Alejandro Valdes

Works (5)

Updated: April 25th, 2025 18:07

2024 journal article

Evaluation of commercial doses of a feed additive and silymarin on broiler performance with and without CCl4-induced liver damage

POULTRY SCIENCE, 103(5).

By: M. Carpio, M. Valdes-Pena, D. Molina, S. Cabello, C. Guerrero, G. Cribillero *, K. Coca*, E. Icochea *

author keywords: phytogenic feed additive; toxin; poultry; productive performance
MeSH headings : Animals; Silymarin / administration & dosage; Silymarin / pharmacology; Chickens; Animal Feed / analysis; Male; Diet / veterinary; Dietary Supplements / analysis; Poultry Diseases / chemically induced; Poultry Diseases / prevention & control; Chemical and Drug Induced Liver Injury / veterinary; Chemical and Drug Induced Liver Injury / prevention & control; Chemical and Drug Induced Liver Injury / etiology; Carbon Tetrachloride; Betaine / administration & dosage; Betaine / pharmacology; Random Allocation; Curcumin / administration & dosage; Curcumin / pharmacology; Liver / drug effects
topics (OpenAlex): Drug-Induced Hepatotoxicity and Protection; Silymarin and Mushroom Poisoning; Antibiotics Pharmacokinetics and Efficacy
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Source: Web Of Science
Added: April 22, 2024

2024 journal article

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Bioorganic & Medicinal Chemistry Letters, 99, 129609.

By: M. Nie n, M. Alejandro Valdes-Pena  n, B. Frohock n, E. Smits n, J. Daiker n, J. Gilbertie n, L. Schnabel n , J. Pierce n 

author keywords: Natural products; Antibiotics; Antimicrobial resistance; Biofilms; 2 3-pyrrolidinedione
MeSH headings : Anti-Bacterial Agents / pharmacology; Staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus; Methicillin Resistance; Biofilms; Microbial Sensitivity Tests
topics (OpenAlex): Antimicrobial Peptides and Activities; Chemical Synthesis and Analysis; Phenothiazines and Benzothiazines Synthesis and Activities
TL;DR: A new library of 2,3-pyrrolidinedione analogues is reported that expands on the previous report on the antimicrobial studies of this heterocyclic scaffold and displayed antibiofilm properties and represent intriguing scaffolds for further optimization and development. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 7, 2024

2024 journal article

Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicate <i>S. aureus</i> biofilms

Chemical Communications, 60(81), 11540–11543.

By: M. Valdes-Pena  n, A. Ratchford n, M. Nie n, L. Schnabel n  & J. Pierce n 

MeSH headings : Biofilms / drug effects; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / chemical synthesis; Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Heterocyclic Compounds / chemistry; Heterocyclic Compounds / pharmacology; Heterocyclic Compounds / chemical synthesis; Molecular Structure; Pyrrolidines / chemistry; Pyrrolidines / pharmacology; Pyrrolidines / chemical synthesis; Humans; Structure-Activity Relationship; Pyrrolidinones / chemistry; Pyrrolidinones / pharmacology; Pyrrolidinones / chemical synthesis
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Antimicrobial agents and applications
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 30, 2024

2024 article

Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues

Breunig, J. L., Valdes-Pena, M. A., Ratchford, A. W., & Pierce, J. G. (2024, January 12). ACS BIO & MED CHEM AU.

By: J. Breunig n, M. Valdes-Pena  n, A. Ratchford n & J. Pierce n 

author keywords: antibiotics; antibiofilm; naturalproducts; multicomponent reactions; heterocycles
topics (OpenAlex): Microbial Natural Products and Biosynthesis; Plant biochemistry and biosynthesis; Natural product bioactivities and synthesis
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 13, 2024

2021 review

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 54(8), 1866–1877.

By: M. Valdes-Pena  n, N. Massaro n, Y. Lin n & J. Pierce n 

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / pharmacology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biological Products / chemical synthesis; Biological Products / chemistry; Biological Products / pharmacology; Drug Resistance, Multiple, Bacterial / drug effects; Guanidine / analogs & derivatives; Guanidine / chemical synthesis; Guanidine / pharmacology; Guanidines / chemical synthesis; Guanidines / pharmacology; Microbial Sensitivity Tests; Oxazolidinones / chemical synthesis; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Staphylococcus aureus / physiology; Stereoisomerism; Structure-Activity Relationship
topics (OpenAlex): Microbial Natural Products and Biosynthesis; Synthesis and Catalytic Reactions; Synthesis and biological activity
TL;DR: These studies provide several distinct platforms for the development of novel therapeutics that can add to the arsenal of scaffolds for preclinical development and can provide insight into the biochemical processes and pathways that can be targeted by small molecules in the fight against antimicrobial-resistant and -tolerant infections. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 19, 2021

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