Mark W. Dewhirst
Works (26)
Updated: August 16th, 2023 21:17
2020 journal article
Cherenkov emissions for studying tumor changes during radiation therapy: An exploratory study in domesticated dogs with naturally-occurring cancer
PLOS ONE, 15(8).
MeSH headings : Animals; Dogs; Image Processing, Computer-Assisted; Neoplasms / diagnostic imaging; Neoplasms / radiotherapy; Particle Accelerators; Pilot Projects; Prospective Studies; Radiotherapy Dosage; Tomography, X-Ray Computed; X-Rays
journals.plos.org (publisher PDF)
Source: Web Of Science
Added: September 21, 2020
2011 journal article
Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics
CLINICAL CANCER RESEARCH, 17(8), 2549–2560.
MeSH headings : Animals; Cluster Analysis; Combined Modality Therapy; Dogs; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomics / methods; Humans; Hyperthermia, Induced; Magnetic Resonance Imaging / methods; Oligonucleotide Array Sequence Analysis; Radiotherapy / methods; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma / genetics; Sarcoma / therapy
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Dynamic Contrast-enhanced Magnetic Resonance Imaging as a Predictor of Clinical Outcome in Canine Spontaneous Soft Tissue Sarcomas Treated with Thermoradiotherapy
CLINICAL CANCER RESEARCH, 15(15), 4993–5001.
MeSH headings : Animals; Combined Modality Therapy / veterinary; Dog Diseases / diagnosis; Dogs; Hyperthermia, Induced / veterinary; Image Enhancement; Kaplan-Meier Estimate; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / veterinary; Prognosis; Radiotherapy / veterinary; Radiotherapy Dosage / veterinary; Sarcoma / diagnosis; Sarcoma / pathology; Sarcoma / veterinary; Soft Tissue Neoplasms / diagnosis; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / veterinary; Treatment Outcome
Source: Web Of Science
Added: August 6, 2018
2007 journal article
A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas
MOLECULAR CANCER THERAPEUTICS, 6(1), 380–389.
MeSH headings : Adenoviridae; Animals; Cats; Cytomegalovirus / genetics; Feasibility Studies; Genetic Therapy / adverse effects; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Hyperthermia, Induced; Interleukin-12 / blood; Interleukin-12 / genetics; Interleukin-12 / therapeutic use; Liver / pathology; Mice; Promoter Regions, Genetic / genetics; Recombinant Proteins / adverse effects; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Recombinant Proteins / therapeutic use; Sarcoma / drug therapy; Sarcoma / genetics; Sarcoma / radiotherapy; Sarcoma / veterinary
Source: Web Of Science
Added: August 6, 2018
2006 journal article
A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral Doxil extravasation
CLINICAL CANCER RESEARCH, 12(22), 6800–6807.
MeSH headings : Animals; Antibiotics, Antineoplastic / pharmacokinetics; Antibiotics, Antineoplastic / therapeutic use; Combined Modality Therapy / methods; Diagnostic Imaging / methods; Dose-Response Relationship, Drug; Doxorubicin / pharmacokinetics; Doxorubicin / therapeutic use; Drug Carriers / administration & dosage; Feasibility Studies; Female; Fibrosarcoma / therapy; Hyperthermia, Induced / methods; Liposomes / administration & dosage; Liposomes / pharmacokinetics; Radioactive Tracers; Rats; Technetium Tc 99m Exametazime / administration & dosage; Thigh / radiation effects; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 22(5), 365–373.
author keywords: hyperthermia; radiation therapy; dog; oxygen measurements
MeSH headings : Animals; Cell Hypoxia / physiology; Cell Hypoxia / radiation effects; Combined Modality Therapy / methods; Combined Modality Therapy / veterinary; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Oxygen / analysis; Oxygen / metabolism; Sarcoma / metabolism; Sarcoma / therapy; Sarcoma / veterinary
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Anesthetic considerations for the study of murine tumor models
Tumor Models in Cancer Research, 407–431.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs
In Vivo (Athens, Greece), 14(6), 709–714.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas
Clinical Cancer Research, 6(9), 3748–3755.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Local 42 degrees C hyperthermia improves vascular conductance of the R3230Ac rat mammary adenocarcinoma during sodium nitroprusside infusion
RADIATION RESEARCH, 154(2), 196–201.
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 46(1), 179–185.
author keywords: tumors; hyperthermia blood how; pO(2); pH; thermal dose
MeSH headings : Animals; Combined Modality Therapy; Dogs; Female; Hydrogen-Ion Concentration; Hyperthermia, Induced / methods; Male; Oxygen / metabolism; Partial Pressure; Sarcoma, Experimental / blood supply; Sarcoma, Experimental / metabolism; Sarcoma, Experimental / radiotherapy; Sarcoma, Experimental / therapy; Soft Tissue Neoplasms / blood supply; Soft Tissue Neoplasms / metabolism; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / therapy
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Using units of CEM 43 degrees C T-90, local hyperthermia thermal dose can be delivered as prescribed
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 16(5), 415–428.
author keywords: dog; hyperthermia; thermal dose
MeSH headings : Animals; Catheterization; Combined Modality Therapy; Dogs; Dose-Response Relationship, Radiation; Hyperthermia, Induced / methods; Radiotherapy / methods; Sarcoma / pathology; Sarcoma / therapy; Sarcoma / veterinary; Temperature; Time Factors
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Tumour cell kinetics as predictors of response in canine lymphoma treated with chemotherapy alone or combined with whole body hyperthermia
International Journal of Hyperthermia, 15(6), 475–486.
