Nicholas Peter Massaro

Works (6)

Updated: March 9th, 2024 05:00

2023 journal article

3-Component Approach to 1,5-Dihydro-2<i>H</i>-pyrrol-2-one Heterocycles

ORGANIC SYNTHESES, 100, 418-+.

By: N. Massaro* & J. Pierce 

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Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024

2022 journal article

Tissue-reactive drugs enable materials-free local depots

JOURNAL OF CONTROLLED RELEASE, 343, 142–151.

By: S. Pandit n, S. Palvai n, N. Massaro n, J. Pierce n  & Y. Brudno n 

author keywords: Sustained release; Materials-free delivery; Paclitaxel; Pancreatic cancer; Extracellular matrix; N-hydroxysuccinimide ester
MeSH headings : Animals; Cell Line, Tumor; Drug Delivery Systems; Drug Liberation; Hydrogels; Mice; Paclitaxel; Pancreatic Neoplasms / drug therapy
TL;DR: It is demonstrated that locally injected TRAPs create dispersed, stable intratumoral depots deep within mouse and human pancreatic tumor tissues, and had better solubility than free paclitaxel and enabled sustained in vitro and in vivo drug release. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2021 review

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 54(8), 1866–1877.

By: M. Valdes-Pena  n, N. Massaro n, Y. Lin n & J. Pierce n 

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / pharmacology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biological Products / chemical synthesis; Biological Products / chemistry; Biological Products / pharmacology; Drug Resistance, Multiple, Bacterial / drug effects; Guanidine / analogs & derivatives; Guanidine / chemical synthesis; Guanidine / pharmacology; Guanidines / chemical synthesis; Guanidines / pharmacology; Microbial Sensitivity Tests; Oxazolidinones / chemical synthesis; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Staphylococcus aureus / physiology; Stereoisomerism; Structure-Activity Relationship
TL;DR: These studies provide several distinct platforms for the development of novel therapeutics that can add to the arsenal of scaffolds for preclinical development and can provide insight into the biochemical processes and pathways that can be targeted by small molecules in the fight against antimicrobial-resistant and -tolerant infections. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 19, 2021

2021 journal article

Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach

TETRAHEDRON LETTERS, 75.

By: N. Massaro n & J. Pierce n 

author keywords: Amaryllidaceae alkaloids; Heterocycles; Multicomponent; Natural products; Total synthesis
TL;DR: A key highlight of the approach is the modularity of the core synthesis, overcoming existing challenges for these scaffolds and providing a path to explore site-selective oxidation to expand the scope of molecules accessible from common intermediates. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 25, 2021

2021 journal article

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture

Acta Biomaterialia, 138, 208–217.

By: C. Moody n, A. Brown n , N. Massaro n, A. Patel n, P. Agarwalla n, A. Simpson  n, A. Brown n, H. Zheng n , J. Pierce n , Y. Brudno n 

author keywords: Alginate; Click chemistry; Bioconjugation; Ionic cross-linking; Drug capture
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 31, 2021

2020 journal article

Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds

ORGANIC LETTERS, 22(13), 5079–5084.

By: N. Massaro n & J. Pierce n 

MeSH headings : Amaryllidaceae Alkaloids / chemistry; Indoles / chemical synthesis; Indoles / chemistry; Stereoisomerism
TL;DR: A highly convergent, diastereoselective, multicomponent approach to access the hydroindole cores present within crinine, haemanthamine, pretazettine, and various other bioactive alkaloids. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 3, 2020

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