Works (171)

Updated: April 5th, 2024 06:02

2024 journal article

Design and Fabrication of 1-D CMUT Arrays for Dual-Mode Dual-Frequency Acoustic Angiography Applications

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 71(1), 191–201.

author keywords: Acoustic angiography (AA); capacitive micromachined ultrasonic transducer (CMUT); dual-mode dual-frequency array; glass substrate
TL;DR: A novel scheme with a capacitive micromachined ultrasonic transducer array to receive high-frequency microbubble harmonics in collapse mode and to transmit a low-frequency high-pressure pulse by releasing the CMUT plate from collapse and pull it back to collapse again in the same transmit-receive cycle. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 13, 2023

2024 article

Element Position Calibration for Matrix Array Transducers with Multiple Disjoint Piezoelectric Panels

McCall, J. R., Chavignon, A., Couture, O., Dayton, P. A., & Pinton, G. F. (2024, February 9). ULTRASONIC IMAGING.

author keywords: 3-D ultrasound; transducer; calibration; ULM
TL;DR: It is shown that the shape of the point spread function (PSF) can be significantly improved and PSF-doubling artifacts can be reduced by up to 10 dB via this simple calibration procedure. (via Semantic Scholar)
Source: Web Of Science
Added: February 26, 2024

2024 journal article

The development of a 1.25 MHz 1024-channel sparse array for human transcranial imaging: <i>in vitro</i> characterization

MEASUREMENT SCIENCE AND TECHNOLOGY, 35(3).

By: J. McCall n, R. Jones n, F. Santibanez n, K. Latham, J. Zou, P. Dayton*, G. Pinton n

author keywords: human; transcranial; ultrasound; 3D ultrasound; volumetric; sparse array
TL;DR: A 1024-channel sparse array with a 65 mm circular aperture and a 1–2 MHz bandwidth is designed and developed that achieves a high focal gain that enables ultrasonic visualization beneath the human skull and at large depths due to its low F-number capabilities. (via Semantic Scholar)
Source: Web Of Science
Added: January 8, 2024

2023 journal article

A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

RESEARCH, 6, 1–13.

By: B. Zhang n, H. Wu n, H. Kim n, P. Welch*, A. Cornett*, G. Stocker*, R. Nogueira*, J. Kim* ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 5, 2023

2023 journal article

An open-source framework for synthetic post-dive Doppler ultrasound audio generation

PLOS ONE, 18(4).

By: D. Le n, A. Hoang n, A. Azarang n, R. Lance*, M. Natoli*, A. Gatrell*, S. Blogg*, P. Dayton n ...

TL;DR: A method to generate synthetic post-dive data using DU signals collected in both precordium and subclavian vein with varying degrees of bubbling matching field-standard grading metrics is developed, allowing for researchers to tune the produced dataset for their desired purpose. (via Semantic Scholar)
Source: Web Of Science
Added: July 10, 2023

2023 review

Current Status of Sub-micron Cavitation-Enhancing Agents for Sonothrombolysis

[Review of ]. ULTRASOUND IN MEDICINE AND BIOLOGY, 49(5), 1049–1057.

By: K. Bautista n, J. Kim n, Z. Xu*, X. Jiang n & P. Dayton n

author keywords: Thrombosis; Sonothrombolysis; Cavitation; Phase-change nanodroplets; Nanoparticles; Nanoemulsions; Contrast agents
MeSH headings : Humans; Ultrasonography; Thrombosis / drug therapy; Ultrasonic Therapy; Fibrinolytic Agents / therapeutic use; High-Intensity Focused Ultrasound Ablation; Mechanical Thrombolysis; Microbubbles; Thrombolytic Therapy
TL;DR: In this article, the applications of different sub-micron particles for sonothrombolysis are discussed and in vitro and in vivo studies that apply these particles as cavitation agents and as adjuvants to thrombotic drugs are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 24, 2023

2023 journal article

Deep Learning-Based Venous Gas Emboli Grade Classification in Doppler Ultrasound Audio Recordings

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 70(5), 1436–1446.

By: A. Azarang n, D. Le n, A. Hoang n, S. Blogg, P. Dayton n, R. Lance*, M. Natoli*, A. Gatrell* ...

author keywords: Ultrasonic imaging; Doppler effect; Ultrasonic variables measurement; Recording; Deep learning; Monitoring; Blood; Decompression bubble; decompression stress; diving research; squeeze-and-excitation deep learning model
MeSH headings : Humans; Decompression Sickness; Deep Learning; Sound Recordings; Embolism, Air / diagnostic imaging; Ultrasonography, Doppler
TL;DR: The present work demonstrates the first application of deep-learning for DU VGE grading using a combination of synthetic and real-world data and can contribute to accelerating DU analysis for decompression research. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 26, 2023

2023 journal article

Effect of Anesthetic Carrier Gas on In Vivo Circulation Times of Intravenously Administered Phospholipid Oxygen Microbubbles in Rats

ULTRASOUND IN MEDICINE AND BIOLOGY, 49(8), 1861–1866.

By: P. Durham n, A. Upadhyay*, J. Navarro-Becerra*, R. Moon*, M. Borden*, P. Dayton n, V. Papadopoulou n

author keywords: Bubble; Contrast-enhanced ultrasound; Ultrasound contrast agent; Tumor hypoxia; Radiation therapy
MeSH headings : Rats; Animals; Oxygen; Phospholipids; Microbubbles; Ultrasonography; Fluorocarbons; Anesthetics; Contrast Media
TL;DR: The findings suggest that the apparent longevity and persistence of oxygen microbubbles in circulation may not be reflective of oxygen delivery when the animal is anesthetized breathing air. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 7, 2023

2023 journal article

Loading Intracranial Drug-Eluting Reservoirs Across the Blood-Brain Barrier With Focused Ultrasound

ULTRASOUND IN MEDICINE AND BIOLOGY, 49(7), 1679–1685.

By: C. Moody n, P. Durham n, P. Dayton n & Y. Brudno n

author keywords: Blood-brain barrier; Brain delivery; Click chemistry; Drug delivery; Focused ultrasound
MeSH headings : Female; Mice; Animals; Blood-Brain Barrier; Drug Delivery Systems / methods; Neurodegenerative Diseases; Brain / diagnostic imaging; Microbubbles; Magnetic Resonance Imaging / methods
TL;DR: The ability to target and retain small molecules at predetermined intracranial sites with pinpoint accuracy provides opportunities to continuously deliver drugs to the brain over weeks and months without excessive BBB opening and with minimal off-target side effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 journal article

Non-invasive transcranial volumetric ultrasound localization microscopy of the rat brain with continuous, high volume-rate acquisition

THERANOSTICS, 13(3), 1235–1246.

By: J. McCall n, F. Santibanez n, H. Belgharbi n, G. Pinton n & P. Dayton n

author keywords: Key words; 3-D ultrasound; transducer; microvascular imaging; brain; super resolution
MeSH headings : Rats; Animals; Microscopy / methods; Ultrasonography / methods; Brain / blood supply; Ultrasonics; Skull / diagnostic imaging
TL;DR: New capabilities to rapidly image and analyze complex vascular networks in 3-D volume space for structural and functional imaging in disease assessment, targeted therapeutic delivery, monitoring response to therapy, and other theranostic applications are demonstrated. (via Semantic Scholar)
Source: Web Of Science
Added: March 20, 2023

2023 journal article

Overcoming biological barriers to improve treatment of a Staphylococcus aureus wound infection

CELL CHEMICAL BIOLOGY, 30(5), 513-+.

By: V. Papadopoulou n, A. Sidders*, K. Lu*, A. Velez*, P. Durham n, D. Bui*, M. Angeles-Solano*, P. Dayton n, S. Rowe*

TL;DR: This study combat the two major barriers to successful aminoglycoside treatment against a biofilm-infected wound: limited antibiotic uptake and limited biofilm penetration by employing palmitoleic acid, a host-produced monounsaturated fatty acid that perturbs the membrane of gram-positive pathogens and induces gentamicin uptake. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 5, 2023

2023 personal communication

Radiotherapy Sensitization With Ultrasound-Stimulated Intravenously Injected Oxygen Microbubbles Can Have Contrary Effects Depending on the Study Model

Papadopoulou, V., Stride, E. P., Borden, M. A., Eisenbrey, J. R., & Dayton, P. A. (2023, September).

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 5, 2023

2023 journal article

The Performance of Flash Replenishment Contrast-Enhanced Ultrasound for the Qualitative Assessment of Kidney Lesions in Patients with Chronic Kidney Disease

JOURNAL OF CLINICAL MEDICINE, 12(20).

By: R. Walmer n, V. Ritter*, A. Sridharan n, S. Kasoji n, E. Altun*, E. Lee*, K. Olinger*, S. Wagner* ...

author keywords: chronic kidney disease; contrast-enhanced ultrasound; kidney lesions; performance metrics; screening tool
TL;DR: In CKD patients, CEUS is a potential low-risk option for screening kidney lesions, and may be particularly beneficial for CKD IV/V patients, where kidney preservation techniques are highly relevant. (via Semantic Scholar)
Source: Web Of Science
Added: November 13, 2023

2022 article

A Dual-Frequency Intravascular Ultrasound Transducer for Amplified Nanodroplet Vaporization Effects in Cavitation-Enhanced Sonothrombolysis

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: S. Moon n, H. Wu n, B. Zhang n, J. Kim*, P. Dayton*, Z. Xu*, X. Jiang n

author keywords: Intravascular transducer; dual-frequency thrombolysis; Nanodroplets
TL;DR: A dual-frequency intravascular transducer intended for nanodroplet-specific sonothrombolysis was developed to improve clot mass reduction rate while retaining lower acoustic pressures than the typical nanODroplet vaporization threshold at sub-megahertz excitation (> 5 MPa). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 journal article

A Handheld Imaging Probe for Acoustic Angiography With an Ultrawideband Capacitive Micromachined Ultrasonic Transducer (CMUT) Array

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 69(7), 2318–2330.

author keywords: Probes; Imaging; Acoustics; Bandwidth; Angiography; Frequency control; Electrodes; Acoustic angiography (AA); alternate amplitude modulation (aAM); capacitive micromachined ultrasonic transducer (CMUT); glass substrate; handheld ultrasound probe; harmonic ultrasound imaging; ultrawideband (UWB) array
MeSH headings : Angiography; Equipment Design; Transducers; Ultrasonics; Ultrasonography / methods
TL;DR: An imaging probe with a 256-element ultrawideband (UWB) 1-D capacitive micromachined ultrasonic transducer (CMUT) array designed for acoustic angiography (AA) demonstrates the suitability of the UWB CMUT for AA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 1, 2022

2022 article

Acoustic Hologram Lens Made of Nanoparticle-Epoxy Composite Molding for Directing Predefined Therapeutic Ultrasound Beams

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: J. Kim n, S. Kasoji*, P. Durham n & P. Dayton n

author keywords: acoustic hologram; acoustic metamaterial; beam focusing; epoxy composite; ultrasound
TL;DR: An acoustic hologram lens fabrication method for prototyping nondeformed hologram lenses with a tailored acoustic impedance and the beam mapping result using the composite lens showed 17% improved structural similarity with the designed pressure pattern compared to the photopolymer result. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 6, 2023

2022 journal article

An Analysis of Sonothrombolysis and Cavitation for Retracted and Unretracted Clots Using Microbubbles Versus Low-Boiling-Point Nanodroplets

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 69(2), 711–719.

author keywords: Ultrasonic imaging; Acoustics; Medical treatment; Frequency control; Coagulation; Transducers; Surface treatment; Cavitation; microbubble (MB); nanodroplet (ND); retracted clot; sonothrombolysis; thrombosis
MeSH headings : Aged; Blood Coagulation; Humans; Microbubbles; Thrombosis / diagnostic imaging; Thrombosis / therapy; Ultrasonic Therapy / methods
TL;DR: It is concluded that ND-mediated sonothrombolysis outperforms MB-mediated therapy regardless of clot retraction, and this advantage of ND- mediated cavitation is emphasized for retracted clots. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 14, 2022

2022 journal article

Association of Contrast-Enhanced Ultrasound-Derived Kidney Cortical Microvascular Perfusion with Kidney Function

KIDNEY360, 3(4), 647–656.

author keywords: chronic kidney disease; contrast-enhanced ultrasound; end stage kidney disease; noninvasive imaging; perfusion; ultrasonography; vascular disease
MeSH headings : Adult; Aged; Biomarkers; Humans; Kidney / diagnostic imaging; Middle Aged; Perfusion; Renal Insufficiency, Chronic / diagnostic imaging; Ultrasonography / methods
Source: Web Of Science
Added: June 13, 2022

2022 journal article

Characterization of the Ultrasound Localization Microscopy Resolution Limit in the Presence of Image Degradation

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 69(1), 124–134.

By: J. McCall n, P. Dayton n & G. Pinton n

author keywords: Image degradation; resolution; super-resolution; ultrasound localization microscopy (ULM)
MeSH headings : Computer Simulation; Microscopy; Ultrasonography
TL;DR: This work investigated the effects of three sources of image degradation on the resolution limit of ULM, and demonstrated the importance of phase aberration correction and clutter filtering in ULM postprocessing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 10, 2022

2022 article

Development of a Robotic Shear Wave Elastography System for Noninvasive Staging of Liver Disease in Murine Models

Czernuszewicz, T. J., Aji, A. M., Moore, C. J., Montgomery, S. A., Velasco, B., Torres, G., … Gessner, R. C. (2022, February 24). HEPATOLOGY COMMUNICATIONS.

By: T. Czernuszewicz n, A. Aji*, C. Moore*, S. Montgomery*, B. Velasco n, G. Torres n, K. Anand n, K. Johnson n ...

MeSH headings : Animals; Disease Models, Animal; Elasticity Imaging Techniques / methods; Female; Liver Cirrhosis / diagnostic imaging; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease / diagnostic imaging; Reproducibility of Results; Robotic Surgical Procedures
TL;DR: Robotic SWE in small animals is feasible and sensitive to small changes in liver disease state, facilitating in vivo staging of rodent liver disease with minimal sonographic expertise. (via Semantic Scholar)
Source: Web Of Science
Added: March 7, 2022

2022 journal article

Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics

PHARMACEUTICS, 14(3).

author keywords: long-acting; in situ; injectable; biodegradable; implants; PLGA; controlled release; drug delivery; ultrasound; pharmacokinetics
TL;DR: There was no statistical difference in drug exposure regardless of the route of administration or number of injections, and dolutegravir-loaded ISFIs along the range of injection volumes tested were present at 90 days post-injection, suggesting that DTG can prolong ISFI degradation. (via Semantic Scholar)
Source: Web Of Science
Added: April 18, 2022

2022 review

Hyperbaric exposure in rodents with non- invasive imaging assessment of decompression bubbles: A scoping review protocol

[Review of ]. PLOS ONE, 17(9).

