Works (26)

Updated: August 16th, 2023 21:17

2020 journal article

Cherenkov emissions for studying tumor changes during radiation therapy: An exploratory study in domesticated dogs with naturally-occurring cancer

PLOS ONE, 15(8).

By: A. Rickard*, H. Yoshikawa n, G. Palmer n, H. Liu*, M. Dewhirst n, M. Nolan n, X. Zhang

MeSH headings : Animals; Dogs; Image Processing, Computer-Assisted; Neoplasms / diagnostic imaging; Neoplasms / radiotherapy; Particle Accelerators; Pilot Projects; Prospective Studies; Radiotherapy Dosage; Tomography, X-Ray Computed; X-Rays
TL;DR: It is demonstrated that it is possible to obtain Cherenkov emissions from canine cancers within a fraction of radiotherapy, and lends credence to the goal of using this method during radiotherapy in human patients and client-owned pets. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: September 21, 2020

2011 journal article

Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics

CLINICAL CANCER RESEARCH, 17(8), 2549–2560.

By: J. Chi n, D. Thrall n, C. Jiang n, S. Snyder n, D. Fels n, C. Landon n, L. McCall n, L. Lan n ...

MeSH headings : Animals; Cluster Analysis; Combined Modality Therapy; Dogs; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomics / methods; Humans; Hyperthermia, Induced; Magnetic Resonance Imaging / methods; Oligonucleotide Array Sequence Analysis; Radiotherapy / methods; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma / genetics; Sarcoma / therapy
TL;DR: This is one of the first successful attempts to link changes in gene expression and functional imaging to understand the response heterogeneity and identify compounds enhancing thermoradiotherapy. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Dynamic Contrast-enhanced Magnetic Resonance Imaging as a Predictor of Clinical Outcome in Canine Spontaneous Soft Tissue Sarcomas Treated with Thermoradiotherapy

CLINICAL CANCER RESEARCH, 15(15), 4993–5001.

By: B. Viglianti n, M. Lora-Michiels n, J. Poulson n, L. Lan n, D. Yu n, L. Sanders n, O. Craciunescu n, Z. Vujaskovic n ...

MeSH headings : Animals; Combined Modality Therapy / veterinary; Dog Diseases / diagnosis; Dogs; Hyperthermia, Induced / veterinary; Image Enhancement; Kaplan-Meier Estimate; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary; Prognosis; Radiotherapy / veterinary; Radiotherapy Dosage / veterinary; Sarcoma / diagnosis; Sarcoma / pathology; Sarcoma / veterinary; Soft Tissue Neoplasms / diagnosis; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / veterinary; Treatment Outcome
TL;DR: DCE- MRI has utility predicting overall and metastasis-free survival in canine patients with soft tissue sarcomas, for the first time that DCE-MRI parameters are predictive of clinical outcome for soft tissue Sarcomas. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas

MOLECULAR CANCER THERAPEUTICS, 6(1), 380–389.

By: F. Siddiqui, C. Li*, S. LaRue, J. Poulson*, P. Avery*, A. Pruitt n, X. Zhang*, R. Ullrich ...

MeSH headings : Adenoviridae; Animals; Cats; Cytomegalovirus / genetics; Feasibility Studies; Genetic Therapy / adverse effects; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Hyperthermia, Induced; Interleukin-12 / blood; Interleukin-12 / genetics; Interleukin-12 / therapeutic use; Liver / pathology; Mice; Promoter Regions, Genetic / genetics; Recombinant Proteins / adverse effects; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Recombinant Proteins / therapeutic use; Sarcoma / drug therapy; Sarcoma / genetics; Sarcoma / radiotherapy; Sarcoma / veterinary
TL;DR: An adenoviral gene therapy vector with IL-12 controlled by a heat-inducible promoter (heat shock promoter 70B) was developed and tested in a phase I clinical trial in cats with spontaneously arising soft tissue sarcoma, finding it possible to localize gene expression and limit systemic toxicity of IL- 12 using the hyperthermia-induced gene therapy approach. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral Doxil extravasation

CLINICAL CANCER RESEARCH, 12(22), 6800–6807.

By: M. Kleiter*, D. Yu, L. Mohammadian*, N. Niehaus, I. Spasojevic*, L. Sanders*, B. Viglianti*, P. Yarmolenko* ...

