Pritha Agarwalla

Works (5)

Updated: April 23rd, 2025 19:47

2024 article

Implantable CAR T cell factories enhance solid tumor treatment

Pandit, S., Agarwalla, P., Song, F., Jansson, A., Dotti, G., & Brudno, Y. (2024, April 15). Biomaterials, Vol. 308.

By: S. Pandit n, P. Agarwalla n, F. Song *, A. Jansson*, G. Dotti* & Y. Brudno n 

author keywords: Biomaterials; CAR T cell; immunotherapy; Cell therapy; implant; porous matrix
MeSH headings : Animals; Humans; Receptors, Chimeric Antigen / immunology; Immunotherapy, Adoptive / methods; Mice; T-Lymphocytes / immunology; Neoplasms / therapy; Neoplasms / immunology; Female; Cell Line, Tumor
topics (OpenAlex): CAR-T cell therapy research; Virus-based gene therapy research; Immunotherapy and Immune Responses
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Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2022 article

Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells

Agarwalla, P., Ogunnaike, E. A., Ahn, S., Froehlich, K. A., Jansson, A., Ligler, F. S., … Brudno, Y. (2022, March 24). Nature Biotechnology, Vol. 3.

By: P. Agarwalla n, E. Ogunnaike *, S. Ahn*, K. Froehlich n, A. Jansson n, F. Ligler n, G. Dotti*, Y. Brudno* 

MeSH headings : Animals; Antigens, CD19; B-Lymphocytes; Humans; Immunotherapy, Adoptive / methods; Leukocytes, Mononuclear / metabolism; Mice; Receptors, Antigen, T-Cell; T-Lymphocytes
topics (OpenAlex): CAR-T cell therapy research; Nanowire Synthesis and Applications; Nanofabrication and Lithography Techniques
TL;DR: An implantable Multifunctional Alginate Scaffold for T Cell Engineering and Release (MASTER) that streamlines in vivo CAR-T cell manufacturing and reduces processing time to a single day is described. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022

2022 article

Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells

VanBlunk, M., Agarwalla, P., Pandit, S., & Brudno, Y. (2022, September 9). Journal of Visualized Experiments, Vol. 9.

By: M. VanBlunk n, P. Agarwalla n, S. Pandit n & Y. Brudno n 

MeSH headings : Alginates; Calcium; Immunotherapy, Adoptive; Receptors, Chimeric Antigen; T-Lymphocytes; Tissue Engineering; Tissue Scaffolds
topics (OpenAlex): CAR-T cell therapy research; Virus-based gene therapy research; Viral Infectious Diseases and Gene Expression in Insects
TL;DR: Dry macroporous alginate scaffolds serve as a cheaper and more convenient alternative to the conventional transduction method for CAR-T cells and are comparable to the transduction efficiency of spinoculation on retronectin-coated plates. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 30, 2023

2021 journal article

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture

Acta Biomaterialia, 138, 208–217.

By: C. Moody n, A. Brown n , N. Massaro n, A. Patel n, P. Agarwalla n, A. Simpson  n, A. Brown, H. Zheng n , J. Pierce n , Y. Brudno n 

author keywords: Alginate; Click chemistry; Bioconjugation; Ionic cross-linking; Drug capture
MeSH headings : Alginates; Cell Adhesion; Hydrogels; Injections; Tissue Engineering
topics (OpenAlex): 3D Printing in Biomedical Research; Hydrogels: synthesis, properties, applications; Tissue Engineering and Regenerative Medicine
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 31, 2021

2020 article

Scaffold‐Mediated Static Transduction of T Cells for CAR‐T Cell Therapy

Agarwalla, P., Ogunnaike, E. A., Ahn, S., Ligler, F. S., Dotti, G., & Brudno, Y. (2020, June 11). Advanced Healthcare Materials, Vol. 9.

By: P. Agarwalla n, E. Ogunnaike *, S. Ahn*, F. Ligler n, G. Dotti* & Y. Brudno n 

author keywords: alginate scaffold; CAR-T cells; cell therapy; immunotherapy; viral transduction
MeSH headings : Antigens, CD19; Cell- and Tissue-Based Therapy; Humans; Immunotherapy, Adoptive; Receptors, Chimeric Antigen / genetics; T-Lymphocytes
topics (OpenAlex): CAR-T cell therapy research; Virus-based gene therapy research; Viral Infectious Diseases and Gene Expression in Insects
TL;DR: The data show that macroporous alginate scaffolds serve as an attractive alternative to current transduction protocols and have high potential for clinical translation to genetically modify T cells for adoptive cellular therapy. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 29, 2020

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