Alejandro Valdes

Works (5)

Updated: October 2nd, 2024 05:01

2024 journal article

Evaluation of commercial doses of a feed additive and silymarin on broiler performance with and without CCl4-induced liver damage

POULTRY SCIENCE, 103(5).

By: M. Carpio, M. Valdes-Pena, D. Molina, S. Cabello, C. Guerrero, G. Cribillero *, K. Coca*, E. Icochea *

author keywords: phytogenic feed additive; toxin; poultry; productive performance
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Source: Web Of Science
Added: April 22, 2024

2024 journal article

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Bioorganic & Medicinal Chemistry Letters, 99, 129609.

By: M. Nie n, M. Alejandro Valdes-Pena  n, B. Frohock n, E. Smits n, J. Daiker n, J. Gilbertie n, L. Schnabel n , J. Pierce n 

author keywords: Natural products; Antibiotics; Antimicrobial resistance; Biofilms; 2 3-pyrrolidinedione
TL;DR: A new library of 2,3-pyrrolidinedione analogues is reported that expands on the previous report on the antimicrobial studies of this heterocyclic scaffold and displayed antibiofilm properties and represent intriguing scaffolds for further optimization and development. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 7, 2024

2024 article

Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicate <i>S. aureus</i> biofilms

Valdes-Pena, M. A., Ratchford, A., Nie, M., Schnabel, L. V., & Pierce, J. G. (2024, September 23). CHEMICAL COMMUNICATIONS, Vol. 9.

By: M. Valdes-Pena  n, A. Ratchford n, M. Nie n, L. Schnabel n  & J. Pierce n 

Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 30, 2024

2024 article

Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues

Breunig, J. L., Valdes-Pena, M. A., Ratchford, A. W., & Pierce, J. G. (2024, January 12). ACS BIO & MED CHEM AU, Vol. 1.

By: J. Breunig n, M. Valdes-Pena  n, A. Ratchford n & J. Pierce n 

author keywords: antibiotics; antibiofilm; naturalproducts; multicomponent reactions; heterocycles
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 13, 2024

2021 review

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 54(8), 1866–1877.

By: M. Valdes-Pena  n, N. Massaro n, Y. Lin n & J. Pierce n 

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / pharmacology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biological Products / chemical synthesis; Biological Products / chemistry; Biological Products / pharmacology; Drug Resistance, Multiple, Bacterial / drug effects; Guanidine / analogs & derivatives; Guanidine / chemical synthesis; Guanidine / pharmacology; Guanidines / chemical synthesis; Guanidines / pharmacology; Microbial Sensitivity Tests; Oxazolidinones / chemical synthesis; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Staphylococcus aureus / physiology; Stereoisomerism; Structure-Activity Relationship
TL;DR: These studies provide several distinct platforms for the development of novel therapeutics that can add to the arsenal of scaffolds for preclinical development and can provide insight into the biochemical processes and pathways that can be targeted by small molecules in the fight against antimicrobial-resistant and -tolerant infections. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 19, 2021

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