Melissa Marie Mitchler

College of Sciences

Works (2)

Updated: July 6th, 2023 21:21

2021 review

Protein engineering for natural product biosynthesis and synthetic biology applications

[Review of ]. PROTEIN ENGINEERING DESIGN & SELECTION, 34.

By: M. Calzini n, A. Malico n, M. Mitchler n & G. Williams n 

author keywords: biosynthesis; natural products; peptides; polyketides; synthetic biology; terpenes
MeSH headings : Biocatalysis; Biological Products; Peptides / metabolism; Protein Engineering; Synthetic Biology
TL;DR: This work details the most recent advances, focusing on polyketides, non-ribosomal peptides and isoprenoids, including their native biosynthetic logic to provide clarity for future applications of these technologies for natural product synthetic biology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2021 review

Transcription factor-based biosensors: a molecular-guided approach for natural product engineering

[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 69, 172–181.

By: M. Mitchler n, J. Garcia n, N. Montero n & G. Williams n 

MeSH headings : Biological Products; Biosensing Techniques; Biosynthetic Pathways; High-Throughput Screening Assays; Metabolic Engineering; Transcription Factors / genetics
TL;DR: The development and application of engineered allosteric transcription factor-based biosensors is described that enable optimization of precursor availability, product titers, and downstream product tailoring for advancing the natural product bioeconomy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2021

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