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Works (4)
Updated: April 5th, 2024 12:49
2022 article
Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells
Agarwalla, P., Ogunnaike, E. A., Ahn, S., Froehlich, K. A., Jansson, A., Ligler, F. S., … Brudno, Y. (2022, March 24). NATURE BIOTECHNOLOGY, Vol. 3.
MeSH headings : Animals; Antigens, CD19; B-Lymphocytes; Humans; Immunotherapy, Adoptive / methods; Leukocytes, Mononuclear / metabolism; Mice; Receptors, Antigen, T-Cell; T-Lymphocytes
TL;DR:
An implantable Multifunctional Alginate Scaffold for T Cell Engineering and Release (MASTER) that streamlines in vivo CAR-T cell manufacturing and reduces processing time to a single day is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022
2022 journal article
Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 9(187).
MeSH headings : Alginates; Calcium; Immunotherapy, Adoptive; Receptors, Chimeric Antigen; T-Lymphocytes; Tissue Engineering; Tissue Scaffolds
TL;DR:
Dry macroporous alginate scaffolds serve as a cheaper and more convenient alternative to the conventional transduction method for CAR-T cells and are comparable to the transduction efficiency of spinoculation on retronectin-coated plates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 30, 2023
2022 journal article
Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture
ACTA BIOMATERIALIA, 138, 208–217.
author keywords: Alginate; Click chemistry; Bioconjugation; Ionic cross-linking; Drug capture
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 31, 2021
2020 journal article
Scaffold-Mediated Static Transduction of T Cells for CAR-T Cell Therapy
ADVANCED HEALTHCARE MATERIALS, 9(14).
author keywords: alginate scaffold; CAR-T cells; cell therapy; immunotherapy; viral transduction
MeSH headings : Antigens, CD19; Cell- and Tissue-Based Therapy; Humans; Immunotherapy, Adoptive; Receptors, Chimeric Antigen / genetics; T-Lymphocytes
TL;DR:
The data show that macroporous alginate scaffolds serve as an attractive alternative to current transduction protocols and have high potential for clinical translation to genetically modify T cells for adoptive cellular therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 29, 2020
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