Michael Warren Nolan

Works (55)

Updated: April 5th, 2024 08:39

2023 journal article

Acute radiotherapy-associated oral pain may promote tumor growth at distant sites

FRONTIERS IN ONCOLOGY, 13.

By: C. Meneses n, E. Gidcumb n, K. Marcus n, Y. Gonzalez  n, Y. Lai n, S. Mishra n, B. Lascelles  n, M. Nolan n

author keywords: pain; radiotherapy; sensory nerves; cancer; mouse; TRPV1
TL;DR: This research points towards radiation-induced activation of capsaicin-responsive (TRPV1) neurons as the cause for accelerated growth of tumors at distant (unirradiated) sites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: June 12, 2023

2023 article

Presumed pituitary apoplexy in 26 dogs: Clinical findings, treatments, and outcomes

Woelfel, C. W., Mariani, C. L., Nolan, M. W., Keenihan, E. K., Topulos, S. P., Early, P. J., … Olby, N. J. (2023, April 21). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 4.

By: C. Woelfel n, C. Mariani n , M. Nolan n, E. Keenihan n, S. Topulos n, P. Early n, K. Munana n , S. Musulin n , N. Olby n 

author keywords: adenoma; carcinoma; endocrionopathy; hemorrhage; magnetic resonance imaging; suprasellar; survival
MeSH headings : Dogs; Animals; Pituitary Apoplexy / therapy; Pituitary Apoplexy / veterinary; Pituitary Apoplexy / diagnosis; Pituitary Neoplasms / complications; Pituitary Neoplasms / diagnostic imaging; Pituitary Neoplasms / therapy; Pituitary Neoplasms / veterinary; Retrospective Studies; Hydrocephalus / veterinary; Infarction / veterinary; Magnetic Resonance Imaging / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / therapy
TL;DR: Dogs with pituitary apoplexy present with a variety of acute signs of neurological disease and inconsistent endocrine dysfunction and dogs that survive to discharge can have a favorable outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 22, 2023

2022 article

A retrospective study of 101 dogs with oral melanoma treated with a weekly or biweekly 6 Gy x 6 radiotherapy protocol

Baja, A. J., Kelsey, K. L., Ruslander, D. M., Gieger, T. L., & Nolan, M. W. (2022, April 3). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 4.

By: A. Baja n, K. Kelsey*, D. Ruslander*, T. Gieger n  & M. Nolan n

author keywords: acute radiation toxicity; oral mucositis; oral tumours; radiodermatitis; veterinary oncology
MeSH headings : Animals; Dog Diseases / radiotherapy; Dogs; Melanoma / radiotherapy; Melanoma / veterinary; Mouth Neoplasms / radiotherapy; Mouth Neoplasms / veterinary; Prognosis; Retrospective Studies
TL;DR: This retrospective study characterizes oncologic outcomes for a relatively large group of dogs treated with this protocol and determines whether radiation dose intensity affected either progression‐free or overall survival (PFS and OS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 18, 2022

2022 journal article

Endocrine response and outcome in 14 cats with insulin resistance and acromegaly treated with stereotactic radiosurgery (17 Gy)

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(1), 64–71.

By: M. Watson-Skaggs n, T. Gieger n , H. Yoshikawa n & M. Nolan n

MeSH headings : Acromegaly / veterinary; Animals; Cat Diseases; Cats; Insulin Resistance; Radiosurgery / adverse effects; Radiosurgery / veterinary
TL;DR: The SRS protocol was well tolerated and associated with survival times similar to those reported previously, emphasizing the need for careful ongoing diabetic monitoring of acromegalic cats after pituitary gland irradiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: February 7, 2022

2022 article

Intensity of perioperative analgesia but not pre-treatment pain is predictive of survival in dogs undergoing amputation plus chemotherapy for extremity osteosarcoma

Nolan, M. W., Uzan, O. C., Green, N. A., Lana, S. E., & Lascelles, B. D. X. (2022, March 21). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 3.

By: M. Nolan n, O. Uzan*, N. Green n, S. Lana* & B. Lascelles  n

author keywords: analgesia; cancer pain; cancer treatment pain; local anaesthesia; malignant osteolysis
MeSH headings : Amputation, Surgical / veterinary; Analgesia / veterinary; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / surgery; Bone Neoplasms / veterinary; Dog Diseases / drug therapy; Dog Diseases / surgery; Dogs; Extremities / surgery; Osteosarcoma / drug therapy; Osteosarcoma / surgery; Osteosarcoma / veterinary; Pain / drug therapy; Pain / veterinary; Retrospective Studies; Treatment Outcome
TL;DR: In dogs treated with limb amputation and adjunctive chemotherapy for osteosarcoma, oncologic outcomes are impacted by either baseline cancer pain severity, or the approaches used for perioperative pain management. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 4, 2022

2022 article

Re-irradiation of canine non-lymphomatous nasal tumours using stereotactic radiation therapy (10 Gy x 3) for both courses: Assessment of outcome and toxicity in 11 dogs

Gieger, T. L., Haney, S. M., & Nolan, M. W. (2022, February 13). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 2.

By: T. Gieger n , S. Haney & M. Nolan n

author keywords: carcinoma; intranasal tumours; radiotherapy; reirradiation; sarcoma
MeSH headings : Animals; Dog Diseases / radiotherapy; Dogs; Neoplasm Recurrence, Local / surgery; Neoplasm Recurrence, Local / veterinary; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Quality of Life; Radiosurgery / adverse effects; Radiosurgery / methods; Radiosurgery / veterinary; Re-Irradiation / veterinary; Retrospective Studies; Treatment Outcome
TL;DR: For these dogs, survival was prolonged, but adverse events after SRT#2 were common (8/11; 73%). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: March 7, 2022

2022 journal article

Stereotactic radiotherapy (10 Gy X 3) for canine nonlymphomatous intranasal tumors is associated with prolonged survival and minimal risk of severe radiotoxicity

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260(12), 1496–1506.