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Cycle; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Doxorubicin / administration & dosage; Hyperthermia, Induced; Indazoles / administration & dosage; Lymphoma / drug therapy; Lymphoma / therapy; Lymphoma / veterinary; Prognosis
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Use of whole body hyperthermia as a method to heat inaccessible tumours uniformly: a phase III trial in canine brain masses
International Journal of Hyperthermia, 15(5), 383–398.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 13(3), 307–316.
author keywords: interstitial fluid pressure; xenograft; hyperthermia
MeSH headings : Animals; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Monoclonal / therapeutic use; Biological Transport, Active; Combined Modality Therapy; Extracellular Space / physiology; Glioma / immunology; Glioma / physiopathology; Glioma / therapy; Humans; Hyperthermia, Induced / methods; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Pressure; Time Factors; Transplantation, Heterologous
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model
Clinical Cancer Research, 3, 63–70.
Source: NC State University Libraries
Added: August 6, 2018
1997 patent
Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Stroma-free human hemoglobin a decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure
RADIATION RESEARCH, 147(2), 185–194.
Source: Web Of Science
Added: August 6, 2018
1997 chapter
The use of blood substitutes in tumor therapy
In R. R. A. S. Rudolph & G. Z. Feuerstein (Eds.), Red blood cell substitutes: Basic principles and clinical application. New York: Marcel Dekker.
Ed(s): R. A. S. Rudolph & G. Feuerstein
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Phase I evaluation of mitoxantrone alone and combined with whole body hyperthermia in dogs with lymphoma
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 12(3), 309–320.
author keywords: hyperthermia; mitoxanthrone; lymphoma; canine
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / toxicity; Blood Cell Count / veterinary; Dogs; Female; Fever / veterinary; Lymphoma / metabolism; Lymphoma / therapy; Lymphoma / veterinary; Male; Mitoxantrone / therapeutic use; Mitoxantrone / toxicity; Neutropenia / complications; Neutropenia / veterinary; Neutrophils / metabolism; Regression Analysis; Thrombocytopenia / complications; Thrombocytopenia / veterinary
Source: Web Of Science
Added: August 6, 2018
1996 journal article
The effects of clinically relevant hyperthermic temperatures on the kinetic binding parameters of a monoclonal antibody
NUCLEAR MEDICINE AND BIOLOGY, 23(4), 551–557.
author keywords: monoclonal antibodies; hyperthermia; antibody binding kinetics; radiotherapy
MeSH headings : Animals; Antibodies, Monoclonal / metabolism; Antibodies, Monoclonal / pharmacokinetics; Dogs; Glioma / metabolism; Humans; Hyperthermia, Induced; Kinetics; Mice; Mice, Nude; Osteosarcoma / metabolism; Tumor Cells, Cultured
Source: Web Of Science
Added: August 6, 2018
1995 chapter
Enhancement of radiolabeled monoclonal antibody uptake in tumors with local hyperthermia
In Handbook of targeted delivery of imaging agents (pp. 333–359).
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
EFFECT OF WHOLE-BODY HYPERTHERMIA ON CARBOPLATIN DISPOSITION AND TOXICITY IN DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 10(6), 807–816.
MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Carboplatin / toxicity; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Female; Hematopoietic System / drug effects; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary
Source: Web Of Science
Added: August 6, 2018
1992 journal article
QUANTITATIVE ESTIMATION OF THE THERMAL DOSE-MODIFYING FACTOR FOR CIS-DIAMMINEDICHLOROPLATINUM (CDDP) IN TUMOR-BEARING DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 8(6), 761–769.
MeSH headings : Animals; Bone Marrow / drug effects; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Drug Tolerance; Female; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Kidney / drug effects; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary; Organoplatinum Compounds / administration & dosage; Organoplatinum Compounds / adverse effects
Source: Web Of Science
Added: August 6, 2018
1987 journal article
PHARMACOKINETICS AND TOXICITY OF INTRAPERITONEAL CISPLATIN COMBINED WITH REGIONAL HYPERTHERMIA
JOURNAL OF CLINICAL ONCOLOGY, 5(10), 1613–1620.
MeSH headings : Animals; Cisplatin / blood; Cisplatin / pharmacokinetics; Cisplatin / toxicity; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Female; Hepatitis, Animal / etiology; Hyperthermia, Induced / adverse effects; Injections, Intraperitoneal; Lymph Nodes / pathology; Male; Ovarian Neoplasms; Peritonitis / etiology; Pulmonary Fibrosis / etiology; Temperature; Tissue Distribution
Source: Web Of Science
Added: August 6, 2018
1986 journal article
Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs
International Journal of Hyperthermia, 2, 351–358.
MeSH headings : Animals; Biotransformation; Cisplatin / blood; Cisplatin / metabolism; Dogs; Half-Life; Hyperthermia, Induced / methods; Kinetics; Platinum / blood; Spectrophotometry, Atomic; Ultrafiltration
Source: NC State University Libraries
Added: August 6, 2018
