Minhua Nie

Works (3)

Updated: April 25th, 2025 18:07

2024 journal article

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Bioorganic & Medicinal Chemistry Letters, 99, 129609.

By: M. Nie n, M. Alejandro Valdes-Pena n, B. Frohock n, E. Smits n, J. Daiker n, J. Gilbertie n, L. Schnabel n , J. Pierce n 

author keywords: Natural products; Antibiotics; Antimicrobial resistance; Biofilms; 2 3-pyrrolidinedione
MeSH headings : Anti-Bacterial Agents / pharmacology; Staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus; Methicillin Resistance; Biofilms; Microbial Sensitivity Tests
topics (OpenAlex): Antimicrobial Peptides and Activities; Chemical Synthesis and Analysis; Phenothiazines and Benzothiazines Synthesis and Activities
TL;DR: A new library of 2,3-pyrrolidinedione analogues is reported that expands on the previous report on the antimicrobial studies of this heterocyclic scaffold and displayed antibiofilm properties and represent intriguing scaffolds for further optimization and development. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 7, 2024

2024 journal article

Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicate S. aureus biofilms

Chemical Communications, 60(81), 11540–11543.

By: M. Valdes-Pena n, A. Ratchford n, M. Nie n, L. Schnabel n  & J. Pierce n 

MeSH headings : Biofilms / drug effects; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / chemical synthesis; Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Heterocyclic Compounds / chemistry; Heterocyclic Compounds / pharmacology; Heterocyclic Compounds / chemical synthesis; Molecular Structure; Pyrrolidines / chemistry; Pyrrolidines / pharmacology; Pyrrolidines / chemical synthesis; Humans; Structure-Activity Relationship; Pyrrolidinones / chemistry; Pyrrolidinones / pharmacology; Pyrrolidinones / chemical synthesis
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Antimicrobial agents and applications
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 30, 2024

2024 article

Toxicology study of a tissue anchoring paclitaxel prodrug

Chinthapatla, R., Stephens, J. Q., Neumann-Rivera, I. B., Henderson, N. M., Nie, M., Haynes, H. R., … Oh, A. (2024, December 5). BMC Pharmacology and Toxicology, Vol. 25.

By: R. Chinthapatla n, J. Stephens n, I. Neumann-Rivera n, N. Henderson n, M. Nie n, H. Haynes  n, J. Pierce n , D. Meritet n, Y. Brudno n , A. Oh n 

author keywords: Tissue-Reactive Anchoring Pharmaceuticals (TRAPs); Paclitaxel; Drug delivery; Cremophor; Local chemotherapy
MeSH headings : Paclitaxel / toxicity; Paclitaxel / pharmacokinetics; Paclitaxel / administration & dosage; Animals; Prodrugs / pharmacokinetics; Prodrugs / administration & dosage; Mice; Antineoplastic Agents, Phytogenic / pharmacokinetics; Antineoplastic Agents, Phytogenic / toxicity; Antineoplastic Agents, Phytogenic / administration & dosage; Female
topics (OpenAlex): Cancer Treatment and Pharmacology; Glioma Diagnosis and Treatment; 3D Printing in Biomedical Research
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Sources: Web Of Science, NC State University Libraries
Added: December 16, 2024

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