Works (5)
Updated: August 9th, 2023 21:15
2015 journal article
Heparin and LPS-induced COX-2 expression in airway cells: a link between its anti-inflammatory effects and GAG sulfation
EXPERIMENTAL LUNG RESEARCH, 41(9), 499–513.
author keywords: COX-2; heparin; LPS; lung; sulfation
MeSH headings : Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cell Line; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Gene Expression / drug effects; Glycosaminoglycans / chemistry; Glycosaminoglycans / metabolism; Heparin / chemistry; Heparin / pharmacology; Humans; Interleukin-8 / genetics; Interleukin-8 / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Signaling System / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism
TL;DR:
Heparin's anti-inflammatory effects result from its nonspecific suppression of signaling and gene expression and are determined by its sulfation, which may reflect the moderating role of GAG sulfation in lung injury and health.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Sustained-Release Celecoxib from Incubated Acrylic Intraocular Lenses Suppresses Lens Epithelial Cell Growth in an Ex Vivo Model of Posterior Capsule Opacity
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 28(4), 359–368.
MeSH headings : Animals; Cataract Extraction; Celecoxib; Corneal Opacity / pathology; Corneal Opacity / prevention & control; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / pharmacokinetics; Cyclooxygenase 2 Inhibitors / therapeutic use; Delayed-Action Preparations; Dogs; Epithelial Cells / drug effects; Epithelium / drug effects; Epithelium / growth & development; In Vitro Techniques; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / growth & development; Lenses, Intraocular; Polymethyl Methacrylate; Posterior Capsule of the Lens / cytology; Posterior Capsule of the Lens / drug effects; Posterior Capsule of the Lens / pathology; Postoperative Complications / pathology; Postoperative Complications / prevention & control; Pyrazoles / administration & dosage; Pyrazoles / pharmacokinetics; Pyrazoles / therapeutic use; Sulfonamides / administration & dosage; Sulfonamides / pharmacokinetics; Sulfonamides / therapeutic use
TL;DR:
A 4-day treatment of LCs with a concentration of 20 μM CXB may effectively prevent PCO and further studies are needed to determine whether C XB-incubated IOLs can effectively prevent the development of PCO in vivo.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Comparison of orbital prosthesis motility following enucleation or evisceration with sclerotomy with or without a motility coupling post in dogs
VETERINARY OPHTHALMOLOGY, 12(3), 139–151.
author keywords: dog; evisceration; motility coupling post; orbital implant; prosthesis; sclerotomy
MeSH headings : Animals; Dogs; Eye Enucleation / adverse effects; Eye Enucleation / veterinary; Eye Evisceration / adverse effects; Eye Evisceration / veterinary; Eye, Artificial / veterinary; Female; Male
TL;DR:
This study supports the use of MCP in silicone orbital implants to enhance corneoscleral prosthesis motility and cosmetics in dogs and significantly enhanced the prosthetic motility in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Ocular toxicity and distribution of subconjunctival and intravitreal rapamycin in horses
Journal of Veterinary Pharmacology and Therapeutics, 31(6), 511–516.
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Chromatography, High Pressure Liquid; Dermatitis, Phototoxic; Horses; Sirolimus / adverse effects; Sirolimus / pharmacokinetics; Sirolimus / therapeutic use; Tissue Distribution; Uveitis / drug therapy; Uveitis / veterinary
TL;DR:
Drug could be detected in both the aqueous and vitreous humor after intravitreal injection and no evidence of ocular toxicity was noted on ophthalmic examination or histopathology, suggesting a lack of RAPA phototoxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Role of bacteria in the pathogenesis of recurrent uveitis in horses from the southeastern United States
American Journal of Veterinary Research, 69(10), 1329–1335.
MeSH headings : Animals; Aqueous Humor / microbiology; Horse Diseases / microbiology; Horses; Leptospira / genetics; Leptospira / isolation & purification; Leptospirosis / microbiology; Leptospirosis / veterinary; Polymerase Chain Reaction; RNA, Ribosomal / genetics; Recurrence; Reference Values; Southeastern United States; Uveitis / microbiology; Uveitis / veterinary; Vitreous Body / microbiology
TL;DR:
In horses from the southeastern United States, Leptospira organisms may have helped initiate ERU in some, but the continued presence of the organisms did not play a direct role in the pathogenesis of this recurrent disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018