By: M. Nolan n, A. Berman n, M. Watson-Skaggs n, C. Quinn n, K. Marcus n, K. Russell n, H. Yoshikawa n, N. Olby n , T. Gieger n 

MeSH headings : Dogs; Animals; Retrospective Studies; Dog Diseases / surgery; Quality of Life; Radiosurgery / methods; Radiosurgery / veterinary; Chondrosarcoma / veterinary; Bone Neoplasms / veterinary; Death; Treatment Outcome
TL;DR: Oncologic outcomes following administration of a uniform stereotactic radiotherapy protocol for canine intranasal tumors are described and any clinical or dosimetric factors were predictive of event-free or overall survival time (EFST or OST) are identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: February 13, 2023

2021 journal article

Behavioral phenotyping of cancer pain in domesticated cats with naturally occurring squamous cell carcinoma of the tongue: initial validation studies provide evidence for regional and widespread algoplasticity

PEERJ, 9.

By: Y. Lai n, B. Lascelles  n & M. Nolan n

author keywords: Comparative oncology; Comparative pain research; Animal models; Translational research; Feline
TL;DR: Based on preliminary assessments, the assays described herein had reasonable inter-rater reliability, and they were able to both discriminate between cats with and without oral cancer, and respond in a predictable manner to analgesic therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 30, 2021

2021 journal article

Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment

VETERINARY RADIOLOGY & ULTRASOUND, 62(2), 255–263.

By: M. Price n, Y. Lai n, K. Marcus n, J. Robertson n , B. Lascelles  n & M. Nolan n

author keywords: glossitis; mucositis; TNF‐ α TRPV1; TRPV4
MeSH headings : Animals; Capsaicin / pharmacology; Histamine / pharmacology; Mice; Pain / prevention & control; Pain / veterinary; Pentoxifylline / therapeutic use; Pilot Projects; Prospective Studies; Radiation-Protective Agents / therapeutic use; Radiotherapy / adverse effects; Sensory System Agents / pharmacology; Signal Transduction / drug effects; Stomatitis / complications; Stomatitis / drug therapy; Stomatitis / etiology; Tumor Necrosis Factor-alpha / analysis; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Although PTX treatment did not reduce glossitis severity or mitigate weight loss in mice with RIM/RAP, it did inhibit the upregulation of TNF-α's receptor that normally accompanies RIM, and it also reduced neuronal responsiveness to each of the aforementioned chemical stimuli. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 11, 2021

2021 journal article

Irradiation of the Normal Murine Tongue Causes Upregulation and Activation of Transient Receptor Potential (TRP) Ion Channels

RADIATION RESEARCH, 196(4), 331–344.

By: Y. Lai, W. Baumer, C. Meneses*, D. Roback*, J. Robertson* , S. Mishra n, B. Lascelles *, M. Nolan n

MeSH headings : Animals; Calcium; Female; Mice; Neurons; Transient Receptor Potential Channels; Trigeminal Ganglion; Up-Regulation
TL;DR: The results intimate that various TRP channels, and TRPV1 in particular, should be explored as analgesic targets for patients experiencing pain after oral irradiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 18, 2021

2021 journal article

Minimally invasive ethyl cellulose ethanol ablation in domesticated cats with naturally occurring head and neck cancers: Six cats

VETERINARY AND COMPARATIVE ONCOLOGY, 19(3), 492–500.

By: Y. Lai n, R. Morhard*, N. Ramanujam * & M. Nolan n

author keywords: head and neck cancer; intratumoral injection; minimally invasive procedure; palliative; surgical alternative
MeSH headings : Animals; Carcinoma, Squamous Cell / drug therapy; Carcinoma, Squamous Cell / veterinary; Cat Diseases / drug therapy; Cats; Cellulose / analogs & derivatives; Cellulose / therapeutic use; Ethanol; Head and Neck Neoplasms / drug therapy; Head and Neck Neoplasms / veterinary; Pilot Projects; Quality of Life
TL;DR: Ethyl cellulose ethanol ablation is not a viable treatment for feline lingual/sublingual SCC; tumor volume was effectively reduced in some cats, but the simultaneous loss of lingual function was poorly tolerated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 15, 2021

2021 journal article

Retrospective evaluation of intranasal carcinomas in cats treated with external-beam radiotherapy: 42 cases

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(2), 1018–1030.

By: H. Yoshikawa n, T. Gieger n , C. Saba *, K. Fredrickson*, L. Kubicek*, S. Haney*, D. Ruslander*, K. Kelsey*, M. McEntee*, M. Nolan n

author keywords: head and neck cancer; nasal cancer; nasal tumor; radiation therapy
MeSH headings : Animals; Carcinoma, Squamous Cell / veterinary; Cat Diseases / radiotherapy; Cats; Neoplasm Recurrence, Local / veterinary; Progression-Free Survival; Retrospective Studies; Treatment Outcome
TL;DR: In cats with INC, DRT is associated with prolonged OST and PFS as compared to PRT, and if tumor progression occurs, a second course of DRT should be considered. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: March 22, 2021

2021 journal article

Risk of erectile dysfunction after modern radiotherapy for intact prostate cancer

PROSTATE CANCER AND PROSTATIC DISEASES, 24(1), 128–134.

By: A. Hunt*, K. Choudhury*, V. Nukala *, M. Nolan n, A. Ahmad*, K. Ashcraft, B. Koontz

MeSH headings : Brachytherapy / adverse effects; Erectile Dysfunction / etiology; Erectile Dysfunction / physiopathology; Humans; Male; Penile Erection / radiation effects; Prostatic Neoplasms / physiopathology; Prostatic Neoplasms / radiotherapy; Radiotherapy Dosage
TL;DR: Diminished erectile function status post RT was common and similar across all studies, and risk of post-RT ED is similar for both LDR brachytherapy and external beam RT with advanced prostate targeting and penile-bulb sparing techniques utilized in modern RT techniques. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 27, 2020

2021 journal article

Treatment of feline gastrointestinal intermediate- or large-cell lymphoma with lomustine chemotherapy and 8 Gy abdominal cavity radiation therapy

JOURNAL OF FELINE MEDICINE AND SURGERY, 23(6), 469–476.

