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Works (29)
Updated: April 5th, 2024 11:01
2024 article
A novel in vitro model of clinical cryoablation to investigate the transition zone for focal tumor ablation
Vrabel, M. R., Fesmire, C. C., Rich, M. J., Kobrin, R. L., Sano, M. B., & Zaharoff, D. A. (2024, March). CRYOBIOLOGY, Vol. 114.
author keywords: Cryoablation; Focal ablation; Prostate cancer; Clinical ablation; Immunogenic cell death; Transition zone; Cryosurgery
TL;DR:
A longer freezing duration, higher freezing intensity, and more freeze thaw cycles led to higher levels of cancer cell death and smaller transition zones, which have the potential to inform future preclinical research and to improve therapeutic combinations with CA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: March 4, 2024
2024 journal article
Investigation of integrated time nanosecond pulse irreversible electroporation against spontaneous equine melanoma
FRONTIERS IN VETERINARY SCIENCE, 11.
author keywords: focal ablation; pulsed field ablation; INSPIRE; skin cancer; clinical trial
TL;DR:
This novel therapeutic approach has the potential to expand the role of pulsed electric fields in veterinary patients, especially when general anesthesia is contraindicated, and warrants future studies to demonstrate the efficacy of INSPIRE as a solid tumor treatment.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 19, 2024
2022 journal article
Polymer Nanoparticles Enhance Irreversible Electroporation In Vitro
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 69(7), 2353–2362.
author keywords: Nanoparticles; Electric fields; Electroporation; Media; Polymers; Electrodes; Tumors; Irreversible electroporation; pulsed electric fields; tumor ablation; oncology; nanoparticle; nanobiotechnology; flash nanoprecipitation; polyelectrolyte
MeSH headings : Ablation Techniques; Electric Conductivity; Electroporation / methods; Nanoparticles; Polymers
TL;DR:
Results demonstrate the synergy of a combined cationic polymer nanoparticle and pulsed electric field treatment for the ablation of cancer cells, and set the foundation for polymer nanoparticles engineered specifically for irreversible electroporation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 11, 2022
2021 journal article
Electro-Thermal Therapy Algorithms and Active Internal Electrode Cooling Reduce Thermal Injury in High Frequency Pulsed Electric Field Cancer Therapies
ANNALS OF BIOMEDICAL ENGINEERING, 49(1), 191–202.
author keywords: Electro-thermal therapy; Focal ablation; Non-thermal irreversible electroporation; H-FIRE; Liver cancer
MeSH headings : Ablation Techniques / adverse effects; Algorithms; Electrodes; Electroporation; Liver / surgery; Neoplasms / therapy; Temperature
TL;DR:
It was demonstrated that the addition of internal electrode cooling and active temperature control algorithms reduced ETT treatment times by 84% (from 343 to 54 s) vs. non-cooled temperature control strategies with equivalent thermal injury volumes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 15, 2020
2020 journal article
Algorithmically Controlled Electroporation: A Technique for Closed Loop Temperature Regulated Pulsed Electric Field Cancer Ablation
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 67(8), 2176–2186.
author keywords: Temperature control; Temperature measurement; Temperature sensors; Electric fields; Protocols; Temperature dependence; In vitro; Non-thermal high frequency irreversible electroporation; electro-thermal therapy; pulsed electric field; bioelectric; electroporation
MeSH headings : Electricity; Electroporation; Humans; Models, Theoretical; Neoplasms; Temperature
TL;DR:
The results of this study indicate ablative outcomes due to exposure to pulses on the order of one microsecond may be thermally mediated and dependent on local tissue temperatures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 10, 2020
2020 journal article
Electro-thermal therapy: Microsecond duration pulsed electric field tissue ablation with dynamic temperature control algorithms
COMPUTERS IN BIOLOGY AND MEDICINE, 121.
author keywords: Cancer therapy; Irreversible electroporation; Thermal ablation; H-FIRE; NK-IRE
MeSH headings : Algorithms; Electrodes; Electroporation; Liver / surgery; Temperature
TL;DR:
The results establish ETT as a viable method for hepatic tumor treatment with ablation profiles equivalent to other energy based techniques and the single applicator and multi-applicator approaches demonstrated may enable the treatment of complex tumor geometries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020
2020 journal article
High-Frequency Irreversible Electroporation Using 5,000-V Waveforms to Create Reproducible 2-and 4-cm Ablation Zones - A Laboratory Investigation Using Mechanically Perfused Liver
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 31(1), 162–168.
