Nataliia Vasylivna Shymanska

Works (3)

Updated: July 10th, 2023 21:19

2017 journal article

Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and beta-Amino Acids

ORGANIC LETTERS, 19(11), 2961–2964.

By: N. Shymanska n & J. Pierce n

MeSH headings : Amino Acids; Cyclization; Molecular Structure; Pyrrolidines / chemistry; Stereoisomerism
TL;DR: A facile, diastereoselective synthesis of highly substituted pyrrolidine-2,3-diones is reported, along with the one-step conversion of these heterocycles to novel β-amino acids and further functionalized derivatives. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4887–4889.

By: N. Shymanska n, I. An n, S. Guevara-Zuluaga n & J. Pierce n

author keywords: Antibiotic; Heterocycle; Oxazolidinone; Natural products
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones / chemical synthesis; Oxazolidinones / chemistry; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Structure-Activity Relationship
TL;DR: These studies revealed the importance of an electron deficient aromatic ring for antimicrobial activity and serve as the basis for future SAR studies around the 4-oxazolidinone core. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

A Rapid Synthesis of 4-Oxazolidinones: Total Synthesis of Synoxazolidinones A and B**

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(21), 5401–5404.

By: N. Shymanska n, I. An n & J. Pierce n

author keywords: antimicrobial agents; heterocycles; natural products; stereoselectivity; total synthesis
MeSH headings : Acinetobacter baumannii / drug effects; Acylation; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Cyclization; Guanidine / analogs & derivatives; Guanidine / chemical synthesis; Guanidine / chemistry; Guanidine / pharmacology; Imines / chemistry; Oxazolidinones / chemical synthesis; Oxazolidinones / chemistry; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Stereoisomerism
TL;DR: These studies confirmed the importance of the chlorine substituent for antimicrobial activity and revealed simplified dichloro derivatives that are equally potent against several bacterial strains. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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