By: T. Gieger n , G. Seiler n & M. Nolan n

author keywords: Gastrointestinal lymphoma; lymphoblastic lymphoma; large-cell lymphoma; chemotherapy; radiation therapy
MeSH headings : Abdominal Cavity; Animals; Antineoplastic Combined Chemotherapy Protocols; Cat Diseases / drug therapy; Cats; Gastrointestinal Tract; Lomustine / therapeutic use; Lymphoma / drug therapy; Lymphoma / veterinary; Prospective Studies; Treatment Outcome
TL;DR: Treatment was seemingly well tolerated in most cats and was relatively cost-effective, so it is plausible that improved disease control may be achievable through continued optimization and intensification of the combinatorial chemoradiotherapy protocol. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 26, 2020

2021 journal article

Treatment of genitourinary carcinoma in dogs using nonsteroidal anti-inflammatory drugs, mitoxantrone, and radiation therapy: A retrospective study

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(2), 1052–1061.

By: B. Clerc-Renaud*, T. Gieger n , S. LaRue * & M. Nolan n

author keywords: definitive‐ intent; dogs; intensity‐ modulated; radiotherapy; urogenital carcinoma
MeSH headings : Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma / veterinary; Dog Diseases / drug therapy; Dog Diseases / radiotherapy; Dogs; Male; Mitoxantrone / therapeutic use; Neoplasm Staging; Pharmaceutical Preparations; Retrospective Studies; Treatment Outcome
TL;DR: Mild clinical signs and lack of prostate involvement were associated with favorable prognosis for survival and client education regarding the risk of urinary incontinence is warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: March 15, 2021

2021 journal article

Treatment outcomes and target delineation utilizingCTandMRIin 13 dogs treated with a uniform stereotactic radiation therapy protocol (16 Gy single fraction) for pituitary masses: (2014-2017)

VETERINARY AND COMPARATIVE ONCOLOGY, 19(1), 17–24.

By: T. Gieger n  & M. Nolan n

author keywords: brain tumour; intracalvarial; radiosurgery; radiotherapy; SRS
MeSH headings : Animals; Dog Diseases / radiotherapy; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Pituitary Neoplasms / diagnostic imaging; Pituitary Neoplasms / radiotherapy; Pituitary Neoplasms / veterinary; Radiosurgery / veterinary; Retrospective Studies; Tomography, X-Ray Computed / veterinary
TL;DR: Use of co-registered CT and MRI images is generally considered advantageous for PM delineation when using SRT, and survival times reported herein are shorter than what has previously been reported for PM treated with finely fractionated full-course RT protocols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 3, 2020

2020 journal article

Cherenkov emissions for studying tumor changes during radiation therapy: An exploratory study in domesticated dogs with naturally-occurring cancer

PLOS ONE, 15(8).

By: A. Rickard *, H. Yoshikawa n, G. Palmer n, H. Liu*, M. Dewhirst n, M. Nolan n, X. Zhang

MeSH headings : Animals; Dogs; Image Processing, Computer-Assisted; Neoplasms / diagnostic imaging; Neoplasms / radiotherapy; Particle Accelerators; Pilot Projects; Prospective Studies; Radiotherapy Dosage; Tomography, X-Ray Computed; X-Rays
TL;DR: It is demonstrated that it is possible to obtain Cherenkov emissions from canine cancers within a fraction of radiotherapy, and lends credence to the goal of using this method during radiotherapy in human patients and client-owned pets. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: September 21, 2020

2020 journal article

Evaluation of variables associated with outcomes in 41 dogs with incompletely excised high-grade soft tissue sarcomas treated with definitive-intent radiation therapy with or without chemotherapy

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 256(7), 783–791.

By: A. Crownshaw n, M. McEntee*, M. Nolan n & T. Gieger n 

MeSH headings : Animals; Dog Diseases; Dogs; Neoplasm Recurrence, Local / veterinary; Retrospective Studies; Sarcoma / veterinary; Soft Tissue Neoplasms / veterinary; Treatment Outcome
TL;DR: Results indicated that improved OST and TTP could be achieved through strict adherence to the prescribed irradiation schedule and avoidance of unnecessary prolongation of the course of RT. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 27, 2020

2020 journal article

Feasibility study evaluating arrhythmogenesis and cardiac damage after heart-base irradiation in mice: A brief communication

VETERINARY MEDICINE AND SCIENCE, 6(4), 1009–1016.

By: J. Elliott n, K. Linder n & M. Nolan n

author keywords: animal models; arrhythmia; radiation; radiobiology; radiotherapy
MeSH headings : Animals; Arrhythmias, Cardiac / etiology; Disease Models, Animal; Feasibility Studies; Female; Heart / radiation effects; Mice; Mice, Inbred C57BL; Myocardium / pathology; Pilot Projects
TL;DR: While this study did not demonstrate significant arrhythmogenesis, certain modifications of the experimental mouse irradiation procedures are discussed which may enable more translationally relevant modelling of the canine cardiac response to SBRT‐like irradiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 29, 2020

2020 journal article

Impact of radiation dose and pre-treatment pain levels on survival in dogs undergoing radiotherapy with or without chemotherapy for presumed extremity osteosarcoma

VETERINARY AND COMPARATIVE ONCOLOGY, 18(4), 538–547.

By: M. Nolan n, N. Green n, E. DiVito n, B. Lascelles  n & S. Haney*

author keywords: analgesia; appendicular bone tumour; malignant osteolysis; palliative; primary bone tumour; radiosurgery
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / mortality; Bone Neoplasms / radiotherapy; Bone Neoplasms / veterinary; Dog Diseases / drug therapy; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Female; Fractures, Bone / complications; Fractures, Bone / veterinary; Lung Neoplasms / radiotherapy; Lung Neoplasms / secondary; Male; North Carolina / epidemiology; Osteosarcoma / drug therapy; Osteosarcoma / mortality; Osteosarcoma / radiotherapy; Osteosarcoma / veterinary; Pain / veterinary; Radiation Dosage; Radiotherapy / methods; Radiotherapy / veterinary; Retrospective Studies; Survival
TL;DR: In a univariate analysis, dogs with pulmonary metastases and high pain at the time of irradiation had short overall survival times; use of high radiation doses and chemotherapy were associated with improved survival. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: March 10, 2020

2020 journal article

Unexpected but transient tumour enlargement preceded complete regression and long-term control after irradiation of squamous cell carcinoma in a red-eared slider (Trachemys scripta elegans)

VETERINARY RECORD CASE REPORTS, 8(2).

