@article{sun_bedlack_armon_beauchamp_bertorini_bowser_bromberg_caress_carter_crayle_et al._2022, title={ALSUntangled #64: butyrates}, ISSN={["2167-9223"]}, DOI={10.1080/21678421.2022.2045323}, abstractNote={Abstract ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review butyrate and its different chemical forms (butyrates). Butyrates have plausible mechanisms for slowing ALS progression and positive pre-clinical studies. One trial suggests that sodium phenylbutyrate (NaPB) in combination with Tauroursodeoxycholic acid (TUDCA) can slow ALS progression and prolong survival, but the specific contribution of NaPB toward this effect is unclear. Butyrates appear reasonably safe for use in humans. Based on the above information, we support a trial of a butyrate in PALS, but we cannot yet recommend one as a treatment.}, journal={AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION}, author={Sun, Yuyao and Bedlack, Richard and Armon, Carmel and Beauchamp, Morgan and Bertorini, Tulio and Bowser, Robert and Bromberg, Mark and Caress, James and Carter, Gregory and Crayle, Jesse and et al.}, year={2022}, month={Feb} }
 @article{bedlack_barkhaus_barnes_beauchamp_bertorini_bromberg_carter_chaudry_cudkowicz_jackson_et al._2021, title={ALSUntangled #63: ketogenic diets}, volume={10}, ISSN={["2167-9223"]}, DOI={10.1080/21678421.2021.1990346}, abstractNote={Abstract ALSUntangled reviews alternative and off label treatments with a goal of helping patients make more informed decisions about them. Here we review ketogenic diets. We shows that these have plausible mechanisms, including augmenting cellular energy balance and reducing excitotoxicity, neuroinflammation and oxidative stress. We review a mouse model study, anecdotal reports and trials in ALS and other diseases. We conclude that there is yet not enough data to recommend ketogenic diets for patients with ALS, especially in light of the many side effects these can have.}, journal={AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION}, author={Bedlack, Richard and Barkhaus, Paul E. and Barnes, Benjamin and Beauchamp, Morgan and Bertorini, Tulio and Bromberg, Mark B. and Carter, Gregory T. and Chaudry, Vinay and Cudkowicz, Merit and Jackson, Ce and et al.}, year={2021}, month={Oct} }