Works (19)

Updated: June 3rd, 2024 08:14

2024 journal article

Erratum: “Drinking Water–Associated PFAS and Fluoroethers and Lipid Outcomes in the GenX Exposure Study”

Erratum: “Drinking Water–Associated PFAS and Fluoroethers and Lipid Outcomes in the GenX Exposure Study.” Environmental Health Perspectives.

By: E. Rosen, N. Kotlarz*, D. Knappe, C. Lea, D. Collier, D. Richardson, J. Hoppin

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: March 21, 2024

2024 journal article

Erratum: “Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina”

Erratum: “Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina.” Environmental Health Perspectives.

By: N. Kotlarz*, J. McCord, D. Collier, C. Lea, M. Strynar, A. Lindstrom, A. Wilkie, J. Islam ...

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: March 21, 2024

2024 article

Estimating Rates of Change to Interpret Quantitative Wastewater Surveillance of Disease Trends

Holcomb, D. A., Christensen, A., Hoffman, K., Lee, A., Blackwood, A. D., Clerkin, T., … Engel, L. S. (2024, April 25).

Source: ORCID
Added: May 1, 2024

2024 article

Measurement of Hydro-EVE and 6:2 FTS in Blood from Wilmington, North Carolina, Residents, 2017-2018

Kotlarz, N., McCord, J., Wiecha, N., Weed, R. A., Cuffney, M., Enders, J. R., … Hoppin, J. A. (2024, February). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 132.

By: N. Kotlarz n, J. McCord*, N. Wiecha n, R. Weed*, M. Cuffney n, J. Enders n, M. Strynar*, D. Knappe n, B. Reich n, J. Hoppin n

Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 21, 2024

2024 article

Reanalysis of PFO5DoA Levels in Blood from Wilmington, North Carolina, Residents, 2017-2018

Kotlarz, N., McCord, J., Wiecha, N., Weed, R. A., Cuffney, M., Enders, J. R., … Hoppin, J. A. (2024, February). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 132.

By: N. Kotlarz n, J. McCord*, N. Wiecha n, R. Weed*, M. Cuffney n, J. Enders n, M. Strynar*, D. Knappe n, B. Reich n, J. Hoppin n

Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 21, 2024

2023 journal article

Estimation of the Half-Lives of Recently Detected Per- and Polyfluorinated Alkyl Ethers in an Exposed Community

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57(41), 15348–15355.

author keywords: exposure; PFAS; water; humans; environment; toxicokinetic modeling
TL;DR: These fluoroethers had biological half-Lives longer than published half-lives for PFHxA and PFHpA but shorter than those for PFOA andPFOS (800-1200 days). (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 7, 2023

2023 journal article

Factors associated with per- and polyfluoroalkyl substances (PFAS) serum concentrations in residents of New Hanover County, North Carolina: The GenX exposure study

ENVIRONMENTAL RESEARCH, 237.

By: M. Cuffney n, A. Wilkie n, N. Kotlarz n, D. Knappe n, C. Lea n, D. Collier n, J. Dewitt n, J. Hoppin n

author keywords: Per-and polyfluoroalkyl substances (PFAS); Fluoroethers; Contaminated drinking water; Environmental exposure predictors
TL;DR: It is shown that drinking water is a primary source for serum PFAS concentrations among New Hanover County residents and years of residence in the lower Cape Fear Region as a surrogate for water consumption were important for both the association and predictive investigations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 4, 2023

2023 journal article

Source apportionment of serum PFASs in two highly exposed communities

SCIENCE OF THE TOTAL ENVIRONMENT, 855.

By: D. Wallis n, K. Barton*, D. Knappe n, N. Kotlarz n, C. McDonough*, C. Higgins*, J. Hoppin n, J. Adgate*

author keywords: Source apportionment; Receptor models; PFAS; Per fluoroalkyl substances
MeSH headings : Humans; Fluorocarbons / analysis; Nutrition Surveys; Drinking Water / analysis; Multivariate Analysis; Principal Component Analysis; Alkanesulfonic Acids / analysis; Water Pollutants, Chemical / analysis
TL;DR: Effectiveness of three source apportionment methods for identifying contributors to human serum PFAS concentrations in two highly exposed populations in Colorado and North Carolina where drinking water was contaminated via upstream sources is assessed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 11, 2022

2023 journal article

Timing and Trends for Municipal Wastewater, Lab-Confirmed Case , and Syndromic Case Surveillance of COVID-19 in Raleigh, North Carolina

AMERICAN JOURNAL OF PUBLIC HEALTH, 113(1), 79–88.

