Nigel Brent Campbell

Works (21)

Updated: July 13th, 2023 18:50

2016 journal article

FEASIBILITY AND SAFETY OF CONTRAST-ENHANCED ULTRASOUND IN THE DISTAL LIMB OF SIX HORSES

VETERINARY RADIOLOGY & ULTRASOUND, 57(3), 282–289.

By: G. Seiler n, N. Campbell n, B. Nixon n, J. Tsuruta  n, P. Dayton n, S. Jennings *, W. Redding n, M. Lustgarten n

author keywords: contrast-enhanced; equine intra-arterial; ultrasound
MeSH headings : Animals; Contrast Media / administration & dosage; Contrast Media / adverse effects; Female; Hindlimb / diagnostic imaging; Horses; Injections, Intra-Arterial / veterinary; Injections, Intravenous / veterinary; Male; Muscle, Skeletal / diagnostic imaging; Pilot Projects; Prospective Studies; Ultrasonography / adverse effects; Ultrasonography / veterinary
TL;DR: Findings from this study indicated that CEUS is a feasible and safe diagnostic test for evaluation of the equine distal limb and future studies are needed to assess the clinical utility of this test for horses with musculoskeletal diseases. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

Feasibility and safety of lumbosacral epiduroscopy in the standing horse

EQUINE VETERINARY JOURNAL, 49(3), 322–328.

By: B. Shrauner n, A. Blikslager n , J. Davis n, N. Campbell n, M. Law  n, M. Lustgarten n, T. Prange n

Contributors: B. Shrauner n, A. Blikslager n , J. Davis n, N. Campbell n, M. Law  n, M. Lustgarten n, T. Prange n

author keywords: horse; back pain; hindlimb lameness; spinal nerve; epiduroscopy; endoscopy
MeSH headings : Animals; Endoscopy / methods; Endoscopy / veterinary; Epidural Space / surgery; Female; Horse Diseases / surgery; Horses; Lumbosacral Region / surgery; Male
TL;DR: Lumbosacral epiduroscopy can be performed safely in sedated standing horses and may become a valuable diagnostic tool in horses with caudal back or hindlimb pain of unknown origin. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2014 journal article

Perianesthetic morbidity and mortality in dogs undergoing cervical and thoracolumbar spinal surgery

VETERINARY ANAESTHESIA AND ANALGESIA, 41(2), 137–144.

By: L. Posner n, C. Mariani n , C. Swanson n, M. Asakawa n, N. Campbell n & A. King n

author keywords: surgery; spinal; morbidity; cervical; mortality; dog
MeSH headings : Anesthesia / adverse effects; Anesthesia / veterinary; Animals; Dogs; Female; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Male; Perioperative Period / adverse effects; Perioperative Period / veterinary; Postoperative Complications / veterinary
TL;DR: Overall, dogs undergoing cervical spinal surgery were less likely to survive until discharge compared with dogs undergoing thoracolumbar spinal surgery, anddogs undergoing cervical intervertebral disc decompression surgery should be considered at risk for aspiration pneumonia. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horses

Journal of Veterinary Pharmacology and Therapeutics, 34(1), 12–16.

By: J. Davis*, J. Marshall*, M. Papich n , A. Blikslager*  & N. Campbell n

Contributors: J. Davis*, J. Marshall*, M. Papich n , A. Blikslager*  & N. Campbell n

MeSH headings : Animals; Cyclooxygenase Inhibitors / blood; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / pharmacology; Horses / blood; Horses / metabolism; Sulfonamides / blood; Sulfonamides / pharmacokinetics; Sulfonamides / pharmacology
TL;DR: It is shown that deracoxib is absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in the dog and horse. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2010 journal article

Efficacy and Pharmacokinetics of Pantoprazole in Alpacas

JOURNAL OF VETERINARY INTERNAL MEDICINE, 24(4), 949–955.

By: G. Smith n , J. Davis n, S. Smith n, M. Gerard n, N. Campbell n & D. Foster n 

author keywords: Camelid; Gastrointestinal agents; Pharmacology; Physiology-gastrointestinal tract
MeSH headings : 2-Pyridinylmethylsulfinylbenzimidazoles / pharmacokinetics; 2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use; Animals; Anti-Ulcer Agents / pharmacokinetics; Anti-Ulcer Agents / therapeutic use; Camelids, New World; Hydrogen-Ion Concentration; Pantoprazole; Stomach Ulcer / prevention & control; Stomach Ulcer / veterinary
TL;DR: Based on the results of this study, pantoprazole represents a safe and effective drug for increasing 3rd compartment pH in camelids and either IV or SC administration is likely to be an effective treatment for gastric ulcers. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 journal article

Evaluation of 30- and 25-diopter intraocular lens implants in equine eyes after surgical extraction of the lens

American Journal of Veterinary Research, 71(7), 809–816.