MeSH headings : Animals; Antibiotics, Antineoplastic / pharmacokinetics; Antibiotics, Antineoplastic / therapeutic use; Combined Modality Therapy / methods; Diagnostic Imaging / methods; Dose-Response Relationship, Drug; Doxorubicin / pharmacokinetics; Doxorubicin / therapeutic use; Drug Carriers / administration & dosage; Feasibility Studies; Female; Fibrosarcoma / therapy; Hyperthermia, Induced / methods; Liposomes / administration & dosage; Liposomes / pharmacokinetics; Radioactive Tracers; Rats; Technetium Tc 99m Exametazime / administration & dosage; Thigh / radiation effects; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
TL;DR: The use of a radiolabeled tracer has potential value to monitor drug delivery and estimate the effect of an intervention aimed to increase liposomal accumulation, such as local hyperthermia. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 22(5), 365–373.

By: D. Thrall n, S. Larue*, A. Pruitt n, B. Case n & M. DeWhirst*

author keywords: hyperthermia; radiation therapy; dog; oxygen measurements
MeSH headings : Animals; Cell Hypoxia / physiology; Cell Hypoxia / radiation effects; Combined Modality Therapy / methods; Combined Modality Therapy / veterinary; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Oxygen / analysis; Oxygen / metabolism; Sarcoma / metabolism; Sarcoma / therapy; Sarcoma / veterinary
TL;DR: There was an increase in oxygenation in tumours with low pre-treatment oxygenation that persisted throughout treatment, an advantageous hyperthermia effect as it may lead to increased radiation cell killing at each fraction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Anesthetic considerations for the study of murine tumor models

Tumor Models in Cancer Research, 407–431.

By: R. Meyer, R. Braun & M. Dewhirst

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs

In Vivo (Athens, Greece), 14(6), 709–714.

By: J. Poulson, M. Dewhirst, A. Gaskin, Z. Vujaskovic, T. Samulski, D. Prescott, R. Meyer, R. Page, D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas

Clinical Cancer Research, 6(9), 3748–3755.

By: M. Matteucci, G. Anyarambhatla, G. Rosner, C. Azuma, P. Fisher, M. Dewhirst, D. Needham, D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Local 42 degrees C hyperthermia improves vascular conductance of the R3230Ac rat mammary adenocarcinoma during sodium nitroprusside infusion

RADIATION RESEARCH, 154(2), 196–201.

By: R. Meyer n, R. Braun*, G. Rosner* & M. Dewhirst*

TL;DR: Local 42°C tumor heating, combined with a moderate reduction in blood pressure with nitroprusside, overrides the vascular steal effect associated with reduced perfusion pressure alone and results in improved tumor perfusion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 46(1), 179–185.

By: Z. Vujaskovic*, J. Poulson*, A. Gaskin*, D. Thrall n, R. Page n, H. Charles*, . MacFall*, D. Brizel* ...

author keywords: tumors; hyperthermia blood how; pO(2); pH; thermal dose
MeSH headings : Animals; Combined Modality Therapy; Dogs; Female; Hydrogen-Ion Concentration; Hyperthermia, Induced / methods; Male; Oxygen / metabolism; Partial Pressure; Sarcoma, Experimental / blood supply; Sarcoma, Experimental / metabolism; Sarcoma, Experimental / radiotherapy; Sarcoma, Experimental / therapy; Soft Tissue Neoplasms / blood supply; Soft Tissue Neoplasms / metabolism; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / therapy
TL;DR: This study suggests that hyperthermia has biphasic effects on tumor physiologic parameters, and suggests that the thermal threshold for vascular damage is higher in spontaneous tumors than in more rapidly growing rodent tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Using units of CEM 43 degrees C T-90, local hyperthermia thermal dose can be delivered as prescribed

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 16(5), 415–428.

By: D. Thrall n, G. Rosner*, C. Azuma n, S. Larue*, B. Case n, T. Samulski*, M. Dewhirst*

author keywords: dog; hyperthermia; thermal dose
MeSH headings : Animals; Catheterization; Combined Modality Therapy; Dogs; Dose-Response Relationship, Radiation; Hyperthermia, Induced / methods; Radiotherapy / methods; Sarcoma / pathology; Sarcoma / therapy; Sarcoma / veterinary; Temperature; Time Factors
TL;DR: Relatively simple but accurate methods of delivering prescribed thermal dose as described herein will aid the translation of clinicalhyperthermia from the research setting into more general practice once the characteristics of the relationship between hyperthermia dose and outcome are understood. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Tumour cell kinetics as predictors of response in canine lymphoma treated with chemotherapy alone or combined with whole body hyperthermia

International Journal of Hyperthermia, 15(6), 475–486.

