Melissa Marie Mitchler

College of Sciences

Works (2)

Updated: July 6th, 2023 21:21

2021 article

Protein engineering for natural product biosynthesis and synthetic biology applications

Calzini, M. A., Malico, A. A., Mitchler, M. M., & Williams, G. J. (2021, January 1). Protein Engineering Design and Selection.

By: M. Calzini n, A. Malico n, M. Mitchler n & G. Williams n 

author keywords: biosynthesis; natural products; peptides; polyketides; synthetic biology; terpenes
MeSH headings : Biocatalysis; Biological Products; Peptides / metabolism; Protein Engineering; Synthetic Biology
topics (OpenAlex): Microbial Natural Products and Biosynthesis; Plant biochemistry and biosynthesis; Biochemical and Structural Characterization
TL;DR: This work details the most recent advances, focusing on polyketides, non-ribosomal peptides and isoprenoids, including their native biosynthetic logic to provide clarity for future applications of these technologies for natural product synthetic biology. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2021 article

Transcription factor-based biosensors: a molecular-guided approach for natural product engineering

Mitchler, M. M., Garcia, J. M., Montero, N. E., & Williams, G. J. (2021, January 23). Current Opinion in Biotechnology.

By: M. Mitchler n, J. Garcia n, N. Montero n & G. Williams n 

MeSH headings : Biological Products; Biosensing Techniques; Biosynthetic Pathways; High-Throughput Screening Assays; Metabolic Engineering; Transcription Factors / genetics
topics (OpenAlex): CRISPR and Genetic Engineering; Viral Infectious Diseases and Gene Expression in Insects; Microbial Metabolic Engineering and Bioproduction
TL;DR: The development and application of engineered allosteric transcription factor-based biosensors is described that enable optimization of precursor availability, product titers, and downstream product tailoring for advancing the natural product bioeconomy. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 26, 2021

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