By: A. Baja n, G. Lewbart n , J. Luff n & M. Nolan n

TL;DR: A red-eared slider with a chronic non-healing ulcerative shell lesion was diagnosed with cutaneous squamous cell carcinoma and underwent surgical debulking and adjuvant hypofractionated radiation therapy, showing an unusual pattern of disease regression, followed by transient growth and then long-term local tumour control. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: March 8, 2021

2019 journal article

Changes in target volume during irradiation of canine intranasal tumors can significantly impact radiation dosimetry

VETERINARY RADIOLOGY & ULTRASOUND, 60(5), 594–604.

By: H. Yoshikawa n & M. Nolan n

author keywords: nasal tumor; normal tissue complications; radiation therapy
MeSH headings : Animals; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dogs; Female; Imaging, Three-Dimensional / veterinary; Male; Nose Neoplasms / pathology; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Radiometry / veterinary; Radiotherapy Planning, Computer-Assisted / veterinary; Radiotherapy, Conformal / veterinary; Radiotherapy, Intensity-Modulated / veterinary
TL;DR: Results suggest that near-complete resolution of GTV warrants plan revision, and describe dosimetric effects of these changing volumes during a course of RT in veterinary medicine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 15, 2019

2019 review

Emerging Translational Opportunities in Comparative Oncology With Companion Canine Cancers: Radiation Oncology

[Review of ]. FRONTIERS IN ONCOLOGY, 9.

By: M. Nolan n, M. Kent * & M. Boss*

author keywords: radiation oncology; radiobiology; canine comparative radiation oncology; medical physics; animal models of cancer; imaging; theranostics; translational research
TL;DR: The purpose of this review article is to inform readers of the potential utility and limitations of using dogs in that manner; the peer-reviewed literature will be critically reviewed, and current research efforts will be discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 30, 2019

2019 journal article

Implementation of total body photon irradiation as part of an institutional bone marrow transplant program for the treatment of canine lymphoma and leukemias

VETERINARY RADIOLOGY & ULTRASOUND, 60(5), 586–593.

By: T. Gieger n , M. Nolan n, D. Roback n & S. Suter n

author keywords: cadaver; lymphosarcoma; myeloablation; thermoluminescent dosimeter
MeSH headings : Animals; Bone Marrow Transplantation / methods; Bone Marrow Transplantation / veterinary; Dog Diseases / radiotherapy; Dogs; Female; Leukemia / radiotherapy; Leukemia / veterinary; Lymphoma / radiotherapy; Lymphoma / veterinary; Male; Photons; Prospective Studies; Radiotherapy Dosage / veterinary; Whole-Body Irradiation / methods; Whole-Body Irradiation / veterinary
TL;DR: A total body irradiation (TBI) protocol was developed to support a bone marrow transplant (BMT) program for the treatment of canine hematologic malignancies and resultant dosimetry was described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: October 7, 2019

2019 journal article

Radiotherapy isocenters verified by matching to bony landmarks of the canine and feline head differ when localized using volumetric versus planar imaging

VETERINARY AND COMPARATIVE ONCOLOGY, 17(4), 562–569.

By: L. Magestro n, J. Cahoon n, T. Gieger n  & M. Nolan n

author keywords: image-guided; immobilization; radiosurgery; radiotherapy; radiotherapy setup errors
MeSH headings : Animals; Body Size; Cats / anatomy & histology; Dogs / anatomy & histology; Head / anatomy & histology; Humans; Observer Variation; Radiotherapy Planning, Computer-Assisted / methods; Radiotherapy Planning, Computer-Assisted / veterinary; Skull / anatomy & histology
TL;DR: The primary aim of this study was to determine if the position of the bony skull, when used as a surrogate for isocenter verification, is different when orthogonal megavoltage portal (MV) or kilovoltage radiographs are used for image-guidance, rather than kV-CBCT. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: September 3, 2019

2019 journal article

Teaching Tip: Virtual Oncology Clinic

JOURNAL OF VETERINARY MEDICAL EDUCATION, 46(3), 367–371.

By: M. Nolan*, M. Balogh & S. Waltman

author keywords: clinical education; teaching and learning innovation; online learning resources; blended learning approaches
MeSH headings : Animals; Dogs; Education, Distance; Education, Veterinary; Educational Technology / methods; Humans; Medical Oncology; Students; Teaching
TL;DR: The purpose of this article is to describe the development and implementation of a learning approach that blends classroom instructor-directed learning with online simulation-based learning, using the VVC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
Source: Web Of Science
Added: September 30, 2019

2019 journal article

Update in Veterinary Radiation Oncology Focus on Stereotactic Radiation Therapy

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 49(5), 933-+.

By: M. Nolan n & T. Gieger n 

author keywords: Radiotherapy; Radiosurgery; Brain tumors; Nasal tumors; Osteosarcoma; Radiobiology
MeSH headings : Animals; Cat Diseases / radiotherapy; Cats; Dog Diseases / radiotherapy; Dogs; Medical Oncology; Neoplasms / radiotherapy; Neoplasms / veterinary; Radiation Oncology / methods; Radiosurgery / methods; Radiosurgery / veterinary; Radiotherapy / methods; Radiotherapy / veterinary; Radiotherapy Dosage / veterinary; Veterinary Medicine
TL;DR: Stereotactic radiotherapy involves the precise delivery of highly conformal, dose-intense radiation to well-demarcated tumors, and common indications in veterinary oncology include nasal, brain, and bone tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: September 16, 2019

2018 journal article

Ga Ion-Enhanced and Particle Shape-Dependent Generation of Reactive Oxygen Species in X-ray-Irradiated Composites

ACS OMEGA, 3(5), 5252–5259.