By: J. Currens n, P. Dayton n, P. Buzzacott* & V. Papadopoulou n

MeSH headings : Animals; Decompression; Humans; Research Design; Research Personnel; Research Report; Review Literature as Topic; Rodentia; Systematic Reviews as Topic
TL;DR: Through a scoping review of published literature, this work will provide an overview of decompression bubble information collected from rodent experiments using various non-invasive methods of ultrasound for decompression Bubble assessment. (via Semantic Scholar)
Source: Web Of Science
Added: January 3, 2023

2022 article

Integration of Forward-viewing and Side-viewing Ultrasound Transducers in an Intravascular Sonothrombolysis Catheter

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: B. Zhang n, H. Wu n, J. Kim*, P. Dayton*, Z. Xu* & X. Jiang n

author keywords: ultrasound transducers; microbubbles; thrombus; thrombolysis; sonothrombolysis
TL;DR: The combination of forward and side-viewing (FSV) ultrasound waves is expected to extend the treatment region and improve thrombolysis efficiency compared to a forward or side-Viewing alone sonication. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 journal article

LOW-INTENSITY FOCUSED ULTRASOUND PRODUCES IMMUNE RESPONSE IN PANCREATIC CANCER

ULTRASOUND IN MEDICINE AND BIOLOGY, 48(11), 2344–2353.

By: J. Joiner, N. Kren, P. Durham, A. McRee, P. Dayton* & Y. Pylayeva-Gupta

author keywords: Immunotherapy; Pancreatic cancer; Ultrasound; Tumor microenvironment
MeSH headings : Adenocarcinoma / immunology; Adenocarcinoma / therapy; Animals; CD8-Positive T-Lymphocytes / immunology; HMGB1 Protein; Immunity; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms / immunology; Pancreatic Neoplasms / therapy; Tumor Microenvironment; Ultrasonic Therapy
TL;DR: It is indicated that focused ultrasound treatments can cause tumoral damage and changes in macrophages and T cells 2 d post-treatment, and the need for additional treatment types and/or combination with immunotherapy is illustrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 14, 2022

2022 journal article

Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis

CANCER RESEARCH, 82(1), 105–113.

By: H. Sendi*, M. Yazdimamaghani*, M. Hu*, N. Sultanpuram*, J. Wang*, A. Moody n, E. McCabe*, J. Zhang* ...

MeSH headings : Animals; Colorectal Neoplasms / complications; Colorectal Neoplasms / genetics; Humans; Liver Neoplasms / secondary; Mice; MicroRNAs / metabolism; Nanoparticles / metabolism; Neoplasm Metastasis; Tumor Microenvironment
TL;DR: Mechanistic studies revealed that delivery of miR-122 was associated with downregulation of key genes involved in metastatic and cancer inflammation pathways, including several proinflammatory factors, matrix metalloproteinases, and other extracellular matrix degradation enzymes, which makes the liver more conducive to antitumor immune response. (via Semantic Scholar)
Source: Web Of Science
Added: January 24, 2022

2022 journal article

POLYVINYL ALCOHOL CRYOGELS FOR ACOUSTIC CHARACTERIZATION OF PHASE-CHANGE CONTRAST AGENTS

ULTRASOUND IN MEDICINE AND BIOLOGY, 48(5), 954–960.

By: P. Durham, J. Kim*, K. Eltz*, C. Caskey & P. Dayton*

author keywords: Phase-change contrast agent; Nanodroplets; Polyvinyl alcohol cryogel
MeSH headings : Acoustics; Contrast Media; Cryogels; Polyvinyl Alcohol; Ultrasonography / methods
TL;DR: The utility of the phantoms is determined by activating droplets with a focused transducer, visualizing the lesions with ultrasound imaging, and a simple method for the incorporation of the low-boiling-point PCCAs using octafluoropropane (OFP) and decafLUorobutane (DFB) into PVA cryogels for a variety of acoustic characterization applications is proposed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 27, 2022

2022 article

Performance Assessment of Ultra-Wideband and Dual-Mode 1D CMUT Arrays for Acoustic Angiography

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: E. Belekov n, K. Bautista*, M. Annayev n, O. Adelegan n, A. Biliroglu n, T. Kierski*, J. Sanders n, R. Kemal n ...

author keywords: capacitive micromachined ultrasonic transducer; ultra-wideband; dual-mode; acoustic angiography; ultrasound handheld probe; contrast agent
TL;DR: A custom 256-channel imaging probe with integrated low-noise amplifiers and supporting power circuitry is designed with a strong use case for the UWB and dual-mode CMUT arrays in acoustic angiography applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 review

Perspective on ultrasound bioeffects and possible implications for continuous post-dive monitoring safety

[Review of ]. DIVING AND HYPERBARIC MEDICINE, 52(2), 136–148.

By: E. McCune n, D. Le n, P. Lindholm*, K. Nightingale*, P. Dayton n & V. Papadopoulou n

author keywords: Bubbles; Cavitation; Decompression; Decompression research; Venous gas emboli
MeSH headings : Decompression Sickness / etiology; Diving; Echocardiography / adverse effects; Embolism, Air / etiology; Humans; Ultrasonography / adverse effects
TL;DR: What can be drawn from the current ultrasound and diving literature on the safety of bubble sonication is discussed and areas where more studies are needed are highlighted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 26, 2022

2022 article

Superharmonic Imaging with Plane Wave Beamforming Techniques

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: J. Yang*, E. Cherin*, J. Yin*, P. Dayton n, F. Foster* & C. Demore*

author keywords: superharmonic imaging; microbubble; dual-frequency; plane wave; coherent compounding
TL;DR: This work implements plane wave imaging approaches on programmable systems and investigates the image acquisition frame rate and image quality of SpHI in vitro and in vivo, using an integrated DF probe comprising a 21 MHz (high-frequency; 256 elements) array stacked on a 2 MHz (low-frequency) array. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 6, 2023

2022 journal article

Transcranial Neuromodulation Array With Imaging Aperture for Simultaneous Multifocus Stimulation in Nonhuman Primates

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 69(1), 261–272.

By: R. Jones n, C. Caskey*, P. Dayton n, O. Oralkan n & G. Pinton n

author keywords: Ultrasonic imaging; Neuromodulation; Brain modeling; Imaging; Focusing; Attenuation; Transducers; Customized array; focused ultrasound; neuromodulation; phase aberration correction; simultaneous stimulation; transcranial
MeSH headings : Animals; Brain / diagnostic imaging; Primates; Skull / diagnostic imaging; Transducers; Ultrasonic Therapy
TL;DR: Using 3-D Fullwave simulations, this work has designed an ultrasound neuromodulation array for nonhuman primates that can simultaneously focus on multiple targets and include an imaging aperture for additional functional imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 1, 2022

2022 journal article

Validation of a combined ultrasound and bioluminescence imaging system with magnetic resonance imaging in orthotopic pancreatic murine tumors

SCIENTIFIC REPORTS, 12(1).

By: J. Rojas*, J. Joiner*, B. Velasco n, K. Bautista n, A. Aji*, C. Moore*, N. Beaumont*, Y. Pylayeva-Gupta* ...

MeSH headings : Animals; Cell Line, Tumor; Disease Progression; Early Detection of Cancer / methods; High-Throughput Screening Assays; Magnetic Resonance Imaging; Mice, Inbred C57BL; Multimodal Imaging; Optical Imaging; Pancreatic Neoplasms / diagnostic imaging; Pancreatic Neoplasms / pathology; Predictive Value of Tests; Reproducibility of Results; Time Factors; Tumor Burden; Ultrasonography
TL;DR: It is concluded that combining BLI with robotic US offers an efficient screening tool for orthotopic tumor models, and offers complementary advantages of detection sensitivity and quantification accuracy, while mitigating individual technological weaknesses. (via Semantic Scholar)
Source: Web Of Science
Added: February 7, 2022

2021 journal article

A multi-pillar piezoelectric stack transducer for nanodroplet mediated intravascular sonothrombolysis

ULTRASONICS, 116.

By: H. Kim n, J. Kim n, H. Wu n, B. Zhang n, P. Dayton n & X. Jiang n

Contributors: H. Kim n, J. Kim n, H. Wu n, B. Zhang n, P. Dayton n & X. Jiang n

author keywords: Intravascular transducer; Sonothrombolysis; Nanodroplet; Piezoelectric stack; Small aperture
TL;DR: The ND-mediated intravascular sonothrombolysis using MPPS transducers was demonstrated with an unprecedented lysis rate, which may offer a new clinical option for DVT treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 16, 2021

2021 journal article

Acoustic holograms for directing arbitrary cavitation patterns

APPLIED PHYSICS LETTERS, 118(5).

By: J. Kim n, S. Kasoji*, P. Durham n & P. Dayton n

TL;DR: This study demonstrates the generation of arbitrary shape two-dimensional microbubble cavitation fields through the use of three-dimensional-printed acoustic lenses and cavitation-sensitive acoustic phantoms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 29, 2021

2021 review

Applications of sub-micron low-boiling point phase change contrast agents for ultrasound imaging and therapy

[Review of ]. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 56.

By: P. Durham* & P. Dayton n

author keywords: Nanodroplet; Perfluorocarbon; Contrast agent; Phase change; Perfluorobutane; Perfluoropropane; Phase shift
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 8, 2021

2021 journal article

Characterization of an Array-Based Dual-Frequency Transducer for Superharmonic Contrast Imaging

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 68(7), 2419–2431.

author keywords: Imaging; Transducers; Probes; Harmonic analysis; Acoustics; Acoustic arrays; Ultrasonic imaging; Acoustic angiography; array transducer; dual-frequency (DF); microbubble (MB) contrast agents; superharmonic imaging
MeSH headings : Angiography; Animals; Contrast Media; Mice; Microbubbles; Phantoms, Imaging; Transducers; Ultrasonography
TL;DR: In vitro contrast channel phantom imaging and in vivo xenograft mouse tumor imaging by this probe with superharmonic imaging showed contrast-to-tissue ratio improvements, compared to line-by-line micro-ultrasound B-mode imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 12, 2021

2021 article

Design and Fabrication of 1D CMUT Arrays for Dual-Mode Acoustic Angiography Applications - Preliminary Results

INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS 2021).

By: M. Annayev n, O. Adelegan n, F. Yamaner n, P. Dayton n & O. Oralkan n

author keywords: Dual-mode dual-frequency; capacitive micromachined ultrasonic transducer; CMUT; acoustic angiography
TL;DR: Finite element model simulation results show that the fabricated devices can transmit at low frequency and receive echoes at high frequency (> 15 MHz), which are verified by experimental results. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 15, 2022

2021 journal article

Dual-Frequency Intravascular Sonothrombolysis: An In Vitro Study

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 68(12), 3599–3607.

By: H. Wu n, L. Goel n, H. Kim n, B. Zhang n, J. Kim*, P. Dayton*, Z. Xu*, X. Jiang n

Contributors: H. Wu n, L. Goel n, H. Kim n, B. Zhang n, J. Kim*, P. Dayton*, Z. Xu*, X. Jiang n

author keywords: Transducers; Acoustics; Ultrasonic imaging; Frequency measurement; Frequency control; Impedance; Broadband communication; Dual-frequency thrombolysis; intravascular ultrasound transducer; passive cavitation; sonothrombolysis
MeSH headings : Acoustics; Contrast Media; Microbubbles; Transducers; Ultrasonic Therapy
TL;DR: A new broadband intravascular transducer is developed and tests indicated that the MB-mediated, dual-frequency (750+500 kHz) sonothrombolysis yields an 85% higher lysis rate compared with the single-frequency treatment, and the lysis Rate increases with the difference between the two frequency components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 24, 2021

2021 journal article

EFFECT OF ACOUSTIC PARAMETERS AND MICROBUBBLE CONCENTRATION ON THE LIKELIHOOD OF ENCAPSULATED MICROBUBBLE COALESCENCE

ULTRASOUND IN MEDICINE AND BIOLOGY, 47(10), 2980–2989.

By: D. Le n, V. Papadopoulou n & P. Dayton n

author keywords: Microbubble coalescence; Ultrasound contrast agent; Ultrasound; Contrast-enhanced ultrasound
MeSH headings : Acoustics; Contrast Media; Microbubbles; Pressure; Ultrasonography
TL;DR: It is suggested that the microbubble coalescence phenomenon can readily occur at acoustic parameters used in therapeutic ultrasound, generating bubbles much larger than those found in commercial contrast agents, although coalescence is unlikely to be significant in diagnostic contrast-enhanced ultrasound imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 20, 2021

2021 journal article

Harnessing ultrasound-stimulated phase change contrast agents to improve antibiotic efficacy against methicillin-resistant Staphylococcus aureus biofilms

BIOFILM, 3.

author keywords: Therapeutic ultrasound; Persister cells; Antibiotic tolerance; Biofilm; Staphylococcus aureus
TL;DR: Data demonstrate that biofilm eradication can be achieved using a combined approach of improving drug penetration of therapeutics that target persister cells, as well as ultrasound-stimulated phase-change contrast agents (US-PCCA), which improve antibiotic penetration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 3, 2022

2021 journal article

IN VIVO PORCINE AGED DEEP VEIN THROMBOSIS MODEL FOR TESTING ULTRASOUND-BASED THROMBOLYSIS TECHNIQUES

ULTRASOUND IN MEDICINE AND BIOLOGY, 47(12), 3447–3457.

By: G. Stocker*, J. Shi*, K. Ives*, A. Maxwell*, P. Dayton n, X. Jiang n, Z. Xu*, G. Owens*

author keywords: Thrombosis; Deep vein thrombosis; DVT; Clot retraction; Sub-acute clot; Non-invasive; Thrombolysis; In vivo
MeSH headings : Animals; Disease Models, Animal; Fibrinolytic Agents / therapeutic use; Swine; Thrombolytic Therapy; Thrombosis / drug therapy; Venous Thrombosis / diagnostic imaging
TL;DR: It is shown that sub-acute clots can consistently be formed with a minimally invasive, percutaneous approach, and the clot formed in this study remained intact for at least 1 wk in all subjects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 29, 2021

2021 review

Imaging methods to evaluate tumor microenvironment factors affecting nanoparticle drug delivery and antitumor response

[Review of ]. CANCER DRUG RESISTANCE, 4(2), 382–413.

