Works (2)
Updated: July 5th, 2023 15:44
2013 journal article
Promiscuity of a modular polyketide synthase towards natural and non-natural extender units
Organic & Biomolecular Chemistry, 11(27), 4449.
MeSH headings : Acyl Coenzyme A / chemistry; Acyl Coenzyme A / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Coenzyme A Ligases / chemistry; Coenzyme A Ligases / metabolism; Polyketide Synthases / chemistry; Polyketide Synthases / metabolism; Protein Structure, Tertiary; Rhizobium / chemistry; Rhizobium / enzymology; Rhizobium / metabolism; Substrate Specificity
TL;DR:
A panel of chemo-enzymatically synthesized acyl-CoA's was used to probe the promiscuity of a polyketide synthase, revealing that the KS is remarkably tolerant to a diverse array of extender units, while the AT likely discriminates betweenextender units that are native to the producing organism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2012 journal article
Poly Specific trans-Acyltransferase Machinery Revealed via Engineered Acyl-CoA Synthetases
ACS Chemical Biology, 8(1), 200–208.
MeSH headings : Acyltransferases / chemistry; Acyltransferases / genetics; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Chromatography, Liquid; Coenzyme A Ligases / chemistry; Coenzyme A Ligases / genetics; Crystallography, X-Ray; Genetic Variation; Models, Molecular; Substrate Specificity
TL;DR:
Results reveal that polyketide biosynthetic machinery might be more tolerant to non-natural substrates than previously established, and that mutant synthetases are valuable tools for probing the specificity of biosynthetics machinery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
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