Pritha Agarwalla

Works (5)

Updated: September 4th, 2024 05:01

2024 journal article

Implantable CAR T cell factories enhance solid tumor treatment

BIOMATERIALS, 308.

By: S. Pandit n, P. Agarwalla n, F. Song *, A. Jansson*, G. Dotti* & Y. Brudno n 

author keywords: Biomaterials; CAR T cell; immunotherapy; Cell therapy; implant; porous matrix
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Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2022 article

Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells

Agarwalla, P., Ogunnaike, E. A., Ahn, S., Froehlich, K. A., Jansson, A., Ligler, F. S., … Brudno, Y. (2022, March 24). NATURE BIOTECHNOLOGY, Vol. 3.

By: P. Agarwalla n, E. Ogunnaike *, S. Ahn*, K. Froehlich n, A. Jansson n, F. Ligler n, G. Dotti*, Y. Brudno n 

MeSH headings : Animals; Antigens, CD19; B-Lymphocytes; Humans; Immunotherapy, Adoptive / methods; Leukocytes, Mononuclear / metabolism; Mice; Receptors, Antigen, T-Cell; T-Lymphocytes
TL;DR: An implantable Multifunctional Alginate Scaffold for T Cell Engineering and Release (MASTER) that streamlines in vivo CAR-T cell manufacturing and reduces processing time to a single day is described. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022

2022 journal article

Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 9(187).

By: M. VanBlunk n, P. Agarwalla n, S. Pandit n & Y. Brudno n 

MeSH headings : Alginates; Calcium; Immunotherapy, Adoptive; Receptors, Chimeric Antigen; T-Lymphocytes; Tissue Engineering; Tissue Scaffolds
TL;DR: Dry macroporous alginate scaffolds serve as a cheaper and more convenient alternative to the conventional transduction method for CAR-T cells and are comparable to the transduction efficiency of spinoculation on retronectin-coated plates. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 30, 2023

2021 journal article

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture

Acta Biomaterialia, 138, 208–217.

By: C. Moody n, A. Brown n , N. Massaro n, A. Patel n, P. Agarwalla n, A. Simpson  n, A. Brown n, H. Zheng n , J. Pierce n , Y. Brudno n 

author keywords: Alginate; Click chemistry; Bioconjugation; Ionic cross-linking; Drug capture
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 31, 2021

2020 journal article

Scaffold-Mediated Static Transduction of T Cells for CAR-T Cell Therapy

ADVANCED HEALTHCARE MATERIALS, 9(14).

By: P. Agarwalla n, E. Ogunnaike *, S. Ahn*, F. Ligler n, G. Dotti * & Y. Brudno n 

author keywords: alginate scaffold; CAR-T cells; cell therapy; immunotherapy; viral transduction
MeSH headings : Antigens, CD19; Cell- and Tissue-Based Therapy; Humans; Immunotherapy, Adoptive; Receptors, Chimeric Antigen / genetics; T-Lymphocytes
TL;DR: The data show that macroporous alginate scaffolds serve as an attractive alternative to current transduction protocols and have high potential for clinical translation to genetically modify T cells for adoptive cellular therapy. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 29, 2020

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