MeSH headings : Ablation Techniques / adverse effects; Animals; Electroporation; Liver / injuries; Liver / pathology; Liver / surgery; Perfusion; Sus scrofa; Time Factors
TL;DR:
Investigating if high-frequency irreversible electroporation treatments can be delivered at higher voltages and with greater energy delivery rates than currently implemented in clinical irreversible Electroporation protocols found that H-FIRE treatments can rapidly and reproducibly create 2-cm ablations using an A+GP configuration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 3, 2020
2020 journal article
Temperature Dependence of High Frequency Irreversible Electroporation Evaluated in a 3D Tumor Model
ANNALS OF BIOMEDICAL ENGINEERING, 48(8), 2233–2246.
author keywords: Nano-knife irreversible electroporation (NK-IRE); Electro thermal therapy; Tissue ablation; Cancer therapy; Integrated energized time (IET); Pulsed electric fields
MeSH headings : Cell Death; Cell Line, Tumor; Cell Survival; Electroporation; Glioblastoma / metabolism; Glioblastoma / pathology; Humans; Models, Biological; Temperature
TL;DR:
Results were found for pancreatic cancer cells which indicate that tissue temperature may be a significant factor affecting H-FIRE ablation size and treatment planning in vivo while lower temperatures may be useful in maintaining cell viability for transfection applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020
2018 journal article
Optimization of a single insertion electrode array for the creation of clinically relevant ablations using high-frequency irreversible electroporation
Computers in Biology and Medicine, 95, 107–117.
author keywords: Focal ablation; HFIRE; Cancer therapy; Non-thermal; Device modeling; Finite element model
MeSH headings : Animals; Cattle; Electrodes; Electroporation / methods; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Models, Theoretical
TL;DR:
Numerical simulations develop numerical simulations that demonstrate the potential for clinically relevant ablations with H-FIRE delivered via a single insertion technique comprised of an expandable array and a distally placed grounding pad and indicate that in vivo investigation of asingle insertion array and grounding pad are warranted.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2018 journal article
Reduction of Muscle Contractions during Irreversible Electroporation Therapy Using High-Frequency Bursts of Alternating Polarity Pulses: A Laboratory Investigation in an Ex Vivo Swine Model
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 29(6), 893–898.
MeSH headings : Animals; Electroporation / methods; Female; In Vitro Techniques; Liver / pathology; Models, Animal; Muscle Contraction / physiology; Swine
TL;DR:
H-FIRE appears to be an effective technique to mitigate the muscle contractions associated with traditional IRE pulses, which may enable the use of voltages greater than 3,000 V necessary for the creation of large ablations in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Synergistically Enhancing the Therapeutic Effect of Radiation Therapy with Radiation Activatable and Reactive Oxygen Species-Releasing Nanostructures
ACS Nano, 12(5), 4946–4958.
author keywords: radiation/chemotherapy; radio sensitizer; reactive oxygen species; gold-titanium oxide nanoparticles; heterogeneous interface; triple-negative breast cancers
MeSH headings : Animals; Apoptosis; Biocompatible Materials / chemistry; Cell Line, Tumor; Cell Survival; Female; Gold / chemistry; Humans; Metal Nanoparticles / chemistry; Mice, Nude; Neoplasm Transplantation; Polyethylene Glycols / chemistry; Radiation-Sensitizing Agents / chemistry; Radiation-Sensitizing Agents / therapeutic use; Reactive Oxygen Species / metabolism; Tissue Distribution; Titanium / chemistry; Triple Negative Breast Neoplasms / metabolism; Triple Negative Breast Neoplasms / radiotherapy
TL;DR:
Significant tumor growth suppression and overall improvement in survival rate in a TNBC tumor model have been successfully demonstrated under DAT uptake for a radio-sensitized radiation therapy.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2017 journal article
A Comprehensive Characterization of Parameters Affecting High-Frequency Irreversible Electroporation Lesions
Annals of Biomedical Engineering, 45(11), 2524–2534.