By: W. Adams n, M. Nolan n & A. Ivanisevic n

TL;DR: The reported results test the effects of the collective behavior hypothesized to contribute to the production of more reactive oxygen species (ROS) in vitro and result in an enhanced radiosensitization. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Linac-based stereotactic radiation therapy for canine non-lymphomatous nasal tumours: 29 cases (2013-2016)

VETERINARY AND COMPARATIVE ONCOLOGY, 16(1), E68–E75.

By: T. Gieger  n & M. Nolan n

author keywords: carcinoma; nasal; radiotherapy; sarcoma; stereotactic
MeSH headings : Animals; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Nose Neoplasms / mortality; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Radiosurgery / veterinary; Radiotherapy Planning, Computer-Assisted / veterinary; Retrospective Studies; Survival Analysis; Treatment Outcome
TL;DR: This SRT protocol appears to be well tolerated, and PFI and ST are comparable or superior to those reported in other definitive-intent radiotherapy protocols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Single fraction stereotactic radiation therapy (stereotactic radiosurgery) is a feasible method for treating intracranial meningiomas in dogs

VETERINARY RADIOLOGY & ULTRASOUND, 59(5), 632–638.

By: K. Kelsey n, T. Gieger n  & M. Nolan n

author keywords: brain tumor; intracalvarial; radiosurgery; radiotherapy; stereotactic radiosurgery
MeSH headings : Animals; Brain Neoplasms / radiotherapy; Dog Diseases / radiotherapy; Dogs; Female; Infratentorial Neoplasms / radiotherapy; Infratentorial Neoplasms / veterinary; Male; Meningeal Neoplasms / radiotherapy; Meningeal Neoplasms / veterinary; Meningioma / radiotherapy; Meningioma / veterinary; Pilot Projects; Radiosurgery / methods; Radiosurgery / veterinary; Retrospective Studies; Treatment Outcome
TL;DR: Findings supported the use of stereotactic radiosurgery as an alternative method for treating dogs with presumed intracranial meningiomas, and there were no factors identified which were predictive of acute adverse event. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

Stereotactic body radiation therapy for heart-base tumors in six dogs

JOURNAL OF VETERINARY CARDIOLOGY, 20(3), 186–197.

By: L. Magestro n, T. Gieger n  & M. Nolan n

author keywords: Aortic body tumor; Chemodectoma; Radiosurgery
MeSH headings : Animals; Aorta; Dog Diseases / radiotherapy; Dogs; Female; Heart Neoplasms / radiotherapy; Heart Neoplasms / veterinary; Male; Paraganglioma, Extra-Adrenal / radiotherapy; Paraganglioma, Extra-Adrenal / veterinary; Radiosurgery / veterinary; Retrospective Studies; Treatment Outcome
TL;DR: SBRT is a potentially useful treatment but may not be appropriate for dogs with incidentally diagnosed, slowly growing tumors, which are not causing cardiovascular disturbances, and jet ventilation effectively reduced treatment delivery times. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 review

The future of radiotherapy in small animals - should the fractions be coarse or fine?

[Review of ]. JOURNAL OF SMALL ANIMAL PRACTICE, 59(9), 521–530.

By: M. Nolan n & J. Dobson*

MeSH headings : Animals; Dog Diseases / radiotherapy; Dogs; Dose Fractionation, Radiation; Neoplasms / radiotherapy; Neoplasms / veterinary; Radiotherapy / adverse effects; Radiotherapy / veterinary
TL;DR: The purpose of this article is to review the evidence base for daily (fine) fractionation versus weekly (coarse) hypofractionation in veterinary oncology, using selected tumour types as examples. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

2017 journal article

Clinical and imaging findings, treatments, and outcomes in 27 dogs with imaging diagnosed trigeminal nerve sheath tumors: A multi-center study

VETERINARY RADIOLOGY & ULTRASOUND, 58(6), 679–689.

By: K. Swift*, S. McGrath *, M. Nolan n, M. Young, M. Reese*, S. Rao *, E. Randall *, D. Leary *, S. LaRue *

author keywords: neurooncology; radiation oncology; small animal oncology; stereotactic radiation therapy
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / radiotherapy; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Nerve Sheath Neoplasms / diagnostic imaging; Nerve Sheath Neoplasms / radiotherapy; Nerve Sheath Neoplasms / veterinary; Radiosurgery / veterinary; Retrospective Studies; Treatment Outcome; Trigeminal Nerve Diseases / diagnostic imaging; Trigeminal Nerve Diseases / radiotherapy; Trigeminal Nerve Diseases / veterinary
TL;DR: Clinical signs, tumor localization characteristics, treatments, and clinical outcomes in a group of dogs with trigeminal nerve sheath tumor diagnosis, magnetic resonance imaging studies, and presentation between 2004 and 2014 are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Gallium containing composites as a tunable material to understand neuronal behavior under variable stiffness and radiation conditions

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 71, 317–321.

By: N. Berg n, B. Pearce n, N. Rohrbaugh n, L. Jiang *, M. Nolan n & A. Ivanisevic n

author keywords: Multifunctional; Gallium; Stiffness; Radiation; Radiosensitizing
MeSH headings : Animals; Cell Survival / drug effects; Cell Survival / radiation effects; Gallium / chemistry; Gallium / pharmacology; Nanocomposites / chemistry; Nerve Growth Factor / chemistry; Nerve Growth Factor / pharmacology; Neurites / metabolism; PC12 Cells; Radiation-Sensitizing Agents / chemistry; Radiation-Sensitizing Agents / pharmacology; Rats
TL;DR: A composite biomaterial containing nanostructured GaOOH and Matrigel™ that can be modulated with respect to its stiffness and radiosensitization properties is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Management of Radiation Side Effects to the Skin

Veterinary Clinics of North America: Small Animal Practice, 47(6), 1165–1180.

By: T. Gieger n  & M. Nolan n

author keywords: Desquamation; Fibrosis; Cutaneous reaction; Radiation dermatitis; Erythema
MeSH headings : Animals; Neoplasms / radiotherapy; Neoplasms / veterinary; Radiation Injuries / prevention & control; Radiation Injuries / veterinary; Skin / radiation effects
TL;DR: Acute and late side effects to the skin and their management of acute radiation treatment planning and appropriate management are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Nocifensive Behaviors in Mice with Radiation-Induced Oral Mucositis

RADIATION RESEARCH, 187(3), 397–403.