By: A. Moody n, P. Dayton n & W. Zamboni*

author keywords: Tumor microenvironment; imaging; drug delivery; nanoparticles
TL;DR: TME factors involved in drug delivery are discussed, and how biomedical imaging tools can be used to evaluate tumor barriers and predict drug delivery to tumors and antitumor response are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: September 19, 2022

2021 journal article

Implementation of a Novel 288-Element Dual-Frequency Array for Acoustic Angiography: In Vitro and In Vivo Characterization

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 68(8), 2657–2666.

author keywords: Imaging; Acoustics; Angiography; Transducers; Frequency measurement; Ultrasonic imaging; In vitro; Acoustic angiography; contrast agent; dual-frequency (DF); microbubbles; microvasculature; superharmonic
MeSH headings : Acoustics; Angiography; Contrast Media; Transducers; Ultrasonography
TL;DR: This work presents a system for performing acoustic angiography with a novel dual-frequency DF transducer—a coaxially stacked DF array (DFA), and evaluates the system both in vitro and in vivo and demonstrates improvements in sensitivity and imaging depth up to 13.1 dB and 10 mm, respectively, compared with previous wobbler probes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 9, 2021

2021 article

Intravascular Dual-frequency Ultrasound Transducer Using a Stack Composite

INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS 2021).

By: H. Wu n, H. Kim n, B. Zhang n, J. Kim*, P. Dayton*, Z. Xu*, X. Jiang n

Contributors: H. Wu n, H. Kim n, B. Zhang n, J. Kim*, P. Dayton*, Z. Xu*, X. Jiang n

author keywords: Intravascular transducer; dual-frequency thrombolysis; sonothrombolysis; ultrasound catheter
TL;DR: An intravascular ultrasound transducer with a composite structure is reported, which can operate with the dual-frequency condition for enhancing the cavitation effect of infused contrast agents and showed a 34% improvement in the lysis rate when theDual-frequency excitation was applied with the nanodroplets infusion. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 15, 2022

2021 journal article

Magneto-sonothrombolysis with combination of magnetic microbubbles and nanodroplets

ULTRASONICS, 116.

By: B. Zhang n, H. Wu n, L. Goel n, H. Kim n, C. Peng n, J. Kim n, P. Dayton n, Y. Gao, X. Jiang n

Contributors: B. Zhang n, H. Wu n, L. Goel n, H. Kim n, C. Peng n, J. Kim n, P. Dayton n, Y. Gao, X. Jiang n

author keywords: Magnetic microbubbles; Magnetic nanoparticles; Nanodroplets; Sonothrombolysis; Cavitation
TL;DR: It is demonstrated that tPA-mediated magneto-sonothrombolysis in combining NDs with MMBs could significantly enhance in vitro lysis of both unretracted clots and retracted clots in a flow model with 30 min treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 23, 2021

2021 journal article

Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots

MICROSYSTEMS & NANOENGINEERING, 7(1).

By: L. Goel n, H. Wu n, B. Zhang n, J. Kim n, P. Dayton n, Z. Xu*, X. Jiang n

Contributors: L. Goel n, H. Wu n, B. Zhang n, J. Kim n, P. Dayton n, Z. Xu*, X. Jiang n

TL;DR: For the first time, it is demonstrated that a sub-megahertz, forward-viewing intravascular (FVI) transducer can be used for ND-mediated sonothrombolysis, in vitro and combined nanodroplet with tPA-mediatedSonothromBolysis was able to significantly enhance retracted clot lysis in retracted blood clots. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 15, 2021

2021 journal article

SAFETY EVALUATION OF A FORWARD-VIEWING INTRAVASCULAR TRANSDUCER FOR SONOTHROMBOLYSIS: AN IN VITRO AND EX VIVO STUDY

ULTRASOUND IN MEDICINE AND BIOLOGY, 47(11), 3231–3239.

By: L. Goel n, H. Wu n, B. Zhang n, J. Kim n, P. Dayton n, Z. Xu*, X. Jiang n

Contributors: L. Goel n, H. Wu n, B. Zhang n, J. Kim n, P. Dayton n, Z. Xu*, X. Jiang n

author keywords: Intravascular sonothrombolysis; Safety; Retracted clots; Nanodroplets; Microbubbles; Ultrasound-assisted thrombolysis; Tissue plasminogen activator
MeSH headings : Animals; Microbubbles; Particle Size; Thrombolytic Therapy; Thrombosis / therapy; Tissue Plasminogen Activator; Transducers; Ultrasonic Therapy
TL;DR: In vitro and ex vivo tests using FVI transducers revealed a temperature rise of less than 1°C, no vessel damage as assessed by histology and no downstream clot particles >500 µm, which indicates that the F VI transducer poses minimal risk for sonothrombolysis applications and should be further evaluated in animal models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 26, 2021

2021 article

Ultrasound Imaging-Guided Microbubble-Mediated Catheter-Directed Sonothrombolysis: An In-Vitro Study

2021 IEEE 16TH NANOTECHNOLOGY MATERIALS AND DEVICES CONFERENCE (NMDC 2021).

By: C. Peng n, B. Zhang n, H. Wu n, P. Dayton n, Z. Xu* & X. Jiang n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2020 journal article

A COMPARISON OF SONOTHROMBOLYSIS IN AGED CLOTS BETWEEN LOWBOILING-POINT PHASE-CHANGE NANODROPLETS AND MICROBUBBLES OF THE SAME COMPOSITION

ULTRASOUND IN MEDICINE AND BIOLOGY, 46(11), 3059–3068.

By: J. Kim n, R. DeRuiter n, L. Goel n, Z. Xu*, X. Jiang n & P. Dayton n

author keywords: Sonothrombolysis; Nanodroplets; Microbubbles; Cavitation; Clot
MeSH headings : Animals; Cattle; Mechanical Thrombolysis / methods; Microbubbles; Nanostructures; Thrombosis / therapy; Time Factors; Transition Temperature; Ultrasonic Therapy
TL;DR: Enhanced cavitation erosion of blood clots exposed to low-boiling-point (-2°C) perfluorocarbon phase-change nanodroplets and pulsed ultrasound, as well as microbubbles with the same formulation under the same conditions are presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 12, 2020

2020 journal article

EXAMINING THE INFLUENCE OF LOW-DOSE TISSUE PLASMINOGEN ACTIVATOR ON MICROBUBBLE-MEDIATED FORWARD-VIEWING INTRAVASCULAR SONOTHROMBOLYSIS

ULTRASOUND IN MEDICINE AND BIOLOGY, 46(7), 1698–1706.

By: L. Goel n, H. Wu n, H. Kim n, B. Zhang n, J. Kim n, P. Dayton n, Z. Xu*, X. Jiang n

Contributors: L. Goel n, H. Wu n, H. Kim n, B. Zhang n, J. Kim n, P. Dayton n, Z. Xu*, X. Jiang n

author keywords: Sonothrombolysis; Intravascular sonothrombolysis; Microbubble-mediated sonothrombolysis; Clot lysis; Tissue plasminogen activator
MeSH headings : Animals; Cattle; Combined Modality Therapy; Mechanical Thrombolysis / methods; Microbubbles / therapeutic use; Thrombolytic Therapy / methods; Thrombosis / drug therapy; Thrombosis / therapy; Tissue Plasminogen Activator / administration & dosage; Tissue Plasminogen Activator / therapeutic use; Ultrasonic Therapy / methods
TL;DR: Changes in stable and inertial cavitation doses were observed, corresponding to changes in clot lysis in MB-mediated FVI sonothrombolysis with and without tPA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 20, 2020

2020 review

Focused Ultrasound for Immunomodulation of the Tumor Microenvironment

[Review of ]. JOURNAL OF IMMUNOLOGY, 205(9), 2327–2341.

MeSH headings : Animals; Drug Delivery Systems / methods; Humans; Immunity / immunology; Immunomodulation / immunology; Neoplasms / immunology; Neoplasms / therapy; Tumor Microenvironment / immunology; Ultrasonic Therapy / methods
TL;DR: This review has categorized and reviewed recent methods of using therapeutic ultrasound to elicit an antitumor immune response with examples that reveal specific solutions and challenges in this new research area. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 9, 2020

2020 journal article

Improving the heating efficiency of high intensity focused ultrasound ablation through the use of phase change nanodroplets and multifocus sonication

PHYSICS IN MEDICINE AND BIOLOGY, 65(20).

By: A. Singh*, A. Nyankima n, M. Anthony Phipps*, V. Chaplin*, P. Dayton n & C. Caskey*

author keywords: high intensity focused ultrasound; ablation; focal steering; phase-shift nanodroplets; non-invasive therapy
MeSH headings : High-Intensity Focused Ultrasound Ablation / methods; Hot Temperature; Humans; Liver / surgery; Nanotechnology; Sonication
TL;DR: Methods for using phase-shift nanodroplets with multi-focus sonications to enhance volumetric ablation and ablation efficiency at constant powers while increasing the pre-focal temperature by less than 6 ∘C are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: October 26, 2020

2020 journal article

Perspectives on high resolution microvascular imaging with contrast ultrasound

APPLIED PHYSICS LETTERS, 116(21).

By: T. Kierski n & P. Dayton n

TL;DR: This Perspective article introduces microvascular imaging strategies and their underlying technology and demonstrates a potential to visualize small blood vessels in vivo, unlike anything possible with traditional grayscale ultrasound. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 22, 2020

2020 journal article

Quantitative sub-resolution blood velocity estimation using ultrasound localization microscopy ex-vivo and in-vivo

BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 6(3).

By: D. Espindola n, R. DeRuiter n, F. Santibanez n, P. Dayton n & G. Pinton n

author keywords: ultrasound imaging; super-resolution; blood flow
MeSH headings : Algorithms; Animals; Blood Flow Velocity; Blood Vessels / diagnostic imaging; Calibration; Contrast Media; Equipment Design; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Mice; Microbubbles; Microscopy / methods; Microvessels / diagnostic imaging; Phantoms, Imaging; Reproducibility of Results; Signal Processing, Computer-Assisted; Transducers; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR: It is shown that the parabolic flow profiles within these micro-vessels are resolvable and velocity measurements are in excellent agreement with theoretical predictions within the considered range of flow rates. (via Semantic Scholar)
Source: Web Of Science
Added: May 18, 2020

2020 review

SUPER-RESOLUTION ULTRASOUND IMAGING

[Review of ]. ULTRASOUND IN MEDICINE AND BIOLOGY, 46(4), 865–891.

By: K. Christensen-Jeffries, O. Couture, P. Dayton*, Y. Eldar, K. Hynynen, F. Kiessling, M. O'Reilly, I. Pinton ...

author keywords: Ultrasound; Microvessels; Super-resolution; Localization; Microscopy; Microbubbles; Contrast agents; Brain; Tumor
MeSH headings : Animals; Blood Vessels / diagnostic imaging; Humans; Microbubbles; Neoplasms / diagnostic imaging; Ultrasonography / methods
TL;DR: Inspired by optical microscopy, ultrasound localization microscopy has bypassed the classic compromise between penetration and resolution in ultrasonic imaging and is being applied pre-clinically and clinically for imaging of the microvasculature of the brain, kidney, skin, tumors and lymph nodes. (via Semantic Scholar)
Source: Web Of Science
Added: March 10, 2020

2020 journal article

Super-Resolution Imaging Through the Human Skull

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 67(1), 25–36.

By: D. Soulioti n, D. Espindola n, P. Dayton n & G. Pinton n

author keywords: Brain mapping; brain vasculature; contrast-enhanced ultrasound; microbubbles; phase aberration correction; super resolution; transcranial; transcranial focusing
MeSH headings : Algorithms; Brain / diagnostic imaging; Brain Mapping / methods; Contrast Media / chemistry; Humans; Image Processing, Computer-Assisted / methods; Microbubbles; Phantoms, Imaging; Skull / diagnostic imaging; Ultrasonography / methods
TL;DR: The feasibility of human transcranial super-resolution imaging is demonstrated using a geometrical focusing approach to efficiently concentrate energy at the region of interest, and a phase correction focusing approach that takes the skull morphology into account. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: January 21, 2020

2020 journal article

Superharmonic Ultrasound for Motion-Independent Localization Microscopy: Applications to Microvascular Imaging From Low to High Flow Rates

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 67(5), 957–967.

author keywords: Acoustic angiography (AA); angiogenesis; contrast agent; microbubble (MB); microvasculature; superharmonic imaging (SHI); ultrasound localization microscopy (ULM)
MeSH headings : Angiography; Animals; Female; Image Processing, Computer-Assisted / methods; Kidney / blood supply; Kidney / diagnostic imaging; Microscopy / methods; Microvessels / diagnostic imaging; Movement; Rats; Ultrasonography / methods
TL;DR: Superharmonic imaging is applied to ULM and an average improvement in SNR of 10.3-dB in vitro when compared with the standard singular value decomposition filter approach and an increase inSNR at low flow from 5 to 16.5 dB. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 26, 2020

2020 journal article

Transient acoustic vaporization signatures unique to low boiling point phase change contrast agents enable super-resolution ultrasound imaging without spatiotemporal filtering

AIP ADVANCES, 10(10).

By: R. DeRuiter n, E. Markley n, J. Rojas n, G. Pinton n & P. Dayton n

TL;DR: The proposed PCCA SR technique does not require the use of user-dependent and flow-dependent spatio-temporal filtering via singular-value decomposition, rather, matched filters selected by Fourier-domain analysis are able to identify and localize PCCAs activations. (via Semantic Scholar)
Source: Web Of Science
Added: November 24, 2020

2020 review

VISUALIZATION OF MICROVASCULAR ANGIOGENESIS USING DUAL-FREQUENCY CONTRAST-ENHANCED ACOUSTIC ANGIOGRAPHY: A REVIEW

[Review of ]. ULTRASOUND IN MEDICINE AND BIOLOGY, 46(10), 2625–2635.

By: I. Newsome n & P. Dayton n

author keywords: Ultrasound; Microbubbles; Contrast agent; Angiography; Angiogenesis; Microvasculature
MeSH headings : Acoustics; Angiography / methods; Angiography / trends; Animals; Contrast Media; Forecasting; Humans; Microvessels / diagnostic imaging; Neoplasms / blood supply; Neoplasms / diagnostic imaging; Neovascularization, Pathologic / diagnostic imaging; Ultrasonography
TL;DR: This review describes the development of acoustic angiography, including the principle, transducer design, and optimization of superharmonic imaging techniques, and details several preclinical applications of this microvascular imaging method. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 28, 2020

2019 article

A preclinical ultrasound platform for widefield 3D imaging of rodent tumors

Czernuszewicz, T., Papadopoulou, V., Rojas, J. D., Rajamahendiran, R., Perdomo, J., Butler, J., … Gessner, R. C. (2019, July). CANCER RESEARCH, Vol. 79.

By: T. Czernuszewicz*, V. Papadopoulou n, J. Rojas*, R. Rajamahendiran*, J. Perdomo*, J. Butler*, M. Harlacher*, G. O'Connell* ...