By: N. Kotlarz n, D. Holcomb n, T. Pasha n, S. Reckling n, J. Kays n, Y. Lai n, S. Daly n, S. Palani n ...

Contributors: N. Kotlarz n, D. Holcomb n, T. Pasha n, S. Reckling n, J. Kays n, Y. Lai n, S. Daly n, S. Palani n ...

MeSH headings : Humans; COVID-19 / epidemiology; SARS-CoV-2; Wastewater; North Carolina / epidemiology; Sentinel Surveillance; RNA, Viral
TL;DR: The results provide evidence for investment in SARS-CoV-2 wastewater and CLI surveillance to complement information provided through lab-confirmed cases, and in a major metropolitan area in 2020, the timing of and trends in municipal wastewater, lab- confirmed case, and syndromic case surveillance of COVID-19 were in general agreement. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 30, 2023

2023 article

Using Detrending to Assess SARS-CoV-2 Wastewater Loads as a Leading Indicator of Fluctuations in COVID-19 Cases at Fine Temporal Scales: Correlations Across Twenty Sewersheds in North Carolina

Hoffman, K., Holcomb, D., Reckling, S., Clerkin, T., Blackwood, D., Beattie, R., … Christensen, A. (2023, June 5).

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: June 4, 2023

2023 journal article

Using detrending to assess SARS-CoV-2 wastewater loads as a leading indicator of fluctuations in COVID-19 cases at fine temporal scales: Correlations across twenty sewersheds in North Carolina

PLOS Water.

Ed(s): V. Kapoor

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: October 19, 2023

2022 journal article

Comparing Rates of Change in SARS-CoV-2 Wastewater Load and Clinical Cases in 19 Sewersheds Across Four Major Metropolitan Areas in the United States

ACS ES&T Water, 7.

author keywords: wastewater-based epidemiology; COVID-19; sensitivity; normalization; threshold; imputation; smoothing
TL;DR: A wastewater sensitivity threshold is estimated-supporting the use of relative, rather than absolute, measures of SARS-CoV-2 wastewater data for more interoperable data sets. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: July 16, 2022

2022 journal article

Drinking Water-Associated PFAS and Fluoroethers and Lipid Outcomes in the GenX Exposure Study

ENVIRONMENTAL HEALTH PERSPECTIVES, 130(9).

By: E. Rosen*, N. Kotlarz n, D. Knappe n, C. Lea*, D. Collier*, D. Richardson*, J. Hoppin n

MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Alkanesulfonic Acids; Child; Cholesterol; Cross-Sectional Studies; Drinking Water; Environmental Pollutants; Fluorocarbons; Humans; Lipids; Middle Aged; Young Adult
TL;DR: PFNA and PFOS were associated with higher levels of total and non-HDL cholesterol, with associations larger in magnitude among older adults, and fluoroethers appeared to be associated with HDL but not non- HDL lipid measures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 8, 2022

2020 journal article

Elevated levels of per- and polyfluoroalkyl substances in Cape Fear River Striped Bass (Morone saxatilis) are associated with biomarkers of altered immune and liver function

ENVIRONMENT INTERNATIONAL, 136.

By: T. Guillette n, J. McCord*, M. Guillette n, M. Polera n, K. Rachels*, C. Morgeson*, N. Kotlarz n, D. Knappe n ...

Contributors: T. Guillette n, J. McCord*, M. Guillette n, M. Polera n, K. Rachels*, C. Morgeson*, N. Kotlarz n, D. Knappe n ...

MeSH headings : Animals; Bass; Biomarkers; Fluorocarbons / toxicity; Liver; Rivers; Water Pollutants, Chemical / toxicity
TL;DR: The elevated PFAS concentrations found in the Cape Fear River Striped Bass were associated with biomarkers of alterations in the liver and immune system, and correlations betweenPFAS concentrations and health-related serum biomarkers were evaluated. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 2, 2020

2020 journal article

Emerging investigator series: bacterial opportunistic pathogen gene markers in municipal drinking water are associated with distribution system and household plumbing characteristics

ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY, 6(11), 3032–3043.

