Works (6)
Updated: July 5th, 2023 15:45
2015 journal article
Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery
Pharmaceutical Research, 32(10), 3248–3260.
author keywords: Microparticle; Nanoparticle; PEGylation; Pulmonary drug delivery
MeSH headings : Animals; Cell Line; Chemokine CXCL2 / metabolism; Dendritic Cells / metabolism; Drug Delivery Systems / methods; Female; Granulocytes / metabolism; Hydrogel, Polyethylene Glycol Dimethacrylate / metabolism; Inflammation / metabolism; Interleukin-6 / metabolism; Lung / metabolism; Macrophages, Alveolar / metabolism; Mice; Mice, Inbred C57BL; Nanoparticles / metabolism; Particle Size; Polyethylene Glycols / metabolism; Polymers / metabolism
TL;DR:
Surface modification with PEGylation was found to significantly increase lung residence times and homogeneous lung distribution, delaying macrophage clearance of all sizes, with the largest increase in residence time observed for 80 × 320 nm particles.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2015 journal article
Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 12(3), 677–687.
author keywords: Nanoparticle; Lung; Dendritic cell; Pulmonary drug delivery; Vaccine
TL;DR:
The interaction of nanoparticles with various types of lung antigen presenting cells is investigated in an attempt to understand the cellular mechanisms that explain the increased efficacy of cationic formulations as a pulmonary vaccine carrier.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance
ACS NANO, 10(1), 861–870.
author keywords: nanoparticle; orthotopie; pharmacokinetic; immunology; intravital
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Cisplatin / chemistry; Cisplatin / pharmacokinetics; Cisplatin / pharmacology; Drug Compounding; Ear / anatomy & histology; Ear / blood supply; Humans; Hydrogels / chemistry; Immunity, Innate; Liver / drug effects; Liver / immunology; Liver / metabolism; Lung / drug effects; Lung / immunology; Lung / pathology; Lung Neoplasms / immunology; Lung Neoplasms / pathology; Lung Neoplasms / therapy; Macrophages / drug effects; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Mice, Nude; Nanoparticles / chemistry; Nanoparticles / metabolism; Neoplasm Transplantation; Primary Cell Culture; Spleen / drug effects; Spleen / metabolism; Time-Lapse Imaging
TL;DR:
It is found that tumor presence significantly increased clearance of PRINT hydrogel nanoparticles from the circulation, resulting in increased accumulation in the liver and spleen, due to an increase in M2-like macrophages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(2), 488–493.
author keywords: vaccine; cationic; nanoparticle; pulmonary; mucosal
MeSH headings : Animals; Antibody Formation; Antigens / administration & dosage; CD4-Positive T-Lymphocytes / immunology; Chemokines / biosynthesis; Cytokines / biosynthesis; Dendritic Cells / immunology; Hydrogels / administration & dosage; Hydrogels / chemistry; Immunity, Mucosal; Immunization / methods; Ligands; Lung / immunology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Ovalbumin / administration & dosage; Ovalbumin / immunology; Static Electricity; Surface Properties; Toll-Like Receptors / metabolism; Vaccines, Subunit / administration & dosage
TL;DR:
It is found that positively charged nanoparticles induce robust mucosal and systemic antibody responses following pulmonary administration, whereas negatively charge nanoparticles fail to do so, and these studies highlight the importance of NP surface charge when designing pulmonary vaccines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Nanoparticle clearance is governed by Th1/Th2 immunity and strain background
JOURNAL OF CLINICAL INVESTIGATION, 123(7), 3061–3073.
MeSH headings : Animals; Area Under Curve; Drug Carriers / pharmacokinetics; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Fluorescence; Nanoparticles; Species Specificity; Th1 Cells / immunology; Th1 Cells / metabolism; Th2 Cells / immunology; Th2 Cells / metabolism
TL;DR:
It is demonstrated that mouse strains that are prone to Th1 immune responses clear nanoparticles at a slower rate than Th2-prone mice, and this effect was confirmed in human monocyte-derived macrophages, suggesting that global immune regulation has a significant impact on nanoparticle clearance in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics
NANO LETTERS, 12(10), 5304–5310.
author keywords: PRINT; nanoparticle; PEGylation; protein adsorption; macrophage association; pharmacokinetics
MeSH headings : Adsorption; Animals; Female; Hydrogels; Macrophages / physiology; Mice; Mice, Inbred BALB C; Molecular Conformation; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanotechnology; Phagocytosis; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacokinetics; Protein Binding; Surface Properties; Tissue Distribution
TL;DR:
Overall, the methodology provides a rapid screening technique to predict particle behavior in vivo and the results deliver further insight to what PEG density is necessary to facilitate long-circulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018