Mickey L. Wilson

Works (9)

Updated: April 25th, 2025 19:09

2024 article

Biomarkers of Metabolic Adaptation to High Dietary Fats in a Mouse Model of Obesity Resistance

Milhem, F., Hamilton, L. M., Skates, E., Wilson, M., Johanningsmeier, S. D., & Komarnytsky, S. (2024, January 20). Metabolites, Vol. 14.

By: F. Milhem n, L. Hamilton  n, E. Skates n, M. Wilson n, S. Johanningsmeier n & S. Komarnytsky n 

author keywords: body composition; metabolic inflexibility; metabolic rate; dietary fats; skeletal muscle remodeling; glucose tolerance; microbiome
topics (OpenAlex): Adipose Tissue and Metabolism; Diet and metabolism studies; Adipokines, Inflammation, and Metabolic Diseases
TL;DR: It is shown that NR mice developed healthier fat/lean body mass ratios compared with the obesity-prone (super-responder, SR) phenotypes by upregulating gene expression networks that promote the accumulation of type 2a, fast-twitch, oxidative muscle tissues. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 26, 2024

2024 article

Functional recovery following traumatic brain injury in rats is enhanced by oral supplementation with bovine thymus extract

Surzenko, N., Bastidas, J., Reid, R. W., Curaba, J., Zhang, W., Bostan, H., … El‐Khodor, B. F. (2024, February 5). The FASEB Journal, Vol. 38.

By: N. Surzenko *, J. Bastidas*, R. Reid *, J. Curaba* , W. Zhang*, H. Bostan*, M. Wilson*, A. Dominique* ...

author keywords: autoantibodies; autophagy; glandular therapy; nutrition; oral tolerance; phagocytosis; RNA-Seq
MeSH headings : Humans; Rats; Animals; Cattle; Thymus Extracts / pharmacology; Thymus Extracts / therapeutic use; Brain Injuries, Traumatic / drug therapy; Neurons; Neuroglia; Hippocampus; Disease Models, Animal
topics (OpenAlex): Traumatic Brain Injury and Neurovascular Disturbances; Vitamin C and Antioxidants Research; Mitochondrial Function and Pathology
TL;DR: The potency of a nutritional supplement containing nuclear fraction of bovine thymus in enhancing the functional recovery from TBI is demonstrated, for the first time, in enhancing the functional recovery from TBI. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 19, 2024

2024 article

Obesity-Resistant Mice on a High-Fat Diet Display a Distinct Phenotype Linked to Enhanced Lipid Metabolism

Milhem, F., Skates, E., Wilson, M., & Komarnytsky, S. (2024, January 4). Nutrients, Vol. 16.

By: F. Milhem n, E. Skates*, M. Wilson* & S. Komarnytsky n 

author keywords: dietary fats; energy substrate; body composition; metabolic rate; individual variability; personalized nutrition
MeSH headings : Animals; Mice; Diet, High-Fat / adverse effects; Lipid Metabolism; Mice, Inbred C57BL; Mice, Obese; Obesity / etiology; Phenotype
topics (OpenAlex): Diet and metabolism studies; Adipose Tissue and Metabolism; Dietary Effects on Health
TL;DR: NR mice showed an increased ability to metabolize excessive dietary fats in skeletal muscle at the expense of reduced exercise capacity that persisted for the duration of the study, underscore the need for further comprehensive investigations into the mechanisms of obesity resistance. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 22, 2024

2024 article

Triptolide Administration Alters Immune Responses to Mitigate Insulin Resistance in Obese States

Grodsky, L., Wilson, M., Rathinasabapathy, T., & Komarnytsky, S. (2024, March 25). Biomolecules, Vol. 14.

By: L. Grodsky n, M. Wilson n, T. Rathinasabapathy n  & S. Komarnytsky n 

author keywords: metabolic syndrome; immunometabolism; metabolic deregulations; metabolic disorders; energy metabolism; diabetes mellitus; mitochondria; molecular targets; biomarkers
MeSH headings : Animals; Insulin Resistance; Epoxy Compounds / pharmacology; Epoxy Compounds / administration & dosage; Diterpenes / pharmacology; Diterpenes / administration & dosage; Phenanthrenes / pharmacology; Phenanthrenes / administration & dosage; Obesity / metabolism; Obesity / immunology; Mice; Mice, Inbred C57BL; Male; Inflammation / metabolism; Adipose Tissue / metabolism; Adipose Tissue / drug effects; Interleukin-17 / metabolism; Interleukin-17 / genetics; Diet, High-Fat / adverse effects; Tumor Necrosis Factor-alpha / metabolism; Diabetes Mellitus, Type 2 / drug therapy; Diabetes Mellitus, Type 2 / metabolism; Diabetes Mellitus, Type 2 / immunology; Cyclooxygenase 2 / metabolism; Cyclooxygenase 2 / genetics; Energy Metabolism / drug effects
topics (OpenAlex): Natural Compounds in Disease Treatment; Adipokines, Inflammation, and Metabolic Diseases; Apelin-related biomedical research
TL;DR: Reduction of diet-induced inflammation confers partial protection against insulin resistance, but not obesity, and the possibility of achieving overweight phenotypes that are accompanied by minimal insulin resistance if inflammation is controlled is suggested. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 1, 2024

2021 article

Rheum rhaponticum Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model

Wilson, M., Konda, V., Heidt, K., Rathinasabapathy, T., Desai, A., & Komarnytsky, S. (2021, January 21). International Journal of Molecular Sciences, Vol. 22, p. 1032.