By: S. Haig*, N. Kotlarz*, L. Kalikin*, T. Chen*, S. Guikema*, J. LiPuma*, L. Raskin*

TL;DR: Municipally-treated drinking water is a potential source of exposure to bacterial opportunistic pathogens (OPs), which can cause infection in susceptible individuals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020

2020 journal article

Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina

ENVIRONMENTAL HEALTH PERSPECTIVES, 128(7).

By: N. Kotlarz n, J. McCord*, D. Collier*, C. Lea*, M. Strynar*, A. Lindstrom*, A. Wilkie n, J. Islam n ...

MeSH headings : Adult; Alkanesulfonic Acids; Caprylates; Child; Drinking Water; Environmental Exposure / statistics & numerical data; Female; Fluorocarbons / analysis; Fluorocarbons / blood; Humans; Male; North Carolina; Nutrition Surveys; Rivers; Water Pollutants, Chemical / analysis
TL;DR: Poorly understood fluoroethers released into the Cape Fear River by a fluorochemical manufacturing facility were detected in blood samples from Wilmington, North Carolina, residents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 24, 2020

2019 journal article

Retrospective Analysis of Nontuberculous Mycobacterial Infection and Monochloramine Disinfection of Municipal Drinking Water in Michigan

MSPHERE, 4(4).

By: N. Kotlarz*, L. Raskin*, M. Zimbric*, J. Errickson*, J. LiPuma* & L. Caverly*

Ed(s): T. Mattes

author keywords: disinfection; drinking water; infection; monochloramine; nontuberculous mycobacteria
MeSH headings : Adult; Aged; Chloramines / pharmacology; Chlorine / pharmacology; Disinfectants / pharmacology; Disinfection / methods; Drinking Water / microbiology; Female; Humans; Male; Michigan / epidemiology; Middle Aged; Mycobacterium Infections, Nontuberculous / epidemiology; Mycobacterium Infections, Nontuberculous / etiology; Nontuberculous Mycobacteria / drug effects; Retrospective Studies; Water Purification / methods; Water Purification / standards
TL;DR: The results suggest that municipal drinking water disinfection with monochloramine compared to chlorine is not associated with higher risk of NTM infection, which is important given that regulations that limit drinking water concentrations of disinfection by-products, which are formed primarily when chlorine disinfection is used, incentivize drinking water utilities to change from chlorine disinfections to monoch chloramine disinfection. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 16, 2019

2018 journal article

A High-Throughput Approach for Identification of Nontuberculous Mycobacteria in Drinking Water Reveals Relationship between Water Age and Mycobacterium avium

MBIO, 9(1).

By: S. Haig*, N. Kotlarz*, J. LiPuma* & L. Raskin*

author keywords: DNA extraction; drinking water; Mycobacterium avium; NTM; PacBio; premise plumbing
MeSH headings : Bacterial Load; DNA, Bacterial / analysis; DNA, Bacterial / isolation & purification; DNA-Directed RNA Polymerases / genetics; Drinking Water / microbiology; High-Throughput Screening Assays; Microbiological Techniques / methods; Molecular Diagnostic Techniques / methods; Mycobacterium Infections, Nontuberculous / prevention & control; Nontuberculous Mycobacteria / classification; Nontuberculous Mycobacteria / genetics; Nontuberculous Mycobacteria / isolation & purification; Sequence Analysis, DNA; Time Factors
TL;DR: This approach allows NTM identification to the species and subspecies levels and can be used in future studies to assess the risk of waterborne infection by providing insight into the similarity between environmental and infection-associated NTM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Biofilms in Full-Scale Drinking Water Ozone Contactors Contribute Viable Bacteria to Ozonated Water

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 52(5), 2618–2628.

By: N. Kotlarz*, N. Rockey*, T. Olson*, S. Haig*, L. Sanford, J. LiPuma*, L. Raskin*

MeSH headings : Bacteria; Biofilms; Drinking Water; Ozone; Water Softening
TL;DR: The results implicate microbial detachment from biofilms on contactor surfaces, and from biomass present within lime softening sediments in a hydraulic dead zone, as a possible reason for increasing cell concentrations in water samples from sequential ozone chambers, as well as the effluent from ozone contactors being treated further in biologically active filters and bacteria in ozonated water continuously seed filter microbial communities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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