Nataliia Vasylivna Shymanska

Works (3)

Updated: July 10th, 2023 21:19

2017 article

Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and β-Amino Acids

Shymanska, N. V., & Pierce, J. G. (2017, May 24). Organic Letters, Vol. 19, pp. 2961–2964.

By: N. Shymanska n & J. Pierce n 

MeSH headings : Amino Acids; Cyclization; Molecular Structure; Pyrrolidines / chemistry; Stereoisomerism
topics (OpenAlex): Asymmetric Synthesis and Catalysis; Synthetic Organic Chemistry Methods; Synthesis and biological activity
TL;DR: A facile, diastereoselective synthesis of highly substituted pyrrolidine-2,3-diones is reported, along with the one-step conversion of these heterocycles to novel β-amino acids and further functionalized derivatives. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 article

Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles

Shymanska, N. V., An, I. H., Guevara-Zuluaga, S., & Pierce, J. G. (2015, June 12). Bioorganic & Medicinal Chemistry Letters, Vol. 25, pp. 4887–4889.

By: N. Shymanska n, I. An n, S. Guevara-Zuluaga  n & J. Pierce n 

author keywords: Antibiotic; Heterocycle; Oxazolidinone; Natural products
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones / chemical synthesis; Oxazolidinones / chemistry; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Structure-Activity Relationship
topics (OpenAlex): Microbial Natural Products and Biosynthesis; Synthesis and Catalytic Reactions; Click Chemistry and Applications
TL;DR: These studies revealed the importance of an electron deficient aromatic ring for antimicrobial activity and serve as the basis for future SAR studies around the 4-oxazolidinone core. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

A Rapid Synthesis of 4‐Oxazolidinones: Total Synthesis of Synoxazolidinones A and B

Shymanska, N. V., An, I. H., & Pierce, J. G. (2014, April 7). Angewandte Chemie International Edition, Vol. 53, pp. 5401–5404.

By: N. Shymanska n, I. An n & J. Pierce n 

author keywords: antimicrobial agents; heterocycles; natural products; stereoselectivity; total synthesis
MeSH headings : Acinetobacter baumannii / drug effects; Acylation; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Cyclization; Guanidine / analogs & derivatives; Guanidine / chemical synthesis; Guanidine / chemistry; Guanidine / pharmacology; Imines / chemistry; Oxazolidinones / chemical synthesis; Oxazolidinones / chemistry; Oxazolidinones / pharmacology; Staphylococcus aureus / drug effects; Stereoisomerism
topics (OpenAlex): Synthesis and Catalytic Reactions; Microbial Natural Products and Biosynthesis; Synthetic Organic Chemistry Methods
TL;DR: These studies confirmed the importance of the chlorine substituent for antimicrobial activity and revealed simplified dichloro derivatives that are equally potent against several bacterial strains. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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