author keywords: Focal ablation; Non-thermal therapy; H-FIRE; Tissue phantom
MeSH headings : Cell Death; Electroporation / methods; Finite Element Analysis; Phantoms, Imaging; Solanum tuberosum
TL;DR:
H-FIRE treatment protocols can be optimized to produce clinically relevant lesions while maintaining the benefits of a non-thermal ablation technique, as shown in a potato tissue phantom model.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2017 journal article
Asymmetric Waveforms Decrease Lethal Thresholds in High Frequency Irreversible Electroporation Therapies
Scientific Reports, 7(1).
MeSH headings : Cell Line, Tumor; Electroporation / methods; Humans; Radio Waves; Spheroids, Cellular; Tumor Cells, Cultured
TL;DR:
This study shows that asymmetric H-FIRE waveforms can be used to create ablation volumes equivalent to standard IRE treatments, and predicts that in vivo investigation of asymmetric waveforms is warranted.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2017 journal article
Irreversible electroporation for the ablation of pancreatic malignancies: A patient‐specific methodology
Journal of Surgical Oncology, 115(6), 711–717.
author keywords: finite element analysis; impedance; IRE; pancreatic adenocarcinoma; real-time feedback; treatment planning
MeSH headings : Ablation Techniques / methods; Aged; Electroporation / methods; Finite Element Analysis; Humans; Male; Models, Anatomic; Pancreatic Neoplasms / diagnostic imaging; Pancreatic Neoplasms / surgery; Precision Medicine / methods
TL;DR:
This group sought to address the challenge of predicting the ablation volume with IRE for pancreatic procedures with a novel, scalable, and scalable approach that addresses the need for real-time information about the volume of ablation activity during surgery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2016 journal article
Production of Spherical Ablations Using Nonthermal Irreversible Electroporation: A Laboratory Investigation Using a Single Electrode and Grounding Pad
Journal of Vascular and Interventional Radiology, 27(9), 1432–1440.e3.
MeSH headings : Ablation Techniques / instrumentation; Animals; Computer Simulation; Electrodes; Electroporation / instrumentation; Equipment Design; Finite Element Analysis; In Vitro Techniques; Liver / pathology; Liver / surgery; Materials Testing; Numerical Analysis, Computer-Assisted; Swine
TL;DR:
Computer modeling showed that the P+GP configuration for IRE procedures yields ablations that are larger than the 2EP configuration, creating substantial ablation zones with a single electrode placement.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth
Scientific Reports, 5(1).
MeSH headings : Animals; Cell Line, Tumor; Disease Models, Animal; Electroporation / methods; Male; Mice; Neoplasms / pathology; Neoplasms / therapy; Tumor Burden; Xenograft Model Antitumor Assays
TL;DR:
This work explored the pulse-duration space between 250 ns and 100 μs and determined the lethal electric field intensity for specific H-FIRE protocols using a 3D tumor mimic, showing the potential for H- FIRE to be used as a focal therapy and merits its investigation in larger pre-clinical models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2015 journal article
Targeted cellular ablation based on the morphology of malignant cells
Scientific Reports, 5(1).