By: S. Larue*, M. Fox, G. Ogilvie, R. Page, D. Getzy, D. Thrall, J. Johnson, M. Dewhirst, E. Gillette

MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Cycle; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Doxorubicin / administration & dosage; Hyperthermia, Induced; Indazoles / administration & dosage; Lymphoma / drug therapy; Lymphoma / therapy; Lymphoma / veterinary; Prognosis
TL;DR: Kinetic parameters including potential doubling time (Tpot), duration of S phase (Ts), labelling index (LI), and DNA index (DI) were obtained from 42 dogs with previously untreated lymphoma and dogs treated only with chemotherapy had significantly longer remission duration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Use of whole body hyperthermia as a method to heat inaccessible tumours uniformly: a phase III trial in canine brain masses

International Journal of Hyperthermia, 15(5), 383–398.

By: D. Thrall, S. Larue, B. Powers, R. Page, J. Johnson, S. George, J. Kornegay, M. McEntee ...

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 13(3), 307–316.

By: M. Hauck*, D. Coffin*, R. Dodge*, M. Dewhirst*, J. Mitchell* & M. Zalutsky*

author keywords: interstitial fluid pressure; xenograft; hyperthermia
MeSH headings : Animals; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Monoclonal / therapeutic use; Biological Transport, Active; Combined Modality Therapy; Extracellular Space / physiology; Glioma / immunology; Glioma / physiopathology; Glioma / therapy; Humans; Hyperthermia, Induced / methods; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Pressure; Time Factors; Transplantation, Heterologous
TL;DR: It is demonstrated that local hyperthermia (4 h, 41.8 degrees C) is capable of significantly enhancing the uptake of radiolabelled monoclonal antibodies (mAbs) in D-54 MG glioma xenografts grown subcutaneously in athymic mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model

Clinical Cancer Research, 3, 63–70.

By: M. Hauck, M. Dewhirst, D. Bigner & M. Zaultsky

Source: NC State University Libraries
Added: August 6, 2018

1997 patent

Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders

Washington, DC: U.S. Patent and Trademark Office.

By: M. Dewhirst, R. Meyer, J. Bonaventura & J. DeAngelo

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Stroma-free human hemoglobin a decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure

RADIATION RESEARCH, 147(2), 185–194.

By: J. Hahn*, R. Braun*, M. Dewhirst*, S. Shan*, S. Snyder*, J. Taube*, E. Ong*, G. Rosner* ...

TL;DR: Vascular NO quenching provides an alternative to NO synthase inhibition as a means to achieve the goal of selective tumor hypoxia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 chapter

The use of blood substitutes in tumor therapy

In R. R. A. S. Rudolph & G. Z. Feuerstein (Eds.), Red blood cell substitutes: Basic principles and clinical application. New York: Marcel Dekker.

By: R. Meyer & M. Dewhirst

Ed(s): R. A. S. Rudolph & G. Feuerstein

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Phase I evaluation of mitoxantrone alone and combined with whole body hyperthermia in dogs with lymphoma

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 12(3), 309–320.

By: M. Hauck*, G. Price, G. Ogilvie, J. Johnson, E. Gillette, D. Thrall*, M. Dewhirst*, R. Page*

author keywords: hyperthermia; mitoxanthrone; lymphoma; canine
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / toxicity; Blood Cell Count / veterinary; Dogs; Female; Fever / veterinary; Lymphoma / metabolism; Lymphoma / therapy; Lymphoma / veterinary; Male; Mitoxantrone / therapeutic use; Mitoxantrone / toxicity; Neutropenia / complications; Neutropenia / veterinary; Neutrophils / metabolism; Regression Analysis; Thrombocytopenia / complications; Thrombocytopenia / veterinary
TL;DR: It is concluded that MX may be administered without dose reduction to dogs undergoing WBH and that MX should be evaluated more thoroughly in future thermochemotherapy studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1996 journal article

The effects of clinically relevant hyperthermic temperatures on the kinetic binding parameters of a monoclonal antibody

NUCLEAR MEDICINE AND BIOLOGY, 23(4), 551–557.