By: R. McMullen n, M. Davidson n, N. Campbell n, J. Salmon n & B. Gilger n 

MeSH headings : Animals; Anterior Chamber / surgery; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / therapeutic use; Euthanasia, Animal; Eye Enucleation / methods; Eye Enucleation / veterinary; Horse Diseases / surgery; Horses; Lens Implantation, Intraocular / methods; Lens Implantation, Intraocular / veterinary; Lens, Crystalline / anatomy & histology; Lens, Crystalline / surgery; Lenses, Intraocular / veterinary; Refraction, Ocular / physiology; Refractive Errors / therapy; Refractive Errors / veterinary; Refractive Surgical Procedures / methods; Refractive Surgical Procedures / veterinary
TL;DR: Investigation of intraocular lens (IOL) implant strength to approximate emmetropia in horses found insertion of 30-D (enucleated globes) and 25-D IOL implants (adult horses) resulted in overcorrection of refractive error. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

The hemodynamic effects of medetomidine continuous rate infusions in the dog

VETERINARY ANAESTHESIA AND ANALGESIA, 37(3), 197–206.

By: J. Carter n, N. Campbell n, L. Posner n & C. Swanson n

author keywords: cardiac output; CRI; medetomidine
MeSH headings : Analgesics, Non-Narcotic / administration & dosage; Analgesics, Non-Narcotic / pharmacology; Animals; Blood Gas Analysis / veterinary; Blood Pressure / drug effects; Cardiac Output / drug effects; Dogs; Dose-Response Relationship, Drug; Heart Rate / drug effects; Hemodynamics / drug effects; Infusions, Intravenous / veterinary; Medetomidine / administration & dosage; Medetomidine / pharmacology; Stroke Volume / drug effects; Vascular Resistance / drug effects
TL;DR: The demonstrated decrease in CO is largely because of bradycardia and the degree of cardiovascular depression appears to be dose-dependent, consistent with previously described hemodynamic changes with single bolus administration of medetomidine. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses

American Journal of Veterinary Research, 70(10), 1259–1268.

By: V. Cook n, J. Jones Shults n, M. McDowell n, N. Campbell n, J. Davis n, J. Marshall n, A. Blikslager n 

Contributors: V. Cook n, J. Jones Shults n, M. McDowell n, N. Campbell n, J. Davis n, J. Marshall n, A. Blikslager n 

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Clonixin / adverse effects; Clonixin / analogs & derivatives; Female; Gene Expression Regulation, Enzymologic / drug effects; Horse Diseases / chemically induced; Horse Diseases / drug therapy; Horses; Intestinal Diseases / chemically induced; Intestinal Diseases / veterinary; Ischemia / chemically induced; Jejunum / drug effects; Lidocaine / therapeutic use; Male; Prostaglandin-Endoperoxide Synthases / genetics; Prostaglandin-Endoperoxide Synthases / metabolism
TL;DR: In horses with ischemia-injured jejunum, lidocaine administered IV reduced plasma prostaglandin E(2) metabolite concentration and mucosal COX-2 expression and coadministration of lidocane with flunixin ameliorated the flunxin-induced increase in mucosal neutrophil counts. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum

American Journal of Veterinary Research, 70(8), 992–1000.

By: V. Cook n, C. Meyer n, N. Campbell n & A. Blikslager n 

Contributors: V. Cook n, C. Meyer n, N. Campbell n & A. Blikslager n 

MeSH headings : 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Blotting, Western / veterinary; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / metabolism; Eicosanoids / blood; Electrophoresis, Polyacrylamide Gel / veterinary; Horse Diseases / drug therapy; Horses; Ischemia / drug therapy; Ischemia / veterinary; Jejunal Diseases / drug therapy; Jejunal Diseases / veterinary; Sulfones / therapeutic use; Thromboxane B2 / blood
TL;DR: Firocoxib may be advantageous in horses recovering from ischemic intestinal injury, while providing effective analgesia in horses treated with flunixin meglumine and firo Coxib. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Third-compartment cannulation in alpacas using a polyurethane gastrostomy tube

AUSTRALIAN VETERINARY JOURNAL, 87(12), 487–491.

By: G. Smith n , M. Gerard n, N. Campbell n, D. Foster n , S. Smith n & J. Davis n

author keywords: alpacas; camelids; cannulation; nutritional support; third compartment
MeSH headings : Animals; Camelids, New World / surgery; Gastrostomy / instrumentation; Gastrostomy / methods; Gastrostomy / veterinary; Male; Polyurethanes; Prospective Studies; Surgery, Veterinary / instrumentation; Surgery, Veterinary / methods; Treatment Outcome
TL;DR: Surgical placement of polyurethane tubes designed for percutaneous endoscopic gastrostomy is a useful method of cannulating the third compartment in camelids and can be used for nutritional support and fluid therapy in sick camelids that might need long-term care. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine

Equine Veterinary Journal, 40(4), 353–357.

