Olivia Manley

Biochemistry

Works (8)

Updated: May 10th, 2025 05:03

2025 article

Regulation of ferryl reactivity by the cytochrome P450 decarboxylase OleT

Gering, H. E., Manley, O. M., Holwerda, A. J., Grant, J. L., Ratigan, S. C., & Makris, T. M. (2025, April 6). Journal of Inorganic Biochemistry, Vol. 270.

By: H. Gering n, O. Manley n, A. Holwerda*, J. Grant*, S. Ratigan* & T. Makris n 

author keywords: Cytochrome P450; Compound I; CYP152
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Pharmacogenetics and Drug Metabolism; Glutathione Transferases and Polymorphisms
Sources: Web Of Science, NC State University Libraries
Added: May 6, 2025

2023 article

Enhancing ferryl accumulation in H2O2-dependent cytochrome P450s

Amaya, J. A., Manley, O. M., Bian, J. C., Rutland, C. D., Leschinsky, N., Ratigan, S. C., & Makris, T. M. (2023, December 20). Journal of Inorganic Biochemistry, Vol. 252.

By: J. Amaya *, O. Manley n, J. Bian*, C. Rutland *, N. Leschinsky*, S. Ratigan*, T. Makris n 

author keywords: Cytochrome P450; Compound I; Ferryl; CYP152; Peroxygenase
MeSH headings : Cytochrome P-450 Enzyme System / chemistry; Hydrogen Peroxide; Fatty Acids / chemistry
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Pharmacogenetics and Drug Metabolism; Enzyme Structure and Function
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Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2023 article

Excision of a Protein-Derived Amine for p-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD

Phan, H. N., Manley, O. M., Skirboll, S. S., Cha, L., Hilovsky, D., Chang, W.-chen, … Makris, T. M. (2023, November 7). Biochemistry, Vol. 62, pp. 3276–3282.

By: H. Phan n , O. Manley n, S. Skirboll n, L. Cha n , D. Hilovsky n, W. Chang n , P. Thompson n , X. Liu n, T. Makris n 

MeSH headings : para-Aminobenzoates / metabolism; 4-Aminobenzoic Acid / metabolism; Folic Acid / metabolism
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Heme Oxygenase-1 and Carbon Monoxide; Porphyrin Metabolism and Disorders
TL;DR: Turnover studies using limiting O2 have identified a para-aminobenzaldehyde metabolic intermediate that is formed on the path to pABA formation and use of pABCHO and other probe substrates shows that the heterobimetallic Fe/Mn form of the enzyme is capable of oxygen insertion to generate the pA BA-carboxylate. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 12, 2023

2023 article

Room-Temperature Aerobic C–CN Bond Activation in Nickel(II) Cyanomethyl Dicarboranyl Complex

Islam, M. J., Park, K. C., Manley, O. M., Smith, M. D., Makris, T. M., & Peryshkov, D. V. (2023, July 12). Organometallics, Vol. 7.

By: M. Islam *, K. Park*, O. Manley n, M. Smith *, T. Makris n  & D. Peryshkov *

topics (OpenAlex): Organoboron and organosilicon chemistry; Organometallic Complex Synthesis and Catalysis; Synthetic Organic Chemistry Methods
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 24, 2023

2022 article

Experimental and Theoretical Examination of the Kinetic Isotope Effect in Cytochrome P450 Decarboxylase OleT

Dutra, M., Amaya, J. A., McElhenney, S., Manley, O. M., Makris, T. M., Rassolov, V., & Garashchuk, S. (2022, May 4). The Journal of Physical Chemistry B, Vol. 126, pp. 3493–3504.

By: M. Dutra *, J. Amaya *, S. McElhenney *, O. Manley n, T. Makris n , V. Rassolov *, S. Garashchuk *

MeSH headings : Carboxy-Lyases / metabolism; Cytochrome P-450 Enzyme System / chemistry; Fatty Acids / chemistry; Hydrogen / chemistry; Isotopes; Kinetics
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Metal-Catalyzed Oxygenation Mechanisms; Enzyme Catalysis and Immobilization
TL;DR: A more fundamental understanding of the OleT reaction coordinate contributes to the development of biomimetic catalysts for controlled C─H bond activation, an outstanding current challenge for (bio)synthetic chemistry. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 13, 2022

2022 article

Modeling the Ligand Effect on the Structure of CYP 450 Within the Density Functional Theory

Dutra, M., McElhenney, S., Manley, O., Makris, T., Rassolov, V., & Garashchuk, S. (2022, May 2). The Journal of Physical Chemistry A, Vol. 126, pp. 2818–2824.

By: M. Dutra *, S. McElhenney *, O. Manley n, T. Makris n , V. Rassolov * & S. Garashchuk *

MeSH headings : Cysteine / chemistry; Density Functional Theory; Heme / chemistry; Iron / chemistry; Ligands
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Metal complexes synthesis and properties; Metalloenzymes and iron-sulfur proteins
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 6, 2022

2022 article

Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para -aminobenzoate in Chlamydia trachomatis

Manley, O. M., Phan, H. N., Stewart, A. K., Mosley, D. A., Xue, S., Cha, L., … Makris, T. M. (2022, September 19). Proceedings of the National Academy of Sciences, Vol. 119.

By: O. Manley n, H. Phan n , A. Stewart n, D. Mosley n, S. Xue *, L. Cha n , H. Bai n, V. Lightfoot* ...

Contributors: T. Williams n 

author keywords: folate biosynthesis; radical transfer; spectroscopy; heterobinuclear cluster
MeSH headings : Bacterial Proteins / metabolism; Chlamydia trachomatis / enzymology; Folic Acid; Iron / metabolism; Manganese / metabolism; Oxygen / metabolism; Oxygenases / metabolism; Tyrosine / metabolism; para-Aminobenzoates / metabolism
topics (OpenAlex): Porphyrin Metabolism and Disorders; Reproductive tract infections research; Urinary Tract Infections Management
TL;DR: High in vitro activity relies on the stoichiometric addition of both Fe and Mn, and CADD is shown to activate O2 to self-sacrificially produce pABA from Tyr27. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 21, 2022

2022 article

Stimuli-Modulated Metal Oxidation States in Photochromic MOFs

Martin, C. R., Park, K. C., Leith, G. A., Yu, J., Mathur, A., Wilson, G. R., … Shustova, N. B. (2022, February 9). Journal of the American Chemical Society, Vol. 144, pp. 4457–4468.

By: C. Martin *, K. Park*, G. Leith *, J. Yu *, A. Mathur*, G. Wilson*, G. Gange*, E. Barth* ...

MeSH headings : Metal-Organic Frameworks / chemistry; Metals; Oxidation-Reduction
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Nanoplatforms for cancer theranostics; Metal-Organic Frameworks: Synthesis and Applications
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Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022

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