TL;DR: A novel robotic preclinical US imaging system that can accurately and consistently evaluate tumors in rodent models is demonstrated and leverages cost-effective robotic technology, and a new scanning paradigm that allows for easy and reproducible data acquisition to enable wide-field, 3D, multi-parametric ultrasound imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: October 21, 2019

2019 journal article

ASSESSMENT OF THE SUPERHARMONIC RESPONSE OF MICROBUBBLE CONTRAST AGENTS FOR ACOUSTIC ANGIOGRAPHY AS A FUNCTION OF MICROBUBBLE PARAMETERS

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(9), 2515–2524.

By: I. Newsome n, T. Kierski n & P. Dayton n

author keywords: Microbubble; Ultrasound; Acoustic angiography; Superharmonic; Perfluorocarbon
MeSH headings : Acoustics; Angiography / methods; Contrast Media / chemistry; Microbubbles
TL;DR: It is suggested that microbubbles around 1 μm in diameter with perfluorocarbon cores and longer-chained lipid shells perform best for superharmonic imaging at 4 MHz, which is similar to prior studies using a narrower frequency bandwidth centered around the excitation frequency. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 26, 2019

2019 journal article

Candle-Soot Carbon Nanoparticles in Photoacoustics Advantages and challenges for laser ultrasound transmitters

IEEE NANOTECHNOLOGY MAGAZINE, 13(3), 13–28.

By: J. Kim*, H. Kim n, W. Chang n, W. Huang*, X. Jiang n & P. Dayton*

TL;DR: This article provides a review of candle-soot nanoparticle (CSNP) composite laser ultrasound transmitters (LUTs) and compares and contrasts this technology with other carbon-composite designs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019

2019 journal article

Dynamic assessment of dual-frequency microbubble-mediated sonothrombolysis in vitro

JOURNAL OF APPLIED PHYSICS, 125(8).

By: D. Suo n, B. Govind n, J. Gu n, P. Dayton n & Y. Jing n

TL;DR: It is found that dual- frequencies excitation in general produces a faster rate of clot dissipation in comparison to single-frequency excitation, and this observation is corroborated by cavitation signal detection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 18, 2019

2019 journal article

EFFECT OF HYDROSTATIC PRESSURE, BOUNDARY CONSTRAINTS AND VISCOSITY ON THE VAPORIZATION THRESHOLD OF LOW-BOILING-POINT PHASE-CHANGE CONTRAST AGENTS

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(4), 968–979.

By: J. Rojas n, M. Borden* & P. Dayton n

author keywords: Phase change; Contrast agents; Acoustic droplet vaporization; Vaporization threshold; Decafluoro-butane; Nanoemulsion
MeSH headings : Animals; Contrast Media / administration & dosage; Female; Hydrostatic Pressure; Image Enhancement / methods; Kidney / anatomy & histology; Models, Animal; Rats; Rats, Inbred F344; Ultrasonography / methods; Viscosity; Volatilization
TL;DR: Constraints caused by the surrounding tissue and capillary walls, as well as increased viscosity in vivo, contribute to the increased vaporization threshold compared with in vitro experiments, although more work is required to confirm all relevant factors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 18, 2019

2019 article

Early treatment response detected in a murine clear cell renal cell carcinoma model in response to combination therapy with antiangiogenic and notch inhibition therapy using a non-invasive imaging tool

Rojas, J. D., Papadopoulou, V., Czernuszewicz, T., Rajamahendiran, R., Chytil, A., Chiang, Y.-C., … Dayton, P. (2019, July). CANCER RESEARCH, Vol. 79.

By: J. Rojas*, V. Papadopoulou n, T. Czernuszewicz*, R. Rajamahendiran*, A. Chytil*, Y. Chiang*, D. Chong*, V. Bautch* ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: October 21, 2019

2019 journal article

Histological and blood chemistry examination of the rodent kidney after exposure to flash-replenishment ultrasound contrast imaging

ULTRASONICS, 98, 1–6.

By: A. Nyankima n, S. Kasoji n, R. Cianciolo*, P. Dayton n & E. Chang*

author keywords: Contrast enhanced ultrasound; Ultrasound contrast agents; Microbubble; Bioeffects
MeSH headings : Animals; Blood Chemical Analysis; Blood Urea Nitrogen; Contrast Media / pharmacology; Female; Fluorocarbons / pharmacology; Kidney / diagnostic imaging; Kidney / drug effects; Microbubbles; Rats; Rats, Inbred F344; Ultrasonography
TL;DR: In conclusion, CEUS with flash-replenishment imaging sequences did not result in kidney bioeffects observable with histology at early or late time points. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 9, 2019

2019 journal article

IN VITRO SUPERHARMONIC CONTRAST IMAGING USING A HYBRID DUAL-FREQUENCY PROBE

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(9), 2525–2539.

By: E. Cherin*, J. Yin*, A. Forbrich*, C. White*, P. Dayton n, F. Foster*, C. Demore*

author keywords: Dual-frequency transducer; Contrast agent; Superharmonic imaging; Acoustic angiography; Plane wave
MeSH headings : Angiography / methods; Contrast Media / chemistry; In Vitro Techniques; Microbubbles; Phantoms, Imaging; Signal-To-Noise Ratio; Transducers; Ultrasonography / instrumentation
TL;DR: A new dual-frequency probe based on array technology, specifically designed for clinical applications of acoustic angiography is reported on, including two 1.7-MHz rectangular transducers positioned one on each side of a 20-MHz 256-element array. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 26, 2019

2019 journal article

IN VIVO MOLECULAR IMAGING USING LOW-BOILING-POINT PHASE-CHANGE CONTRAST AGENTS: A PROOF OF CONCEPT STUDY

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(1), 177–191.

By: J. Rojas n & P. Dayton n

author keywords: Ultrasound molecular imaging; Molecular targeting; Phase-change contrast agents; Acoustic droplet vaporization
MeSH headings : Animals; Contrast Media; Disease Models, Animal; Feasibility Studies; Fibrosarcoma / diagnostic imaging; Image Enhancement / methods; Molecular Imaging / methods; Proof of Concept Study; Rats; Rats, Inbred F344; Ultrasonography / methods
TL;DR: Data indicate that PCCA-specific imaging is more sensitive to small numbers of bound agents than conventional contrast imaging, however, data also revealed that contrast from targeted microbubbles was greater than that provided by PCCAs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 20, 2020

2019 journal article

ON THE RELATIONSHIP BETWEEN DYNAMIC CONTRAST-ENHANCED ULTRASOUND PARAMETERS AND THE UNDERLYING VASCULAR ARCHITECTURE EXTRACTED FROM ACOUSTIC ANGIOGRAPHY

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(2), 539–548.

By: A. Panfilova*, S. Shelton n, C. Caresio*, R. Sloun*, F. Molinari*, H. Wijkstra*, P. Dayton n, M. Mischi*

author keywords: Acoustic angiography; Dynamic contrast-enhanced ultrasound; Cancer; Dispersion; Perfusion; Ultrasound contrast agents
MeSH headings : Acoustics; Angiography / methods; Animals; Contrast Media; Disease Models, Animal; Fibrosarcoma / blood supply; Fibrosarcoma / diagnostic imaging; Image Enhancement / methods; Imaging, Three-Dimensional / methods; Rats; Rats, Inbred F344; Ultrasonography / methods
TL;DR: It is hypothesize that dispersion characterizes vessels that are smaller than those visible with acoustic angiography, because dispersion provided better cancer classification than perfusion. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 20, 2020

2019 journal article

On Command Drug Delivery via Cell-Conveyed Phototherapeutics

SMALL, 15(37).

By: C. Marvin*, S. Ding*, R. White n, N. Orlova*, Q. Wang*, E. Zywot*, B. Vickerman*, L. Harr* ...

author keywords: drug delivery; photolysis; prodrugs; red blood cells; vitamin B12
MeSH headings : Animals; Bridged-Ring Compounds / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / methods; Erythrocytes / cytology; Female; Flow Cytometry; Humans; Mice; Photolysis; Prodrugs / chemistry; Taxoids / chemistry; Vitamin B 12 / chemistry
TL;DR: Herein, the use of red blood cells (RBCs) as carriers of cytoplasmically interned phototherapeutic agents is described, and photolysis promotes drug release from the RBC carrier thereby providing the means to target specific diseased sites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 19, 2019

2019 journal article

Precision mouse models with expanded tropism for human pathogens

NATURE BIOTECHNOLOGY, 37(10), 1163-+.

By: A. Wahl, C. De, M. Fernandez*, E. Lenarcic*, Y. Xu*, A. Cockrell*, R. Cleary, C. Johnson ...

MeSH headings : Animals; Antibodies, Viral; Antigen-Presenting Cells; Coronavirus Infections / immunology; Coronavirus Infections / virology; Cytokines / genetics; Cytokines / metabolism; Cytomegalovirus / physiology; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Lung / physiology; Male; Mice; Mice, SCID; Middle East Respiratory Syndrome Coronavirus / immunology; Tropism / immunology; Virus Replication; Zika Virus / immunology; Zika Virus Infection / immunology; Zika Virus Infection / virology
TL;DR: Implantation of lung tissue into humanized mice enables in vivo study of the human immune response to pathogens, and shows robust antigen-specific humoral and T-cell responses following cytomegalovirus infection that control virus replication. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 18, 2019

2019 article

The biological response of rodent kidneys to low frequency, full volume diagnostic contrast-enhanced ultrasound imaging: Pilot data

Nyankima, A. G., Kasoji, S., Cianciolo, R., Dayton, P. A., & Chang, E. H. (2019, August). DATA IN BRIEF, Vol. 25.

By: A. Nyankima n, S. Kasoji n, R. Cianciolo*, P. Dayton n & E. Chang*

author keywords: Contrast enhanced ultrasound; Ultrasound contrast agents; Microbubble; Bioeffects
TL;DR: The data presented are results from a pilot study, which explored flash-replenishment with high and moderate MI imaging sequences at time points of 24 hours and 2 weeks post imaging. (via Semantic Scholar)
Source: Web Of Science
Added: November 25, 2019

2019 article

Tracking angiogenesis induced microvascular changes in a lymphoma model via a new high throughput non-invasive dual modality imaging platform

Rojas, J. D., Rajamahendiran, R., Czernuszewicz, T. J., Velasco, B., Perdomo, J., Harlacher, M., … Gessner, R. C. (2019, July). CANCER RESEARCH, Vol. 79.

By: J. Rojas*, R. Rajamahendiran*, T. Czernuszewicz*, B. Velasco n, J. Perdomo*, M. Harlacher*, G. O'Connell*, J. Butler* ...

TL;DR: It is demonstrated that non-invasive measurements of in vivo microvascular remodeling can be precisely mapped to changes in tumor growth with a hybrid modality system, and should prove valuable when using antiangiogenic therapies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: October 21, 2019

2019 journal article

ULTRASOUND-STIMULATED PHASE-CHANGE CONTRAST AGENTS FOR TRANSEPITHELIAL DELIVERY OF MACROMOLECULES, TOWARD GASTROINTESTINAL DRUG DELIVERY

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(7), 1762–1776.

author keywords: Ultrasound; Transepithelial delivery; Acoustic droplet vaporization; Phase-change contrast agents; Nanodroplet
MeSH headings : Cells, Cultured; Contrast Media; Dextrans / administration & dosage; Drug Delivery Systems / methods; Fluorescein-5-isothiocyanate / administration & dosage; Fluorescein-5-isothiocyanate / analogs & derivatives; Gastrointestinal Agents / administration & dosage; Humans; Image Enhancement / methods; In Vitro Techniques; Ultrasonography / methods
TL;DR: It is demonstrated that ultrasound-stimulated phase change contrast agents (PCCAs) can transiently disrupt confluent colorectal adenocarcinoma monolayers and improve the transepithelial transport of a macromolecular model drug. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: June 24, 2019

2019 journal article

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

NATURE COMMUNICATIONS, 10.

By: S. Benhabbour n, M. Kovarova*, C. Jones*, D. Copeland*, R. Shrivastava n, M. Swanson*, C. Sykes*, P. Ho* ...

MeSH headings : Anti-Retroviral Agents / pharmacokinetics; Biodegradable Plastics / chemistry; Chemistry, Pharmaceutical; Delayed-Action Preparations / chemistry; Delayed-Action Preparations / pharmacology; Drug Delivery Systems / methods; Drug Liberation; HIV Infections / drug therapy; Humans; Kinetics; Materials Testing; Polymers / metabolism; Pyrrolidinones; Rheology; Solubility
TL;DR: An ultra-long-acting tunable, biodegradable, and removable polymer-based delivery system that offers sustained drug delivery for up to one year for HIV treatment or prophylaxis and optimize and demonstrate the release of 6 different drugs over a period of up to a year. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 7, 2019

2019 journal article

Ultrasound Measurement of Vascular Density to Evaluate Response to Anti-Angiogenic Therapy in Renal Cell Carcinoma

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 66(3), 873–880.

By: J. Rojas n, V. Papadopoulou n, T. Czernuszewicz*, R. Rajamahendiran*, A. Chytil*, Y. Chiang*, D. Chong*, V. Bautch ...

author keywords: Microvasculature; angiogenesis; ultrasound; contrast agents; response to therapy; acoustic angiography
MeSH headings : Angiogenesis Inhibitors / pharmacology; Angiography / methods; Animals; Carcinoma, Renal Cell / blood supply; Carcinoma, Renal Cell / diagnostic imaging; Drug Monitoring; Female; Heterografts; Kidney / blood supply; Kidney / diagnostic imaging; Kidney Neoplasms / blood supply; Kidney Neoplasms / diagnostic imaging; Mice; Mice, Inbred NOD; Mice, SCID; Microvessels / diagnostic imaging; Microvessels / drug effects; Microvessels / pathology; Ultrasonography / methods
TL;DR: Results suggest that future applications utilizing ultrasound imaging to monitor tumor response to therapy may be able to provide earlier insight into tumor behavior from metrics of microvascular density rather than anatomical tumor size measurements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 11, 2019

2019 journal article

Ultrasound multiple scattering with microbubbles can differentiate between tumor and healthy tissue in vivo

PHYSICS IN MEDICINE AND BIOLOGY, 64(11).

author keywords: multiple scattering; ultrasound imaging; diffusion constant; fibrosarcoma; contrast enhanced ultrasound; microbubbles
MeSH headings : Animals; Disease Models, Animal; Fibrosarcoma / blood supply; Fibrosarcoma / diagnostic imaging; Fibrosarcoma / pathology; Microbubbles; Neovascularization, Pathologic; Rats; Ultrasonography
TL;DR: The diffusion constant and its anisotropy are shown to be significantly different between fibrosarcoma tumors and control tissue in a rat animal model in vivo, offering a promising way to quantitatively assess vascular networks when combined with contrast agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2019

2019 journal article

VAPORIZATION DETECTIONIMAGING: A TECHNIQUE FOR IMAGING LOW-BOILING-POINTPHASE-CHANGE ONTRAST AGENTS WITH A HIGH DEPTH OF PENETRATION AND CONTRAST-TO-TISSUERATIO

ULTRASOUND IN MEDICINE AND BIOLOGY, 45(1), 192–207.