By: M. Hauck*, M. Dewhirst* & M. Zalutsky*

author keywords: monoclonal antibodies; hyperthermia; antibody binding kinetics; radiotherapy
MeSH headings : Animals; Antibodies, Monoclonal / metabolism; Antibodies, Monoclonal / pharmacokinetics; Dogs; Glioma / metabolism; Humans; Hyperthermia, Induced; Kinetics; Mice; Mice, Nude; Osteosarcoma / metabolism; Tumor Cells, Cultured
TL;DR: The effects of clinically relevant levels of hyperthermia on the kinetic binding parameters were investigated for 81C6, an antibody undergoing Phase I/II clinical trials for the treatment of brain tumors and neoplastic meningitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1995 chapter

Enhancement of radiolabeled monoclonal antibody uptake in tumors with local hyperthermia

In Handbook of targeted delivery of imaging agents (pp. 333–359).

By: M. Hauck, M. Dewhirst & M. Zalutsky

Source: NC State University Libraries
Added: August 6, 2018

1994 journal article

EFFECT OF WHOLE-BODY HYPERTHERMIA ON CARBOPLATIN DISPOSITION AND TOXICITY IN DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 10(6), 807–816.

By: R. Page n, M. Mcentee n, P. Williams n, S. George*, G. Price n, C. Novotney n, M. Hauck n, J. Riviere n, M. Dewhirst*, D. Thrall n

MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Carboplatin / toxicity; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Female; Hematopoietic System / drug effects; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary
TL;DR: A randomized phase II evaluation should be initiated to determine if a therapeutic gain can be achieved using combined CBDCA and WBH and further refinement of the CBDCA dose in such a trial should be based on both pharmacokinetic parameters and normal tissue response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1992 journal article

QUANTITATIVE ESTIMATION OF THE THERMAL DOSE-MODIFYING FACTOR FOR CIS-DIAMMINEDICHLOROPLATINUM (CDDP) IN TUMOR-BEARING DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 8(6), 761–769.

By: R. Page n, D. Thrall n, S. George*, G. Price n, G. Heidner n, M. Mcentee n, C. Novotney n, M. Hauck n, M. Dewhirst n

MeSH headings : Animals; Bone Marrow / drug effects; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Drug Tolerance; Female; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Kidney / drug effects; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary; Organoplatinum Compounds / administration & dosage; Organoplatinum Compounds / adverse effects
TL;DR: A statistical method for estimating clinical toxicity was used to determine a theoretical isoeffect dose-modifying factor for dogs with disseminated or refractory neoplasia treated with cis-diammine dichloroplatinum (II) plus whole-body hyperthermia or CDDP alone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1987 journal article

PHARMACOKINETICS AND TOXICITY OF INTRAPERITONEAL CISPLATIN COMBINED WITH REGIONAL HYPERTHERMIA

JOURNAL OF CLINICAL ONCOLOGY, 5(10), 1613–1620.

By: E. Zakris, M. Dewhirst*, J. Riviere*, P. Hoopes, R. Page & . Oleson

MeSH headings : Animals; Cisplatin / blood; Cisplatin / pharmacokinetics; Cisplatin / toxicity; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Female; Hepatitis, Animal / etiology; Hyperthermia, Induced / adverse effects; Injections, Intraperitoneal; Lymph Nodes / pathology; Male; Ovarian Neoplasms; Peritonitis / etiology; Pulmonary Fibrosis / etiology; Temperature; Tissue Distribution
TL;DR: The hypothesis that, with IP temperature elevation, there is an increased rate of generation and retention of reactive metabolites of cisplatin in the peritoneal cavity relative to unheated controls is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1986 journal article

Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs

International Journal of Hyperthermia, 2, 351–358.

By: J. Riviere n, R. Page n, M. Dewhirst*, K. Tyczkowska n & D. Thrall n

MeSH headings : Animals; Biotransformation; Cisplatin / blood; Cisplatin / metabolism; Dogs; Half-Life; Hyperthermia, Induced / methods; Kinetics; Platinum / blood; Spectrophotometry, Atomic; Ultrafiltration
TL;DR: Data from in vitro and in vivo cisplatin pharmacokinetic studies in dogs would indicate that at the elevated temperatures encountered in whole body hyperthermia, the rate of formation of reactive metabolites from parent cisPlatin is increased. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.