By: V. Cook, J. Shults, M. McDowell, N. Campbell, J. Davis & A. Blikslager 

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2008 journal article

Evaluation of a novel epicardial atrial fibrillation treatment system

ANNALS OF THORACIC SURGERY, 85(1), 300–304.

By: A. Kiser *, L. Nifong*, J. Raman *, V. Kasirajan*, N. Campbell n & W. Chitwood*

MeSH headings : Animals; Atrial Fibrillation / pathology; Atrial Fibrillation / surgery; Catheter Ablation / instrumentation; Catheter Ablation / methods; Disease Models, Animal; Equipment Design; Equipment Safety; Immunohistochemistry; Laser Coagulation / instrumentation; Pericardium / surgery; Pulmonary Veins / pathology; Pulmonary Veins / surgery; Sensitivity and Specificity; Sheep
TL;DR: This novel epicardial coagulation system successfully created continuous and transmural atrial lesions in a beating-heart ovine model. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 article

A novel instrumented retractor to monitor tissue-disruptive forces during lateral thoracotomy

Bolotin, G., Buckner, G. D., Jardine, N. J., Kiefer, A. J., Campbell, N. B., Kocherginsky, M., … Jeevanandam, V. (2007, April). JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol. 133, pp. 949–954.

By: G. Bolotin*, G. Buckner n, N. Jardine n, A. Kiefer n, N. Campbell n, M. Kocherginsky*, J. Raman *, V. Jeevanandam *

MeSH headings : Animals; Biomechanical Phenomena; Models, Animal; Monitoring, Intraoperative / instrumentation; Sheep; Thoracotomy / adverse effects; Thoracotomy / instrumentation
TL;DR: Use of the novel instrumented retractor resulted in significantly lower average and peak retraction forces during lateral thoracotomy, as documented by lower systolic blood pressures and fewer rib fractures. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum

American Journal of Veterinary Research, 68(6), 614–624.

By: D. Little n, S. Brown, N. Campbell*, A. Moeser*, J. Davis* & A. Blikslager* 

Contributors: D. Little n, S. Brown, N. Campbell*, A. Moeser*, J. Davis* & A. Blikslager* 

MeSH headings : Animals; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Horse Diseases / drug therapy; Horses; Intestinal Diseases / drug therapy; Intestinal Diseases / veterinary; Ischemia / veterinary; Jejunum / injuries; Meloxicam; Thiazines / pharmacokinetics; Thiazines / therapeutic use; Thiazoles / pharmacokinetics; Thiazoles / therapeutic use
TL;DR: It is suggested that IV administration of meloxicam may be a useful alternative to flunixin meglumine for postoperative treatment of horses with colic. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Pharmacokinetics of etodolac in the horse following oral and intravenous administration

Journal of Veterinary Pharmacology and Therapeutics, 30(1), 43–48.

By: J. Davis n, M. Papich n , A. Morton *, J. Gayle*, A. Blikslager*  & N. Campbell n

Contributors: J. Davis n, M. Papich n , A. Morton *, J. Gayle*, A. Blikslager*  & N. Campbell n

MeSH headings : Administration, Oral; Animals; Area Under Curve; Cross-Over Studies; Cyclooxygenase 1 / drug effects; Cyclooxygenase 2 / drug effects; Cyclooxygenase Inhibitors / administration & dosage; Cyclooxygenase Inhibitors / blood; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / pharmacology; Etodolac / administration & dosage; Etodolac / blood; Etodolac / pharmacokinetics; Etodolac / pharmacology; Female; Horses / metabolism; Injections, Intravenous / veterinary; Male
TL;DR: It was showed that etodolac is well absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in thehorse. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2005 journal article

Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis

Research in Veterinary Science, 78(2), 189–192.

By: A. Morton n, N. Campbell n, J. Gayle n, W. Redding n & A. Blikslager n 

Contributors: A. Morton n, N. Campbell n, J. Gayle n, W. Redding n & A. Blikslager n 

author keywords: prostaglandin; synovitis; etodolac; phenylbutazone; thromboxane
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Dinoprostone / analysis; Enzyme-Linked Immunosorbent Assay / veterinary; Etodolac / pharmacology; Horse Diseases / drug therapy; Horse Diseases / enzymology; Horse Diseases / pathology; Horses; Leukocyte Count / veterinary; Lipopolysaccharides; Phenylbutazone / pharmacology; Random Allocation; Synovial Fluid / chemistry; Synovitis / drug therapy; Synovitis / enzymology; Synovitis / pathology; Synovitis / veterinary; T-Box Domain Proteins / analysis
TL;DR: Etodolac may serve as a more selective anti-inflammatory agent than phenylbutazone for treatment of equine synovitis, as compared to non-selective COX inhibitors. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Stringhalt associated with a pasture infested with Hypochoeris radicata

Equine Veterinary Education, 17(3), 118–122.