MeSH headings : Animals; Brain Neoplasms / pathology; Brain Neoplasms / therapy; Brain Neoplasms / veterinary; Cell Line, Tumor; Cell Nucleus Size; Cell Shape; Cell Survival; Coculture Techniques; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Electroporation; Finite Element Analysis; Glioblastoma / pathology; Glioblastoma / therapy; Glioblastoma / veterinary; Humans; Hydrogels / chemistry; Single-Cell Analysis
TL;DR:
A physical treatment method based on electrical disruption of cells, whose action depends strongly on cellular morphology, that may be useful in safely targeting the therapy-resistant cell niches that cause recurrence of GBM tumors is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2014 journal article
In-vitro bipolar nano- and microsecond electro-pulse bursts for irreversible electroporation therapies
Bioelectrochemistry, 100, 69–79.
author keywords: High frequency; Cancer; Non-thermal; Ablation
MeSH headings : Animals; Cell Line, Tumor; Cell Membrane; Cell Membrane Permeability; Electric Stimulation Therapy / adverse effects; Electric Stimulation Therapy / methods; Electroporation / methods; Mice; Models, Biological; Nuclear Envelope; Time Factors
TL;DR:
It is shown that these bursts result in instantaneous and delayed cell death mechanisms and that there exists an inverse relationship between pulse-width and toxicity despite the delivery of equal quantities of energy.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Investigating dielectric properties of different stages of syngeneic murine ovarian cancer cells
Biomicrofluidics, 7(1), 011809.
author keywords: bioelectric phenomena; biomedical measurement; biomembranes; bioMEMS; cancer; capacitance; cellular biophysics; electrophoresis; microfluidics
TL;DR:
Studying the electrical properties of MOSE cells provides important information as a first step to develop cancer-treatment techniques which could partially reverse the cytoskeleton disorganization of malignant cells to a morphology more similar to that of benign cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
Joule heating effects on particle immobilization in insulator-based dielectrophoretic devices
ELECTROPHORESIS, 35(2-3), 352–361.
author keywords: Dielectrophoresis; Electrokinetic; Joule heating; Microchannel
MeSH headings : Electric Conductivity; Electrophoresis / instrumentation; Finite Element Analysis; Hot Temperature; Kinetics; Microfluidic Analytical Techniques / instrumentation; Microspheres
TL;DR:
It was observed that a temperature gradient is formed along the microchannel, which redistributes the conductivity of the suspending medium leading to an increase of the dielectrophoretic force toward the inlet of the channel while decreasing toward the outlet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
Simultaneous electrokinetic flow and dielectrophoretic trapping using perpendicular static and dynamic electric fields
Microfluidics and Nanofluidics, 15(5), 599–609.
author keywords: Microfluidics; Numerical model; Electrokinetic micropump; Electro-osmosis; Contactless dielectrophoresis
Source: Crossref
Added: August 28, 2020
2012 journal article
Dielectrophoretic differentiation of mouse ovarian surface epithelial cells, macrophages, and fibroblasts using contactless dielectrophoresis
Biomicrofluidics, 6(2), 024104.
TL;DR:
It is predicted that cDEP can be utilized for isolation of ovarian cancer cells from peritoneal fluid as an early cancer detection tool.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Multilayer contactless dielectrophoresis: Theoretical considerations
ELECTROPHORESIS, 33(13), 1938–1946.
author keywords: Cancer detection; High throughput; Microfluidics; Numerical model; Rare cell isolation
MeSH headings : Cell Line, Tumor; Cell Separation / instrumentation; Cell Separation / methods; Computer Simulation; Electric Conductivity; Electrophoresis / instrumentation; Electrophoresis / methods; Humans; Models, Theoretical; Reproducibility of Results
TL;DR:
This work investigates, for the first time, the properties of multilayer devices in which the sample and electrode channels occupy distinct layers, and concludes that the ultimate limiting factors in device performance resides in breakdown voltage of the barrier material and the ability to generate high‐voltage, high‐frequency signals.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Contactless dielectrophoretic spectroscopy: Examination of the dielectric properties of cells found in blood
ELECTROPHORESIS, 32(22), 3164–3171.
