Michelle Marie Miller

Works (7)

Updated: August 29th, 2023 11:24

2014 journal article

CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ / GARP-mediated mechanism

Virology Journal, 11(1), 7.

By: M. Miller n, C. Petty, M. Tompkins n & J. Fogle n

author keywords: FIV; HIV; AIDS; Lentivirus; Treg cells; mTGF beta; GARP
MeSH headings : Animals; CD4-Positive T-Lymphocytes / chemistry; CD4-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Interleukin-2 Receptor alpha Subunit / analysis; Membrane Proteins / metabolism; Signal Transduction; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / metabolism
TL;DR: Th to Treg conversion may initiate a cascade of events that contributes to the maintenance of virus reservoirs, progressive Th cell immunosuppression, and the development of immunodeficiency, all of which are central to the pathogenesis of AIDS lentivirus infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Lentivirus-Activated T Regulatory Cells Suppress T Helper Cell Interleukin-2 Production by Inhibiting Nuclear Factor of Activated T Cells 2 Binding to the Interleukin-2 Promoter

AIDS RESEARCH AND HUMAN RETROVIRUSES, 30(1), 58–66.

By: L. Meng n, M. Tompkins n, M. Miller n & J. Fogle n

MeSH headings : Amino Acid Sequence; Animals; Cats; Cell Proliferation; Cells, Cultured; Coculture Techniques; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / biosynthesis; Interleukin-2 / genetics; Lentivirus Infections / immunology; Lentivirus Infections / pathology; Lentivirus Infections / virology; Lymph Nodes / cytology; Lymph Nodes / virology; Lymphocyte Activation / immunology; Molecular Sequence Data; NFATC Transcription Factors / antagonists & inhibitors; NFATC Transcription Factors / genetics; Promoter Regions, Genetic / immunology; Protein Binding / immunology; RNA, Messenger / biosynthesis; Receptors, Transforming Growth Factor beta / biosynthesis; Sequence Alignment; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / virology; Transforming Growth Factor beta / biosynthesis; Transforming Growth Factor beta / pharmacology; Up-Regulation
TL;DR: Data suggest that TGF-β-mediated Treg cell suppression of IL-2 transcription is modulated through alterations in NFAT2 binding to the IL-1 promoter in suppressed Th cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Modulating DNA Methylation in Activated CD8+ T Cells Inhibits Regulatory T Cell–Induced Binding of Foxp3 to the CD8+ T Cell IL-2 Promoter

The Journal of Immunology, 194(3), 990–998.

By: M. Miller n, N. Akaronu n, E. Thompson n, S. Hood n & J. Fogle n

MeSH headings : Animals; Base Sequence; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Cats; Chromatin Assembly and Disassembly; Coculture Techniques; DNA Methylation; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Expression Regulation; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / chemistry; Interleukin-2 / genetics; Lentivirus / immunology; Lymphocyte Activation; Models, Biological; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism
TL;DR: Using the FIV model for lentiviral persistence, these studies provide a framework for understanding how immune activation combined with Treg-mediated suppression may affect CD8+ T cell IL-2 transcription, maturation, and antiviral function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

CD8+ clonality is associated with prolonged acute plasma viremia and altered mRNA cytokine profiles during the course of Feline Immunodeficiency Virus infection

Veterinary Immunology and Immunopathology, 152(3-4), 200–208.

By: M. Miller n, E. Thompson n, S. Suter n & J. Fogle n

author keywords: FIV; AIDS; CTL; CD8(+) clonality; PARR
MeSH headings : Animals; CD8 Antigens / metabolism; CD8-Positive T-Lymphocytes / immunology; Cat Diseases / genetics; Cat Diseases / immunology; Cats; Clonal Selection, Antigen-Mediated / genetics; Cytokines / genetics; Gene Rearrangement, T-Lymphocyte; Immunodeficiency Virus, Feline; Lentivirus Infections / genetics; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Male; RNA, Messenger / genetics; RNA, Messenger / metabolism; Transcriptome; Viremia / genetics; Viremia / immunology; Viremia / veterinary
TL;DR: Using PARR to assess changes in CD8(+) clonality during the progression from acute to chronic FIV infection may help to better characterize the factors which contribute to CD8 (+) anergy and lentiviral persistence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

Feline Glycoprotein A Repetitions Predominant Anchors Transforming Growth Factor Beta on the Surface of Activated CD4(+)CD25(+) Regulatory T Cells and Mediates AIDS Lentivirus-Induced T Cell Immunodeficiency

AIDS RESEARCH AND HUMAN RETROVIRUSES, 29(4), 641–651.

By: M. Miller n, J. Fogle n, P. Ross n & M. Tompkins n

MeSH headings : Amino Acid Sequence; Animals; Cats; Feline Acquired Immunodeficiency Syndrome / etiology; Feline Acquired Immunodeficiency Syndrome / immunology; Glycoproteins / genetics; Glycoproteins / immunology; Glycoproteins / metabolism; Humans; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / pathogenicity; Membrane Proteins / genetics; Membrane Proteins / immunology; Membrane Proteins / metabolism; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes / metabolism; Protein Conformation; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Homology, Amino Acid; Species Specificity; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / metabolism
TL;DR: It is demonstrated that the GARP(+) Treg cells from FIV-infected cats suppress T helper cells in vivo and that blocking GARP or TGFb eliminates this suppression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Human intravenous immunoglobulin (hIVIG) inhibits anti-CD32 antibody binding to canine DH82 cells and canine monocytes in vitro

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 151(3-4), 229–234.

By: T. Sibley, M. Miller* & J. Fogle*

author keywords: Fc gamma receptor; CD16; CD32; Intravenous immunoglobulin
MeSH headings : Animals; Antibodies, Blocking / metabolism; Antibodies, Heterophile / metabolism; Antigen-Antibody Complex / metabolism; Antigen-Antibody Reactions; Cell Line; Dogs / immunology; Humans; Immunoglobulins, Intravenous / metabolism; Monocytes / immunology; Receptors, IgG / antagonists & inhibitors; Receptors, IgG / metabolism
TL;DR: This is the first report to demonstrate Fc(γ) receptors CD16 and CD32 expression on canine monocytes and in vitro CD32 binding by human IgG, which may represent one of the immunomodulatory mechanisms of hIVIG. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Infection with Feline Immunodeficiency Virus Directly Activates CD4+ CD25+ T Regulatory Cells

Journal of Virology, 87(16), 9373–9378.

By: M. Miller n, J. Fogle n & M. Tompkins n

MeSH headings : Animals; CD4-Positive T-Lymphocytes / chemistry; CD4-Positive T-Lymphocytes / immunology; Cats; Cells, Cultured; Gene Expression Profiling; Immunodeficiency Virus, Feline / immunology; Immunosuppression Therapy; Interleukin-2 Receptor alpha Subunit / analysis; T-Lymphocyte Subsets / chemistry; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology
TL;DR: In vitro feline immunodeficiency virus (FIV) infection, but not UV-inactivated virus, activates Treg cells as measured by immunosuppressive function and upregulation of GARP, FoxP3, and membrane-bound transforming growth factor β (TGF-β). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

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