By: S. Gardner n, A. Cook*, B. Jortner *, B. Troan  n, N. Sharp n, N. Campbell n, C. Brownie n

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Physiological concentrations of bile salts inhibit recovery of ischemic-injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(2), G399–G407.

By: N. Campbell n, C. Ruaux *, D. Shifflett n, J. Steiner *, D. Williams * & A. Blikslager n 

Contributors: N. Campbell n, C. Ruaux *, D. Shifflett n, J. Steiner *, D. Williams * & A. Blikslager n 

author keywords: mucosa; barrier function; deoxycholic acid; tight junction
MeSH headings : Animals; Bile Acids and Salts / analysis; Calcium / metabolism; Deoxycholic Acid / pharmacology; Female; Ileum / blood supply; Ileum / chemistry; Ileum / pathology; Ileum / physiopathology; Ischemia / metabolism; Ischemia / pathology; Ischemia / physiopathology; Male; Microscopy, Electron; Osmolar Concentration; Permeability / drug effects; Recovery of Function / drug effects; Swine; Taurodeoxycholic Acid / pharmacology
TL;DR: Deoxycholic acid at physiological concentrations significantly impairs recovery of epithelial barrier function by an effect on paracellular pathways, and these effects appear to be Ca(2+) dependent. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2002 article

The effects of cyclo-oxygenase inhibitors on bile-injured and normal equine colon

Campbell, N. B., Jones, S. L., & Blikslager, A. T. (2002, July). EQUINE VETERINARY JOURNAL, Vol. 34, pp. 493–498.

By: N. Campbell n, S. Jones n  & A. Blikslager n 

author keywords: horse; colon; mucosa; cyclo-oxygenase; flunixin; etodolac
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Clonixin / administration & dosage; Clonixin / adverse effects; Clonixin / analogs & derivatives; Colitis / chemically induced; Colitis / veterinary; Colon / drug effects; Colon / pathology; Colon / physiopathology; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / administration & dosage; Cyclooxygenase Inhibitors / adverse effects; Deoxycholic Acid / adverse effects; Etodolac / administration & dosage; Etodolac / adverse effects; Horse Diseases / chemically induced; Horses; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Isoenzymes / metabolism; Permeability; Prostaglandin Antagonists / administration & dosage; Prostaglandin Antagonists / adverse effects; Prostaglandin-Endoperoxide Synthases / metabolism; Prostaglandins / biosynthesis
TL;DR: Although recovery from bile-induced colonic injury maybe independent of COX-elaborated prostanoids, treatment of control tissues with nonselective COX inhibitors may lead to marked increases in permeability, and selective inhibition ofCOX-2 may reduce the incidence of adverse effects in horses requiring NSAID therapy. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

The role of cyclooxygenase inhibitors in repair of ischaemic-injured jejunal mucosa in the horse

Equine Veterinary Journal. Supplement, (32), 59–64.

By: N. Campbell n & A. Blikslager n 

MeSH headings : Animals; Clonixin / analogs & derivatives; Clonixin / pharmacology; Clonixin / therapeutic use; Colic / prevention & control; Colic / veterinary; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Cyclooxygenase Inhibitors / therapeutic use; Etodolac / pharmacology; Etodolac / therapeutic use; Horse Diseases / prevention & control; Horses; Intestinal Mucosa / drug effects; Isoenzymes / antagonists & inhibitors; Jejunal Diseases / prevention & control; Jejunal Diseases / veterinary; Jejunum / blood supply; Jejunum / drug effects; Male; Prostaglandin Antagonists / pharmacology; Prostaglandin Antagonists / therapeutic use; Prostaglandin-Endoperoxide Synthases; Reperfusion Injury / veterinary
TL;DR: It is suggested that specific COX-2 inhibitors may provide an advantageous alternative to nonspecific cyclooxygenase inhibitors in horses with colic. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

journal article

surgical tendonitis model in horses: Techinque, clinical, ultrasonographic and histological characterisation

Schramme, M., Hunter, S., Campbell, N., Blikslager, A., & Smith, R. Veterinary and Comparative Orthopaedics and Traumatology, 23(4), 231–239.

By: M. Schramme, S. Hunter, N. Campbell, A. Blikslager  & R. Smith

Source: NC State University Libraries
Added: August 6, 2018

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