Meghan Scobee Blackledge

Works (5)

Updated: July 5th, 2023 15:43
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2017 journal article

Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome

JOURNAL OF DENTAL RESEARCH, 96(7), 807–814.

By: S. Garcia*, M. Blackledge n, S. Michalek*, L. Su *, T. Ptacek *, P. Eipers*, C. Morrow*, E. Lefkowitz *, C. Melander n, H. Wu *

author keywords: microbiota; rats; dental enamel; microscopy; bacteria; microbial ecology
MeSH headings : Animals; Biofilms / drug effects; Dental Caries / prevention & control; Dental Enamel / drug effects; Imidazoles / pharmacology; Microbiota / drug effects; Microscopy, Confocal; Polymerase Chain Reaction; Rats; Streptococcus gordonii / drug effects; Streptococcus mutans / drug effects; Streptococcus sanguis / drug effects
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii

CURRENT DRUG DELIVERY, 12(2), 223–230.

By: S. Stowe*, R. Thompson*, L. Peng*, Z. Su*, M. Blackledge*, G. Draughn, W. Coe, E. Johannes* ...

author keywords: 2-aminoimidazole; Acinetobacter baumannii; biofilm; membrane permeabilization; reverse amide; SEM
MeSH headings : Acinetobacter baumannii / drug effects; Amides / chemistry; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Cell Membrane Permeability / drug effects; Cells, Cultured; Cross Infection; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Biologically inspired strategies for combating bacterial biofilms

CURRENT OPINION IN PHARMACOLOGY, 13(5), 699–706.

By: M. Blackledge n, R. Worthington n & C. Melander n

MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / metabolism; Bacterial Physiological Phenomena / drug effects; Biofilms / drug effects; Humans; Quorum Sensing / drug effects; Signal Transduction / drug effects
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Programmable DNA-binding small molecules

BIOORGANIC & MEDICINAL CHEMISTRY, 21(20), 6101–6114.

By: M. Blackledge n & C. Melander n

author keywords: Polyamide; Transcription; Minor groove; DNA binding
MeSH headings : Animals; DNA / chemistry; DNA / drug effects; DNA / genetics; Gene Expression / drug effects; Humans; Imidazoles / chemistry; Imidazoles / pharmacology; Pyrroles / chemistry; Pyrroles / pharmacology
Source: Web Of Science
Added: August 6, 2018

2013 review

Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence

[Review of ]. FUTURE MEDICINAL CHEMISTRY, 5(11), 1265–1284.

By: R. Worthington n, M. Blackledge n & C. Melander n

MeSH headings : Bacteria / metabolism; Bacteria / pathogenicity; Bacterial Infections / drug therapy; Bacterial Proteins / antagonists & inhibitors; Bacterial Proteins / metabolism; Biofilms / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Histidine Kinase; Humans; Protein Kinases / chemistry; Protein Kinases / metabolism; Signal Transduction / drug effects; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; Small Molecule Libraries / therapeutic use; Virulence / drug effects
Source: Web Of Science
Added: August 6, 2018