court rulings on US stem
   cell patents and research}, volume={9}, DOI={{10.2217/rme.13.93}}, number={2}, journal={REGENERATIVE MEDICINE}, author={Matthews, Kirstin R. W. and Cuchiara, Maude L.}, pages={{191–200}} }
 @article{zhang_xu_puperi_yonezawa_wu_tseng_cuchiara_west_grande-allen, title={Integrating valve-inspired design features into poly(ethylene glycol)
   hydrogel scaffolds for heart valve tissue engineering}, volume={14}, DOI={{10.1016/j.actbio.2014.11.042}}, journal={ACTA BIOMATERIALIA}, author={Zhang, Xing and Xu, Bin and Puperi, Daniel S. and Yonezawa, Aline L. and Wu, Yan and Tseng, Hubert and Cuchiara, Maude L. and West, Jennifer L. and Grande-Allen, K. Jane}, pages={{11–21}} }
 @inbook{ali_cuchiara_west, title={Micropatterning of Poly(ethylene glycol) Diacrylate Hydrogels}, volume={121}, DOI={{10.1016/B978-0-12-800281-0.00008-7}}, booktitle={MICROPATTERNING IN CELL BIOLOGY, PT C}, author={Ali, Saniya and Cuchiara, Maude L. and West, Jennifer L.}, editor={Piel, M and Thery, MEditors}, pages={{105+}} }
 @article{cuchiara_olive_matthews, title={Regulating the therapeutic translation of regenerative medicine}, volume={15}, DOI={{10.1517/14712598.2015.1064895}}, number={10}, journal={EXPERT OPINION ON BIOLOGICAL THERAPY}, author={Cuchiara, Maude L. and Olive, Jackie K. and Matthews, Kirstin}, pages={{1387–1390}} }
 @article{matthews_rowland, title={Stem cell policy in the Obama age: UK and US perspectives}, volume={6}, DOI={{10.2217/RME.10.92}}, number={1}, journal={REGENERATIVE MEDICINE}, author={Matthews, Kirstin R. W. and Rowland, Maude L.}, pages={{125–132}} }
 @article{matthews_cuchiara, title={U.S. National Football League Athletes Seeking Unproven Stem Cell
   Treatments}, volume={23}, DOI={{10.1089/scd.2014.0358}}, number={1}, journal={STEM CELLS AND DEVELOPMENT}, author={Matthews, Kirstin R. W. and Cuchiara, Maude L.}, pages={{60–64}} }