By: J. Rojas n & P. Dayton n

author keywords: Phasechange; Contrast agents; Acoustic droplet vaporization; Vaporization detection; Perfluorobutane; Perfluoropropane; Nanodroplet
MeSH headings : Animals; Contrast Media; Kidney / diagnostic imaging; Models, Animal; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Ultrasonography; Volatilization
TL;DR: This work explores the effect of pulse length and concentration on the vaporization signal of PCCAs and a new technique to capture and use the signals to make high contrast-to-tissue ratio images in vivo and indicates that using a short pulse may be ideal for imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 20, 2020

2018 journal article

A Dual-Frequency Colinear Array for Acoustic Angiography in Prostate Cancer Evaluation

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 65(12), 2418–2428.

By: S. Li n, J. Kim n, Z. Wang*, S. Kasoji n, B. Lindsey*, P. Dayton n, X. Jiang n

author keywords: Harmonic analysis; in vivo; oncology; ultrasonic imaging; ultrasonic transducer arrays
MeSH headings : Abdomen / blood supply; Abdomen / diagnostic imaging; Angiography / methods; Animals; Contrast Media; Humans; Image Interpretation, Computer-Assisted / methods; Male; Microbubbles; Models, Biological; Phantoms, Imaging; Prostate / blood supply; Prostate / diagnostic imaging; Prostatic Neoplasms / blood supply; Prostatic Neoplasms / diagnostic imaging; Rats; Transducers; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR: The development of a dual frequency, dual-layer colinear array transducer for transrectal acoustic angiography and identification of regions of neovascularization for the guidance of prostate biopsies are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019

2018 journal article

Adaptive Multifocus Beamforming for Contrast-Enhanced-Super-Resolution Ultrasound Imaging in Deep Tissue

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 65(12), 2255–2263.

By: D. Espindola n, F. Lin n, D. Soulioti n, P. Dayton n & G. Pinton n

author keywords: Adaptive beamforming; sensitivity; super-resolution imaging
MeSH headings : Abdomen / diagnostic imaging; Animals; Contrast Media; Databases, Factual; Female; Humans; Image Processing, Computer-Assisted / methods; Microbubbles; Muscles / diagnostic imaging; Phantoms, Imaging; Swine; Ultrasonography / methods
TL;DR: An “adaptive multifocus” sequence is proposed, a new ultrasound imaging sequence that combines the high frame rate feature of a plane wave with the increased bubble detection sensitivity of a focused beam, retaining a high frame rates, yet achieving improved sensitivity to microbubbles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 14, 2019

2018 journal article

Cavitation enhancement increases the efficiency and consistency of chromatin fragmentation from fixed cells for downstream quantitative applications

Biochemistry, 57(19), 2756–2761.

By: A. Chiarella*, A. Quimby*, M. Mehrab-Mohseni n, B. Velasco n, S. Kasoji n, I. Davis*, P. Dayton n, N. Hathaway*, S. Pattenden*

MeSH headings : Animals; Cell Cycle Proteins / chemistry; Cell Cycle Proteins / genetics; Chromatin / radiation effects; Chromatin Immunoprecipitation / methods; DNA / chemistry; DNA / genetics; DNA / radiation effects; DNA Fragmentation / radiation effects; Euchromatin / radiation effects; Heterochromatin / radiation effects; Mice; Nanoparticles / chemistry; Octamer Transcription Factor-3 / chemistry; Octamer Transcription Factor-3 / genetics; Sonication / methods
TL;DR: It is shown that nanodroplets increase sonication efficiency by 16-fold and provide more consistent levels of chromatin fragmentation, which drastically reduces the amount of processing time and provides consistently fragmented chromatin of high quality for downstream applications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Focused ultrasound-facilitated brain drug delivery using optimized nanodroplets: vaporization efficiency dictates large molecular delivery

PHYSICS IN MEDICINE AND BIOLOGY, 63(3).

By: S. Wu*, S. Fix*, C. Arena n, C. Chen*, W. Zheng*, O. Olumolade*, V. Papadopoulou n, A. Novell n, P. Dayton n, E. Konofagou*

author keywords: ultrasound; blood-brain barrier; drug delivery; nanodroplet; cavitation
MeSH headings : Acoustics; Animals; Biological Transport; Blood-Brain Barrier / metabolism; Brain / metabolism; Dextrans / administration & dosage; Drug Delivery Systems; Fluorocarbons / administration & dosage; Male; Mice; Mice, Inbred C57BL; Nanostructures / chemistry; Sonication / methods; Volatilization
TL;DR: It was found that at low pressures, OFP droplets vaporized into a greater number of microbubbles compared to DFB droplets at higher pressures in the in vitro study, and the vaporization efficiency of nanodroplets positively impacted the amount of molecules delivered to the brain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Variability in circulating gas emboli after a same scuba diving exposure

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 118(6), 1255–1264.

By: V. Papadopoulou n, P. Germonpre*, D. Cosgrove*, R. Eckersley*, P. Dayton n, G. Obeid*, A. Boutros*, M. Tang*, S. Theunissen*, C. Balestra*

author keywords: Echocardiography; Venous gas emboli; Ultrasound; Decompression sickness; Microbubble
MeSH headings : Adult; Biological Variation, Individual; Decompression Sickness / diagnostic imaging; Decompression Sickness / etiology; Decompression Sickness / physiopathology; Diving / adverse effects; Diving / physiology; Echocardiography; Embolism, Air / diagnostic imaging; Embolism, Air / etiology; Embolism, Air / physiopathology; Humans; Male; Middle Aged; Veins / diagnostic imaging
TL;DR: Since VGE evolution post-dive varies between people, more work is clearly needed to isolate contributing factors, and going toward a more continuous evaluation, or developing new means to detect decompression stress markers, may offer the ability to better assess dynamic correlations to other physiological parameters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

3-D Ultrasound Localization Microscopy for Identifying Microvascular Morphology Features of Tumor Angiogenesis at a Resolution Beyond the Diffraction Limit of Conventional Ultrasound

Theranostics, 7(1), 196–204.

By: F. Lin n, S. Shelton n, D. Espíndola n, J. Rojas n, G. Pinton n & P. Dayton n

author keywords: Angiogenesis; super-resolution; ultrasound localization microscopy; microbubble contrast agent; acoustic angiography; biomarker
MeSH headings : Animals; Disease Models, Animal; Female; Fibrosarcoma / pathology; Imaging, Three-Dimensional / methods; Microscopy / methods; Microvessels / pathology; Neovascularization, Pathologic; Pilot Projects; Rats, Inbred F344; Ultrasonography / methods
TL;DR: The ability to image complex microvascular patterns associated with tumor angiogenesis in-vivo at a resolution of tens of microns is demonstrated - substantially better than the diffraction limit of traditional clinical ultrasound, yet using an 8 MHz clinical ultrasound probe. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

A Pilot Clinical Study in Characterization of Malignant Renal-cell Carcinoma Subtype with Contrast-enhanced Ultrasound

ULTRASONIC IMAGING, 39(2), 126–136.

By: S. Kasoji n, E. Chang*, L. Mullin n, W. Chong*, W. Rathmell & P. Dayton n

author keywords: contrast-enhanced ultrasound; renal cell carcinoma; time intensity curve; renal perfusion; microbubbles
MeSH headings : Carcinoma, Renal Cell / diagnostic imaging; Carcinoma, Renal Cell / pathology; Contrast Media; Diagnosis, Differential; Fluorocarbons; Humans; Kidney Neoplasms / diagnostic imaging; Kidney Neoplasms / pathology; Ultrasonography / methods
TL;DR: Results suggest that CEUS may be a feasible test for characterizing RCC subtypes and suggest that different disease subtypes have different prognoses and involve varying treatment regimens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

An evaluation of the sonoporation potential of low-boiling point phase-change ultrasound contrast agents in vitro

JOURNAL OF THERAPEUTIC ULTRASOUND, 5, 1–11.

By: S. Fix*, A. Novell n, Y. Yun*, P. Dayton n & C. Arena n

author keywords: Sonoporation; Ultrasound; Drug delivery; Acoustic droplet vaporization; Nanodroplet
TL;DR: It is concluded that phase-change ultrasound contrast agents can be used to induce the sonoporation of cells in vitro, and the results warrant further investigation into the use of PCCAs as extravascularSonoporation agents in vivo. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Assessment of Molecular Acoustic Angiography for Combined Microvascular and Molecular Imaging in Preclinical Tumor Models

Molecular Imaging and Biology, 19(2), 194–202.

By: B. Lindsey n, S. Shelton n, F. Foster* & P. Dayton n

author keywords: Microbubble; Superharmonic; Microvasculature; Angiogenesis; Tortuosity; Targeted imaging; Ultrasound; Contrast imaging; VEGFR2; Selectin
MeSH headings : Acoustics; Angiography / methods; Animals; Contrast Media / chemistry; Disease Models, Animal; Image Processing, Computer-Assisted; Microvessels / pathology; Molecular Imaging / methods; Neoplasms / blood supply; Neoplasms / diagnostic imaging; Rats, Inbred F344
TL;DR: Analysis of registered microvascular and molecular imaging volumes indicated that vessel tortuosity decreases with increasing distance from both VEGFR2- and selectin-targeting sites, and superharmonic imaging had significantly higher contrast-to-tissue ratio (CTR) than multi-pulse imaging. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Contrast Enhanced Superharmonic Imaging for Acoustic Angiography Using Reduced Form-Factor Lateral Mode Transmitters for Intravascular and Intracavity Applications

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 64(2), 311–319.

By: Z. Wang n, K. Martin n, W. Huang*, P. Dayton n & X. Jiang n

author keywords: Dual frequency; lateral mode transducer; superharmonic; ultrasound transducer
MeSH headings : Acoustics / instrumentation; Angiography / instrumentation; Contrast Media / chemistry; Equipment Design; Humans; Microbubbles; Transducers; Ultrasonography / instrumentation
TL;DR: Results show that superharmonic imaging with a low frequency lateral mode transmitter is a feasible alternative to thickness mode transmitters when the final transducer size requirements dictate design choices. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Dual-Frequency Piezoelectric Endoscopic Transducer for Imaging Vascular Invasion in Pancreatic Cancer

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 64(7), 1078–1086.

By: B. Lindsey n, J. Kim n, P. Dayton n & X. Jiang n

author keywords: Acoustic angiography; endoscope; high frequency; interventional imaging; microbubble; superharmonic
MeSH headings : Angiography / instrumentation; Animals; Contrast Media; Microbubbles; Pancreatic Neoplasms / diagnostic imaging; Pancreatic Neoplasms / pathology; Phantoms, Imaging; Rats; Splenic Artery / diagnostic imaging; Splenic Artery / pathology; Swine; Transducers; Ultrasonography, Interventional / instrumentation
TL;DR: A dual-frequency piezoelectric transducer for rotational endoscopic imaging designed to transmit at 4 MHz and receive at 20 MHz in order to image microbubble-specific superharmonic signals is described, suggesting such a device may enable direct visualization of small vessels from within the lumen of larger vessels such as the portal vein or superior mesenteric vein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Electrical switching of antiferromagnets via strongly spin-orbit coupled materials

Journal of Applied Physics, 121(2), 023907.

By: X. Li n, X. Duan n, Y. Semenov n & K. Kim n

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

First-in-Human Study of Acoustic Angiography in the Breast and Peripheral Vasculature

Ultrasound in Medicine & Biology, 43(12), 2939–2946.

By: S. Shelton n, B. Lindsey n, P. Dayton n & Y. Lee*

author keywords: Contrast-enhanced ultrasound; Breast imaging; Angiography; Superharmonic; Microbubble; Micro-vasculature; Dual frequency
MeSH headings : Acoustics; Angiography; Breast / anatomy & histology; Breast / blood supply; Contrast Media; Feasibility Studies; Female; Fluorocarbons; Hand / anatomy & histology; Hand / blood supply; Humans; Image Enhancement / methods; Male; Microbubbles; Reference Values; Sensitivity and Specificity; Ultrasonography / methods; Wrist / anatomy & histology; Wrist / blood supply
TL;DR: The translation of a contrast-enhanced ultrasound technique, acoustic angiography, to human imaging is described and results indicate that sensitivity and spatial resolution are sufficient to image vessels as small as 0.2 mm in diameter at depths of ~15‬mm in the human breast. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography

ANNALS OF BIOMEDICAL ENGINEERING, 45(4), 939–948.

By: B. Lindsey n, S. Shelton n, K. Martin n, K. Ozgun n, J. Rojas n, F. Foster*, P. Dayton*

author keywords: Ultrasound; Perfusion; Microbubble; High frequency; Low flow imaging; Quantitative imaging; Angiogenesis; Superharmonic
MeSH headings : Angiography / methods; Animals; Chick Embryo; Chorioallantoic Membrane / blood supply; Chorioallantoic Membrane / diagnostic imaging; Contrast Media / pharmacology; Microbubbles / therapeutic use; Perfusion Imaging / methods; Ultrasonography / methods
TL;DR: The feasibility of dynamic contrast-enhanced superharmonic perfusion imaging at low flow rates is demonstrated and the feasibility of quantitatively mapping perfusion rate in 2D in a mouse model with spatial resolution of ~100 μm is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis

SCIENTIFIC REPORTS, 7.

By: J. Kim n, B. Lindsey n, W. Chang n, X. Dai*, J. Stavas*, P. Dayton n, X. Jiang*

MeSH headings : Humans; Microbubbles; Thrombolytic Therapy / instrumentation; Thrombolytic Therapy / methods; Transducers; Ultrasonic Waves
TL;DR: It is hypothesized that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

OPTIMIZING SENSITIVITY OF ULTRASOUND CONTRAST-ENHANCED SUPER-RESOLUTION IMAGING BY TAILORING SIZE DISTRIBUTION OF MICROBUBBLE CONTRAST AGENT

ULTRASOUND IN MEDICINE AND BIOLOGY, 43(10), 2488–2493.

By: F. Lin n, J. Tsuruta n, J. Rojas n & P. Dayton n

author keywords: Super resolution; Microbubble contrast agent; Sensitivity; Size distribution
MeSH headings : Animals; Contrast Media; Disease Models, Animal; Female; Fibrosarcoma / blood supply; Fibrosarcoma / diagnostic imaging; Image Enhancement / methods; Microbubbles; Microvessels / diagnostic imaging; Particle Size; Phantoms, Imaging; Rats; Rats, Inbred F344; Ultrasonography / methods
TL;DR: Experiments in phantom vessels and in vivo experiments imaging rat tumors revealed that the sensitivity of contrast-enhanced super-resolution imaging can be improved by using microbubbles with a larger diameter. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Optimizing Acoustic Activation of Phase Change Contrast Agents With the Activation Pressure Matching Method: A Review

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 64(1), 264–272.

