Works (8)
Updated: July 5th, 2023 15:42
2019 journal article
Iron-induced transferrin receptor-1 mRNA destabilization: A response to "Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation"
RNA, 25(11), 1416–1420.
MeSH headings : Iron; MicroRNAs; RNA Stability; RNA, Messenger; Receptors, Transferrin
TL;DR:
There are several critical issues contained in the article by Connell and colleagues that require further consideration and the opportunity to reply here.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 28, 2019
2018 journal article
Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2
CELL CHEMICAL BIOLOGY, 26(1), 85-+.
MeSH headings : Adolescent; Adult; Aged; Animals; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Cell Proliferation / drug effects; Cell Survival / drug effects; Cells, Cultured; Cisplatin / metabolism; Cisplatin / pharmacology; Drug Screening Assays, Antitumor; Female; Fetus; Humans; Iron / metabolism; Iron Deficiencies; Iron Regulatory Protein 2 / antagonists & inhibitors; Iron Regulatory Protein 2 / genetics; Iron Regulatory Protein 2 / metabolism; Male; Mice; Middle Aged; Molecular Structure; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / metabolism; Neoplasms, Experimental / pathology
TL;DR:
Cisplatin is an inhibitor of IRP2 that induces intracellular iron deficiency and combination of cisplatin and the iron chelator desferrioxamine enhanced cytotoxicity through augmented iron depletion in culture and xenograft mouse model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019
2016 journal article
Analyzing consortial "big deals" via a cost-per-cited-reference (CPCR) metric
Serials Review, 42(4), 293–305.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models
Mechanisms of Ageing and Development, 155, 22–35.
Source: NC State University Libraries
Added: August 6, 2018
2016 review
Siderophores in Iron Metabolism: From Mechanism to Therapy Potential
[Review of ]. TRENDS IN MOLECULAR MEDICINE, 22(12), 1077–1090.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / immunology; Bacteria / metabolism; Bacterial Infections / drug therapy; Bacterial Infections / immunology; Bacterial Infections / metabolism; Drug Discovery; Host-Pathogen Interactions / drug effects; Humans; Iron / immunology; Iron / metabolism; Lipocalin-2 / immunology; Lipocalin-2 / metabolism; Siderophores / immunology; Siderophores / metabolism
TL;DR:
This review discusses the recently described molecular mechanisms of siderophore iron trafficking between host and bacteria, highlighting the therapeutic potential of exploiting pathogen sidersophore machinery for the treatment of antibiotic-resistant bacterial infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 review
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease
[Review of ]. TRENDS IN BIOCHEMICAL SCIENCES, 41(3), 274–286.
MeSH headings : Cell Death; Homeostasis; Humans; Iron / metabolism
TL;DR:
New regulators of iron metabolism are highlighted, including iron-trafficking proteins [solute carrier family 39, SLC39, also known as ZRT/IRT-like protein, ZIP; and poly-(rC)-binding protein, PCBP] and a cargo receptor (NCOA4) that is crucial for release of ferritin-bound iron.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels
CELLULAR SIGNALLING, 26(12), 2702–2709.
author keywords: Hypoxia; Cobalt chloride; Hypoxia inducible factor (HIF); Iron regulatory protein (IRP); Nrf2; Ferritin
MeSH headings : Apoferritins / genetics; Cell Line, Tumor; Cobalt / pharmacology; Ferritins / genetics; Gene Expression Regulation / genetics; Humans; Hypoxia / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Iron-Regulatory Proteins / genetics; Protein Processing, Post-Translational / drug effects; Protein Processing, Post-Translational / genetics; RNA, Messenger / genetics; Transcription, Genetic / drug effects; Transcription, Genetic / genetics; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR:
It is demonstrated that hypoxia and cobalt chloride regulate ferritin heavy chain (ferritin H) expression by two distinct mechanisms through the interplay between DNA and mRNA elements at the transcriptional and post-transcriptional levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene
MOLECULAR BIOLOGY OF THE CELL, 25(13), 2116–2127.
MeSH headings : Antioxidants / physiology; Apoptosis; Cell Differentiation; Erythroid Cells / metabolism; Hemin / pharmacology; Humans; K562 Cells; Mitochondria / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Phosphorylation; Protein Isoforms / physiology; Protein Processing, Post-Translational; Protein Transport; Reactive Oxygen Species / metabolism; Response Elements; Shc Signaling Adaptor Proteins / physiology; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcription, Genetic; Transcriptional Activation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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