By: M. Nolan*, C. Long, K. Marcus*, S. Sarmadi, D. Roback*, T. Fukuyama *, W. Baeumer*, B. Lascelles

MeSH headings : Animals; Behavior, Animal / radiation effects; Mice; Neurons / pathology; Neurons / radiation effects; Nociception / radiation effects; Radiation Injuries, Experimental / pathology; Radiation Injuries, Experimental / physiopathology; Stomatitis / pathology; Stomatitis / physiopathology; Trigeminal Ganglion / pathology
TL;DR: Data validate an appropriate model for cancer treatment related discomfort in humans and quantify resultant discomfort, and characterize peripheral sensitization following radiation-induced glossitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Outcomes of Spatially Fractionated Radiotherapy (GRID) for Bulky Soft Tissue Sarcomas in a Large Animal Model

Technology in Cancer Research & Treatment, 16(3), 357–365.

By: M. Nolan n, T. Gieger n , A. Karakashian*, M. Nikolova-Karakashian *, L. Posner n, D. Roback*, J. Rivera*, S. Chang n

author keywords: canine; microenvironment; ablative; endothelial; abscopal
MeSH headings : Animals; Combined Modality Therapy; Disease Models, Animal; Dogs; Dose Fractionation, Radiation; Female; Humans; Male; Pilot Projects; Radiotherapy / methods; Radiotherapy / standards; Sarcoma / pathology; Sarcoma / radiotherapy; Sarcoma / surgery
TL;DR: Pet dogs with spontaneous soft tissue sarcomas are an appealing model for studying the radiobiologic responses to spatially fractionated radiotherapy, and data suggest that GRID may be associated with at least short-term reduction in serum concentration of vascular endothelial growth factor and serum activity of secretory sphingomyelinase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2017 journal article

Pilot study to determine the feasibility of radiation therapy for dogs with right atrial masses and hemorrhagic pericardial effusion

Journal of Veterinary Cardiology, 19(2), 132–143.

By: M. Nolan n, M. Arkans n, D. LaVine n, T. DeFrancesco n , J. Myers *, E. Griffith n, L. Posner n, B. Keene n ...

author keywords: Heart-base tumor; Cardiac hemangiosarcoma; Canine
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / radiotherapy; Dogs; Echocardiography; Female; Heart Atria; Heart Neoplasms / complications; Heart Neoplasms / radiotherapy; Heart Neoplasms / veterinary; Hemangiosarcoma / complications; Hemangiosarcoma / radiotherapy; Hemangiosarcoma / veterinary; Hemorrhage / complications; Hemorrhage / veterinary; Male; Pericardial Effusion / complications; Pericardial Effusion / veterinary; Pilot Projects; Postoperative Complications / veterinary; Treatment Outcome
TL;DR: RT alone, or in combination with chemotherapy, may provide clinical benefit to dogs with presumptive diagnoses of cardiac hemangiosarcoma, and appears to have reduced the frequency of periacardial tamponade that necessitated pericardiocentesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2017 journal article

The impact of carboplatin and toceranib phosphate on serum vascular endothelial growth factor (VEGF) and metalloproteinase-9 (MMP-9) levels and survival in canine osteosarcoma

Canadian Journal of Veterinary Research, 81(3), 199–205.

By: T. Gieger , J. Nettifee-Osborne, B. Hallman, C. Johannes, D. Clarke, M. Nolan, L. Williams

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Utilizing a diagnostic kV imaging system for x-ray psoralen activated cancer therapy (X-PACT)

Biomedical Physics & Engineering Express, 3(3).

By: J. Adamson, S. Mein, B. Meng, R. Gunasingha, S. Yoon, D. Miles, H. Walder, Z. Fathi ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Interfaces with Tunable Mechanical and Radiosensitizing Properties

ACS APPLIED MATERIALS & INTERFACES, 8(34), 21956–21961.

By: N. Berg*, B. Pearce*, P. Snyder*, N. Rohrbaugh*, M. Nolan n, P. Adhikari*, S. Khan* , A. Ivanisevic*

author keywords: GaOOH; extracellular matrix composite; nanocomposite; X-ray radiation; mechanobiology; NIH 3T3 Cells
MeSH headings : Cell Survival; Fibroblasts; Nanostructures; Reactive Oxygen Species
TL;DR: Reactive oxygen species data demonstrated that one can reduce the amount of radiation needed to modulate the behavior of cells on interfaces with different stiffness containing a radiosensitizing material. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Retrospective evaluation of interfractional ureteral movement in dogs undergoing radiation therapy to elucidate appropriate setup margins

Veterinary Radiology & Ultrasound, 57(2), 170–179.

By: H. Yoshikawa*, M. Nolan n, D. Lewis & S. Larue *

author keywords: organs at risk; planning target volume expansion; radiation therapy; ureter
MeSH headings : Animals; Dog Diseases / radiotherapy; Dogs; Patient Positioning / methods; Patient Positioning / veterinary; Radiotherapy, Image-Guided / veterinary; Reference Values; Retrospective Studies; Tomography, X-Ray Computed / veterinary; Ureter / diagnostic imaging; Urinary Bladder Neoplasms / radiotherapy; Urinary Bladder Neoplasms / veterinary
TL;DR: This retrospective and descriptive study of 17 dogs with genitourinary carcinomas that underwent intensity-modulated, image-guided radiation therapy (IM-IGRT) was conducted to help radiation oncologists use appropriate ureter expansions for specific patient orientations and positioning verification methods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 journal article

Stereotactic radiation therapy for treatment of canine intracranial meningiomas

VETERINARY AND COMPARATIVE ONCOLOGY, 14(4), E158–E170.