By: J. Rojas n & P. Dayton n

author keywords: Acoustic droplet vaporization (ADV); activation pressure matching (APM); nanodroplet; optimized droplet activation; perfluorocarbon (PFC); phase change contrast agents (PCCAs)
MeSH headings : Animals; Contrast Media / chemistry; Fluorocarbons / chemistry; Image Processing, Computer-Assisted; Kidney / diagnostic imaging; Microbubbles; Pressure; Rats; Transducers; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR: This paper discusses the application of this method with a Verasonics V1 Research Ultrasound System to modulate the output pressure from an ATL L11-5 transducer and demonstrates the feasibility of this approach both in vivo and in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Optimizing ultrasound molecular imaging of secreted frizzled related protein 2 expression in angiosarcoma

PLOS ONE, 12(3).

By: J. Tsuruta n, N. Schaub*, J. Rojas n, J. Streeter n, N. Klauber-DeMore* & P. Dayton n

MeSH headings : Animals; Avidin / metabolism; Biomarkers, Tumor / metabolism; Cell Line, Tumor; Contrast Media / metabolism; Hemangiosarcoma / metabolism; Humans; Membrane Proteins / metabolism; Membrane Proteins / ultrastructure; Mice, Nude; Microbubbles; Molecular Imaging / methods; Neoplasm Transplantation; Ultrasonography / methods
TL;DR: Basing the targeted contrast on NeutrAvidin™-functionalized microbubbles, using IgY antibodies for the authors' control contrast, and optimizing the imaging protocol significantly increased the SFRP2-specific signal returned from angiosarcoma vasculature, and may provide new opportunities for targeted molecular imaging. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 conference paper

A dual-frequency co-linear array for prostate acoustic angiography

2016 ieee international ultrasonics symposium (ius).

By: S. Li n, J. Kim n, Z. Wang n, X. Jiang n, S. Kasoji n, B. Lindsey n, P. Dayton n

TL;DR: The development of a dual layer co-linear array ultrasound transducer for transrectal acoustic angiography is described, suggesting that the prototype co- linear array is capable of performing dual-frequency superharmonic imaging of microbubbles for prostate cancer assessment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2016 conference paper

A dual-frequency endoscopic transducer for imaging vascular invasion in pancreatic cancer

2016 ieee international ultrasonics symposium (ius).

By: B. Lindsey*, P. Dayton*, J. Kim n & X. Jiang n

TL;DR: The development of a single element dual-frequency transducer for rotational endoscopic imaging designed to operate at 4/20 MHz to image microbubble superharmonics is described, suggesting such a device may be suitable for direct visualization of small vessels from within the lumen of larger vessels such as the portal vein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2016 article

Acoustic angiography: A new high frequency contrast ultrasound technique for biomedical imaging

SENSING AND ANALYSIS TECHNOLOGIES FOR BIOMEDICAL AND COGNITIVE APPLICATIONS 2016, Vol. 9871.

author keywords: Ultrasound; contrast agent; microbubble; microvasculature; angiogenesis; broadband; superharmonic; transducer; dual-frequency; acoustic angiography
TL;DR: Data shows that acoustic angiography can provide important information about the presence of disease based on vascular patterns, and may enable a new paradigm in medical imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Adaptive windowing in contrast-enhanced intravascular ultrasound imaging

ULTRASONICS, 70, 123–135.

By: B. Lindsey n, K. Martin n, X. Jiang n & P. Dayton n

author keywords: Intravascular ultrasound; Contrast-enhanced ultrasound; Adaptive beamforming; Phase coherence factor; High frequency ultrasound; Superharmonic
MeSH headings : Algorithms; Animals; Atherosclerosis / diagnostic imaging; Chick Embryo; Computer Simulation; Contrast Media; Data Interpretation, Statistical; Image Enhancement / methods; Image Interpretation, Computer-Assisted / methods; Models, Statistical; Phantoms, Imaging; Reproducibility of Results; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Swine; Ultrasonography, Interventional / instrumentation; Ultrasonography, Interventional / methods; Vasa Vasorum / diagnostic imaging
TL;DR: Applying signal processing approaches based on minimum variance (MV) beamforming and the phase coherence factor (PCF) for improving the spatial resolution and contrast-to-tissue ratio (CTR) in IVUS imaging can enhance image quality in conventional B-mode IVUS or in contrast-enhanced IVUS, where signal- to-noise ratio is relatively low and resolution is at a premium. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 conference paper

Adaptive windowing in mechanically-steered intravascular ultrasound imaging: Ex vivo and in vivo studies with contrast enhancement

2016 ieee international ultrasonics symposium (ius).

By: B. Lindsey*, P. Dayton* & X. Jiang n

TL;DR: Processing techniques for improving spatial resolution and image contrast in mechanically steered ultrasound imaging based on minimum variance (MV) beamforming and the phase coherence factor (PCF) are presented and may improve image quality in both conventional B-mode IVUS and contrast-enhanced IVUS. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

An Integrated System for Superharmonic Contrast-Enhanced Ultrasound Imaging: Design and Intravascular Phantom Imaging Study

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 63(9), 1933–1943.

By: Y. Li*, J. Ma n, K. Martin n, M. Yu*, T. Ma*, P. Dayton n, X. Jiang n, K. Shung*, Q. Zhou*

author keywords: Acoustic angiography; biomedical electronics; field-programmable gate arrays (FPGA); intravascular ultrasound (IVUS); microbubble contrast agent (MCA); ultrasonic imaging; ultrasonic transducer
MeSH headings : Arteries / diagnostic imaging; Contrast Media; Elasticity Imaging Techniques / instrumentation; Elasticity Imaging Techniques / methods; Equipment Design; Equipment Failure Analysis; Humans; Image Enhancement / instrumentation; Image Enhancement / methods; Phantoms, Imaging; Reproducibility of Results; Sensitivity and Specificity; Signal Processing, Computer-Assisted / instrumentation; Systems Integration; Ultrasonography, Interventional / instrumentation; Ultrasonography, Interventional / methods
TL;DR: The system greatly reduced the cost and complexity of the superharmonic imaging intended for preclinical study and showed promise for high-contrast intravascular microvascular imaging, which may have significant importance in assessment of the vasa vasorum associated with atherosclerotic plaques. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

FEASIBILITY AND SAFETY OF CONTRAST-ENHANCED ULTRASOUND IN THE DISTAL LIMB OF SIX HORSES

VETERINARY RADIOLOGY & ULTRASOUND, 57(3), 282–289.

By: G. Seiler n, N. Campbell n, B. Nixon n, J. Tsuruta n, P. Dayton n, S. Jennings*, W. Redding n, M. Lustgarten n

author keywords: contrast-enhanced; equine intra-arterial; ultrasound
MeSH headings : Animals; Contrast Media / administration & dosage; Contrast Media / adverse effects; Female; Hindlimb / diagnostic imaging; Horses; Injections, Intra-Arterial / veterinary; Injections, Intravenous / veterinary; Male; Muscle, Skeletal / diagnostic imaging; Pilot Projects; Prospective Studies; Ultrasonography / adverse effects; Ultrasonography / veterinary
TL;DR: Findings from this study indicated that CEUS is a feasible and safe diagnostic test for evaluation of the equine distal limb and future studies are needed to assess the clinical utility of this test for horses with musculoskeletal diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Intracellular delivery and ultrasonic activation of folate receptor-targeted phase-change contrast agents in breast cancer cells in vitro

JOURNAL OF CONTROLLED RELEASE, 243, 69–77.

By: J. Marshalek*, P. Sheeran*, P. Ingram*, P. Dayton n, R. Witte* & T. Matsunaga*

author keywords: Ultrasound; Phase-change contrast agent; Microbubble; Nanodroplet; Perfluorocarbon; Decafluorobutane; Octafluoropropane; Folate receptor; Breast cancer
MeSH headings : Breast Neoplasms / diagnostic imaging; Breast Neoplasms / metabolism; Cell Line, Tumor; Contrast Media / administration & dosage; Drug Delivery Systems; Female; Fluorocarbons / chemistry; Folate Receptors, GPI-Anchored / metabolism; Humans; MCF-7 Cells; Microscopy, Confocal; Particle Size; Tissue Distribution; Ultrasonics / methods
TL;DR: Evidence for the intracellular delivery and ultrasound-stimulated activation of folate receptor (FR)-targeted phase-change contrast agents (PCCAs) in MDA-MB-231 and MCF-7 breast cancer cells in vitro is presented. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 conference paper

Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis

2016 ieee international ultrasonics symposium (ius).

By: J. Kim n, W. Chang n, B. Lindsey*, P. Dayton*, X. Dai*, J. Stavas*, X. Jiang*

TL;DR: In vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision highLytic rate sonothrombolysis. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

MOLECULAR ACOUSTIC ANGIOGRAPHY: A NEW TECHNIQUE FOR HIGH-RESOLUTION SUPERHARMONIC ULTRASOUND MOLECULAR IMAGING

ULTRASOUND IN MEDICINE AND BIOLOGY, 42(3), 769–781.

author keywords: Microbubble; Targeted imaging; Angiogenesis; Microvasculature; Biomarker
MeSH headings : Angiography; Animals; Cell Line, Tumor; Contrast Media / pharmacokinetics; Elasticity Imaging Techniques / instrumentation; Elasticity Imaging Techniques / methods; Equipment Design; Equipment Failure Analysis; Fibrosarcoma / diagnostic imaging; Fibrosarcoma / metabolism; Fluorocarbons; Image Enhancement / instrumentation; Image Enhancement / methods; Image Interpretation, Computer-Assisted / instrumentation; Image Interpretation, Computer-Assisted / methods; Integrin alphaVbeta3 / metabolism; Molecular Imaging; Oligopeptides / pharmacokinetics; Phantoms, Imaging; Rats; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution
TL;DR: The combined information provided by these scans may present new opportunities for analyzing relationships between microvascular anatomy and vascular targets, subject only to limitations of the current mechanically scanned system and microbubble persistence to repeated imaging at moderate mechanical indices. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 conference paper

Molecular acoustic angiography: Comparison of contrast-to-tissue ratio with multi-pulse techniques and imaging multiple targeted microbubbles

2016 IEEE International Ultrasonics Symposium (IUS). Presented at the 2016 IEEE International Ultrasonics Symposium (IUS).

By: S. Shelton n, B. Lindsey n, P. Dayton n & F. Foster*

Event: 2016 IEEE International Ultrasonics Symposium (IUS)

TL;DR: The contrast-to-tissue ratio (CTR) between superharmonic and multi-pulse molecular imaging is compared and images of microbubbles targeted to different biomarkers expressed by the vascular endothelial cells are presented. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Targeted Transthoracic Acoustic Activation of Systemically Administered Nanodroplets to Detect Myocardial Perfusion Abnormalities

CIRCULATION-CARDIOVASCULAR IMAGING, 9(1).

By: T. Porter n, C. Arena n, S. Sayyed n, J. Lof n, R. High n, F. Xie n, P. Dayton n

author keywords: acoustic activation; angiography; echocardiography; fluorocarbons; perfusion
MeSH headings : Animals; Contrast Media / administration & dosage; Contrast Media / chemistry; Contrast Media / pharmacology; Echocardiography / methods; Fluorocarbons / administration & dosage; Fluorocarbons / chemistry; Fluorocarbons / pharmacology; Gadolinium DTPA / administration & dosage; Gadolinium DTPA / chemistry; Gadolinium DTPA / pharmacology; Magnetic Resonance Imaging; Microcirculation; Myocardial Infarction / diagnostic imaging; Nanostructures / administration & dosage; Nanostructures / chemistry; Staining and Labeling; Swine; Transducers
TL;DR: Targeted transthoracic acoustic activation of infused intravenous C3 nanodroplets is effective, resulting in echogenic and persistent microbubbles which provide real-time high MI visualization of perfusion defects. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

The "Fingerprint" of Cancer Extends Beyond Solid Tumor Boundaries: Assessment With a Novel Ultrasound Imaging Approach

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 63(5), 1082–1086.

By: S. Rao n, S. Shelton n & P. Dayton

author keywords: Acoustic angiography; angiogenesis; spatial heterogeneity; tortuosity; ultrasound
MeSH headings : Angiography; Animals; Image Interpretation, Computer-Assisted / methods; Imaging, Three-Dimensional / methods; Mice; Microvessels / diagnostic imaging; Neoplasms / blood supply; Neoplasms / diagnostic imaging; Neovascularization, Pathologic / diagnostic imaging; Ultrasonography / methods
TL;DR: Visualization of abnormal vascular tortuosity may make acoustic angiography an invaluable tool for early tumor detection based on quantifying the vascular footprint of small tumors and a sensitive method for understanding changes in the vascular microenvironment during tumor progression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 conference paper

The application of acoustic angiography to assess the progression of angiogenesis in a spontaneous mouse model of breast cancer

2016 IEEE International Ultrasonics Symposium (IUS). Presented at the 2016 IEEE International Ultrasonics Symposium (IUS).

By: S. Shelton n, P. Dayton n, S. Aylward & F. Foster*

Event: 2016 IEEE International Ultrasonics Symposium (IUS)

TL;DR: Results indicate that acoustic angiography images can reveal microvasculature in sufficient detail for vascular morphology to be used as a biomarker for cancer imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Wideband acoustic activation and detection of droplet vaporization events using a capacitive micromachined ultrasonic transducer

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 139(6), 3193–3198.

By: A. Novell n, C. Arena n, O. Oralkan n & P. Dayton n

MeSH headings : Contrast Media / chemistry; Equipment Design; Fluorocarbons / chemistry; Lipids / chemistry; Microbubbles; Time Factors; Transducers; Ultrasonography / instrumentation; Volatilization
TL;DR: This study exploited the wide bandwidth of a 128-element capacitive micromachined ultrasonic transducer array for activation and real-time imaging of ADV events from droplets circulating in a tube to provide a substantial increase of the contrast-to-noise ratio. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

A 3 MHz/18 MHz Dual-layer Co-Linear Array for Transrectal Acoustic Angiography

2015 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS).

By: S. Li n, J. Kim n, Z. Wang n, X. Jiang n, S. Kasoji n, B. Lindsey n, P. Dayton n

author keywords: acoustic angiography; dual frequency; ultrasound contrast agent; transrectal ultrasound; prostate cancer
TL;DR: Results suggest that the prototyped co-linear array is capable of performing dual-frequency superharmonic imaging of microbubbles (“acoustic angiography”) for prostate cancer assessment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Cavitation Enhancing Nanodroplets Mediate Efficient DNA Fragmentation in a Bench Top Ultrasonic Water Bath

PLOS ONE, 10(7).

