Olivia Manley

Biochemistry

Works (7)

Updated: February 14th, 2024 05:03

2023 journal article

Enhancing ferryl accumulation in H2O2-dependent cytochrome P450s

JOURNAL OF INORGANIC BIOCHEMISTRY, 252.

By: J. Amaya *, O. Manley n, J. Bian*, C. Rutland *, N. Leschinsky*, S. Ratigan*, T. Makris n 

author keywords: Cytochrome P450; Compound I; Ferryl; CYP152; Peroxygenase
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Added: February 12, 2024

2023 journal article

Excision of a Protein-Derived Amine for <i>p</i>-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD

BIOCHEMISTRY, 62(22), 3276–3282.

By: H. Phan n , O. Manley n, S. Skirboll n, L. Cha n , D. Hilovsky n, W. Chang n , P. Thompson n , X. Liu n, T. Makris n 

TL;DR: Turnover studies using limiting O2 have identified a para-aminobenzaldehyde metabolic intermediate that is formed on the path to pABA formation and use of pABCHO and other probe substrates shows that the heterobimetallic Fe/Mn form of the enzyme is capable of oxygen insertion to generate the pA BA-carboxylate. (via Semantic Scholar)
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Added: December 12, 2023

2023 article

Room-Temperature Aerobic C-CN Bond Activation in Nickel(II) Cyanomethyl Dicarboranyl Complex

Islam, M. J., Park, K. C., Manley, O. M. M., Smith, M. D. D., Makris, T. M. M., & Peryshkov, D. V. V. (2023, July 12). ORGANOMETALLICS, Vol. 7.

By: M. Islam *, K. Park*, O. Manley n, M. Smith *, T. Makris n  & D. Peryshkov *

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Added: July 24, 2023

2022 journal article

Experimental and Theoretical Examination of the Kinetic Isotope Effect in Cytochrome P450 Decarboxylase OleT

JOURNAL OF PHYSICAL CHEMISTRY B, 126(19), 3493–3504.

By: M. Dutra *, J. Amaya *, S. McElhenney *, O. Manley n, T. Makris n , V. Rassolov *, S. Garashchuk *

MeSH headings : Carboxy-Lyases / metabolism; Cytochrome P-450 Enzyme System / chemistry; Fatty Acids / chemistry; Hydrogen / chemistry; Isotopes; Kinetics
TL;DR: A more fundamental understanding of the OleT reaction coordinate contributes to the development of biomimetic catalysts for controlled C─H bond activation, an outstanding current challenge for (bio)synthetic chemistry. (via Semantic Scholar)
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Added: June 13, 2022

2022 journal article

Modeling the Ligand Effect on the Structure of CYP 450 Within the Density Functional Theory

JOURNAL OF PHYSICAL CHEMISTRY A, 126(18), 2818–2824.

By: M. Dutra *, S. McElhenney *, O. Manley n, T. Makris  n, V. Rassolov * & S. Garashchuk *

MeSH headings : Cysteine / chemistry; Density Functional Theory; Heme / chemistry; Iron / chemistry; Ligands
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Added: June 6, 2022

2022 journal article

Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(39).

By: O. Manley n, H. Phan n , A. Stewart n, D. Mosley n, S. Xue *, L. Cha n , H. Bai n, V. Lightfoot* ...

Contributors: T. Williams n 

author keywords: folate biosynthesis; radical transfer; spectroscopy; heterobinuclear cluster
MeSH headings : Bacterial Proteins / metabolism; Chlamydia trachomatis / enzymology; Folic Acid; Iron / metabolism; Manganese / metabolism; Oxygen / metabolism; Oxygenases / metabolism; Tyrosine / metabolism; para-Aminobenzoates / metabolism
TL;DR: High in vitro activity relies on the stoichiometric addition of both Fe and Mn, and CADD is shown to activate O2 to self-sacrificially produce pABA from Tyr27. (via Semantic Scholar)
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Added: September 21, 2022

2022 journal article

Stimuli-Modulated Metal Oxidation States in Photochromic MOFs

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 144(10), 4457–4468.

By: C. Martin *, K. Park*, G. Leith *, J. Yu *, A. Mathur*, G. Wilson*, G. Gange*, E. Barth* ...

MeSH headings : Metal-Organic Frameworks / chemistry; Metals; Oxidation-Reduction
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Added: April 18, 2022

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