Matthew Hart

College of Sciences

2019 journal article

Genetically Encoded, Functional Single-Strand RNA Origami: Anticoagulant


By: A. Krissanaprasit n, C. Key n, M. Fergione n, K. Froehlich n, S. Pontula, M. Hart n, P. Carriel n, J. Kjems*, E. Andersen*, T. LaBean n

author keywords: anticoagulants; in vitro transcription; nucleic acid nanotechnology; RNA aptamers; RNA origami
MeSH headings : Anticoagulants / chemistry; Anticoagulants / pharmacology; Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / metabolism; Aptamers, Nucleotide / pharmacology; Humans; Nucleic Acid Conformation; Partial Thromboplastin Time; RNA / chemistry; RNA / pharmacology; Thrombin / antagonists & inhibitors; Thrombin / genetics; Thrombin / metabolism
TL;DR: A family of self‐folding, functional RNA origami molecules bearing multiple thrombin‐binding RNA aptamers and showing significantly improved anticoagulant activity is described, paving the way for development of RNA Origami for potential therapeutic applications especially as a safer surgical anticogulant. (via Semantic Scholar)
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Source: Web Of Science
Added: July 29, 2019

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