By: S. Kasoji n, S. Pattenden*, E. Malc*, C. Jayakody*, J. Tsuruta n, P. Mieczkowski*, W. Janzen*, P. Dayton n

MeSH headings : DNA Fragmentation / radiation effects; DNA, Fungal; Microbubbles; Sonication / instrumentation; Sonication / methods
TL;DR: A perfluorocarbon nanodroplet formulation is shown to be an effective cavitation enhancement agent, enabling rapid and consistent fragmentation of genomic DNA in a standard ultrasonic water bath, and enables widespread access to fast bench-top genomic DNA fragmentation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Dual-Frequency Acoustic Droplet Vaporization Detection for Medical Imaging

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 62(9), 1623–1633.

By: C. Arena n, A. Novell n, P. Sheeran n, C. Puett n, L. Moyer n & P. Dayton n

MeSH headings : Fluorocarbons / chemistry; Microbubbles; Microscopy, Acoustic / methods; Phantoms, Imaging; Transducers; Ultrasonography / methods
TL;DR: Results indicate that it is possible to generate high-sensitivity, high-contrast images of vaporization events and has the potential to be applied in combination with dropletmediated therapy to track treatment outcomes or as a standalone diagnostic system to monitor the physical properties of the surrounding environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Dual-frequency Super Harmonic Imaging Piezoelectric Transducers for Transrectal Ultrasound

HEALTH MONITORING OF STRUCTURAL AND BIOLOGICAL SYSTEMS 2015, Vol. 9438.

By: J. Kim n, S. Li n, S. Kasoji n, P. Dayton n & X. Jiang n

author keywords: Dual-frequency transducer; transrectal ultrasound; prostate probe; super-harmonic imaging; contrast imaging; mode coupling
TL;DR: Two dual-frequency transducers were developed for contrast enhanced super-harmonic ultrasound imaging of prostate cancer with the low frequency ultrasound transducer as a transmitter for contrast agent (microbubble) excitation and the high frequency transducher as a receiver for detection of nonlinear responses from microbubbles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

ON THE RELATIONSHIP BETWEEN MICROBUBBLE FRAGMENTATION, DEFLATION AND BROADBAND SUPERHARMONIC SIGNAL PRODUCTION

ULTRASOUND IN MEDICINE AND BIOLOGY, 41(6), 1711–1725.

By: B. Lindsey, J. Rojas* & P. Dayton*

author keywords: Contrast agent; Microbubble; Harmonic; Superharmonic; Cavitation; Acoustic angiography; Dual frequency
MeSH headings : Acoustics; Angiography / methods; Animals; Contrast Media / chemistry; Kidney / blood supply; Kidney / diagnostic imaging; Microbubbles; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Signal-To-Noise Ratio; Ultrasonography
TL;DR: Although the existence of superharmonic signals when bubbles shrink has the potential to prolong the imaging efficacy of microbubbles, parameters such as frame rate and peak pressure must be balanced with expected re-perfusion rate to maintain adequate contrast during in vivo imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Optimization of Contrast-to-Tissue Ratio Through Pulse Windowing in Dual-Frequency “Acoustic Angiography” Imaging

Ultrasound in Medicine & Biology, 41(7), 1884–1895.

By: B. Lindsey n, S. Shelton n & P. Dayton n

author keywords: Microbubbles; Superharmonic; Harmonic; Pulse shape; Pulse window; High-frequency ultrasound; Acoustic angiography; Contrast agent
TL;DR: In this study, shaped transmit pulses were used to image the higher broadband harmonic echoes of microbubble contrast agents, and the effects of varying pulse window and phasing on microbubbles and tissue harmonic echoes were evaluated using a dual-frequency transducer in vitro and in vivo. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Optimization of multi-pulse sequences for nonlinear contrast agent imaging using a cMUT array

PHYSICS IN MEDICINE AND BIOLOGY, 60(8), 3111–3127.

By: A. Novell n, C. Arena n, S. Kasoji n & P. Dayton n

author keywords: bias voltage; chirp; cMUT; contrast agent; microbubbles; multi-pulse sequence; nonlinearity
MeSH headings : Diagnostic Imaging; Electric Capacitance; Humans; Image Enhancement / instrumentation; Image Enhancement / methods; Image Processing, Computer-Assisted / methods; Micro-Electrical-Mechanical Systems / instrumentation; Microbubbles; Phantoms, Imaging; Transducers; Ultrasonography / instrumentation
TL;DR: This study proposes to optimize contrast agent detection by combining the BVM sequence with PI and/or chirp reversal (CR) and results in a significant increase of the contrast-to-noise ratio. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Phantom evaluation of stacked-type dual-frequency 1-3 composite transducers: A feasibility study on intracavitary acoustic angiography

ULTRASONICS, 63, 7–15.

By: J. Kim n, S. Li n, S. Kasoji n, P. Dayton n & X. Jiang n

author keywords: Dual-frequency transducer; 1-3 composite transducer; Superharmonic imaging; Ultrasound contrast agents; Intracavitary probe
MeSH headings : Acoustics; Angiography / instrumentation; Contrast Media; Equipment Design; Feasibility Studies; Humans; Image Enhancement / methods; Microbubbles; Phantoms, Imaging; Signal-To-Noise Ratio; Transducers; Ultrasonography, Interventional / instrumentation; Ultrasonography, Interventional / methods
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

QUANTIFICATION OF MICROVASCULAR TORTUOSITY DURING TUMOR EVOLUTION USING ACOUSTIC ANGIOGRAPHY

ULTRASOUND IN MEDICINE AND BIOLOGY, 41(7), 1896–1904.

By: S. Shelton n, Y. Lee*, M. Lee*, E. Cherin*, F. Foster*, S. Aylward, P. Dayton n

author keywords: Tortuosity; Contrast agent; Microbubble; Ultrasound; Acoustic angiography; Microvasculature; Angiogenesis; Superharmonic imaging
MeSH headings : Algorithms; Angiography / methods; Animals; Breast Neoplasms / blood supply; Breast Neoplasms / complications; Breast Neoplasms / pathology; Elasticity Imaging Techniques / methods; Female; Humans; Image Enhancement / methods; Image Interpretation, Computer-Assisted / methods; Male; Mice; Microvessels / diagnostic imaging; Neovascularization, Pathologic / complications; Neovascularization, Pathologic / pathology; Reproducibility of Results; Sensitivity and Specificity
TL;DR: Quantitative morphologic analysis of tumor vessels revealed significantly increased vascular tortuosity abnormalities associated with tumor growth, with the distance metric elevated approximately 14% and the sum of angles metric increased 60% in tumor vessels versus controls. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 review

Therapeutic gas delivery via microbubbles and liposomes

[Review of ]. JOURNAL OF CONTROLLED RELEASE, 209, 139–149.

By: S. Fix*, M. Borden* & P. Dayton n

author keywords: Microbubble; Liposome; Oxygen; Nitric oxide; Xenon; Ultrasound
MeSH headings : Animals; Humans; Liposomes; Microbubbles; Nitric Oxide / administration & dosage; Nitric Oxide / therapeutic use; Oxygen / administration & dosage; Oxygen / therapeutic use; Xenon / administration & dosage; Xenon / therapeutic use
TL;DR: A review provides a summary of recent advances in therapeutic gas delivery using microbubbles and liposomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Acoustic Characterization of Contrast-to-issue Ratio and Axial Resolution for Dual-Frequency Contrast-Specific Acoustic Angiography Imaging

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 61(10), 1668–1687.

By: B. Lindsey n, J. Rojas n, K. Martin n, S. Shelton n & P. Dayton n

MeSH headings : Angiography / methods; Animals; Cattle; Contrast Media / chemistry; Iliac Artery / diagnostic imaging; Mice; Microbubbles; Muscles / diagnostic imaging; Particle Size; Pressure; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Signal-To-Noise Ratio; Transducers; Ultrasonography, Interventional / instrumentation; Ultrasonography, Interventional / methods
TL;DR: CTR dependence on transmit frequency and peak pressure were confirmed through in vivo imaging in two rodents and may lead to improved imaging of vascular remodeling in superficial or luminal cancers such as those of the breast, prostate, and colon. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

An array transmitter for dual-frequency contrast enhanced intravascular ultrasound imaging

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 2104–2107.

By: Z. Wang n, J. Ma n, X. Jiang n, K. Martin n & P. Dayton n

author keywords: contrast ultrasound; transmitting array transducer; angiography lateral mode transducer; superharmonic; acoustic angiography
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 review

Dual-Frequency Piezoelectric Transducers for Contrast Enhanced Ultrasound Imaging

[Review of ]. SENSORS, 14(11), 20825–20842.

By: K. Martin n, B. Lindsey n, J. Ma n, M. Lee*, S. Li n, F. Foster*, X. Jiang n, P. Dayton n

author keywords: acoustics; acoustic angiography; dual-frequency; superharmonic; harmonic; broadband; microbubbles
MeSH headings : Aircraft / instrumentation; Contrast Media; Equipment Design; Equipment Failure Analysis; Image Enhancement / instrumentation; Materials Testing / instrumentation; Micro-Electrical-Mechanical Systems / instrumentation; Miniaturization; Radio Waves; Reproducibility of Results; Sensitivity and Specificity; Transducers; Ultrasonography / instrumentation
TL;DR: The background principles and recent developments of ultrasound transducer technology for receiving signals produced by contrast agents while rejecting signals arising from soft tissue are described and this approach relies on transmitting at a low-frequency and receiving microbubble harmonic signals at frequencies many times higher than the transmitted frequency. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 article

Dynamics of volatile phase-change contrast agents: Theoretical model and experimental measurements

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 2273–2276.

author keywords: contrast agent; acoustic droplet vaporization; perfluorocarbon; ultrasound imaging; modeling
TL;DR: A new theoretical model is reported on that describes the conversion of a PFC droplet into a vapor bubble and subsequent bubble evolution and is validated by comparison with in vitro experimental data acquired by ultra-high-speed video microscopy for decafluorobutane (DFB) and octafLUoropropane (OFP) microdroplets of different sizes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Evaluation of bias voltage modulation sequence for nonlinear contrast agent imaging using a capacitive micromachined ultrasonic transducer array

PHYSICS IN MEDICINE AND BIOLOGY, 59(17), 4879–4896.

By: A. Novell n, M. Legros*, J. Gregoire*, P. Dayton n & A. Bouakaz*

author keywords: amplitude modulation; bias voltage; cMUT; multi-pulse sequence; contrast agent imaging; harmonic; nonlinear behavior
MeSH headings : Algorithms; Contrast Media; Humans; Microbubbles; Phantoms, Imaging; Transducers; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR: A new contrast imaging sequence, called bias voltage modulation (BVM), specifically developed for cMUTs to suppress their inherent nonlinear behavior is proposed, revealing that the problem of cM UT nonlinearity can be addressed, thus expanding the potential of this new transducer technology for nonlinear contrast agent detection and imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 article

In Vivo Quantification of Image Enhancement and Circulation Kinetics for Phase Change Perfluorocarbon Agents Using Custom Pulse Sequences

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 417–420.

By: P. Sheeran n, J. Rojas n, C. Puett n, J. Hjelmquist n, C. Arena n & P. Dayton n

TL;DR: This study develops a custom pulse sequence to vaporize and image droplets using the Verasonics research platform, and demonstrates a novel concept in contrast-enhanced ultrasound: capture of droplet-generated contrast wash-out in the target organ. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 article

Optimization of Contrast-to-tissue Ratio and Role of Bubble Destruction in Dual-Frequency Contrast-Specific "Acoustic Angiography" Imaging

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 1774–1777.

By: B. Lindsey n, J. Rojas n, K. Martin n, S. Shelton n & P. Dayton n

author keywords: superharmonic; microbubble; high frequency ultrasound; cavitation; dual-frequency; contrast-to-tissue ratio
TL;DR: This work examines the imaging parameters for optimizing contrast-to-tissue ratio (CTR) for dual-frequency imaging and the relationship between bubble destruction and broadband harmonic signal production and indicates that superharmonic signals having the broadest bandwidth and highest energy are associated with shell fragmentation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Phase change events of volatile liquid perfluorocarbon contrast agents produce unique acoustic signatures

PHYSICS IN MEDICINE AND BIOLOGY, 59(2), 379–401.

By: P. Sheeran n, T. Matsunaga* & P. Dayton n

MeSH headings : Acoustics; Contrast Media / chemistry; Fluorocarbons / chemistry; Volatilization
TL;DR: This study demonstrates through high-speed video microscopy and US interrogation that PCCAs composed of highly volatile perfluorocarbons (PFCs) exhibit unique acoustic behavior that can be detected and differentiated from standard microbubble contrast agents. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Pulse sequences for uniform perfluorocarbon droplet vaporization and ultrasound imaging

ULTRASONICS, 54(7), 2024–2033.

By: C. Puett n, P. Sheeran n, J. Rojas n & P. Dayton n

author keywords: Phase-change; Ultrasound contrast agent; Perfluorocarbon; Vaporization
MeSH headings : Acoustics; Animals; Contrast Media / chemistry; Fluorocarbons / chemistry; Kidney / diagnostic imaging; Microbubbles; Rats; Rats, Inbred F344; Transducers; Ultrasonography; Volatilization
TL;DR: The development and evaluation of protocols for PCCA-enhanced ultrasound imaging using a commercial array transducer are described and pulse sequences designed to manipulate the geometries of discrete microbubble clouds using electronic steering and cloud spacing were tailored to build a uniform vaporization field. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 article

Ultrasound Imaging from Vaporization Signals Emitted by Phase Change Contrast Agents

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 1778–1781.

By: C. Arena n, A. Novell n, P. Sheeran n, C. Puett n, L. Phillips n & P. Dayton n

author keywords: acoustic droplet vaporization; contrast enhanced ultrasound; nanodroplet; nanoemulsion; perfluorocarbon
TL;DR: It is demonstrated that this event can be used to generate an ultrasound image, and that the signal can be separated from that of a conventional microbubble. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Vaporization dynamics of volatile perfluorocarbon droplets: A theoretical model and in vitro validation

MEDICAL PHYSICS, 41(10).