author keywords: Cancer detection; Clausius-Mossotti factor; Dielectrophoresis; Microfluidics; Sample isolation
MeSH headings : Cell Line, Tumor; Cell Separation / instrumentation; Cell Separation / methods; Computer Simulation; Electrophoresis / instrumentation; Humans; Neoplastic Cells, Circulating / chemistry; Spectrum Analysis / instrumentation
TL;DR:
By first establishing the dielectrophoretic responses of cancerous cells within this cDEP device, conditions to detect and enrich tumor cells from mixtures with non‐transformed cells can be determined providing further information to develop methods to isolate these rare cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Modeling and development of a low frequency contactless dielectrophoresis (cDEP) platform to sort cancer cells from dilute whole blood samples
Biosensors and Bioelectronics, 30(1), 13–20.
author keywords: Electrokinetics; Enrichment; Selective isolation; Cancer detection; Lab on a chip
MeSH headings : Biosensing Techniques / instrumentation; Blood Component Removal / instrumentation; Cell Separation / instrumentation; Computer Simulation; Computer-Aided Design; Conductometry / instrumentation; Electrophoresis / instrumentation; Equipment Design; Equipment Failure Analysis; Microfluidic Analytical Techniques / instrumentation; Models, Theoretical; Neoplasms / pathology
TL;DR:
This work presents a continuous sorting device which is the first cDEP design capable of exploiting the Clausius-Mossotti factor at frequencies where it is both positive and negative for mammalian cells.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Selective concentration of human cancer cells using contactless dielectrophoresis
ELECTROPHORESIS, 32(18), 2523–2529.
author keywords: Clausius-Mossotti factor; Dielectrophoresis; Enrichment; Microfluidics; Sample isolation
MeSH headings : Cell Line, Tumor; Cell Separation / instrumentation; Cell Separation / methods; Electrodes; Electrophoresis / instrumentation; Electrophoresis / methods; Humans; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Neoplasms / chemistry; Neoplasms / pathology
TL;DR:
This work is the first to demonstrate the ability of contactless dielectrophoresis (cDEP) to isolate target cell species from a heterogeneous sample of live cells and could provide a workbench for clinicians to detect transformed cells at their earliest stage, screen drug therapies prior to patient treatment, increasing the probability of success, and eliminate unsuccessful treatment options.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2010 journal article
Electromagnetically Controlled Biological Assembly of Aligned Bacterial Cellulose Nanofibers
Annals of Biomedical Engineering, 38(8), 2475–2484.
author keywords: Acetobacter xylinum; Biological assembly; Directed biofabrication; Electrokinetics
MeSH headings : Air; Bacteria; Cellulose / biosynthesis; Cellulose / ultrastructure; Culture Media; Electricity; Gluconacetobacter xylinus / metabolism; Magnetics; Nanofibers; Oxygen / metabolism
TL;DR:
A new biofabrication process in which the precise control of bacterial motion is used to fabricate customizable networks of cellulose nanofibrils, demonstrating a new concept of bottom up material synthesis by the control of a biological assembly process.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Selective isolation of live/dead cells using contactless dielectrophoresis (cDEP)
Lab on a Chip, 10(4), 438.
MeSH headings : Animals; Cell Death; Cell Line, Tumor; Cell Separation / instrumentation; Cell Separation / methods; Cell Survival; Electric Conductivity; Electrophoresis; Humans
TL;DR:
Two microfluidic devices capable of selectively isolating live human leukemia cells from dead cells utilizing their electrical signatures are presented, achieving greater than 95% removal efficiency and 100% selectivity between live and dead cells.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2009 journal article
Contactless dielectrophoresis: a new technique for cell manipulation
Biomedical Microdevices, 11(5), 997–1006.
author keywords: BioMEMS; Biochip; Dielectrophoretic; Microfluidics; Sample handling; Electrorotation; Sample preparation
MeSH headings : Cell Line, Tumor; Cell Separation / instrumentation; Dimethylpolysiloxanes / chemistry; Electric Impedance; Electrodes; Electrophoresis / instrumentation; Humans; Microfluidic Analytical Techniques / instrumentation; Models, Theoretical; Rotation
TL;DR:
This technique combines the cell manipulation abilities of traditional DEP with the ease of fabrication found in insulator-based technologies and was able to demonstrate cell responses unique to the DEP effect in three separate cell lines.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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