By: L. Griffin *, M. Nolan n, L. Selmic*, E. Randall *, J. Custis* & S. LaRue *

author keywords: Comparative Oncology; Oncology; Pathology; Radiation Oncology; Small Animal
MeSH headings : Animals; Dog Diseases / radiotherapy; Dogs; Female; Male; Meningeal Neoplasms / radiotherapy; Meningeal Neoplasms / veterinary; Meningioma / radiotherapy; Meningioma / veterinary; Radiotherapy / methods; Radiotherapy / veterinary; Stereotaxic Techniques / veterinary
TL;DR: Volume of normal brain that received full dose at a prescription of 8Gy × 3 fractions was predictive of death due to neurological problems within this 6-month period and death within 6 months of treatment as a result of worsening neurologic signs was seen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Dosimetric consequences of using contrast-enhanced computed tomographic images for intensity-modulated stereotactic body radiotherapy planning

Veterinary Radiology & Ultrasound, 56(6), 687–695.

By: H. Yoshikawa*, D. Roback*, S. Larue * & M. Nolan n

author keywords: dogs; intensity-modulated radiation therapy; stereotactic radiation therapy; translational research; veterinary
MeSH headings : Animals; Brain / radiation effects; Contrast Media; Cross-Sectional Studies; Dog Diseases / radiotherapy; Dogs; Extremities / radiation effects; Eye / radiation effects; Heart / radiation effects; Iohexol; Mouth Mucosa / radiation effects; Neoplasms / radiotherapy; Neoplasms / veterinary; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Organs at Risk; Palate, Hard / radiation effects; Pelvic Neoplasms / radiotherapy; Pelvic Neoplasms / veterinary; Radiation Dosage; Radiographic Image Enhancement; Radiotherapy Dosage / veterinary; Radiotherapy Planning, Computer-Assisted / veterinary; Radiotherapy, Intensity-Modulated / veterinary; Retrospective Studies; Stereotaxic Techniques / veterinary; Tomography, X-Ray Computed / veterinary; Urinary Bladder / radiation effects
TL;DR: Although caution would be recommended when planning IM-SBRT for tumors near "reservoirs" for contrast media (such as the heart and urinary bladder), findings supported the use of ceCT with this dose calculation algorithm for both target delineation and IM- SBRT treatment planning. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 article

Management of transitional cell carcinoma of the urinary bladder in dogs: Important challenges to consider

Nolan, M. W., Gieger, T. L., & Vaden, S. L. (2015, August). VETERINARY JOURNAL, Vol. 205, pp. 126–127.

By: M. Nolan n, T. Gieger n  & S. Vaden n

MeSH headings : Animals; Carcinoma, Transitional Cell; Dog Diseases; Dogs; Urinary Bladder; Urinary Bladder Neoplasms
TL;DR: Opinions on diagnosis and staging of TCC are shared, and how these may impact on treatment decisions are shared. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Misadministration of radiation therapy in veterinary medicine: a case report and literature review

Veterinary and Comparative Oncology, 15(1), 237–246.

By: M. Arkans n, T. Gieger n  & M. Nolan n

author keywords: error; medical incident; oncology; small animal; technology
MeSH headings : Animals; Dog Diseases / radiotherapy; Dogs; Humans; Medical Errors / veterinary; Neoplasms / radiotherapy; Neoplasms / veterinary; Radiation Dosage; Radiosurgery / methods; Radiosurgery / veterinary; Radiotherapy Setup Errors / veterinary; Radiotherapy, Intensity-Modulated / methods; Radiotherapy, Intensity-Modulated / veterinary; Schools, Veterinary; Tomography, X-Ray Computed / veterinary; Veterinary Medicine
TL;DR: A medical incident is described that occurred at an academic veterinary referral hospital, in a dog receiving a combination of stereotactic radiation therapy and full-course intensity-modulated, image-guided radiation therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2015 journal article

Pudendal Nerve and Internal Pudendal Artery Damage May Contribute to Radiation-Induced Erectile Dysfunction

International Journal of Radiation Oncology*Biology*Physics, 91(4), 796–806.

By: M. Nolan n, A. Marolf *, E. Ehrhart*, S. Rao *, S. Kraft*, S. Engel *, H. Yoshikawa*, A. Golden*, T. Wasserman*, S. LaRue *

MeSH headings : Animals; Arteries / pathology; Arteries / radiation effects; Disease Models, Animal; Dogs; Erectile Dysfunction / drug therapy; Erectile Dysfunction / etiology; Impotence, Vasculogenic / drug therapy; Impotence, Vasculogenic / etiology; Male; Penis / blood supply; Penis / innervation; Penis / radiation effects; Prostate / blood supply; Prostate / innervation; Prostate / radiation effects; Pudendal Nerve / drug effects; Pudendal Nerve / pathology; Pudendal Nerve / physiopathology; Pudendal Nerve / radiation effects; Radiation Dosage; Radiosurgery / adverse effects; Radiosurgery / methods; Systole / physiology; Systole / radiation effects; Veins / pathology; Veins / radiation effects
TL;DR: This is the first report in which prostatic irradiation was shown to cause morphologic arterial damage that was coincident with altered internal pudendal arterial tone, and in which decreased motor function in the pudendedal nerve was attributed to axonal degeneration and loss. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Surface Characterization of Gallium Nitride Modified with Peptides before and after Exposure to Ionizing Radiation in Solution

Langmuir, 30(51), 15477–15485.

By: N. Berg*, M. Nolan n, T. Paskova* & A. Ivanisevic*

MeSH headings : Amino Acid Sequence; Gallium / chemistry; Oligopeptides / chemistry; Solutions; Surface Properties / radiation effects
TL;DR: It is hypothesized that during radiation exposure of the samples, the radiolysis of water produces peroxide and other reactive species on the sample surface which promotes the formation of a more stable layer of gallium oxyhydroxide which passivates the surface better than other oxide species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2013 journal article

Accuracy of CT and MRI for contouring the feline optic apparatus for radiation therapy planning

Veterinary Radiology & Ultrasound, 54(5), 560–566.

