Works (8)

Updated: February 21st, 2024 05:02

2024 journal article

Biomarkers of Metabolic Adaptation to High Dietary Fats in a Mouse Model of Obesity Resistance

METABOLITES, 14(1).

By: F. Milhem n, L. Hamilton n, E. Skates n, M. Wilson n, S. Johanningsmeier n & S. Komarnytsky n

author keywords: body composition; metabolic inflexibility; metabolic rate; dietary fats; skeletal muscle remodeling; glucose tolerance; microbiome
TL;DR: It is shown that NR mice developed healthier fat/lean body mass ratios compared with the obesity-prone (super-responder, SR) phenotypes by upregulating gene expression networks that promote the accumulation of type 2a, fast-twitch, oxidative muscle tissues. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 26, 2024

2024 journal article

Functional recovery following traumatic brain injury in rats is enhanced by oral supplementation with bovine thymus extract

FASEB JOURNAL, 38(3).

By: N. Surzenko*, J. Bastidas*, R. Reid*, J. Curaba*, W. Zhang*, H. Bostan*, M. Wilson*, A. Dominique* ...

author keywords: autoantibodies; autophagy; glandular therapy; nutrition; oral tolerance; phagocytosis; RNA-Seq
TL;DR: The potency of a nutritional supplement containing nuclear fraction of bovine thymus in enhancing the functional recovery from TBI is demonstrated, for the first time, in enhancing the functional recovery from TBI. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 19, 2024

2024 journal article

Obesity-Resistant Mice on a High-Fat Diet Display a Distinct Phenotype Linked to Enhanced Lipid Metabolism

NUTRIENTS, 16(1).

By: F. Milhem n, E. Skates*, M. Wilson* & S. Komarnytsky n

author keywords: dietary fats; energy substrate; body composition; metabolic rate; individual variability; personalized nutrition
TL;DR: NR mice showed an increased ability to metabolize excessive dietary fats in skeletal muscle at the expense of reduced exercise capacity that persisted for the duration of the study, underscore the need for further comprehensive investigations into the mechanisms of obesity resistance. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 22, 2024

2021 journal article

Rheum rhaponticum Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(3).

By: M. Wilson n, V. Konda*, K. Heidt n, T. Rathinasabapathy n, A. Desai* & S. Komarnytsky n

Contributors: M. Wilson n, V. Konda*, K. Heidt n, T. Rathinasabapathy n, A. Desai* & S. Komarnytsky n

author keywords: postmenopausal; estrogens; hot flashes; HRT; ERr 731
MeSH headings : Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / metabolism; Hot Flashes; Menopause / drug effects; Molecular Structure; Ovariectomy; Phytoestrogens / chemistry; Phytoestrogens / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Roots / chemistry; Postmenopause; Rats; Rheum / chemistry; Vasomotor System / drug effects
TL;DR: Data validate the OVX/Tskin rat model as a suitable screening platform to evaluate botanical and pharmaceutical treatments of menopause, while providing further evidence for the efficacy of ERr 731 towards alleviating vasomotor menopausal symptoms and improving wellbeing during the menopausal transition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID
Added: January 21, 2021

2018 journal article

Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage

FOOD AND CHEMICAL TOXICOLOGY, 111, 445–453.

By: E. Skates n, J. Overall n, K. DeZego n, M. Wilson n, D. Esposito n, M. Lila n, S. Komarnytsky n

author keywords: Bioactive food components; Polyphenols; Obesity; Diabetes; Bioenergetics; Functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Diet; Diet, High-Fat / adverse effects; Energy Metabolism; Fruit / chemistry; Lipid Metabolism; Male; Metabolic Diseases; Methylation; Mice; Mice, Inbred C57BL; Rubus / chemistry
TL;DR: It is shown that consumption of berries containing anthocyanins with enhanced methylation profiles (malvidin and petunidin) is more effective at reducing high fat diet-induced metabolic damage in the C57BL/6 mouse model of polygenic obesity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript

JOURNAL OF ETHNOPHARMACOLOGY, 203, 171–181.

By: C. Wagner n, J. De Gezelle n, M. Robertson, K. Robertson, M. Wilson n & S. Komarnytsky n

author keywords: Traditional use; ethnobotany; medicinal plants; microbial infections; antibiotics
MeSH headings : Anti-Bacterial Agents / history; Anti-Bacterial Agents / isolation & purification; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacterial Infections / drug therapy; Bacterial Infections / history; Ethnobotany / history; Ethnopharmacology / history; History, Medieval; Humans; Medicine, Traditional / history; Phytotherapy / history; Phytotherapy / methods; Plant Preparations / history; Plant Preparations / pharmacology; Plants, Medicinal / chemistry; Scotland
TL;DR: Using historical medical sources such as those associated with traditional Celtic medicine to guide rigorous, evidence-based scientific investigation, provides additional leads for new and alternative bioactive molecules for combating bacterial diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Metabolic Effects of Berries with Structurally Diverse Anthocyanins

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2).

By: J. Overall n, S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n, D. Esposito n, M. Lila n, S. Komarnytsky n

Contributors: J. Overall n, S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n, D. Esposito n, M. Lila n, S. Komarnytsky n

author keywords: berry; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Anthocyanins / metabolism; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Supplements; Feces / chemistry; Fruit / metabolism; Gastrointestinal Microbiome; Glucose / metabolism; Humans; Insulin Resistance; Mice; Molecular Structure; Oxygen Consumption
TL;DR: Examination of effects of six berries with structurally diverse anthocyanin profiles on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocianins that could be explained by differences in their structure and metabolism in the gut. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63(27), 6172–6180.

By: D. Esposito n, T. Damsud n, M. Wilson n, M. Grace n, R. Strauch n, X. Li n, M. Lila n, S. Komarnytsky n

Contributors: D. Esposito n, T. Damsud n, M. Wilson n, M. Grace n, R. Strauch n, X. Li n, M. Lila n, S. Komarnytsky n

author keywords: gastrointestinal tract; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animals; Anthocyanins / administration & dosage; Anthocyanins / chemistry; Fruit / chemistry; Gastrointestinal Microbiome / drug effects; Glucose / metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity / drug therapy; Obesity / metabolism; Obesity / microbiology; Obesity / physiopathology; Plant Extracts / administration & dosage; Plant Extracts / chemistry; Ribes / chemistry; Weight Gain / drug effects
TL;DR: The data clearly demonstrate that gut microbiome and the type of the anthocyanin aglycone moiety can alter the protective effect of Anthocyanins against obesity and associated insulin resistance. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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