Nicholas E. Hardison

Works (7)

Updated: July 5th, 2023 15:53

2013 journal article

Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas

Placenta, 34(7), 599–605.

By: L. Guo  n, S. Tsai *, N. Hardison n, A. James *, A. Motsinger-Reif n, B. Thames*, E. Stone n, C. Deng*, J. Piedrahita n 

author keywords: Placenta; Preeclampsia; IUGR; MiR-194; MiR-149
MeSH headings : Down-Regulation; Female; Fetal Growth Retardation / genetics; Fetal Growth Retardation / metabolism; Humans; MicroRNAs / biosynthesis; Placenta / metabolism; Pre-Eclampsia / genetics; Pre-Eclampsia / metabolism; Pregnancy; Transcriptome
TL;DR: Modulated modularity clustering (MMC) allowed the elucidation of a molecular signature associated with preeclampsia and a subset of IUGR samples, which allowed the identification of genes, pathways, and microRNAs affected in these diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

Genomic Profiling in CEPH Cell Lines Distinguishes between the Camptothecins and Indenoisoquinolines

MOLECULAR CANCER THERAPEUTICS, 10(10), 1839–1845.

By: V. Watson n, N. Hardison n, T. Harris n, A. Motsinger-Reif n & H. McLeod  n

MeSH headings : Antineoplastic Agents, Phytogenic / pharmacology; Camptothecin / pharmacology; Cell Line; Drug Evaluation, Preclinical / methods; Gene Expression Profiling; Genomics / methods; Humans; Isoquinolines / pharmacology; Oligonucleotide Array Sequence Analysis; Quantitative Trait Loci; Topoisomerase I Inhibitors / pharmacology
TL;DR: In vitro sensitivity of the same panel of CEPH cell lines to the indenisoquinolones, a structurally distinct class of Top1 inhibitors, is characterized, revealing a pattern of 7 quantitative trait loci (QTL) shared by all of the camptothecins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees

PLoS One, 6(5).

By: V. Watson, A. Motsinger-Reif, N. Hardison, E. Peters, T. Havener, L. Everitt, J. Auman, D. Comins, H. McLeod

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Pharmacogenomic characterization of US FDA-approved cytotoxic drugs

PHARMACOGENOMICS, 12(10), 1407–1415.

By: E. Peters*, A. Motsinger-Reif n, T. Havener *, L. Everitt*, N. Hardison n, V. Watson*, M. Wagner *, K. Richards *, M. Province*, H. McLeod *

author keywords: cancer; cell line; chemotherapy; cytotoxicity; pharmacogenetics; pharmacogenomic; QTL
MeSH headings : Antineoplastic Agents / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Approval; Genetic Linkage; Humans; Pharmacogenetics; Quantitative Trait Loci / genetics; United States; United States Food and Drug Administration
TL;DR: The results of this systematic study highlight the variable role that genetics plays in response to cytotoxic drugs, and inform the prioritization of chemotherapeutic drugs with a sizable genetic response component for future investigation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways

PLACENTA, 32(2), 175–182.

By: S. Tsai n, N. Hardison n, A. James *, A. Motsinger-Reif n, S. Bischoff n, B. Thames*, J. Piedrahita n 

author keywords: Placenta; Preeclampsia; Maternal hypertension; Sialic acid acetylesterase
MeSH headings : Acetylesterase / biosynthesis; Antigens, CD / biosynthesis; Endoglin; Female; Genome-Wide Association Study; Humans; Infant, Newborn; Inhibins / biosynthesis; Male; Pre-Eclampsia / etiology; Pre-Eclampsia / metabolism; Pregnancy; Protein Array Analysis; Receptors, Cell Surface / biosynthesis; Trophoblasts / physiology; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 / biosynthesis
TL;DR: Evidence is found of preeclampsia-associated placental upregulation of sialic acid acetylesterase (SIAE), a gene functionally associated with autoimmune diseases, and changes in immune-associated signaling pathways, offering a potential upstream explanation for the shallow trophoblast invasion and inadequate uterine remodeling typically observed in pathogenesis of preeClampsia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Characterization of Conserved and Nonconserved Imprinted Genes in Swine

BIOLOGY OF REPRODUCTION, 81(5), 906–920.

By: S. Bischoff n, S. Tsai n, N. Hardison n, A. Motsinger-Reif n, B. Freking *, D. Nonneman *, G. Rohrer *, J. Piedrahita n 

author keywords: assisted reproductive technology; comparative genomic imprinting; epigenetics; gene regulation; genomic imprinting; parthenogenesis; placenta; swine parthenote
MeSH headings : Animals; Female; Fetus / anatomy & histology; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Oligonucleotide Array Sequence Analysis; Organ Size; Parthenogenesis / genetics; Placenta / anatomy & histology; Polymorphism, Single Nucleotide; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Staining and Labeling; Swine / genetics
TL;DR: To increase the understanding of imprinted genes in swine, a comprehensive analysis of this gene family was carried out using two complementary approaches: expression and phenotypic profiling of parthenogenetic fetuses, and analysis of imprinting by pyrosequencing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Identification of SNPs and INDELS in swine transcribed sequences using short oligonucleotide microarrays

BMC Genomics, 9(1), 252.

By: S. Bischoff n, S. Tsai n, N. Hardison n, A. York n, B. Freking *, D. Nonneman *, G. Rohrer *, J. Piedrahita n 

MeSH headings : Animals; Base Sequence; Computational Biology; DNA / genetics; Female; Fetus / metabolism; Gene Expression Profiling; INDEL Mutation; Linear Models; Male; Oligonucleotide Array Sequence Analysis / methods; Oligonucleotide Array Sequence Analysis / statistics & numerical data; Placenta / metabolism; Polymorphism, Single Nucleotide; Pregnancy; RNA / genetics; Species Specificity; Swine / genetics
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

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