By: M. Nolan*, E. Randall *, S. LaRue *, K. Lunn n , J. Stewart* & S. Kraft*

author keywords: acromegaly; brain tumors; optic chiasm; optic pathway; stereotactic radiation therapy; radiosurgery
MeSH headings : Acromegaly / diagnosis; Acromegaly / etiology; Acromegaly / pathology; Acromegaly / veterinary; Animals; Cadaver; Cat Diseases / diagnosis; Cat Diseases / etiology; Cat Diseases / pathology; Cats / anatomy & histology; Magnetic Resonance Imaging / methods; Magnetic Resonance Imaging / standards; Magnetic Resonance Imaging / veterinary; Optic Chiasm / anatomy & histology; Optic Chiasm / diagnostic imaging; Optic Chiasm / pathology; Optic Nerve / anatomy & histology; Optic Nerve / diagnostic imaging; Optic Nerve / pathology; Prospective Studies; Reference Values; Tomography, X-Ray Computed / methods; Tomography, X-Ray Computed / standards; Tomography, X-Ray Computed / veterinary
TL;DR: Findings from the current study supported the use of a combination of CT and MR images and a priori knowledge of the shape of the optic apparatus to guide accurate contouring, especially where image contrast is not sufficient to clearly delineate the margins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Stereotactic body radiation therapy for treatment of injection-site sarcomas in cats: 11 cases (2008–2012)

Journal of the American Veterinary Medical Association, 243(4), 526–531.

By: M. Nolan*, L. Griffin, J. Custis & S. LaRue

MeSH headings : Animals; Cat Diseases / etiology; Cat Diseases / radiotherapy; Cats; Female; Injections / adverse effects; Injections / veterinary; Male; Radiosurgery / veterinary; Retrospective Studies; Sarcoma / etiology; Sarcoma / radiotherapy; Sarcoma / veterinary; Vaccines / adverse effects
TL;DR: Stereotactic body radiation therapy provided a means for palliation of ISS; further investigation is required to determine whether SBRT is a valid treatment option for downstaging disease prior to definitive surgery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 20, 2019

2012 journal article

Intensity-Modulated and Image-Guided Radiation Therapy for Treatment of Genitourinary Carcinomas in Dogs

Journal of Veterinary Internal Medicine, 26(4), 987–995.

By: M. Nolan*, L. Kogan, L. Griffin, J. Custis, J. Harmon *, B. Biller, S. LaRue

author keywords: Bladder; Dog; Genitourinary; IGRT; IMRT; Prostate; Urethra
MeSH headings : Animals; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dogs; Female; Kaplan-Meier Estimate; Male; Radiotherapy, Image-Guided / adverse effects; Radiotherapy, Image-Guided / methods; Radiotherapy, Image-Guided / veterinary; Retrospective Studies; Survival Analysis; Urogenital Neoplasms / pathology; Urogenital Neoplasms / radiotherapy; Urogenital Neoplasms / veterinary
TL;DR: IM/IGRT is generally well-tolerated and provides an effective option for locoregional control of CGUC and inclusion in multimodal treatment protocols for CGUC can result in superior survival times; controlled prospective evaluation is warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 20, 2019

2010 journal article

Pathology in Practice

Journal of the American Veterinary Medical Association, 236(6), 631–633.

By: M. Nolan*, H. Roberts*, K. Zimmerman* & S. Smith *

MeSH headings : Animals; Antiparasitic Agents / therapeutic use; Diagnosis, Differential; Enrofloxacin; Fatal Outcome; Fish Diseases / drug therapy; Fish Diseases / parasitology; Fish Diseases / pathology; Fluoroquinolones / therapeutic use; Goldfish; Male; Myxobolus / isolation & purification; Parasitic Diseases, Animal / drug therapy; Parasitic Diseases, Animal / parasitology; Parasitic Diseases, Animal / pathology
Source: Crossref
Added: July 20, 2019

2009 journal article

Chemical Carcinogenesis of the Gastrointestinal Tract in Rodents: An Overview with Emphasis on NTP Carcinogenesis Bioassays

Toxicologic Pathology, 38(1), 188–197.

By: S. Chandra*, M. Nolan* & D. Malarkey*

author keywords: cancer; gastrointestinal tract; forestomach; stomach; intestine; rat; mouse; rodent; carcinoid; papilloma; carcinoma; adenoma; adenocarcinoma; neuroendocrine tumor; colon; colorectal; carcinogens; genotoxic; non-genotoxic; molecular biology; review; p53; animal model; NTP
MeSH headings : Animals; Carcinogenicity Tests / methods; Female; Gastrointestinal Neoplasms / chemically induced; Gastrointestinal Neoplasms / pathology; Humans; Intestinal Neoplasms / chemically induced; Male; Mice; Rats; Stomach Neoplasms / chemically induced
TL;DR: The most common induced GIT tumors are squamous neoplasm of the forestomach, glandular neoplasms of the stomach are rare, and rats appear more prone to developing LI (colorectal) cancer compared to mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 20, 2019

2007 journal article

Amphibian Resources on the Internet

ILAR Journal, 48(3), 290–296.

By: M. Nolan* & S. Smith

author keywords: amphibian; animal model; Anura; Caudata; Gymnophiora; herpetology; Internet resources; veterinary medicine
MeSH headings : Amphibians / anatomy & histology; Amphibians / embryology; Amphibians / genetics; Amphibians / physiology; Amphibians / surgery; Animal Husbandry; Animals; Animals, Domestic; Classification; Conservation of Natural Resources; Databases, Factual; Internet; Natural History
TL;DR: The use of amphibians in classrooms and research laboratories has increased, along with a corresponding increase in the amount of information about these animals on the Internet, which is intended to aid both novices and experts in the search of such information. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2007 journal article

Pharmacokinetics of oxytetracycline in the American horseshoe crab, Limulus polyphemus

Journal of Veterinary Pharmacology and Therapeutics, 30(5), 451–455.

By: M. Nolan*, S. Smith * & D. Jones*

MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Female; Horseshoe Crabs / metabolism; Injections, Intravenous; Male; Oxytetracycline / administration & dosage; Oxytetracycline / blood; Oxytetracycline / pharmacokinetics
TL;DR: The American horseshoe crab, Limulus polyphemus, is regularly cultured and maintained in research laboratories and public aquaria and the kinetics of oxytetracyline following either intravascular or oral dosing is investigated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Crossref
Added: July 20, 2019

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