@article{khaled_kulkarni_kaeser_gimeno_2024, title={Temporal Changes in Splenic Immune Cell Populations following Infection with a Very Virulent plus MDV in Commercial Meat-Type Chickens}, url={http://dx.doi.org/10.3390/v16071092}, DOI={10.3390/v16071092}, abstractNote={Marek’s disease virus (MDV) can cause severe immunosuppression in chickens. Our previous study showed that infection with very virulent plus (vv+) MDV strains of one-day-old commercial meat-type chickens possessing maternal antibodies against MDV resulted in severe depletion of splenocytes at 28–30 days of age. In the present study, we have investigated the effect of vv+MDV strain 686 on splenic immunophenotypes at 6, 20, and 30 days post-infection (dpi). Both live and dead cells were analyzed, and the data were statistically compared to the uninfected control. The results revealed a decrease in the total live cell population starting on day 20, primarily affecting B cells, CD8β+, and gamma delta (γδ) T cells, while the frequencies of both live and dead CD3+ and CD4+ T cells were increased. The MHC-I expression of CD3+ and CD4+ T cells was higher at 20 and 30 dpi, while the expression of MHC-II on these cells was downregulated at 6 dpi but was upregulated at 30 dpi. Collectively, these results suggest that maternal antibodies seem to delay the negative effects of vv+MDV on the splenic lymphoid populations, albeit being non-protective. Our results emphasize the importance of MD vaccination in vv+MDV endemic areas.}, journal={Viruses}, author={Khaled, Nagwa and Kulkarni, Raveendra and Kaeser, Tobias and Gimeno, Isabel M.}, year={2024}, month={Jul} }
 @article{sequence analysis of seven equine herpes type 1 viruses circulating in non- vaccinated arabian and foreign horses in egypt_2019, url={http://www.j-virol-sci.com/?mno=1402}, journal={Journal of Virological Sciences}, year={2019} }