By: A. Doinikov*, P. Sheeran n, A. Bouakaz* & P. Dayton n

author keywords: ultrasound imaging; ultrasound contrast agent; acoustic droplet vaporization; perfluorocarbon; theoretical model
MeSH headings : Acoustic Stimulation; Acoustics; Algorithms; Computer Simulation; Contrast Media / chemistry; Fluorocarbons / chemistry; Gases / chemistry; Hydrodynamics; Microfluidics; Microscopy, Video; Models, Theoretical; Thermodynamics; Volatilization
TL;DR: An improved theoretical model is developed that allows one to simulate the growth of a vapor bubble inside a PFC droplet until the liquid PFC is completely converted into vapor, and the subsequent overexpansion and damped oscillations of the vapor bubble, including the influence of an externally applied acoustic pulse. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Vascular channels formed by subpopulations of PECAM1+ melanoma cells

Nature Communications, 5(1).

By: J. Dunleavey*, L. Xiao*, J. Thompson*, M. Kim*, J. Shields*, S. Shelton n, D. Irvin*, V. Brings* ...

MeSH headings : Angiogenesis Inhibitors / chemistry; Animals; Cell Line, Tumor; Female; Flow Cytometry; Green Fluorescent Proteins / metabolism; Humans; Melanoma / metabolism; Melanoma, Experimental / metabolism; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic / metabolism; Platelet Endothelial Cell Adhesion Molecule-1 / metabolism; RNA, Small Interfering / metabolism; Skin Neoplasms / metabolism; Transcription Factor AP-2 / metabolism; Up-Regulation; Vascular Endothelial Growth Factor A / metabolism; Vascular Endothelial Growth Factor Receptor-2 / metabolism
TL;DR: VM-competent subpopulations, rather than all cells within a tumour, may instigate VM, supplant host-derived endothelium, and form PECAM1-dependent conduits that are not diminished by neutralizing VEGF. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

A Comparative Evaluation of Ultrasound Molecular Imaging, Perfusion Imaging, and Volume Measurements in Evaluating Response to Therapy in Patient-Derived Xenografts

TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 12(4), 311–321.

By: J. Streeter n, S. Herrera-Loeza*, N. Neel*, J. Yeh* & P. Dayton n

author keywords: Ultrasound; 3-D; Microbubbles; Molecular imaging; Perfusion imaging; Response to therapy
MeSH headings : Animals; Azepines / therapeutic use; Contrast Media; Humans; Imaging, Three-Dimensional; Mice; Molecular Imaging / methods; Perfusion Imaging / methods; Pyrimidines / therapeutic use; Tumor Burden; Ultrasonics; Xenograft Model Antitumor Assays
TL;DR: The data suggests that volumetric USMI and DCE-PI may be used to earlier classify and robustly characterize tumor response in two different types of patient-derived xenografts. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

A system for acoustical and optical analysis of encapsulated microbubbles at ultrahigh hydrostatic pressures

REVIEW OF SCIENTIFIC INSTRUMENTS, 84(5).

By: A. Zhushma*, N. Lebedeva, P. Sen*, M. Rubinstein*, S. Sheiko* & P. Dayton n

MeSH headings : Acoustics / instrumentation; Capsules; Equipment Design; Hydrostatic Pressure; Microbubbles; Optical Phenomena
TL;DR: The design and application of a high-pressure cell designed for acoustical and optical studies of microbubbles at hydrostatic pressures up to 27.5 MPa (271 atm) are presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

An In Vivo Evaluation of the Effect of Repeated Administration and Clearance of Targeted Contrast Agents on Molecular Imaging Signal Enhancement

THERANOSTICS, 3(2), 93–98.

By: J. Streeter n & P. Dayton n

author keywords: Microbubble; Contrast Agents; Molecular Imaging; Ultrasound; Targeted; cRGD
MeSH headings : Animals; Contrast Media / administration & dosage; Contrast Media / pharmacokinetics; Disease Models, Animal; Fibrosarcoma / diagnosis; Fibrosarcoma / diagnostic imaging; Imaging, Three-Dimensional; Molecular Imaging / methods; Rats; Rats, Inbred F344; Ultrasonography / methods
TL;DR: Data suggest that multiple injections of targeted microbubbles do not block sufficient binding sites to bias molecular imaging data in serial studies, and repeated administration and clearance of targeted agents has on successive adhesion. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 review

Current status and prospects for microbubbles in ultrasound theranostics

[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 5(4), 329–345.

By: K. Martin n & P. Dayton n

MeSH headings : Humans; Microbubbles / therapeutic use; Microbubbles / trends; Ultrasonics / trends
TL;DR: Encapsulated microbubbles have been developed over the past two decades to provide improvements both in imaging as well as new therapeutic applications, and may be one of the most universal theranostic tools. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Experimental Validation of Displacement Underestimation in ARFI Ultrasound

ULTRASONIC IMAGING, 35(3), 196–213.

author keywords: acoustic radiation force; ARFI; optical tracking; differential motion decorrelation; shearing artifact; displacement underestimation
MeSH headings : Acoustics; Elasticity; Elasticity Imaging Techniques / standards; Image Processing, Computer-Assisted / methods; Microspheres; Motion; Phantoms, Imaging; Reproducibility of Results; Ultrasonics / methods
TL;DR: Optical tracking was utilized to experimentally measure the displacement underestimation achieved by acoustic tracking using a clinical ultrasound system and sets up a framework for future displacement tracking validation studies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Flow-focusing regimes for accelerated production of monodisperse drug-loadable microbubbles toward clinical-scale applications

LAB ON A CHIP, 13(24), 4816–4826.

By: R. Shih*, D. Bardin*, T. Martz*, P. Sheeran n, P. Dayton n & A. Lee*

MeSH headings : Contrast Media / chemistry; Drug Carriers / chemistry; Gases; Microbubbles; Microfluidic Analytical Techniques / methods; Pressure; Time Factors
TL;DR: Analysis and characterization of high-speed dual-layer bubble generation will enable more-predictive production control, at rates practical for in vivo or clinical use, before clinical use can be practical. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

In Vivo Demonstration of Cancer Molecular Imaging with Ultrasound Radiation Force and Buried-Ligand Microbubbles

MOLECULAR IMAGING, 12(6).

By: M. Borden n, J. Streeter n, S. Sirsi n & P. Dayton n

TL;DR: The use of acoustically active buried-ligand microbubbles for ultrasound molecular imaging bridges the demand for low immunogenicity with the necessity of maintaining targeting efficacy and imaging conspicuity in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Microfluidic Fabrication of Stable Gas-Filled Microcapsules for Acoustic Contrast Enhancement

LANGMUIR, 29(40), 12352–12357.

MeSH headings : Acoustics; Capsules; Microfluidics / methods
TL;DR: The gas-filled microcapsules have a solid polymer shell making them resistant to pressure-induced buckling, which makes them more mechanically robust than traditional prestabilized microbubbles; this should increase the potential of their utility for acoustic imaging of porous media with high hydrostatic pressures such as oil reservoirs. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Nanoparticle Delivery Enhancement With Acoustically Activated Microbubbles

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 60(1), 65–77.

By: L. Mullin n, L. Phillips n & P. Dayton n

MeSH headings : Animals; Gene Transfer Techniques; Mice; Microbubbles; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Ultrasonics / methods
TL;DR: The underlying mechanisms of enhanced nanoparticle delivery with ultrasound and microbubbles and various proposed delivery techniques are discussed, including types of nanoparticles currently being investigated in preclinical studies, as well as the general limitations and benefits. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Parallel generation of uniform fine droplets at hundreds of kilohertz in a flow-focusing module

BIOMICROFLUIDICS, 7(3).

By: D. Bardin n, M. Kendall n, P. Dayton n & A. Lee n

TL;DR: This work presents the operation of a parallel module with eight flow-focusing orifices in the dripping regime of droplet formation for the generation of uniform fine droplets at rates in the hundreds of kilohertz, offering a novel means to amass uniformfine droplets in practical amounts to satisfy clinical needs. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Phase-transition thresholds and vaporization phenomena for ultrasound phase-change nanoemulsions assessed via high-speed optical microscopy

PHYSICS IN MEDICINE AND BIOLOGY, 58(13), 4513–4534.

By: P. Sheeran*, T. Matsunaga & P. Dayton*

MeSH headings : Emulsions / analysis; Emulsions / chemistry; Emulsions / radiation effects; Gases / analysis; Gases / chemistry; Gases / radiation effects; High-Energy Shock Waves; Materials Testing / methods; Microscopy, Video / methods; Nanoparticles / chemistry; Nanoparticles / radiation effects; Nanoparticles / ultrastructure; Phase Transition / radiation effects; Radiation Dosage; Sonication / methods
TL;DR: Results show that decafluorobutane nanoemulsions with peak diameters on the order of 200 nm can be optimally vaporized with short pulses using pressures amenable to clinical diagnostic ultrasound machines. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

TOWARD ULTRASOUND MOLECULAR IMAGING WITH PHASE-CHANGE CONTRAST AGENTS: AN IN VITRO PROOF OF PRINCIPLE

ULTRASOUND IN MEDICINE AND BIOLOGY, 39(5), 893–902.

By: P. Sheeran n, J. Streeter n, L. Mullin n, T. Matsunaga* & P. Dayton n

author keywords: Perfluorocarbon droplet; Acoustic droplet vaporization; Molecular imaging; Contrast agent; Phase-change
MeSH headings : Cells, Cultured; Contrast Media / analysis; Contrast Media / chemical synthesis; Endothelial Cells / diagnostic imaging; Female; Fluorocarbons / chemical synthesis; Humans; Molecular Imaging / methods; Pilot Projects; Ultrasonography / methods
TL;DR: A PCCA-based platform for molecular imaging using α(v)β(3)-targeted nanoscale PCCAs composed of low-boiling-point perfluorocarbons is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets

JOURNAL OF CONTROLLED RELEASE, 172(3), 795–804.

By: C. Chen*, P. Sheeran n, S. Wu*, O. Olumolade*, P. Dayton n & E. Konofagou*

author keywords: Acoustically-activated nanodroplets; Phase-shift droplets; Microbubbles; Focused ultrasound; Blood
MeSH headings : Acoustics; Animals; Blood-Brain Barrier / metabolism; Contrast Media / chemistry; Contrast Media / metabolism; Dextrans / administration & dosage; Drug Delivery Systems / methods; Hippocampus / metabolism; Male; Mice; Mice, Inbred C57BL; Nanostructures / chemistry; Sonication / methods
Source: Web Of Science
Added: August 6, 2018

2012 journal article

AN IN VIVO VALIDATION OF THE APPLICATION OF ACOUSTIC RADIATION FORCE TO ENHANCE THE DIAGNOSTIC UTILITY OF MOLECULAR IMAGING USING 3-D ULTRASOUND

ULTRASOUND IN MEDICINE AND BIOLOGY, 38(4), 651–660.

By: R. Gessner n, J. Streeter n, R. Kothadia n, S. Feingold n & P. Dayton n

author keywords: Microbubble; Molecular imaging; Targeted imaging; Radiation force
MeSH headings : Animals; Contrast Media / administration & dosage; Contrast Media / chemical synthesis; Elasticity Imaging Techniques / methods; Equipment Design; Fibrosarcoma / diagnostic imaging; Fibrosarcoma / pathology; Image Enhancement / methods; Imaging, Three-Dimensional / methods; Microbubbles; Molecular Imaging / methods; Rats, Inbred F344; Sensitivity and Specificity; Transducers
TL;DR: This is the first noninvasive in vivo validation of ARF-enhanced MI with an unmodified clinical system and demonstrates that a 78% increase in image intensity from targeted microbubbles can be achieved when using ARF relative to the passive targeting studies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons

BIOMATERIALS, 33(11), 3262–3269.

By: P. Sheeran n, S. Luois*, L. Mullin n, T. Matsunaga* & P. Dayton n

author keywords: Ultrasound; Nanoparticle; Fluorocarbon; Phospholipid; Thermally responsive material; Acoustically responsive material
MeSH headings : Contrast Media / chemical synthesis; Contrast Media / radiation effects; Fluorocarbons / chemistry; Fluorocarbons / radiation effects; Gases / chemical synthesis; Gases / radiation effects; Materials Testing; Nanoparticles / chemistry; Nanoparticles / radiation effects; Phase Transition / radiation effects; Sonication / methods; Transition Temperature; Ultrasonography / methods
TL;DR: The relationship between size, thermal stability and sensitivity to ultrasound as a function of PFC boiling point and ambient temperature is illustrated and the potential for low boiling point PFCs is demonstrated as a useful new class of compounds for activatable agents, which can be tailored to the desired application. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Mapping Microvasculature with Acoustic Angiography Yields Quantifiable Differences between Healthy and Tumor-bearing Tissue Volumes in a Rodent Model

RADIOLOGY, 264(3), 733–740.

By: R. Gessner n, S. Aylward* & P. Dayton n

MeSH headings : Animals; Contrast Media; Disease Models, Animal; Female; Fibrosarcoma / diagnostic imaging; Image Processing, Computer-Assisted; Imaging, Three-Dimensional / methods; Microbubbles; Microcirculation; Neovascularization, Pathologic / diagnostic imaging; Prospective Studies; Rats; Rats, Inbred F344; Transducers; Ultrasonography
TL;DR: Vascular network quantification by using high-spatial-resolution acoustic angiographic images is feasible and suggests that the angiogenic processes associated with tumor development in the models studied result in higher instances of vessel tortuosity near the tumor site. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Microfluidic Generation of Acoustically Active Nanodroplets

SMALL, 8(12), 1876–1879.

By: T. Martz*, D. Bardin*, P. Sheeran n, A. Lee* & P. Dayton n

author keywords: microfluidics; nanodroplets; contrast agents; pressure-controlled flow; biomedical applications
MeSH headings : Acoustics; Drug Delivery Systems; Equipment Design; Fluorocarbons / chemistry; Glycerol / chemistry; Lymphatic System / drug effects; Microfluidic Analytical Techniques; Microfluidics; Microscopy / methods; Microscopy, Electron, Transmission / methods; Nanotechnology / methods; Optics and Photonics / methods; Particle Size; Pressure; Viscosity
TL;DR: A microfluidic approach for the generation of perfluorocarbon nanodroplets as the primary emulsion with diameters as small as 300-400 nm is described, which results in generation of droplets in the sub-micrometer range. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 review

Phase-change contrast agents for imaging and therapy

[Review of ]. Current Pharmaceutical Design, 18(15), 2152–2165.

By: P. Sheeran* & P. Dayton*

MeSH headings : Acoustics; Animals; Contrast Media / chemistry; Drug Design; Emulsions; Humans; Microbubbles; Particle Size; Phase Transition; Ultrasonography / methods; Volatilization
TL;DR: The history of PCCAs, physical mechanisms involved, and proposed applications are discussed with a summary of studies demonstrated in vivo and the need for future studies to characterize potential bioeffects for administration in humans and optimization of ultrasound parameters is discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Theranostic Oxygen Delivery Using Ultrasound and Microbubbles

THERANOSTICS, 2(12), 1174–1184.