By: M. Wilson n, V. Konda*, K. Heidt n, T. Rathinasabapathy n , A. Desai* & S. Komarnytsky n 

Contributors: M. Wilson n, V. Konda*, K. Heidt n, T. Rathinasabapathy , A. Desai* & S. Komarnytsky n 

author keywords: postmenopausal; estrogens; hot flashes; HRT; ERr 731
MeSH headings : Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / metabolism; Hot Flashes; Menopause / drug effects; Molecular Structure; Ovariectomy; Phytoestrogens / chemistry; Phytoestrogens / pharmacology; Plant Extracts / chemistry; Plant Extracts / pharmacology; Plant Roots / chemistry; Postmenopause; Rats; Rheum / chemistry; Vasomotor System / drug effects
topics (OpenAlex): Estrogen and related hormone effects; Menopause: Health Impacts and Treatments; Ovarian function and disorders
TL;DR: Data validate the OVX/Tskin rat model as a suitable screening platform to evaluate botanical and pharmaceutical treatments of menopause, while providing further evidence for the efficacy of ERr 731 towards alleviating vasomotor menopausal symptoms and improving wellbeing during the menopausal transition. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 21, 2021

2017 article

Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript

Wagner, C. S., Gezelle, J. D., Robertson, M., Robertson, K., Wilson, M., & Komarnytsky, S. (2017, March 27). Journal of Ethnopharmacology, Vol. 203, pp. 171–181.

By: C. Wagner n , J. Gezelle n, M. Robertson, K. Robertson, M. Wilson n & S. Komarnytsky n 

author keywords: Traditional use; ethnobotany; medicinal plants; microbial infections; antibiotics
MeSH headings : Anti-Bacterial Agents / history; Anti-Bacterial Agents / isolation & purification; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacterial Infections / drug therapy; Bacterial Infections / history; Ethnobotany / history; Ethnopharmacology / history; History, Medieval; Humans; Medicine, Traditional / history; Phytotherapy / history; Phytotherapy / methods; Plant Preparations / history; Plant Preparations / pharmacology; Plants, Medicinal / chemistry; Scotland
topics (OpenAlex): Ethnobotanical and Medicinal Plants Studies; Leech Biology and Applications; Yersinia bacterium, plague, ectoparasites research
TL;DR: Using historical medical sources such as those associated with traditional Celtic medicine to guide rigorous, evidence-based scientific investigation, provides additional leads for new and alternative bioactive molecules for combating bacterial diseases. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
3. Good Health and Well-being (Web of Science; OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 article

Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage

Skates, E., Overall, J., DeZego, K., Wilson, M., Esposito, D., Lila, M. A., & Komarnytsky, S. (2017, November 28). Food and Chemical Toxicology, Vol. 111, pp. 445–453.

By: E. Skates n, J. Overall n , K. DeZego n, M. Wilson n, D. Esposito n , M. Lila n , S. Komarnytsky n 

author keywords: Bioactive food components; Polyphenols; Obesity; Diabetes; Bioenergetics; Functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Diet; Diet, High-Fat / adverse effects; Energy Metabolism; Fruit / chemistry; Lipid Metabolism; Male; Metabolic Diseases; Methylation; Mice; Mice, Inbred C57BL; Rubus / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Adipose Tissue and Metabolism; Sirtuins and Resveratrol in Medicine
TL;DR: It is shown that consumption of berries containing anthocyanins with enhanced methylation profiles (malvidin and petunidin) is more effective at reducing high fat diet-induced metabolic damage in the C57BL/6 mouse model of polygenic obesity. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 article

Metabolic Effects of Berries with Structurally Diverse Anthocyanins

Overall, J., Bonney, S., Wilson, M., Beermann, A., Grace, M., Esposito, D., … Komarnytsky, S. (2017, February 15). International Journal of Molecular Sciences, Vol. 18.

By: J. Overall n , S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n , D. Esposito n , M. Lila n , S. Komarnytsky n 

Contributors: J. Overall n , S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n , D. Esposito n , M. Lila n , S. Komarnytsky n 

author keywords: berry; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Anthocyanins / metabolism; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Supplements; Feces / chemistry; Fruit / metabolism; Gastrointestinal Microbiome; Glucose / metabolism; Humans; Insulin Resistance; Mice; Molecular Structure; Oxygen Consumption
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Diet and metabolism studies; Metabolomics and Mass Spectrometry Studies
TL;DR: Examination of effects of six berries with structurally diverse anthocyanin profiles on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocianins that could be explained by differences in their structure and metabolism in the gut. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome

Esposito, D., Damsud, T., Wilson, M., Grace, M. H., Strauch, R., Li, X., … Komarnytsky, S. (2015, June 12). Journal of Agricultural and Food Chemistry, Vol. 63, pp. 6172–6180.

By: D. Esposito n , T. Damsud  n, M. Wilson n, M. Grace n , R. Strauch n, X. Li n , M. Lila n , S. Komarnytsky n 

Contributors: D. Esposito n , T. Damsud  n, M. Wilson n, M. Grace n , R. Strauch n, X. Li n , M. Lila n , S. Komarnytsky n 

author keywords: gastrointestinal tract; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animals; Anthocyanins / administration & dosage; Anthocyanins / chemistry; Fruit / chemistry; Gastrointestinal Microbiome / drug effects; Glucose / metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity / drug therapy; Obesity / metabolism; Obesity / microbiology; Obesity / physiopathology; Plant Extracts / administration & dosage; Plant Extracts / chemistry; Ribes / chemistry; Weight Gain / drug effects
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Biochemical Analysis and Sensing Techniques; Gut microbiota and health
TL;DR: The data clearly demonstrate that gut microbiome and the type of the anthocyanin aglycone moiety can alter the protective effect of Anthocyanins against obesity and associated insulin resistance. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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